FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 6278

FusionGeneSummary for CD81_SUPT16H

check button Fusion gene summary
Fusion gene informationFusion gene name: CD81_SUPT16H
Fusion gene ID: 6278
HgeneTgene
Gene symbol

CD81

SUPT16H

Gene ID

975

11198

Gene nameCD81 moleculeSPT16 homolog, facilitates chromatin remodeling subunit
SynonymsCVID6|S5.7|TAPA1|TSPAN28CDC68|FACTP140|SPT16|SPT16/CDC68
Cytomap

11p15.5

14q11.2

Type of geneprotein-codingprotein-coding
DescriptionCD81 antigen26 kDa cell surface protein TAPA-1CD81 antigen (target of antiproliferative antibody 1)tetraspanin-28tspan-28FACT complex subunit SPT16FACT 140 kDa subunitchromatin-specific transcription elongation factor 140 kDa subunitfacilitates chromatin remodeling 140 kDa subunitfacilitates chromatin transcription complex subunit SPT16hSPT16suppressor of Ty 16 homolo
Modification date2018052320180523
UniProtAcc

P60033

Q9Y5B9

Ensembl transtripts involved in fusion geneENST00000263645, ENST00000492627, 
ENST00000381036, ENST00000526072, 
ENST00000524805, ENST00000481687, 
ENST00000216297, ENST00000555943, 
Fusion gene scores* DoF score11 X 6 X 8=52837 X 4 X 15=2220
# samples 1240
** MAII scorelog2(12/528*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(40/2220*10)=-2.47248777146274
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CD81 [Title/Abstract] AND SUPT16H [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD81

GO:0000187

activation of MAPK activity

14676841

HgeneCD81

GO:0008104

protein localization

14676841

HgeneCD81

GO:0008284

positive regulation of cell proliferation

14676841

HgeneCD81

GO:0030890

positive regulation of B cell proliferation

10400713

HgeneCD81

GO:0043128

positive regulation of 1-phosphatidylinositol 4-kinase activity

14676841

HgeneCD81

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

14676841


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-FG-5963-02ACD81chr11

2418627

+SUPT16Hchr14

21829491

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000263645ENST00000216297CD81chr11

2418627

+SUPT16Hchr14

21829491

-
3UTR-intronENST00000263645ENST00000555943CD81chr11

2418627

+SUPT16Hchr14

21829491

-
intron-intronENST00000492627ENST00000216297CD81chr11

2418627

+SUPT16Hchr14

21829491

-
intron-intronENST00000492627ENST00000555943CD81chr11

2418627

+SUPT16Hchr14

21829491

-
intron-intronENST00000381036ENST00000216297CD81chr11

2418627

+SUPT16Hchr14

21829491

-
intron-intronENST00000381036ENST00000555943CD81chr11

2418627

+SUPT16Hchr14

21829491

-
intron-intronENST00000526072ENST00000216297CD81chr11

2418627

+SUPT16Hchr14

21829491

-
intron-intronENST00000526072ENST00000555943CD81chr11

2418627

+SUPT16Hchr14

21829491

-
intron-intronENST00000524805ENST00000216297CD81chr11

2418627

+SUPT16Hchr14

21829491

-
intron-intronENST00000524805ENST00000555943CD81chr11

2418627

+SUPT16Hchr14

21829491

-
intron-intronENST00000481687ENST00000216297CD81chr11

2418627

+SUPT16Hchr14

21829491

-
intron-intronENST00000481687ENST00000555943CD81chr11

2418627

+SUPT16Hchr14

21829491

-

Top

FusionProtFeatures for CD81_SUPT16H


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD81

P60033

SUPT16H

Q9Y5B9

May play an important role in the regulation of lymphomacell growth. Interacts with a 16-kDa Leu-13 protein to form acomplex possibly involved in signal transduction. May act as theviral receptor for HCV. (Microbial infection) Acts as a receptor for hepatitis Cvirus (HCV) in hepatocytes. Associates with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell.{ECO:0000269|PubMed:20375010, ECO:0000269|PubMed:21516087}. Component of the FACT complex, a general chromatinfactor that acts to reorganize nucleosomes. The FACT complex isinvolved in multiple processes that require DNA as a template suchas mRNA elongation, DNA replication and DNA repair. Duringtranscription elongation the FACT complex acts as a histonechaperone that both destabilizes and restores nucleosomalstructure. It facilitates the passage of RNA polymerase II andtranscription by promoting the dissociation of one histone H2A-H2Bdimer from the nucleosome, then subsequently promotes thereestablishment of the nucleosome following the passage of RNApolymerase II. The FACT complex is probably also involved inphosphorylation of 'Ser-392' of p53/TP53 via its association withCK2 (casein kinase II). {ECO:0000269|PubMed:10912001,ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006,ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704,ECO:0000269|PubMed:9836642}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CD81_SUPT16H


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CD81_SUPT16H


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CD81DLG5, INO80B, ZBTB16, KIT, CD9, CD46, CD19, CR2, TSPAN4, ITGA4, ITGB1, PTGFRN, CD4, CD81, IFITM1, IGSF8, RBBP6, CD63, MYOC, CTSC, VKORC1, ACTN1, FLNA, NCL, AKT1, EEF1A1, ACTB, MSN, ACTN4, CFL1, CFL2, CNN2, LASP1, SAMHD1, SERPINB9, IMMT, STK10, UBXN1, IBTK, GNB2L1, INPP4A, CCT3, CCT4, HIST1H1D, HIST1H1C, HIST1H1E, HIST1H2BD, HIST1H2BJ, HIST1H2BK, HIST1H2BH, HIST1H2BO, HIST1H2BL, HIST1H2BM, HIST1H2BN, HIST1H1A, HIST1H2BB, HIST1H2BE, HIST2H2BF, HIST1H3E, HIST3H3, HIST2H3C, H3F3B, RBBP4, HIST1H2BA, GAPDH, PKM, PFKP, PDIA6, ATP5A1, MTHFD1, ATP5O, NAMPT, EIF3A, DDX17, HNRNPU, SYNCRIP, SFPQ, EIF3L, PABPC1, EIF3B, EIF3C, EIF3CL, SUPT16H, HNRNPA2B1, DHX15, HNRNPA1, NONO, SET, EIF3F, HNRNPK, NPM1, EIF3E, HNRNPH1, DDX3X, DDX5, MCM5, ANP32B, EEF1A2, SERBP1, EIF3I, HNRNPD, HNRNPA3, SNRPD3, PDCD4, EIF3H, EWSR1, SNRPD1, SRSF3, EEF1D, HNRNPM, DDX3Y, CPSF6, TUFM, LRRC47, SNRPB, ALYREF, NUDT21, EIF3G, EIF3K, KHDRBS1, KHSRP, LUC7L2, SF3B3, EIF4A1, CRIP1, FUBP1, PCBP1, PCBP2, RTF1, SRSF8, EIF4A2, WARS, SNRPC, RGPD6, RAC2, PKN1, TMPO, TUBB, TUBB4B, TUBA1A, TUBA1B, TUBB2B, TUBB2A, TUBB3, TUBB4A, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBB7P, TUBB6, TUBA8, TUBE1, FAM98B, RPS4X, RPS9, RPS18, RPS19, RPLP0, RPS3, RPL12, RPL6, RPS25, RPS8, RPLP2, RPS16, RPS2, RPS3A, RPL4, RPL22, RPL27, RPS13, RPS4Y1, RPS14, RPL5, RPL23A, RPL27A, RPL31, RPS6, RPL11, FAU, RPL13, RPL17, RPL35, RPS15, RPS23, RPL24, RPS28, GLP1R, CSNK2B, JAK3, GGT1, CD53, CD82, ADRB2, TFR2, TRIM25, LMNASUPT16HBRCC3, PRKAA1, POLR1A, POLR1E, SSRP1, CHD1L, MCM4, PAF1, PARP1, H2AFX, MKL1, H3F3A, TRIM33, TAL1, CDK9, SUPT16H, MMS22L, TONSL, SMARCAD1, SREK1, SOX2, HDGF, ELAVL1, XRCC5, CUL3, CDK2, CAND1, FYTTD1, CSNK2A1, CSNK2B, SAP18, RTF1, LEO1, TOP1, DHX15, CTR9, IK, PRPF4B, SNRPD2, NCSTN, S100A9, HNRNPM, NHP2L1, DDX21, PRPF6, SF3A1, SNRPD1, PRPF3, ACIN1, EEF1A1, RBM25, MSH6, PRPF8, USP39, MSH2, PSIP1, CENPA, ESR1, FMNL1, VCP, PNKP, CD81, IGSF8, ICAM1, SRPK2, FTH1, QRICH1, RNF20, ATRX, HIST1H2AB, MOV10, NXF1, BRCA1, CUL7, OBSL1, EED, RNF2, BMI1, SUMO2, ABCE1, RPA4, SPIN2B, RPA2, SPIN1, TIPIN, RNF146, POLB, APLF, HIST1H2BA, MAFF, FBXW11, BRD3, CDK12, HMGB1, IWS1, NAP1L1, PES1, SRRM1, CDK11A, HMGB2, HMGB3, KRI1, TOP2B, ZC3H18, SFN, NTRK1, IFI16, MED4, EWSR1, CEP97, CNTROB, SPICE1, CEP164, DCTN1, POC1B, STIL, HIST1H3E, DAXX, HNRNPU, NPM1, RPL10, ETAA1, CENPQ, NF2, NANOG, UBR5, SBF1, HIST1H3A, MACROD1, H2AFY2, XPC, XRCC6, HIST1H4A, NAA40, WDR76, ALX3, TEAD2, L3MBTL1, CETN1, SIX2, POLL, RPA3, WRN, COX15, DLD, PDHA1, VDAC1, TRIM25, YAP1, MTF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CD81_SUPT16H


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CD81_SUPT16H


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCD81C0019196Hepatitis C1CTD_human