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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 618

FusionGeneSummary for ACTR1B_HLA-B

check button Fusion gene summary
Fusion gene informationFusion gene name: ACTR1B_HLA-B
Fusion gene ID: 618
HgeneTgene
Gene symbol

ACTR1B

HLA-B

Gene ID

10120

3106

Gene nameARP1 actin related protein 1 homolog Bmajor histocompatibility complex, class I, B
SynonymsARP1B|CTRN2|PC3AS|B-4901|HLAB
Cytomap

2q11.2

6p21.33

Type of geneprotein-codingprotein-coding
Descriptionbeta-centractinARP1 actin-related protein 1 homolog B, centractin betaactin-related protein 1Bcentractin betamajor histocompatibility complex, class I, BHLA class I antigen HLA-BHLA class I histocompatibility antigen, B alpha chainMHC HLA-B cell surface glycoproteinMHC HLA-B transmembrane glycoproteinMHC class 1 antigenMHC class I antigen HLA-B alpha chain
Modification date2018051920180527
UniProtAcc

P42025

Q95365

Ensembl transtripts involved in fusion geneENST00000289228, ENST00000412585, 
ENST00000425848, ENST00000450871, 
ENST00000359635, ENST00000435618, 
ENST00000421349, 
Fusion gene scores* DoF score3 X 3 X 1=96 X 7 X 1=42
# samples 37
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/42*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ACTR1B [Title/Abstract] AND HLA-B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU679127ACTR1Bchr2

98272524

+HLA-Bchr6

2655608

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000289228ENST00000412585ACTR1Bchr2

98272524

+HLA-Bchr6

2655608

-
intron-intronENST00000289228ENST00000425848ACTR1Bchr2

98272524

+HLA-Bchr6

2655608

-
intron-intronENST00000289228ENST00000450871ACTR1Bchr2

98272524

+HLA-Bchr6

2655608

-
intron-intronENST00000289228ENST00000359635ACTR1Bchr2

98272524

+HLA-Bchr6

2655608

-
intron-intronENST00000289228ENST00000435618ACTR1Bchr2

98272524

+HLA-Bchr6

2655608

-
intron-3UTRENST00000289228ENST00000421349ACTR1Bchr2

98272524

+HLA-Bchr6

2655608

-

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FusionProtFeatures for ACTR1B_HLA-B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACTR1B

P42025

HLA-B

Q95365

Component of a multi-subunit complex involved inmicrotubule based vesicle motility. It is associated with thecentrosome.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ACTR1B_HLA-B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ACTR1B_HLA-B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACTR1B_HLA-B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ACTR1B_HLA-B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHLA-BC0038325Stevens-Johnson Syndrome9CTD_human;ORPHANET
TgeneHLA-BC0041755Adverse reaction to drug5CTD_human
TgeneHLA-BC0013182Drug Allergy4CTD_human
TgeneHLA-BC0033687Proteinuria4CTD_human
TgeneHLA-BC0038013Ankylosing spondylitis3CTD_human
TgeneHLA-BC0004943Behcet Syndrome2CTD_human;ORPHANET
TgeneHLA-BC0011603Dermatitis2CTD_human
TgeneHLA-BC0026896Myasthenia Gravis2CTD_human
TgeneHLA-BC0036341Schizophrenia2PSYGENET
TgeneHLA-BC0011609Drug Eruptions1CTD_human
TgeneHLA-BC0011633Dermatomyositis1CTD_human
TgeneHLA-BC0015230Exanthema1CTD_human
TgeneHLA-BC0017638Glioma1CTD_human
TgeneHLA-BC0019693HIV Infections1CTD_human
TgeneHLA-BC0020517Hypersensitivity1CTD_human
TgeneHLA-BC0027697Nephritis1CTD_human
TgeneHLA-BC0033975Psychotic Disorders1PSYGENET
TgeneHLA-BC0039103Synovitis1CTD_human
TgeneHLA-BC4277682Chemical and Drug Induced Liver Injury1CTD_human