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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6204

FusionGeneSummary for CD55_CENPL

check button Fusion gene summary
Fusion gene informationFusion gene name: CD55_CENPL
Fusion gene ID: 6204
HgeneTgene
Gene symbol

CD55

CENPL

Gene ID

1604

91687

Gene nameCD55 molecule (Cromer blood group)centromere protein L
SynonymsCHAPLE|CR|CROM|DAF|TCC1orf155|CENP-L|dJ383J4.3
Cytomap

1q32.2

1q25.1

Type of geneprotein-codingprotein-coding
Descriptioncomplement decay-accelerating factorCD55 antigenCD55 molecule, decay accelerating factor for complement (Cromer blood group)Cromer blood group antigencentromere protein Linterphase centromere complex protein 33
Modification date2018051920180522
UniProtAcc

P08174

Q8N0S6

Ensembl transtripts involved in fusion geneENST00000367064, ENST00000367063, 
ENST00000391921, ENST00000367067, 
ENST00000314754, ENST00000391920, 
ENST00000367062, ENST00000367065, 
ENST00000465534, 
ENST00000356198, 
ENST00000345664, ENST00000367710, 
ENST00000495275, 
Fusion gene scores* DoF score6 X 3 X 5=904 X 2 X 3=24
# samples 74
** MAII scorelog2(7/90*10)=-0.362570079384708
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CD55 [Title/Abstract] AND CENPL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD55

GO:0007204

positive regulation of cytosolic calcium ion concentration

8223854

HgeneCD55

GO:0031664

regulation of lipopolysaccharide-mediated signaling pathway

12731067

HgeneCD55

GO:0035743

CD4-positive, alpha-beta T cell cytokine production

16818763

HgeneCD55

GO:0045916

negative regulation of complement activation

6211481

HgeneCD55

GO:2000516

positive regulation of CD4-positive, alpha-beta T cell activation

16818763

HgeneCD55

GO:2000563

positive regulation of CD4-positive, alpha-beta T cell proliferation

16818763


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-FS-A1ZD-06ACD55chr1

207510163

+CENPLchr1

173780444

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000367064ENST00000356198CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-5UTRENST00000367064ENST00000345664CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-5UTRENST00000367064ENST00000367710CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-intronENST00000367064ENST00000495275CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-5UTRENST00000367063ENST00000356198CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-5UTRENST00000367063ENST00000345664CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-5UTRENST00000367063ENST00000367710CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-intronENST00000367063ENST00000495275CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-5UTRENST00000391921ENST00000356198CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-5UTRENST00000391921ENST00000345664CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-5UTRENST00000391921ENST00000367710CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-intronENST00000391921ENST00000495275CD55chr1

207510163

+CENPLchr1

173780444

-
3UTR-5UTRENST00000367067ENST00000356198CD55chr1

207510163

+CENPLchr1

173780444

-
3UTR-5UTRENST00000367067ENST00000345664CD55chr1

207510163

+CENPLchr1

173780444

-
3UTR-5UTRENST00000367067ENST00000367710CD55chr1

207510163

+CENPLchr1

173780444

-
3UTR-intronENST00000367067ENST00000495275CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-5UTRENST00000314754ENST00000356198CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-5UTRENST00000314754ENST00000345664CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-5UTRENST00000314754ENST00000367710CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-intronENST00000314754ENST00000495275CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-5UTRENST00000391920ENST00000356198CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-5UTRENST00000391920ENST00000345664CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-5UTRENST00000391920ENST00000367710CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-intronENST00000391920ENST00000495275CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-5UTRENST00000367062ENST00000356198CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-5UTRENST00000367062ENST00000345664CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-5UTRENST00000367062ENST00000367710CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-intronENST00000367062ENST00000495275CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-5UTRENST00000367065ENST00000356198CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-5UTRENST00000367065ENST00000345664CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-5UTRENST00000367065ENST00000367710CD55chr1

207510163

+CENPLchr1

173780444

-
5CDS-intronENST00000367065ENST00000495275CD55chr1

207510163

+CENPLchr1

173780444

-
3UTR-5UTRENST00000465534ENST00000356198CD55chr1

207510163

+CENPLchr1

173780444

-
3UTR-5UTRENST00000465534ENST00000345664CD55chr1

207510163

+CENPLchr1

173780444

-
3UTR-5UTRENST00000465534ENST00000367710CD55chr1

207510163

+CENPLchr1

173780444

-
3UTR-intronENST00000465534ENST00000495275CD55chr1

207510163

+CENPLchr1

173780444

-

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FusionProtFeatures for CD55_CENPL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD55

P08174

CENPL

Q8N0S6

Component of the CENPA-CAD (nucleosome distal) complex,a complex recruited to centromeres which is involved in assemblyof kinetochore proteins, mitotic progression and chromosomesegregation. May be involved in incorporation of newly synthesizedCENPA into centromeres via its interaction with the CENPA-NACcomplex. {ECO:0000269|PubMed:16716197}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CD55_CENPL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CD55_CENPL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CD55CD55, NDUFB7, MPV17, MAN2A1, RAB31, PTCD3, SLC2A1, MRPL4, GNAI3, INF2, ZMPSTE24, PTRH2, S100A10, SYNJ2BP, TIMM50, SLC12A4, NDUFS7, ATP6V1E1, SLC25A24, PICALM, CHI3L1, C6orf120, LCK, C2, TRIM25CENPLELAVL1, CENPM, CENPN, CENPU, JMJD6, FAM9B, ICK, EGFR, SCN3B, RRP8, GORASP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CD55_CENPL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCD55P08174DB00446ChloramphenicolComplement decay-accelerating factorsmall moleculeapproved|vet_approved

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RelatedDiseases for CD55_CENPL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCD55C0014175Endometriosis1CTD_human
HgeneCD55C0236733Amphetamine-Related Disorders1CTD_human