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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6234

FusionGeneSummary for CD72_DDX58

check button Fusion gene summary
Fusion gene informationFusion gene name: CD72_DDX58
Fusion gene ID: 6234
HgeneTgene
Gene symbol

CD72

DDX58

Gene ID

971

23586

Gene nameCD72 moleculeDExD/H-box helicase 58
SynonymsCD72b|LYB2RIG-I|RIGI|RLR-1|SGMRT2
Cytomap

9p13.3

9p21.1

Type of geneprotein-codingprotein-coding
DescriptionB-cell differentiation antigen CD72CD72 antigenlyb-2probable ATP-dependent RNA helicase DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 58DEAD box protein 58DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptideRNA helicase RIG-Iretinoic acid-inducible gene 1 proteinretinoic acid-inducible gene I protein
Modification date2018051920180527
UniProtAcc

P21854

O95786

Ensembl transtripts involved in fusion geneENST00000396757, ENST00000259633, 
ENST00000490239, ENST00000378431, 
ENST00000378430, 
ENST00000379882, 
ENST00000379868, ENST00000379883, 
ENST00000545044, ENST00000542096, 
Fusion gene scores* DoF score2 X 1 X 2=43 X 3 X 3=27
# samples 23
** MAII scorelog2(2/4*10)=2.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CD72 [Title/Abstract] AND DDX58 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDDX58

GO:0009597

detection of virus

17079289

TgeneDDX58

GO:0010628

positive regulation of gene expression

24409285

TgeneDDX58

GO:0030334

regulation of cell migration

19122199

TgeneDDX58

GO:0032725

positive regulation of granulocyte macrophage colony-stimulating factor production

24409285

TgeneDDX58

GO:0032727

positive regulation of interferon-alpha production

19576794

TgeneDDX58

GO:0032728

positive regulation of interferon-beta production

17079289

TgeneDDX58

GO:0032755

positive regulation of interleukin-6 production

24409285

TgeneDDX58

GO:0032757

positive regulation of interleukin-8 production

24409285

TgeneDDX58

GO:0045944

positive regulation of transcription by RNA polymerase II

17079289

TgeneDDX58

GO:0051091

positive regulation of DNA binding transcription factor activity

17079289

TgeneDDX58

GO:0051607

defense response to virus

21478870


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDKIRCTCGA-B0-5116-01ACD72chr9

35646400

-DDX58chr9

32459512

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000396757ENST00000379882CD72chr9

35646400

-DDX58chr9

32459512

-
intron-3CDSENST00000396757ENST00000379868CD72chr9

35646400

-DDX58chr9

32459512

-
intron-3CDSENST00000396757ENST00000379883CD72chr9

35646400

-DDX58chr9

32459512

-
intron-intronENST00000396757ENST00000545044CD72chr9

35646400

-DDX58chr9

32459512

-
intron-intronENST00000396757ENST00000542096CD72chr9

35646400

-DDX58chr9

32459512

-
intron-3CDSENST00000259633ENST00000379882CD72chr9

35646400

-DDX58chr9

32459512

-
intron-3CDSENST00000259633ENST00000379868CD72chr9

35646400

-DDX58chr9

32459512

-
intron-3CDSENST00000259633ENST00000379883CD72chr9

35646400

-DDX58chr9

32459512

-
intron-intronENST00000259633ENST00000545044CD72chr9

35646400

-DDX58chr9

32459512

-
intron-intronENST00000259633ENST00000542096CD72chr9

35646400

-DDX58chr9

32459512

-
intron-3CDSENST00000490239ENST00000379882CD72chr9

35646400

-DDX58chr9

32459512

-
intron-3CDSENST00000490239ENST00000379868CD72chr9

35646400

-DDX58chr9

32459512

-
intron-3CDSENST00000490239ENST00000379883CD72chr9

35646400

-DDX58chr9

32459512

-
intron-intronENST00000490239ENST00000545044CD72chr9

35646400

-DDX58chr9

32459512

-
intron-intronENST00000490239ENST00000542096CD72chr9

35646400

-DDX58chr9

32459512

-
intron-3CDSENST00000378431ENST00000379882CD72chr9

35646400

-DDX58chr9

32459512

-
intron-3CDSENST00000378431ENST00000379868CD72chr9

35646400

-DDX58chr9

32459512

-
intron-3CDSENST00000378431ENST00000379883CD72chr9

35646400

-DDX58chr9

32459512

-
intron-intronENST00000378431ENST00000545044CD72chr9

35646400

-DDX58chr9

32459512

-
intron-intronENST00000378431ENST00000542096CD72chr9

35646400

-DDX58chr9

32459512

-
intron-3CDSENST00000378430ENST00000379882CD72chr9

35646400

-DDX58chr9

32459512

-
intron-3CDSENST00000378430ENST00000379868CD72chr9

35646400

-DDX58chr9

32459512

-
intron-3CDSENST00000378430ENST00000379883CD72chr9

35646400

-DDX58chr9

32459512

-
intron-intronENST00000378430ENST00000545044CD72chr9

35646400

-DDX58chr9

32459512

-
intron-intronENST00000378430ENST00000542096CD72chr9

35646400

-DDX58chr9

32459512

-

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FusionProtFeatures for CD72_DDX58


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD72

P21854

DDX58

O95786

Plays a role in B-cell proliferation anddifferentiation. Innate immune receptor which acts as a cytoplasmicsensor of viral nucleic acids and plays a major role in sensingviral infection and in the activation of a cascade of antiviralresponses including the induction of type I interferons andproinflammatory cytokines. Its ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb inlength). In addition to the 5'-triphosphate moiety, blunt-end basepairing at the 5'-end of the RNA is very essential. Overhangs atthe non-triphosphorylated end of the dsRNA RNA have no majorimpact on its activity. A 3'overhang at the 5'triphosphate enddecreases and any 5'overhang at the 5' triphosphate end abolishesits activity. Upon ligand binding it associates with mitochondriaantiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferonregulatory factors: IRF3 and IRF7 which in turn activatetranscription of antiviral immunological genes, includinginterferons (IFNs); IFN-alpha and IFN-beta. Detects both positiveand negative strand RNA viruses including members of the familiesParamyxoviridae: Human respiratory syncytial virus and measlesvirus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV),Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japaneseencephalitis virus (JEV), hepatitis C virus (HCV), dengue virus(DENV) and west Nile virus (WNV). It also detects rotavirus andreovirus. Also involved in antiviral signaling in response toviruses containing a dsDNA genome such as Epstein-Barr virus(EBV). Detects dsRNA produced from non-self dsDNA by RNApolymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs).May play important roles in granulocyte production anddifferentiation, bacterial phagocytosis and in the regulation ofcell migration. {ECO:0000269|PubMed:15208624,ECO:0000269|PubMed:15708988, ECO:0000269|PubMed:16125763,ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868,ECO:0000269|PubMed:17190814, ECO:0000269|PubMed:18636086,ECO:0000269|PubMed:19122199, ECO:0000269|PubMed:19211564,ECO:0000269|PubMed:19576794, ECO:0000269|PubMed:19609254,ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:21742966}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CD72_DDX58


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CD72_DDX58


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CD72SEMA4D, PTPN6, LYN, SYK, BLNK, CD5, SIGLEC10, KLHL15, CALML3, LMNADDX58CYLD, IRF3, UBE2K, UBE2D1, UBE2D2, UBE2D3, TRIM25, MAVS, RAI14, WRNIP1, RBCK1, RNF31, PRKRIR, PRKCA, PRKCB, PRKCG, ISG15, TRIM32, TSPAN6, SRC, DDX58, MBP, USP4, NLRC5, RNF135, TBK1, IKBKE, IKBKG, USP21, USP3, MEX3C, UBC, IFIT3, USP15, TIA1, VAPA, IRGM, UBD, GLTSCR2, HDAC6, RNF122


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CD72_DDX58


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CD72_DDX58


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDDX58C0019196Hepatitis C1CTD_human
TgeneDDX58C0021400Influenza1CTD_human
TgeneDDX58C0033860Psoriasis1CTD_human
TgeneDDX58C4225380SINGLETON-MERTEN SYNDROME 21UNIPROT