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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6134

FusionGeneSummary for CD164_PNRC1

check button Fusion gene summary
Fusion gene informationFusion gene name: CD164_PNRC1
Fusion gene ID: 6134
HgeneTgene
Gene symbol

CD164

PNRC1

Gene ID

8763

10957

Gene nameCD164 moleculeproline rich nuclear receptor coactivator 1
SynonymsDFNA66|MGC-24|MGC-24v|MUC-24|endolynB4-2|PNAS-145|PROL2|PRR2
Cytomap

6q21

6q15

Type of geneprotein-codingprotein-coding
Descriptionsialomucin core protein 24CD164 antigen, sialomucinmulti-glycosylated core protein 24proline-rich nuclear receptor coactivator 1proline rich 2 proteinproline-rich polypeptide 2proline-rich protein 2proline-rich protein with nuclear targeting signalprotein B4-2
Modification date2018052320180523
UniProtAcc

Q04900

Q12796

Ensembl transtripts involved in fusion geneENST00000413644, ENST00000368961, 
ENST00000310786, ENST00000275080, 
ENST00000324953, ENST00000512821, 
ENST00000504373, ENST00000506649, 
ENST00000369472, ENST00000336032, 
ENST00000354922, 
Fusion gene scores* DoF score3 X 3 X 1=92 X 2 X 1=4
# samples 32
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/4*10)=2.32192809488736
Context

PubMed: CD164 [Title/Abstract] AND PNRC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD164

GO:0007155

cell adhesion

10491205

HgeneCD164

GO:0007157

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

10491205


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU655987CD164chr6

109703405

-PNRC1chr6

89793470

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000413644ENST00000369472CD164chr6

109703405

-PNRC1chr6

89793470

+
5CDS-5UTRENST00000413644ENST00000336032CD164chr6

109703405

-PNRC1chr6

89793470

+
5CDS-5UTRENST00000413644ENST00000354922CD164chr6

109703405

-PNRC1chr6

89793470

+
5CDS-5UTRENST00000368961ENST00000369472CD164chr6

109703405

-PNRC1chr6

89793470

+
5CDS-5UTRENST00000368961ENST00000336032CD164chr6

109703405

-PNRC1chr6

89793470

+
5CDS-5UTRENST00000368961ENST00000354922CD164chr6

109703405

-PNRC1chr6

89793470

+
5CDS-5UTRENST00000310786ENST00000369472CD164chr6

109703405

-PNRC1chr6

89793470

+
5CDS-5UTRENST00000310786ENST00000336032CD164chr6

109703405

-PNRC1chr6

89793470

+
5CDS-5UTRENST00000310786ENST00000354922CD164chr6

109703405

-PNRC1chr6

89793470

+
5CDS-5UTRENST00000275080ENST00000369472CD164chr6

109703405

-PNRC1chr6

89793470

+
5CDS-5UTRENST00000275080ENST00000336032CD164chr6

109703405

-PNRC1chr6

89793470

+
5CDS-5UTRENST00000275080ENST00000354922CD164chr6

109703405

-PNRC1chr6

89793470

+
5CDS-5UTRENST00000324953ENST00000369472CD164chr6

109703405

-PNRC1chr6

89793470

+
5CDS-5UTRENST00000324953ENST00000336032CD164chr6

109703405

-PNRC1chr6

89793470

+
5CDS-5UTRENST00000324953ENST00000354922CD164chr6

109703405

-PNRC1chr6

89793470

+
5CDS-5UTRENST00000512821ENST00000369472CD164chr6

109703405

-PNRC1chr6

89793470

+
5CDS-5UTRENST00000512821ENST00000336032CD164chr6

109703405

-PNRC1chr6

89793470

+
5CDS-5UTRENST00000512821ENST00000354922CD164chr6

109703405

-PNRC1chr6

89793470

+
intron-5UTRENST00000504373ENST00000369472CD164chr6

109703405

-PNRC1chr6

89793470

+
intron-5UTRENST00000504373ENST00000336032CD164chr6

109703405

-PNRC1chr6

89793470

+
intron-5UTRENST00000504373ENST00000354922CD164chr6

109703405

-PNRC1chr6

89793470

+
intron-5UTRENST00000506649ENST00000369472CD164chr6

109703405

-PNRC1chr6

89793470

+
intron-5UTRENST00000506649ENST00000336032CD164chr6

109703405

-PNRC1chr6

89793470

+
intron-5UTRENST00000506649ENST00000354922CD164chr6

109703405

-PNRC1chr6

89793470

+

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FusionProtFeatures for CD164_PNRC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD164

Q04900

PNRC1

Q12796

Nuclear receptor coactivator. May play a role in signaltransduction. {ECO:0000269|PubMed:10894149}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CD164_PNRC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CD164_PNRC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CD164GRB2, ELAVL1, KRTAP10-3, NOTCH2NLPNRC1RARB, RARG, RORA, RORB, HNF4A, HNF4G, ESR2, ESRRG, NR5A2, MAPK8, ELAVL1, DCP1A, DCP1B, DDX6, UNK, CRKL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CD164_PNRC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CD164_PNRC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCD164C0000786Spontaneous abortion1CTD_human