FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 6146

FusionGeneSummary for CD27-AS1_NUDT5

check button Fusion gene summary
Fusion gene informationFusion gene name: CD27-AS1_NUDT5
Fusion gene ID: 6146
HgeneTgene
Gene symbol

CD27-AS1

NUDT5

Gene ID

678655

11164

Gene nameCD27 antisense RNA 1nudix hydrolase 5
Synonyms-YSA1|YSA1H|YSAH1|hNUDT5
Cytomap

12p13.31

10p14

Type of genencRNAprotein-coding
DescriptionCD27 antisense RNA 1 (non-protein coding)ADP-sugar pyrophosphatase8-oxo-dGDP phosphatasenuclear ATP-synthesis protein NUDIX5nudix (nucleoside diphosphate linked moiety X)-type motif 5
Modification date2018032920180519
UniProtAcc

Q9UKK9

Ensembl transtripts involved in fusion geneENST00000545339, ENST00000399492, 
ENST00000491614, ENST00000378937, 
ENST00000537776, ENST00000378952, 
ENST00000378940, ENST00000378927, 
Fusion gene scores* DoF score2 X 2 X 1=43 X 3 X 3=27
# samples 23
** MAII scorelog2(2/4*10)=2.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CD27-AS1 [Title/Abstract] AND NUDT5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNUDT5

GO:0006338

chromatin remodeling

27257257

TgeneNUDT5

GO:0009191

ribonucleoside diphosphate catabolic process

18462755|19699693|21389046

TgeneNUDT5

GO:0019303

D-ribose catabolic process

21389046

TgeneNUDT5

GO:1990966

ATP generation from poly-ADP-D-ribose

27257257


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU857456CD27-AS1chr12

6559509

-NUDT5chr10

12231916

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000545339ENST00000491614CD27-AS1chr12

6559509

-NUDT5chr10

12231916

+
5UTR-intronENST00000545339ENST00000378937CD27-AS1chr12

6559509

-NUDT5chr10

12231916

+
5UTR-intronENST00000545339ENST00000537776CD27-AS1chr12

6559509

-NUDT5chr10

12231916

+
5UTR-intronENST00000545339ENST00000378952CD27-AS1chr12

6559509

-NUDT5chr10

12231916

+
5UTR-intronENST00000545339ENST00000378940CD27-AS1chr12

6559509

-NUDT5chr10

12231916

+
5UTR-intronENST00000545339ENST00000378927CD27-AS1chr12

6559509

-NUDT5chr10

12231916

+
intron-intronENST00000399492ENST00000491614CD27-AS1chr12

6559509

-NUDT5chr10

12231916

+
intron-intronENST00000399492ENST00000378937CD27-AS1chr12

6559509

-NUDT5chr10

12231916

+
intron-intronENST00000399492ENST00000537776CD27-AS1chr12

6559509

-NUDT5chr10

12231916

+
intron-intronENST00000399492ENST00000378952CD27-AS1chr12

6559509

-NUDT5chr10

12231916

+
intron-intronENST00000399492ENST00000378940CD27-AS1chr12

6559509

-NUDT5chr10

12231916

+
intron-intronENST00000399492ENST00000378927CD27-AS1chr12

6559509

-NUDT5chr10

12231916

+

Top

FusionProtFeatures for CD27-AS1_NUDT5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD27-AS1

NUDT5

Q9UKK9

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Enzyme that can either act as an ADP-sugarpyrophosphatase in absence of diphosphate or catalyze thesynthesis of ATP in presence of diphosphate (PubMed:27257257). Inabsence of diphosphate, hydrolyzes with similar activities variousmodified nucleoside diphosphates such as ADP-ribose, ADP-mannose,ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213,PubMed:10722730, PubMed:19699693, PubMed:21389046,PubMed:17052728). Can also hydrolyze other nucleotide sugars withlow activity (PubMed:19699693, PubMed:21389046). In presence ofdiphosphate, mediates the synthesis of ATP in the nucleus bycatalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylatedat Thr-45 (PubMed:27257257). Nuclear ATP generation is requiredfor extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Does not play a role in U8 snoRNAdecapping activity (By similarity). Binds U8 snoRNA (Bysimilarity). {ECO:0000250|UniProtKB:Q9JKX6,ECO:0000269|PubMed:10567213, ECO:0000269|PubMed:10722730,ECO:0000269|PubMed:17052728, ECO:0000269|PubMed:19699693,ECO:0000269|PubMed:21389046, ECO:0000269|PubMed:27257257}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CD27-AS1_NUDT5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CD27-AS1_NUDT5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CD27-AS1_NUDT5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CD27-AS1_NUDT5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource