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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6115

FusionGeneSummary for CCT7_MOSPD3

check button Fusion gene summary
Fusion gene informationFusion gene name: CCT7_MOSPD3
Fusion gene ID: 6115
HgeneTgene
Gene symbol

CCT7

MOSPD3

Gene ID

10574

64598

Gene namechaperonin containing TCP1 subunit 7motile sperm domain containing 3
SynonymsCCTETA|CCTH|NIP7-1|TCP1ETACDS3|NET30
Cytomap

2p13.2

7q22.1

Type of geneprotein-codingprotein-coding
DescriptionT-complex protein 1 subunit etaCCT-etaHIV-1 Nef interacting proteinTCP-1-etachaperonin containing t-complex polypeptide 1, eta subunitmotile sperm domain-containing protein 3
Modification date2018052320180518
UniProtAcc

Q99832

O75425

Ensembl transtripts involved in fusion geneENST00000540468, ENST00000539919, 
ENST00000258091, ENST00000398422, 
ENST00000537131, ENST00000538797, 
ENST00000473786, 
ENST00000223054, 
ENST00000379527, ENST00000393950, 
ENST00000424091, 
Fusion gene scores* DoF score5 X 6 X 4=1201 X 1 X 1=1
# samples 61
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: CCT7 [Title/Abstract] AND MOSPD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI183764CCT7chr2

73479943

-MOSPD3chr7

100211320

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000540468ENST00000223054CCT7chr2

73479943

-MOSPD3chr7

100211320

-
Frame-shiftENST00000540468ENST00000379527CCT7chr2

73479943

-MOSPD3chr7

100211320

-
Frame-shiftENST00000540468ENST00000393950CCT7chr2

73479943

-MOSPD3chr7

100211320

-
Frame-shiftENST00000540468ENST00000424091CCT7chr2

73479943

-MOSPD3chr7

100211320

-
Frame-shiftENST00000539919ENST00000223054CCT7chr2

73479943

-MOSPD3chr7

100211320

-
Frame-shiftENST00000539919ENST00000379527CCT7chr2

73479943

-MOSPD3chr7

100211320

-
Frame-shiftENST00000539919ENST00000393950CCT7chr2

73479943

-MOSPD3chr7

100211320

-
Frame-shiftENST00000539919ENST00000424091CCT7chr2

73479943

-MOSPD3chr7

100211320

-
In-frameENST00000258091ENST00000223054CCT7chr2

73479943

-MOSPD3chr7

100211320

-
In-frameENST00000258091ENST00000379527CCT7chr2

73479943

-MOSPD3chr7

100211320

-
In-frameENST00000258091ENST00000393950CCT7chr2

73479943

-MOSPD3chr7

100211320

-
In-frameENST00000258091ENST00000424091CCT7chr2

73479943

-MOSPD3chr7

100211320

-
In-frameENST00000398422ENST00000223054CCT7chr2

73479943

-MOSPD3chr7

100211320

-
In-frameENST00000398422ENST00000379527CCT7chr2

73479943

-MOSPD3chr7

100211320

-
In-frameENST00000398422ENST00000393950CCT7chr2

73479943

-MOSPD3chr7

100211320

-
In-frameENST00000398422ENST00000424091CCT7chr2

73479943

-MOSPD3chr7

100211320

-
In-frameENST00000537131ENST00000223054CCT7chr2

73479943

-MOSPD3chr7

100211320

-
In-frameENST00000537131ENST00000379527CCT7chr2

73479943

-MOSPD3chr7

100211320

-
In-frameENST00000537131ENST00000393950CCT7chr2

73479943

-MOSPD3chr7

100211320

-
In-frameENST00000537131ENST00000424091CCT7chr2

73479943

-MOSPD3chr7

100211320

-
Frame-shiftENST00000538797ENST00000223054CCT7chr2

73479943

-MOSPD3chr7

100211320

-
Frame-shiftENST00000538797ENST00000379527CCT7chr2

73479943

-MOSPD3chr7

100211320

-
Frame-shiftENST00000538797ENST00000393950CCT7chr2

73479943

-MOSPD3chr7

100211320

-
Frame-shiftENST00000538797ENST00000424091CCT7chr2

73479943

-MOSPD3chr7

100211320

-
intron-3CDSENST00000473786ENST00000223054CCT7chr2

73479943

-MOSPD3chr7

100211320

-
intron-3CDSENST00000473786ENST00000379527CCT7chr2

73479943

-MOSPD3chr7

100211320

-
intron-3CDSENST00000473786ENST00000393950CCT7chr2

73479943

-MOSPD3chr7

100211320

-
intron-3CDSENST00000473786ENST00000424091CCT7chr2

73479943

-MOSPD3chr7

100211320

-

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FusionProtFeatures for CCT7_MOSPD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCT7

Q99832

MOSPD3

O75425

Molecular chaperone; assists the folding of proteinsupon ATP hydrolysis. Known to play a role, in vitro, in thefolding of actin and tubulin (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCT7_MOSPD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CCT7_ENST00000258091_chr2_73479943_-_MOSPD3_ENST00000223054_chr7_100211320_-_0aa

>In-frame_CCT7_ENST00000258091_chr2_73479943_-_MOSPD3_ENST00000379527_chr7_100211320_-_0aa

>In-frame_CCT7_ENST00000258091_chr2_73479943_-_MOSPD3_ENST00000393950_chr7_100211320_-_0aa

>In-frame_CCT7_ENST00000258091_chr2_73479943_-_MOSPD3_ENST00000424091_chr7_100211320_-_0aa

>In-frame_CCT7_ENST00000398422_chr2_73479943_-_MOSPD3_ENST00000223054_chr7_100211320_-_0aa

>In-frame_CCT7_ENST00000398422_chr2_73479943_-_MOSPD3_ENST00000379527_chr7_100211320_-_0aa

>In-frame_CCT7_ENST00000398422_chr2_73479943_-_MOSPD3_ENST00000393950_chr7_100211320_-_0aa

>In-frame_CCT7_ENST00000398422_chr2_73479943_-_MOSPD3_ENST00000424091_chr7_100211320_-_0aa

>In-frame_CCT7_ENST00000537131_chr2_73479943_-_MOSPD3_ENST00000223054_chr7_100211320_-_0aa

>In-frame_CCT7_ENST00000537131_chr2_73479943_-_MOSPD3_ENST00000379527_chr7_100211320_-_0aa

>In-frame_CCT7_ENST00000537131_chr2_73479943_-_MOSPD3_ENST00000393950_chr7_100211320_-_0aa

>In-frame_CCT7_ENST00000537131_chr2_73479943_-_MOSPD3_ENST00000424091_chr7_100211320_-_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CCT7_ENST00000258091_chr2_73479943_-_MOSPD3_ENST00000223054_chr7_100211320_-_0nt

>In-frame_CCT7_ENST00000258091_chr2_73479943_-_MOSPD3_ENST00000379527_chr7_100211320_-_0nt

>In-frame_CCT7_ENST00000258091_chr2_73479943_-_MOSPD3_ENST00000393950_chr7_100211320_-_0nt

>In-frame_CCT7_ENST00000258091_chr2_73479943_-_MOSPD3_ENST00000424091_chr7_100211320_-_0nt

>In-frame_CCT7_ENST00000398422_chr2_73479943_-_MOSPD3_ENST00000223054_chr7_100211320_-_0nt

>In-frame_CCT7_ENST00000398422_chr2_73479943_-_MOSPD3_ENST00000379527_chr7_100211320_-_0nt

>In-frame_CCT7_ENST00000398422_chr2_73479943_-_MOSPD3_ENST00000393950_chr7_100211320_-_0nt

>In-frame_CCT7_ENST00000398422_chr2_73479943_-_MOSPD3_ENST00000424091_chr7_100211320_-_0nt

>In-frame_CCT7_ENST00000537131_chr2_73479943_-_MOSPD3_ENST00000223054_chr7_100211320_-_0nt

>In-frame_CCT7_ENST00000537131_chr2_73479943_-_MOSPD3_ENST00000379527_chr7_100211320_-_0nt

>In-frame_CCT7_ENST00000537131_chr2_73479943_-_MOSPD3_ENST00000393950_chr7_100211320_-_0nt

>In-frame_CCT7_ENST00000537131_chr2_73479943_-_MOSPD3_ENST00000424091_chr7_100211320_-_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_CCT7_ENST00000258091_chr2_73479943_-_MOSPD3_ENST00000223054_chr7_100211320_-_0nt

>In-frame_CCT7_ENST00000258091_chr2_73479943_-_MOSPD3_ENST00000379527_chr7_100211320_-_0nt

>In-frame_CCT7_ENST00000258091_chr2_73479943_-_MOSPD3_ENST00000393950_chr7_100211320_-_0nt

>In-frame_CCT7_ENST00000258091_chr2_73479943_-_MOSPD3_ENST00000424091_chr7_100211320_-_0nt

>In-frame_CCT7_ENST00000398422_chr2_73479943_-_MOSPD3_ENST00000223054_chr7_100211320_-_0nt

>In-frame_CCT7_ENST00000398422_chr2_73479943_-_MOSPD3_ENST00000379527_chr7_100211320_-_0nt

>In-frame_CCT7_ENST00000398422_chr2_73479943_-_MOSPD3_ENST00000393950_chr7_100211320_-_0nt

>In-frame_CCT7_ENST00000398422_chr2_73479943_-_MOSPD3_ENST00000424091_chr7_100211320_-_0nt

>In-frame_CCT7_ENST00000537131_chr2_73479943_-_MOSPD3_ENST00000223054_chr7_100211320_-_0nt

>In-frame_CCT7_ENST00000537131_chr2_73479943_-_MOSPD3_ENST00000379527_chr7_100211320_-_0nt

>In-frame_CCT7_ENST00000537131_chr2_73479943_-_MOSPD3_ENST00000393950_chr7_100211320_-_0nt

>In-frame_CCT7_ENST00000537131_chr2_73479943_-_MOSPD3_ENST00000424091_chr7_100211320_-_0nt


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FusionGenePPI for CCT7_MOSPD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCT7_MOSPD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCT7_MOSPD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCCT7C0019693HIV Infections1CTD_human
HgeneCCT7C0038356Stomach Neoplasms1CTD_human