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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 612

FusionGeneSummary for ACTR1A_ARL3

check button Fusion gene summary
Fusion gene informationFusion gene name: ACTR1A_ARL3
Fusion gene ID: 612
HgeneTgene
Gene symbol

ACTR1A

ARL3

Gene ID

10121

403

Gene nameARP1 actin related protein 1 homolog AADP ribosylation factor like GTPase 3
SynonymsARP1|Arp1A|CTRN1ARFL3
Cytomap

10q24.32

10q24.32

Type of geneprotein-codingprotein-coding
Descriptionalpha-centractinARP1 actin-related protein 1 homolog A, centractin alphaactin-RPVcentractincentrosome-associated actin homologADP-ribosylation factor-like protein 3ADP-ribosylation factor-like 3ARF-like 3
Modification date2018052220180523
UniProtAcc

P61163

P36405

Ensembl transtripts involved in fusion geneENST00000369905, ENST00000470322, 
ENST00000487599, ENST00000545684, 
ENST00000446605, 
ENST00000260746, 
Fusion gene scores* DoF score6 X 3 X 4=726 X 4 X 5=120
# samples 67
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACTR1A [Title/Abstract] AND ARL3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneARL3

GO:0007264

small GTPase mediated signal transduction

22085962


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A1FD-01AACTR1Achr10

104262357

-ARL3chr10

104436698

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000369905ENST00000260746ACTR1Achr10

104262357

-ARL3chr10

104436698

-
intron-3CDSENST00000470322ENST00000260746ACTR1Achr10

104262357

-ARL3chr10

104436698

-
Frame-shiftENST00000487599ENST00000260746ACTR1Achr10

104262357

-ARL3chr10

104436698

-
5UTR-3CDSENST00000545684ENST00000260746ACTR1Achr10

104262357

-ARL3chr10

104436698

-
5UTR-3CDSENST00000446605ENST00000260746ACTR1Achr10

104262357

-ARL3chr10

104436698

-

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FusionProtFeatures for ACTR1A_ARL3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACTR1A

P61163

ARL3

P36405

Component of a multi-subunit complex involved inmicrotubule based vesicle motility. It is associated with thecentrosome. Small GTP-binding protein which cycles between aninactive GDP-bound and an active GTP-bound form, and the rate ofcycling is regulated by guanine nucleotide exchange factors (GEF)and GTPase-activating proteins (GAP). Required for normalcytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cyclebetween inactive GDP-bound and active GTP-bound forms. Requiredfor targeting proteins such as NPHP3 to the ciliary membrane byreleasing myristoylated NPHP3 from UNC119B cargo adapter into thecilium. Does not act as an allosteric activator of the choleratoxin catalytic subunit. {ECO:0000269|PubMed:16525022,ECO:0000269|PubMed:18588884, ECO:0000269|PubMed:22085962}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ACTR1A_ARL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ACTR1A_ARL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ACTR1ANUMA1, BICD2, SPTBN2, DCTN4, HDAC6, UBC, CUL3, CUL1, COPS5, DCTN2, ACTR1B, PSMC4, MYH9, PSMD1, RRS1, MCM7, SMURF1, ACTR10, COG3, DCTN3, LMNB1, MYCBP, NUP133, HUWE1, MOV10, NXF1, CAPZA2, ACADSB, CAD, CCAR1, CDC45, KPNA3, KPNA4, SF3A1, SF3A3, UBR5, ZW10, DCTN1, DCTN5, PACSIN3, POLR2D, NTRK1, MED4, NIN, DYNC1H1, MAPRE1, IWS1, ZFC3H1, SNW1, CDC5L, DUSP13, DCTN6, KLHL2, DEFB127, RIC8A, PDGFD, C16orf45, MIS18A, C1orf106, CYLD, DLD, DNM1L, G3BP1ARL3PDE6D, LRIF1, TLE1, TP53, UBR1, UNC119, RP2, GOLGA4, ARL2BP, ARL2, ALKBH2, SPRR2A, UNC119B, ESF1, WRN, NPHP3, CAMK2A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACTR1A_ARL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ACTR1A_ARL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource