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Fusion gene ID: 6128 |
FusionGeneSummary for CD14_CD14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CD14_CD14 | Fusion gene ID: 6128 | Hgene | Tgene | Gene symbol | CD14 | CD14 | Gene ID | 929 | 929 |
| Gene name | CD14 molecule | CD14 molecule | |
| Synonyms | - | - | |
| Cytomap | 5q31.3 | 5q31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | monocyte differentiation antigen CD14myeloid cell-specific leucine-rich glycoprotein | monocyte differentiation antigen CD14myeloid cell-specific leucine-rich glycoprotein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P08571 | P08571 | |
| Ensembl transtripts involved in fusion gene | ENST00000302014, ENST00000401743, | ENST00000302014, ENST00000401743, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: CD14 [Title/Abstract] AND CD14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CD14 | GO:0032760 | positive regulation of tumor necrosis factor production | 12594207|15294986 |
| Hgene | CD14 | GO:0071219 | cellular response to molecule of bacterial origin | 15039339 |
| Hgene | CD14 | GO:0071222 | cellular response to lipopolysaccharide | 12594207 |
| Hgene | CD14 | GO:0071223 | cellular response to lipoteichoic acid | 12594207 |
| Hgene | CD14 | GO:0071726 | cellular response to diacyl bacterial lipopeptide | 16880211 |
| Hgene | CD14 | GO:0071727 | cellular response to triacyl bacterial lipopeptide | 16880211 |
| Hgene | CD14 | GO:1901224 | positive regulation of NIK/NF-kappaB signaling | 15294986 |
| Tgene | CD14 | GO:0032760 | positive regulation of tumor necrosis factor production | 12594207|15294986 |
| Tgene | CD14 | GO:0071219 | cellular response to molecule of bacterial origin | 15039339 |
| Tgene | CD14 | GO:0071222 | cellular response to lipopolysaccharide | 12594207 |
| Tgene | CD14 | GO:0071223 | cellular response to lipoteichoic acid | 12594207 |
| Tgene | CD14 | GO:0071726 | cellular response to diacyl bacterial lipopeptide | 16880211 |
| Tgene | CD14 | GO:0071727 | cellular response to triacyl bacterial lipopeptide | 16880211 |
| Tgene | CD14 | GO:1901224 | positive regulation of NIK/NF-kappaB signaling | 15294986 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA986581 | CD14 | chr5 | 140012299 | - | CD14 | chr5 | 140012730 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000302014 | ENST00000302014 | CD14 | chr5 | 140012299 | - | CD14 | chr5 | 140012730 | - |
| intron-5UTR | ENST00000302014 | ENST00000401743 | CD14 | chr5 | 140012299 | - | CD14 | chr5 | 140012730 | - |
| intron-5UTR | ENST00000401743 | ENST00000302014 | CD14 | chr5 | 140012299 | - | CD14 | chr5 | 140012730 | - |
| intron-5UTR | ENST00000401743 | ENST00000401743 | CD14 | chr5 | 140012299 | - | CD14 | chr5 | 140012730 | - |
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FusionProtFeatures for CD14_CD14 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CD14 | CD14 |
| Coreceptor for bacterial lipopolysaccharide(PubMed:1698311, PubMed:23264655). In concert with LBP, binds tomonomeric lipopolysaccharide and delivers it to the LY96/TLR4complex, thereby mediating the innate immune response to bacteriallipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Actsvia MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation,cytokine secretion and the inflammatory response (PubMed:8612135).Acts as a coreceptor for TLR2:TLR6 heterodimer in response todiacylated lipopeptides and for TLR2:TLR1 heterodimer in responseto triacylated lipopeptides, these clusters trigger signaling fromthe cell surface and subsequently are targeted to the Golgi in alipid-raft dependent pathway (PubMed:16880211). Bindselectronegative LDL (LDL(-)) and mediates the cytokine releaseinduced by LDL(-) (PubMed:23880187). {ECO:0000269|PubMed:16880211,ECO:0000269|PubMed:1698311, ECO:0000269|PubMed:20133493,ECO:0000269|PubMed:23264655, ECO:0000269|PubMed:23880187,ECO:0000269|PubMed:8612135}. | Coreceptor for bacterial lipopolysaccharide(PubMed:1698311, PubMed:23264655). In concert with LBP, binds tomonomeric lipopolysaccharide and delivers it to the LY96/TLR4complex, thereby mediating the innate immune response to bacteriallipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Actsvia MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation,cytokine secretion and the inflammatory response (PubMed:8612135).Acts as a coreceptor for TLR2:TLR6 heterodimer in response todiacylated lipopeptides and for TLR2:TLR1 heterodimer in responseto triacylated lipopeptides, these clusters trigger signaling fromthe cell surface and subsequently are targeted to the Golgi in alipid-raft dependent pathway (PubMed:16880211). Bindselectronegative LDL (LDL(-)) and mediates the cytokine releaseinduced by LDL(-) (PubMed:23880187). {ECO:0000269|PubMed:16880211,ECO:0000269|PubMed:1698311, ECO:0000269|PubMed:20133493,ECO:0000269|PubMed:23264655, ECO:0000269|PubMed:23880187,ECO:0000269|PubMed:8612135}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CD14_CD14 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CD14_CD14 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CD14_CD14 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CD14_CD14 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CD14 | C0004096 | Asthma | 1 | CTD_human |
| Hgene | CD14 | C0011991 | Diarrhea | 1 | CTD_human |
| Hgene | CD14 | C0013595 | Eczema | 1 | CTD_human |
| Hgene | CD14 | C0018099 | Gout | 1 | CTD_human |
| Hgene | CD14 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
| Hgene | CD14 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | CD14 | C0400966 | Non-alcoholic Fatty Liver Disease | 1 | CTD_human |
| Hgene | CD14 | C3495559 | Juvenile arthritis | 1 | CTD_human |
| Tgene | CD14 | C0004096 | Asthma | 1 | CTD_human |
| Tgene | CD14 | C0011991 | Diarrhea | 1 | CTD_human |
| Tgene | CD14 | C0013595 | Eczema | 1 | CTD_human |
| Tgene | CD14 | C0018099 | Gout | 1 | CTD_human |
| Tgene | CD14 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
| Tgene | CD14 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | CD14 | C0400966 | Non-alcoholic Fatty Liver Disease | 1 | CTD_human |
| Tgene | CD14 | C3495559 | Juvenile arthritis | 1 | CTD_human |
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