|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 6122 |
FusionGeneSummary for CCZ1_COG7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CCZ1_COG7 | Fusion gene ID: 6122 | Hgene | Tgene | Gene symbol | CCZ1 | COG7 | Gene ID | 51622 | 91949 |
| Gene name | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated | component of oligomeric golgi complex 7 | |
| Synonyms | C7orf28A|CCZ1A|CGI-43|H_DJ1163J12.2 | CDG2E | |
| Cytomap | 7p22.1 | 16p12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | vacuolar fusion protein CCZ1 homologCCZ1 vacuolar protein trafficking and biogenesis associated homologH_NH0577018.2 | conserved oligomeric Golgi complex subunit 7COG complex subunit 7 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P86791 | P83436 | |
| Ensembl transtripts involved in fusion gene | ENST00000325974, ENST00000537980, ENST00000496860, | ENST00000307149, ENST00000569635, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 4 X 4=64 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CCZ1 [Title/Abstract] AND COG7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | R54035 | CCZ1 | chr7 | 5938551 | + | COG7 | chr16 | 23428445 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000325974 | ENST00000307149 | CCZ1 | chr7 | 5938551 | + | COG7 | chr16 | 23428445 | - |
| 5CDS-intron | ENST00000325974 | ENST00000569635 | CCZ1 | chr7 | 5938551 | + | COG7 | chr16 | 23428445 | - |
| 5UTR-3CDS | ENST00000537980 | ENST00000307149 | CCZ1 | chr7 | 5938551 | + | COG7 | chr16 | 23428445 | - |
| 5UTR-intron | ENST00000537980 | ENST00000569635 | CCZ1 | chr7 | 5938551 | + | COG7 | chr16 | 23428445 | - |
| intron-3CDS | ENST00000496860 | ENST00000307149 | CCZ1 | chr7 | 5938551 | + | COG7 | chr16 | 23428445 | - |
| intron-intron | ENST00000496860 | ENST00000569635 | CCZ1 | chr7 | 5938551 | + | COG7 | chr16 | 23428445 | - |
Top |
FusionProtFeatures for CCZ1_COG7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CCZ1 | COG7 |
| Acts in concert with MON1A, as a guanine exchange factor(GEF) for RAB7, promotes the exchange of GDP to GTP, converting itfrom an inactive GDP-bound form into an active GTP-bound form(PubMed:23084991). {ECO:0000269|PubMed:23084991}. | Required for normal Golgi function. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for CCZ1_COG7 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CCZ1_ENST00000325974_chr7_5938551_+_COG7_ENST00000307149_chr16_23428445_-_432aa MAAAAAGAGSGPWAAQEKQFPPALLSFFIYNPRFGPREGQEHGEVIDCVQELSHSVNKLFGLASAAVDRCVRFTNGLGTCGLLSALKSLF AKYVSDFTSTLQSIRKKCKLDHIPPNSLFQEDWTAFQNSIRIIATCGELLRHCGDFEQQLANRILSTAGKYLSDSCSPRSLAGFQESILT DKKNSAKNPWQEYNYLQKDNPAEYASLMEILYTLKEKGSSNHNLLAAPRAALTRLNQQAHQLAFDSVFLRIKQQLLLISKMDSWNTAGIG ETLTDELPAFSLTPLEYISNIGQYIMSLPLNLEPFVTQEDSALELALHAGKLPFPPEQGDELPELDNMADNWLGSIARATMQTYCDAILQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CCZ1_ENST00000325974_chr7_5938551_+_COG7_ENST00000307149_chr16_23428445_-_1296nt ATGGCTGCAGCGGCGGCCGGGGCCGGGAGCGGGCCCTGGGCGGCCCAGGAGAAGCAGTTCCCGCCGGCGCTGCTGAGTTTCTTCATCTAC AACCCGCGCTTCGGGCCGCGCGAAGGACAGGAGCATGGGGAAGTGATTGACTGTGTGCAGGAGCTGAGCCACTCCGTGAACAAGCTGTTT GGTCTGGCGTCTGCAGCCGTTGACAGATGCGTCAGATTCACCAATGGCCTGGGGACCTGCGGCCTGTTGTCAGCCCTGAAATCCCTCTTT GCCAAGTATGTGTCTGATTTCACCAGCACTCTCCAGTCCATACGAAAGAAGTGCAAACTGGACCACATTCCTCCCAACTCCCTCTTCCAG GAAGATTGGACGGCTTTTCAGAACTCCATTAGGATAATAGCCACCTGTGGAGAGCTTTTGCGGCATTGTGGGGACTTCGAGCAGCAGCTA GCCAACAGGATTTTGTCCACAGCTGGGAAGTATCTATCTGATTCCTGCAGCCCCCGGAGCCTGGCTGGTTTTCAGGAGAGCATCTTGACA GACAAGAAGAACTCTGCCAAGAACCCATGGCAAGAATATAATTACCTCCAGAAAGATAACCCTGCTGAATATGCCAGTTTAATGGAAATA CTTTATACCCTTAAGGAAAAAGGGTCAAGCAACCACAACCTGCTGGCTGCACCTCGAGCAGCGCTGACTCGGCTTAACCAGCAGGCCCAC CAGCTGGCTTTCGATTCCGTGTTCCTGCGCATCAAACAACAGCTGTTGCTTATTTCGAAGATGGACAGCTGGAATACGGCTGGCATCGGA GAAACCCTCACAGATGAACTGCCCGCCTTTAGTCTCACCCCTCTCGAGTACATCAGCAACATCGGGCAGTACATCATGTCCCTCCCCCTG AATCTTGAGCCATTTGTGACTCAGGAGGACTCTGCCTTAGAGTTGGCATTGCACGCTGGAAAGCTGCCATTTCCTCCTGAGCAGGGGGAT GAATTGCCCGAGCTGGACAACATGGCTGACAACTGGCTGGGCTCGATCGCCAGAGCCACAATGCAGACCTACTGTGATGCGATCCTACAG ATCCCTGAGCTGAGCCCACACTCTGCCAAGCAGCTGGCCACTGACATCGACTATCTGATCAACGTGATGGATGCCCTGGGCCTGCAGCCG TCCCGCACCCTCCAGCACATCGTGACGCTACTGAAGACCAGGCCTGAGGACTATAGACAGGTCAGCAAAGGCCTGCCCCGTCGCCTGGCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CCZ1_ENST00000325974_chr7_5938551_+_COG7_ENST00000307149_chr16_23428445_-_1789nt TTTTAGCCGGTGGCTGCTGTCTCTGGGCGGGCCGTGGGAGGCTCCCGAGGTGGGGGCCGGGGCGGGATGGCTGCAGCGGCGGCCGGGGCC GGGAGCGGGCCCTGGGCGGCCCAGGAGAAGCAGTTCCCGCCGGCGCTGCTGAGTTTCTTCATCTACAACCCGCGCTTCGGGCCGCGCGAA GGACAGGAGCATGGGGAAGTGATTGACTGTGTGCAGGAGCTGAGCCACTCCGTGAACAAGCTGTTTGGTCTGGCGTCTGCAGCCGTTGAC AGATGCGTCAGATTCACCAATGGCCTGGGGACCTGCGGCCTGTTGTCAGCCCTGAAATCCCTCTTTGCCAAGTATGTGTCTGATTTCACC AGCACTCTCCAGTCCATACGAAAGAAGTGCAAACTGGACCACATTCCTCCCAACTCCCTCTTCCAGGAAGATTGGACGGCTTTTCAGAAC TCCATTAGGATAATAGCCACCTGTGGAGAGCTTTTGCGGCATTGTGGGGACTTCGAGCAGCAGCTAGCCAACAGGATTTTGTCCACAGCT GGGAAGTATCTATCTGATTCCTGCAGCCCCCGGAGCCTGGCTGGTTTTCAGGAGAGCATCTTGACAGACAAGAAGAACTCTGCCAAGAAC CCATGGCAAGAATATAATTACCTCCAGAAAGATAACCCTGCTGAATATGCCAGTTTAATGGAAATACTTTATACCCTTAAGGAAAAAGGG TCAAGCAACCACAACCTGCTGGCTGCACCTCGAGCAGCGCTGACTCGGCTTAACCAGCAGGCCCACCAGCTGGCTTTCGATTCCGTGTTC CTGCGCATCAAACAACAGCTGTTGCTTATTTCGAAGATGGACAGCTGGAATACGGCTGGCATCGGAGAAACCCTCACAGATGAACTGCCC GCCTTTAGTCTCACCCCTCTCGAGTACATCAGCAACATCGGGCAGTACATCATGTCCCTCCCCCTGAATCTTGAGCCATTTGTGACTCAG GAGGACTCTGCCTTAGAGTTGGCATTGCACGCTGGAAAGCTGCCATTTCCTCCTGAGCAGGGGGATGAATTGCCCGAGCTGGACAACATG GCTGACAACTGGCTGGGCTCGATCGCCAGAGCCACAATGCAGACCTACTGTGATGCGATCCTACAGATCCCTGAGCTGAGCCCACACTCT GCCAAGCAGCTGGCCACTGACATCGACTATCTGATCAACGTGATGGATGCCCTGGGCCTGCAGCCGTCCCGCACCCTCCAGCACATCGTG ACGCTACTGAAGACCAGGCCTGAGGACTATAGACAGGTCAGCAAAGGCCTGCCCCGTCGCCTGGCCACCACCGTGGCCACCATGCGGAGT GTGAATTACTGACCCCACCACACACCGGACCACCAAGAGAGCCAGGGCTGCTGTTTCGCGACTCACCAGCACAGATTTGCTCAGAAACTC TGCCCAAGATTGGGCAGAAGTTACTTTAAAAAGACTTGGTTCAGCTGGTCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCC AAGCCAGATGGATCATGAAGCCAGGAGTTCGAGACCAGCCTGACCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAACAG CAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAGACTTGGTTCATTTGTATAATCAAAAAGAGTTGTAAATTAAAGATGTATTATT |
Top |
FusionGenePPI for CCZ1_COG7 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CCZ1 | FYCO1, SPINT2, SP6, THBS3, PPAT, CDC5L, LMO2, RPS14, KIF16B, LYRM5, KLHDC2 | COG7 | COG4, COG5, TRAF5, CDK2, COG1, COG6, COG8, COG3, COG2, EGFR, HNRNPD, KRT7, MAP4, TAX1BP1, ZNF471, BSG, CD274, VSIG2, CA14, DTNBP1, RP2, STAM2, NTRK1, C10orf76, PTAR1, RAB1A, RAB1B, COMMD8, BIN3, OPRM1, ILVBL |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CCZ1_COG7 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CCZ1_COG7 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|