FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 6180

FusionGeneSummary for CD3G_TRIM10

check button Fusion gene summary
Fusion gene informationFusion gene name: CD3G_TRIM10
Fusion gene ID: 6180
HgeneTgene
Gene symbol

CD3G

TRIM10

Gene ID

917

10107

Gene nameCD3g moleculetripartite motif containing 10
SynonymsCD3-GAMMA|IMD17|T3GHERF1|RFB30|RNF9
Cytomap

11q23.3

6p22.1

Type of geneprotein-codingprotein-coding
DescriptionT-cell surface glycoprotein CD3 gamma chainCD3g antigen, gamma polypeptide (TiT3 complex)CD3g molecule, epsilon (CD3-TCR complex)CD3g molecule, gamma (CD3-TCR complex)T-cell antigen receptor complex, gamma subunit of T3T-cell receptor T3 gamma chaintripartite motif-containing protein 10B30-RING finger proteinZn-finger proteinhematopoietic RING finger 1ring finger protein 9tripartite motif protein 10
Modification date2018052320180519
UniProtAcc

P09693

Q9UDY6

Ensembl transtripts involved in fusion geneENST00000392883, ENST00000532917, 
ENST00000532903, 		ENST00000376704, 
ENST00000449742, ENST00000446013, 
ENST00000449208, ENST00000553167, 
ENST00000451727, ENST00000417411, 
ENST00000548891, ENST00000426996, 
ENST00000413055, ENST00000551474, 
ENST00000416714, ENST00000456988, 
ENST00000546716, ENST00000354038, 
ENST00000259941, ENST00000548533, 
ENST00000447465, ENST00000431258, 
ENST00000551591, ENST00000428611, 
ENST00000448645, ENST00000553004, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: CD3G [Title/Abstract] AND TRIM10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1R93335CD3Gchr11

118223867

-TRIM10chr6

1450352

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000392883ENST00000376704CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000392883ENST00000449742CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000392883ENST00000446013CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000392883ENST00000449208CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000392883ENST00000553167CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000392883ENST00000451727CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000392883ENST00000417411CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000392883ENST00000548891CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000392883ENST00000426996CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000392883ENST00000413055CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000392883ENST00000551474CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000392883ENST00000416714CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000392883ENST00000456988CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000392883ENST00000546716CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000392883ENST00000354038CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000392883ENST00000259941CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000392883ENST00000548533CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000392883ENST00000447465CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000392883ENST00000431258CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000392883ENST00000551591CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-3UTRENST00000392883ENST00000428611CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-3UTRENST00000392883ENST00000448645CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000392883ENST00000553004CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532917ENST00000376704CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532917ENST00000449742CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532917ENST00000446013CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532917ENST00000449208CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532917ENST00000553167CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532917ENST00000451727CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532917ENST00000417411CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532917ENST00000548891CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532917ENST00000426996CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532917ENST00000413055CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532917ENST00000551474CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532917ENST00000416714CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532917ENST00000456988CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532917ENST00000546716CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532917ENST00000354038CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532917ENST00000259941CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532917ENST00000548533CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532917ENST00000447465CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532917ENST00000431258CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532917ENST00000551591CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-3UTRENST00000532917ENST00000428611CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-3UTRENST00000532917ENST00000448645CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532917ENST00000553004CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532903ENST00000376704CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532903ENST00000449742CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532903ENST00000446013CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532903ENST00000449208CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532903ENST00000553167CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532903ENST00000451727CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532903ENST00000417411CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532903ENST00000548891CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532903ENST00000426996CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532903ENST00000413055CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532903ENST00000551474CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532903ENST00000416714CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532903ENST00000456988CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532903ENST00000546716CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532903ENST00000354038CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532903ENST00000259941CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532903ENST00000548533CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532903ENST00000447465CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532903ENST00000431258CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532903ENST00000551591CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-3UTRENST00000532903ENST00000428611CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-3UTRENST00000532903ENST00000448645CD3Gchr11

118223867

-TRIM10chr6

1450352

+
3UTR-intronENST00000532903ENST00000553004CD3Gchr11

118223867

-TRIM10chr6

1450352

+

Top

FusionProtFeatures for CD3G_TRIM10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD3G

P09693

TRIM10

Q9UDY6

Part of the TCR-CD3 complex present on T-lymphocyte cellsurface that plays an essential role in adaptive immune response.When antigen presenting cells (APCs) activate T-cell receptor(TCR), TCR-mediated signals are transmitted across the cellmembrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3chains contain immunoreceptor tyrosine-based activation motifs(ITAMs) in their cytoplasmic domain. Upon TCR engagement, thesemotifs become phosphorylated by Src family protein tyrosinekinases LCK and FYN, resulting in the activation of downstreamsignaling pathways (PubMed:2470098). In addition to this role ofsignal transduction in T-cell activation, CD3G plays an essentialrole in the dynamic regulation of TCR expression at the cellsurface (PubMed:8187769). Indeed, constitutive TCR cycling isdependent on the di-leucine-based (diL) receptor-sorting motifpresent in CD3G. {ECO:0000269|PubMed:2470098,ECO:0000269|PubMed:8187769, ECO:0000269|PubMed:8636209}. Seems to play an important role in erythropoiesis.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CD3G_TRIM10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CD3G_TRIM10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CD3G_TRIM10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCD3GP09693DB00075MuromonabT-cell surface glycoprotein CD3 gamma chainbiotechapproved|investigational

Top

RelatedDiseases for CD3G_TRIM10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource