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Fusion gene ID: 6151 |
FusionGeneSummary for CD276_TSPAN15 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CD276_TSPAN15 | Fusion gene ID: 6151 | Hgene | Tgene | Gene symbol | CD276 | TSPAN15 | Gene ID | 80381 | 23555 |
| Gene name | CD276 molecule | tetraspanin 15 | |
| Synonyms | 4Ig-B7-H3|B7-H3|B7H3|B7RP-2 | 2700063A19Rik|NET-7|NET7|TM4SF15 | |
| Cytomap | 15q24.1 | 10q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CD276 antigenB7 homolog 3costimulatory molecule | tetraspanin-15tetraspan NET-7transmembrane 4 superfamily member 15transmembrane 4 superfamily member tetraspan NET-7tspan-15 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q5ZPR3 | O95858 | |
| Ensembl transtripts involved in fusion gene | ENST00000318443, ENST00000537340, ENST00000318424, ENST00000561213, ENST00000564751, | ENST00000373290, ENST00000459981, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 3 X 2 X 3=18 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CD276 [Title/Abstract] AND TSPAN15 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CD276 | GO:0042102 | positive regulation of T cell proliferation | 11224528 |
| Hgene | CD276 | GO:0042110 | T cell activation | 18650384 |
| Hgene | CD276 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process | 11224528 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AY358934 | CD276 | chr15 | 74002261 | - | TSPAN15 | chr10 | 71211269 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000318443 | ENST00000373290 | CD276 | chr15 | 74002261 | - | TSPAN15 | chr10 | 71211269 | + |
| intron-intron | ENST00000318443 | ENST00000459981 | CD276 | chr15 | 74002261 | - | TSPAN15 | chr10 | 71211269 | + |
| intron-5UTR | ENST00000537340 | ENST00000373290 | CD276 | chr15 | 74002261 | - | TSPAN15 | chr10 | 71211269 | + |
| intron-intron | ENST00000537340 | ENST00000459981 | CD276 | chr15 | 74002261 | - | TSPAN15 | chr10 | 71211269 | + |
| intron-5UTR | ENST00000318424 | ENST00000373290 | CD276 | chr15 | 74002261 | - | TSPAN15 | chr10 | 71211269 | + |
| intron-intron | ENST00000318424 | ENST00000459981 | CD276 | chr15 | 74002261 | - | TSPAN15 | chr10 | 71211269 | + |
| intron-5UTR | ENST00000561213 | ENST00000373290 | CD276 | chr15 | 74002261 | - | TSPAN15 | chr10 | 71211269 | + |
| intron-intron | ENST00000561213 | ENST00000459981 | CD276 | chr15 | 74002261 | - | TSPAN15 | chr10 | 71211269 | + |
| intron-5UTR | ENST00000564751 | ENST00000373290 | CD276 | chr15 | 74002261 | - | TSPAN15 | chr10 | 71211269 | + |
| intron-intron | ENST00000564751 | ENST00000459981 | CD276 | chr15 | 74002261 | - | TSPAN15 | chr10 | 71211269 | + |
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FusionProtFeatures for CD276_TSPAN15 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CD276 | TSPAN15 |
| May participate in the regulation of T-cell-mediatedimmune response. May play a protective role in tumor cells byinhibiting natural-killer mediated cell lysis as well as a role ofmarker for detection of neuroblastoma cells. May be involved inthe development of acute and chronic transplant rejection and inthe regulation of lymphocytic activity at mucosal surfaces. Couldalso play a key role in providing the placenta and fetus with asuitable immunological environment throughout pregnancy. Bothisoform 1 and isoform 2 appear to be redundant in their ability tomodulate CD4 T-cell responses. Isoform 2 is shown to enhance theinduction of cytotoxic T-cells and selectively stimulatesinterferon gamma production in the presence of T-cell receptorsignaling. {ECO:0000269|PubMed:11224528,ECO:0000269|PubMed:12906861, ECO:0000269|PubMed:14764704,ECO:0000269|PubMed:15314238, ECO:0000269|PubMed:15682454,ECO:0000269|PubMed:15961727}. | Regulates maturation and trafficking of thetransmembrane metalloprotease ADAM10. Promotes ADAM10-mediatedcleavage of CDH2. Negatively regulates ligand-induced Notchactivity probably by regulating ADAM10 activity.{ECO:0000269|PubMed:26686862}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CD276_TSPAN15 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CD276_TSPAN15 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CD276_TSPAN15 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CD276_TSPAN15 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CD276 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | CD276 | C2239176 | Liver carcinoma | 1 | CTD_human |
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