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Fusion gene ID: 6119 |
FusionGeneSummary for CCT8_LHX4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CCT8_LHX4 | Fusion gene ID: 6119 | Hgene | Tgene | Gene symbol | CCT8 | LHX4 | Gene ID | 10694 | 89884 |
| Gene name | chaperonin containing TCP1 subunit 8 | LIM homeobox 4 | |
| Synonyms | C21orf112|Cctq|D21S246|PRED71 | CPHD4 | |
| Cytomap | 21q21.3 | 1q25.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | T-complex protein 1 subunit thetaCCT-thetaTCP-1-thetachaperonin containing T-complex polypeptide 1 subunit 8chaperonin containing TCP1, subunit 8 (theta)renal carcinoma antigen NY-REN-15 | LIM/homeobox protein Lhx4LIM homeobox protein 4 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P50990 | Q969G2 | |
| Ensembl transtripts involved in fusion gene | ENST00000470450, ENST00000286788, ENST00000542732, ENST00000540844, | ENST00000263726, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 3 X 2 X 3=18 |
| # samples | 1 | 3 | |
| ** MAII score | log2(1/4*10)=1.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CCT8 [Title/Abstract] AND LHX4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | LHX4 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 15998782 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-EW-A6SA-01A | CCT8 | chr21 | 30432862 | - | LHX4 | chr1 | 180217420 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000470450 | ENST00000263726 | CCT8 | chr21 | 30432862 | - | LHX4 | chr1 | 180217420 | + |
| Frame-shift | ENST00000286788 | ENST00000263726 | CCT8 | chr21 | 30432862 | - | LHX4 | chr1 | 180217420 | + |
| In-frame | ENST00000542732 | ENST00000263726 | CCT8 | chr21 | 30432862 | - | LHX4 | chr1 | 180217420 | + |
| Frame-shift | ENST00000540844 | ENST00000263726 | CCT8 | chr21 | 30432862 | - | LHX4 | chr1 | 180217420 | + |
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FusionProtFeatures for CCT8_LHX4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CCT8 | LHX4 |
| Molecular chaperone; assists the folding of proteinsupon ATP hydrolysis. As part of the BBS/CCT complex may play arole in the assembly of BBSome, a complex involved in ciliogenesisregulating transports vesicles to the cilia. Known to play a role,in vitro, in the folding of actin and tubulin.{ECO:0000269|PubMed:20080638}. | May play a critical role in the development ofrespiratory control mechanisms and in the normal growth andmaturation of the lung. Binds preferentially to methylated DNA(PubMed:28473536). {ECO:0000250, ECO:0000269|PubMed:28473536}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CCT8_LHX4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CCT8_ENST00000542732_chr21_30432862_-_LHX4_ENST00000263726_chr1_180217420_+_365aa RFPSALAATSTSWTSSSXRSWTDTGTAPASSVQTARCSWRTGASPGLGASTARRTSSSASAQNARPASRVSPQPRWSARPRTLSTTCTAL LASSATGSWPRGTNSTSWRTGGWCARKTTRQPSRTMTQRLELSGPGPPSQPSSWRHXRMHTRTPPSLPGTXGSSCPQRQAWTXGSYRFGF RTEGPKRNAXRRMQGGTAGGSSIRASRGAGAAASRRRRALQRTVGLVTVSXASERIKFSQNLATPIGFMATWGTLQADSXXMGASPWTGQ DNPIRTXGMGAPMESPSLHPPYRPCHPTLLCSMGWITRWTVIWASLRMQGREXARRXEPWLGDPPLTSPQEAVXAIPTFQLAQALGSMKW |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CCT8_ENST00000542732_chr21_30432862_-_LHX4_ENST00000263726_chr1_180217420_+_1097nt AGATTCCCCAGTGCGCTGGCTGCAACCAGCACATCCTGGACAAGTTCATCCTGAAGGTCCTGGACAGACACTGGCACAGCTCCTGCCTCA AGTGTGCAGACTGCCAGATGCAGCTGGCGGACAGGTGCTTCTCCAGGGCTGGGAGCGTCTACTGCAAGGAGGACTTCTTCAAGCGCTTCG GCACAAAATGCACGGCCTGCCAGCAGGGTATCCCCCCAACCCAGGTGGTCCGCAAGGCCCAGGACTTTGTCTACCACCTGCACTGCTTTG CTTGCATCATCTGCAACCGGCAGCTGGCCACGGGGGACGAATTCTACCTCATGGAGGACGGGCGGCTGGTGTGCAAGGAAGACTACGAGA CAGCCAAGCAGAACGATGACTCAGAGGCTGGAGCTAAGCGGCCCCGGACCACCATCACAGCCAAGCAGCTGGAGACATTAAAGAATGCAT ACAAGAACTCCCCCAAGCCTGCCCGGCACGTGAGGGAGCAGCTGTCCTCAGAGACAGGCCTGGACATGAGGGTCGTACAGGTTTGGTTTC AGAACAGAAGGGCCAAAGAGAAACGCCTGAAGAAGGATGCAGGGCGGCACCGCTGGGGGCAGTTCTATAAGAGCGTCAAGAGGAGCCGGG GCAGCAGCAAGCAGGAGAAGGAGAGCTCTGCAGAGGACTGTGGGGTTAGTGACAGTGAGCTGAGCTTCCGAGAGGATCAAATTCTCTCAG AACTTGGCCACACCAATAGGATTTATGGCAACGTGGGGGACGTTACAGGCGGACAGTTAATGAATGGGAGCTTCTCCATGGACGGGACAG GACAATCCTATCAGGACTTGAGGGATGGGAGCCCCTATGGAATCCCCCAGTCTCCATCCTCCATATCGTCCCTGCCATCCCACGCTCCTT TGCTCAATGGGCTGGATTACACGGTGGACAGTAATTTGGGCATCATTGCGCATGCAGGGCAGGGAGTAAGCCAGACGCTGAGAGCCATGG CTGGGGGACCCACCTCTGACATCTCCACAGGAAGCAGTGTAGGCTATCCCGACTTTCCAACTAGCCCAGGCTCTTGGCTCGATGAAATGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CCT8_ENST00000542732_chr21_30432862_-_LHX4_ENST00000263726_chr1_180217420_+_8401nt ACTTCTCTTCTTCCGCGACCGGGAGAAGGCCGAGGGATCGGCGGCACGATCGACATTGTACACCTTGAAGGTGGACGGATGTGAAGCCGC GCGTTGTAGGGCTGAAGCTTACCAAAGAAAGGAAGAATGCACTTTTCAGGATTAGAAGAGGCTGTGTATAGAAACATACAAGCTTGCAAG GAGCTTGCCCAAACCACTCGTACAGCATATGGACCAAATGGAATGAACAAAATGGTTATCAACCACTTGGAGAAGTTGTTTGTGACAAAC GATGCAGCAACTATTTTAAGAGAACTAGAAGTACAGCATCCTGCTGCAAAAATGATTGTAATGGCTTCTCATATGCAAGAGCAAGAAGTT GGAGATGGCACAAACTTTGTTCTGGTATTTGCTGGAGCTCTCCTGGAATTAGCTGAAGAACTTCTGAGGATTGGCCTGTCAGTTTCAGAG GTCATAGAAGGTTATGAAATAGCCTGCAGAAAAGCTCATGAGATTCTTCCTAATTTGGTATGTTGTTCTGCAAAAAACCTTCGAGATATT GATGAAGTCTCATCTCTACTTCGTACCTCCATAATGAGTAAACAATATGGTAATGAAGTATTTCTGGCCAAGCTTATTGCTCAGGCATGC GTATCTATTTTTCCTGATTCCGGCCATTTCAATGTTGATAACATCAGAGTTTGTAAAATTCTGGGCTCTGGTATCAGTTCCTCTTCAGTA TTGCATGGCATGGTTTTTAAGAAGGAAACCGAAGGTGATGTAACATCTGTCAAAGATGCAAAAATAGCAGTGTACTCTTGTCCTTTTGAT GGCATGATAACAGAAACTAAGGGAACAGTGTTGATAAAGACTGCTGAAGAATTGATGAATTTTAGTAAGGGAGAAGAAAACCTCATGGAT GCACAAGTCAAAGCTATTGCTGATACTGGTGCAAATGTCGTAGTAACAGGTGGCAAAGTGGCAGACATGGCTCTTCATTATGCAAATAAA TATAATATCATGTTAGTGAGGCTAAACTCAAAATGGGATCTCCGAAGACTTTGTAAAACTGTTGGTGCTACAGCTCTTCCTAGATTGACA CCTCCTGTCCTTGAAGAAATGGGACACTGTGACAGTGTTTACCTCTCAGAAGTTGGAGATACTCAGGTGGTGGTTTTTAAGCATGAAAAG GAAGATGGCGCCATTTCTACCATAGTACTTCGAGGCTCTACAGACAATCTGATGGATGACATAGAAAGGGCAGTAGACGATGGTGTTAAT ACTTTCAAAGTTCTTACAAGGGATAAACGTCTTGTACCCGGAGGTGGAGCAACAGAAATTGAATTAGCCAAACAGATCACATCATATGGA GAGACATGTCCTGGACTTGAACAGTATGCTATTAAGAAGTTTGCTGAGGCATTTGAAGCTATTCCCCGCGCACTGGCAGAAAACTCTGGA GTTAAGGCCAATGAAGTAATCTCTAAACTTTATGCAGTACATCAAGAAGGAAATAAAAACGTTGGATTAGATATTGAGGCTGAAGTCCCT GCTGTAAAGGACATGCTGGAAGCTGGTATTCTAGATACTTACCTGGGAAAATATTGGGCTATCAAACTCGCTACTAATGCTGCAGTCACT GTACTTAGAGTGGATCAGAGATTCCCCAGTGCGCTGGCTGCAACCAGCACATCCTGGACAAGTTCATCCTGAAGGTCCTGGACAGACACT GGCACAGCTCCTGCCTCAAGTGTGCAGACTGCCAGATGCAGCTGGCGGACAGGTGCTTCTCCAGGGCTGGGAGCGTCTACTGCAAGGAGG ACTTCTTCAAGCGCTTCGGCACAAAATGCACGGCCTGCCAGCAGGGTATCCCCCCAACCCAGGTGGTCCGCAAGGCCCAGGACTTTGTCT ACCACCTGCACTGCTTTGCTTGCATCATCTGCAACCGGCAGCTGGCCACGGGGGACGAATTCTACCTCATGGAGGACGGGCGGCTGGTGT GCAAGGAAGACTACGAGACAGCCAAGCAGAACGATGACTCAGAGGCTGGAGCTAAGCGGCCCCGGACCACCATCACAGCCAAGCAGCTGG AGACATTAAAGAATGCATACAAGAACTCCCCCAAGCCTGCCCGGCACGTGAGGGAGCAGCTGTCCTCAGAGACAGGCCTGGACATGAGGG TCGTACAGGTTTGGTTTCAGAACAGAAGGGCCAAAGAGAAACGCCTGAAGAAGGATGCAGGGCGGCACCGCTGGGGGCAGTTCTATAAGA GCGTCAAGAGGAGCCGGGGCAGCAGCAAGCAGGAGAAGGAGAGCTCTGCAGAGGACTGTGGGGTTAGTGACAGTGAGCTGAGCTTCCGAG AGGATCAAATTCTCTCAGAACTTGGCCACACCAATAGGATTTATGGCAACGTGGGGGACGTTACAGGCGGACAGTTAATGAATGGGAGCT TCTCCATGGACGGGACAGGACAATCCTATCAGGACTTGAGGGATGGGAGCCCCTATGGAATCCCCCAGTCTCCATCCTCCATATCGTCCC TGCCATCCCACGCTCCTTTGCTCAATGGGCTGGATTACACGGTGGACAGTAATTTGGGCATCATTGCGCATGCAGGGCAGGGAGTAAGCC AGACGCTGAGAGCCATGGCTGGGGGACCCACCTCTGACATCTCCACAGGAAGCAGTGTAGGCTATCCCGACTTTCCAACTAGCCCAGGCT CTTGGCTCGATGAAATGGATCATCCTCCTTTTTAAACTTCTCTCCTCCCCACCCTACCTGCCCCCCTGGCTTGAGAGAATATCTTCAAGG ATCAAAAGAGACTTGCCTTTTAAGGATCGAAAGTACGCCAATGTGAATTTCCATTATTTTCAATGGAAGTCCTCCGCTGATTCCTAGAAG GCTGTGAGACCACACTAGGGCATTGTTTCCCTGGGGAAGCAGTGGGAGAGCAGACTCATCTCAGAACACAGCACAGGGGGTAATGGCCTA GAGCTCTAGGGACACTGGCTTGTTGGGTCTCTCCCCTGCTGTTCTGCTTAGGGGCTTGGCTGCTCAGTGCTTTGGTAGCACAAGGTGACT GTGATAGGCCCCCTTGGCCTTTGGGAACTTTGCTCCAACTGGTGTGTCTCACACAATGCCTCCCAAAACACTGCTCTCACCAGAACTGAG ACTCCTAAGGTAGAGGCCTCACAGCCCTTGAGTAAAATAAAAGTGATTTCTGGACCATCCTTATTGAACCCTATATTTCAAAATGAAAAG ATCAGTTATTAAAGGTCAGTGAACACTTTGATGGCCAGTTTGATATTAAAAACATGCCCCCTCCTTTTTTATTTTTGCTGTGAAGATATG AATTCTTTCCTACAAACCAGAGAATATGAACCTGTTTTGGTTTTTAAGTGTCCCATCTATATCATTGACTCTGATGGCAAGAGGTGGTTT TCATTGCAGGTGACTGAGGCTGAGCTGAGTAGCCCTGGACCACCGCTGCAGATTGCCTGAGTCGTCCCCTTGGTGCACAGTGTGCCTTCT TCAATTGCTTGTATCATTTATTCCACAAGACAGGCTGTGGGCTGTAAAATGAGCAAAACTAAAATGTGGGGAGAACAAAATGACAATCAA TCAGTGAACATTTGTAGACACATTTGGATTCCAAACCTGCAGTCTGTTCAGCCATATCGGCTGATGCCAGTCTTCCAGAGTTCCCCATCC CTTGTAGGGTGAAATATTTGGAGTCTGTTTTGAAGGAGTTGGTTTAGATGAGCTTGCAAGTCTACCCCTCTGAAAGCTTTCTCTGCTGTC CTAGCTGACTCAATTGGAGGACAGTTTTGGTCATTTCCAGGAACCAGCAATTTTTTTTTGGCCTACCTTGGTTGGGAAGAGTAATTTAGG GAGCAGCCCTAAAATTGTCCAAAGGGTTCTAAGTGGTTCTTGGGCTGCATCTCTCTGGATTGCTGGCTGGACACCTGCCATGCCTTGGGC TGCAGTCCCATGGTCAGAAAGCCAGAACTCTCTGGCCAGTGGTGGTGCAGGGACTCCCCGTTGTGCAGGTTTGCAGTAGCAAATCACTAA GCCTGAGGCCAGAGCAAGGCCAACCCCCGCTTTACGAGTTGCCACTCCTGCGACAGACTGCACTGCTGTGGGAAACGCTGTCCTGAATGG TGCTGCAGCTCCCACCCACCTTGTGCACCCATCTACCATCAGGAAGCTCTCCATGTGCAAACTGGAATTTAGCCAGCTGGAATTTATTCC TGTCCCTCTGGGAAGCTGTGTTTGCTTCTTCTGGCCTCCCATTCTCTTAAATGAGATCAGCAGAGTAGGAAAGGGTGAGAAGGCATTGCC TATCACATGAAGTGATGGGGCCAGAGACCCTAAGGACCCTTCCTTCTACGAATGGTTGGTCACCTTTTGAGGACTGCAAAGACTTAGGCA TGTCATAGGCAGACTAAAGGAAGAATACACAGTTCCTCTTGGACTGCTACATCTTTTGTAAGCCCTTTTCCAGGACTAAACTAAGTTCAA TTAAGTAAGTTCTTTAAAACAGTAAATTCCGGGATCAGCCTTCGGGCCCTCTTCTCTGACCAATTTTATAGCGTACCCTCGTTTTTTGGT GTGCTGCAGTGGTCATGATTTTTGCTTGAGAAGTCTGCAAACATAGACACTTCTCTTGAGGTTCCATGTTTATGGATGATGTTGTGTTAA TCCTAGCCAATTCTGTGCTATTGGGAATTCTCCAATCATGAACACTGGGGTGGGGAGGAAGACACAAATGCCATGTGAGGAAAGGAAAAT GCAGTCGTCTTTTTGGAGGATGGCTTTTTAAATACACCCTTCTTAGCAGGCTGCTTAAAATACACAGGAGAAAAGGCTCTGCTGGGCAAT GAACCAGATGAAAAGCTGCCCACCCAGATCACTGTTGCAGGTTGACTATTTGGCTTAGCAACTCATGGGATTTCAGAGGCCCTTGAAGTT TTTGGTGAGTATAGTGTGGGGGAGAGCAGGCTTTTTAAAAGGGGGGGGGGCATCCTCCTCTGTGTAGCACTGTTTAAGATCACTGTAAGT AAGTTGACCAGTTTTTGTAAGTTAATCATACTAATTCCCAGTTCAATAGTGGAAGGAGAGGCCTTCCTCATTTATACTAATAATATAATA AATCTCTTGAGGAACTCAGTGAGCAGTTGACGAGGTCAATAGTTCTTTGGCATCAGTAGGGCTGGTTAGCTGGAAAAACCCTTGAGAGCA CTGGCCTGAAAACCAGGAGAGCTTTGTTTTCCAGAGCCACCTCCCCAGAAAGCAGCAAACACTGCTGCCTGTTTAGAAGCACAGCCACAG TAGGTCTAAGATTTTAAATGGATCTCCCTACAGGTTGGGTTAGCATTATGGGTGGGCTGGTGCCACTAATGAGCCATTGCATGACAGGAC TCTTCTGGGGTTTGGAAATGGAGAAAAGCCGGGCATTCATTACTTTTAGCTTCTCTTAGAGGCACTCCTCTGTTGCTTGGAAGTCTATTA TGGGGTATAAGGTGCTACATGGTAGCTGTTTCCCCCCTTGCTAAAATGACATGGATGAATTTTAAAAATGAAATGAGACCTTCTAGAGGC AACCATTATCTGCAGTGCCTGGCTGGTCGACTTTAGAGTAGGAAGCTCTTGAATCCAGGAGCAAATTAGTTAAAACCCCAAGTTCCAGTG GTAACTGGTATAAGCAAAATGGAAACTGAGGGGCTATGGAGGAATCTCTGTTTGTTGGAACGTAATGAAACCATGGAGGAAATACCAGAT TTAAGGGCTAAGAAGCTGGCCCGATGGGTAAATCAGTGTTGGGAGTCAGGTTCTTGGCCCTTCAAGGACTTGCTATGCAACCTCAGGCAA ATTCCTCTCAGTCTTTGTGCTTTCTCTTTCTTGTCTCATCTGACAGTTATGAATATAACGTAAAATAAAGATCAACTATCATTGATAACA CTGTTCCTGCAAATGAATACTGTGAAACATCAGGGAAAGAGGAAAAAATTAAGCCACAAGAAAACCATTTGGCAGTGTCCTTAAACTTTT TTTGGGGGGGGGCAGTGTAAAACATGAAACCTAGTAAGATAATTGGGCCATTAGATCTTCATCATTAAACTCACTTTGCAAGGAAGTGTA AGAAATCTGTAAAACAAAAGACATTCCTATCTCAGAAGCTCAAACTGGTGATTTCCAACTGCCTCTTTACAGGAGGGGGCTCAAGGCTTC TGATGAGCAAAGGCTGTGTGTTGTATGACAGTCCACTCTCTGCACCTACACTTCCACGTGCCACGACTGACAACTTGGTTATAACCATGA AAATAATGACCATACCTCCCCAGCCAGCAGGGTCTGGAAGGCCTGAGGAGGCTCATTTTTAAACACTGCACTTTAAAAATTGGAAACCGT GAGATGAAGAAAAATTCAATTAAGCGGAAATGAGTTTTGTTTTATTGCCTGCTGCTGAAGGGCTCTGGGCATGCTGAAAGCTAAATGAAA AGCACATCACTGGCTCTCTTCTTTCTTGGATTGGTCAATTGGCCCTTTTTGCAGTAGTTGCTCCAACTGTTCTAAACAGTGAGTGACTGG AGCCAAAAAGAGAGAGCTCAGCAAAGCCATCCCATCCACACTCTGCTTGGTAGGACCACACTAAAAGCACAGTTTCATGCTGCTAGCTCT GGTAAGGAGACAGCTGCAGGTTTGGGAGGTGCACCAAGCATTCCTTTGCTTAGGGAGGCAGAGCACAGGTGAACAGAGGAAGGACACCCC CACTCTCATCTATTGCCCACCGAGAGGCAAGAATCACACCAACTTTCCCACTTGAGGACTGTGTTCGGCCAAACAAGCAGGTTCAGGGCT GCGGGATTCCAGAAGTTGCTCTGAGCTTGCAATCAGACCTCAAAGCCCCAGATCCCCTCAGCTCTGGATCGTTGCCCTCATCCTTCACAA TGTAAATTTTGTACAGTTAAAGAGAAATGAAGTCTCGTTTCCTGGGGAAAAAAAAGAAAAAAAGAAAAAAAAAAGACCCACCCATCCTTA TTTATTGCCATATGACTTTGGAAAACAGAAGCTGGTGCGTTTGTTTGTATATGCCTCCTGTGTGTTGGCATGAGATGTGTACGGTAAAAT TATGTAAAATAAATATGGAAATTCTTTAGATGCTGATGTGTCTTGCTTTTCATTTGGTTTGCTGGAAGTTTTTTCTCTTGACATAAATAG AATAAAAACTGAGTGATGTGAGGTCCTTTCCTTTTATCATCAGAAGGAAACCAAATATACAACTCTGAATGCCAGAACTATTATACTTAG AGCCATGAAATACCAGAACCACTCAATAAAGGACTGATTAGAGGAAGTTCCCTGGTTTTTCTAATAGTCATTTCCTGGGCACGATCCTCT GCCCCCAGACTTAGGAAATGAGCAGTAGAAATGTTGACCATATAACTTTTAGTTCCTGTTTGTTCAGTGGCATTTTTAAAATTTTTTTTT GAGACAGAGTCTTGCGCTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCACTGCAACCTCTGCTTCCTGGGTTCGAGTGATTT TCGTGCCTCAGCCTCCAGAGTACGTGGGATTACAGGCATGCGCAAACACGCCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTT GCCACGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCGCCCACCTGGGCCTCCCAAAGTGCTGGAATTACAGGTGTGAGCC ACCATGCCCGGCCTGTCCAGTAGCATTTTAAAAGTCCTTCACACTCATACATTTTTCTTTCTAGAGAAAGTATATGCAAATGTCTATATT TACAGAGGGACAGAAACACCTCATCAGAGTCATCAGGGCTCCTGGACAAACATTTTCCAGGAGAATCTCCATTTAGGTTTGTTTTCTCTG CAGGAGTCTTTATTAGTGTGCAGACCCTAAGTTTAGCTGGAATGGAAACAGCAACAGGGACTTTTTCATTACATTAAAAAAAAAAAAAGT CATAGCATTTCTTTACAGCTGGGATTCCACTGTGGAAAAACTACAGCGTGTTTCTTTTCCCCACTAGTCATTAGTTTTGTTTGGCTGAAG AGAAGATCCAAAGCAGTGGCACTGTCCAATATGGTAGCTACTAGCCACACATGGCTATTTAAATTTAAATTAGTATTAAATAAAACTAAA AGTTTAGTTCCTTACACTAGACACATTTTAGGTGCTCAACAGCTTCATGTGACCAGTGGCTACTGTATTTGGACGACACTGATATAAAAC AGTTCTATCATTGCAGATGGCTCTACTGGACGGTGCTCATAGAGTCTTGTTAGGGAGAGTGGGCAAGGAAATCTCATTCATCACATGTTT |
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FusionGenePPI for CCT8_LHX4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CCT8 | CTTNBP2, MOB4, PPP2CA, STK24, STRN, STRN3, TRAF3IP3, PPP2CB, PPP2R2C, PPP4C, IGBP1, TCP1, MEPCE, CDK9, GPN1, RFWD2, HDAC1, MYC, PPP2R2A, PPP2R2B, PPP2R2D, PPP2R4, HDAC5, PSMA3, VHL, RAD21, NELFB, FBXO25, CUL3, CDK2, CUL1, COPS5, CBL, UBASH3B, GRB2, UBXN6, APP, CCT2, CCT5, CCT3, CCT7, CCT6A, CCT4, PFDN5, PSMC2, RUFY1, TRIM28, KARS, ATP6V1B2, PSMA6, UBA5, NOTCH1, SMURF1, VCP, FN1, VCAM1, TP63, PEX14, NOS2, CAMKMT, FAM86B2, METTL18, METTL20, METTL21B, ITGA4, PAN2, HDAC3, FBXW4, FBXO6, ASB13, CDK5, ILK, UBC, CDC20, LGALS3BP, NEDD1, TP53, TUBG1, HUWE1, FUS, CUL7, OBSL1, CCDC8, SIRT6, IKBKE, IRAK1, JAK3, MAPK8, PTK6, RAF1, SGK2, TSSK6, TYK2, WDR76, POC1A, NXF5, WDR83, RPS6KB2, DCAF7, FBXW11, AMBRA1, UNK, ATP1A1, CAD, CCT6B, EHD2, FAXC, GFPT2, IDH3A, PDCL3, STOM, UQCRC2, GFPT1, KPNA4, MESDC2, RPN1, TUBB, NTRK1, NUP43, B9D1, AHSA1, DDB2, GBA, PDK3, PPP1CB, XRCC3, NSMAF, NIPSNAP1, PRPF4, ACTR2, FGFR1OP2, WRAP53, RFWD3, KIF21A, TUBA1C, ARMC6, GAN, CRY1, CRY2, ALKBH3, MCM2, SNW1, CDC5L, U2AF2, CDC73, CRBN, CDH1, FLCN, BUB3, KLHL33, PEX7, KLHDC8A, ACTR3B, KDM4B, ACTBL2, CYLD, WDR92, DLD, DNM1L, HSD17B10, PARK7, PDHA1, SDHA, SOD1, VDAC1, HEY1, BRCA1, DCAF4L2 | LHX4 | IFT172, ISL1, SSX1, LDB2, SH2D1A, USP2, ORC6, CHCHD2, SNRNP25, TXNDC5, LONRF1, FDX1L, SSBP2, SSBP4, CEP97, ZNF574, CHMP1A, CYFIP2, CYFIP1, PRKRIR, ARID2, LDB1, ISL2, SMAD4, ABI2, ABI1, WASF2, C1orf52, DCAF5, TCAP, CETN1, TSC22D4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CCT8_LHX4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CCT8_LHX4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | LHX4 | C2678408 | PITUITARY HORMONE DEFICIENCY, COMBINED, 4 | 2 | CTD_human;ORPHANET;UNIPROT |
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