	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 61

FusionGeneSummary for AASDH_IRF3

Fusion gene summary

Fusion gene information	Fusion gene name: AASDH_IRF3
	Fusion gene ID: 61
		Hgene	Tgene
	Gene symbol	AASDH	IRF3
	Gene ID	132949	3661
	Gene name	aminoadipate-semialdehyde dehydrogenase	interferon regulatory factor 3
	Synonyms	ACSF4\|LYS2\|NRPS1098\|NRPS998	IIAE7
	Cytomap	4q12	19q13.33
	Type of gene	protein-coding	protein-coding
	Description	beta-alanine-activating enzyme2-aminoadipic 6-semialdehyde dehydrogenaseacyl-CoA synthetase family member 4non-ribosomal peptide synthetase 1098non-ribosomal peptide synthetase 998	interferon regulatory factor 3
	Modification date	20180519	20180527
	UniProtAcc	Q4L235	Q14653
	Ensembl transtripts involved in fusion gene	ENST00000513376, ENST00000205214, ENST00000434343, ENST00000451613, ENST00000602986, ENST00000502617, ENST00000510762,	ENST00000599680, ENST00000309877, ENST00000600911, ENST00000596822, ENST00000601291, ENST00000377139, ENST00000597198, ENST00000593922, ENST00000600022, ENST00000599223, ENST00000596765, ENST00000599144, ENST00000598808, ENST00000377135, ENST00000442265,
Fusion gene scores	* DoF score	5 X 5 X 3=75	6 X 5 X 4=120
	# samples	5	6
	** MAII score	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: AASDH [Title/Abstract] AND IRF3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	IRF3	GO:0045944	positive regulation of transcription by RNA polymerase II	9660935

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BG315188	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000513376	ENST00000599680	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000513376	ENST00000309877	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000513376	ENST00000600911	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000513376	ENST00000596822	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000513376	ENST00000601291	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000513376	ENST00000377139	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000513376	ENST00000597198	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000513376	ENST00000593922	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000513376	ENST00000600022	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000513376	ENST00000599223	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000513376	ENST00000596765	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000513376	ENST00000599144	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000513376	ENST00000598808	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000513376	ENST00000377135	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000513376	ENST00000442265	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000205214	ENST00000599680	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000205214	ENST00000309877	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000205214	ENST00000600911	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000205214	ENST00000596822	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000205214	ENST00000601291	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000205214	ENST00000377139	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000205214	ENST00000597198	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000205214	ENST00000593922	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000205214	ENST00000600022	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000205214	ENST00000599223	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000205214	ENST00000596765	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000205214	ENST00000599144	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000205214	ENST00000598808	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000205214	ENST00000377135	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000205214	ENST00000442265	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000434343	ENST00000599680	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000434343	ENST00000309877	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000434343	ENST00000600911	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000434343	ENST00000596822	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000434343	ENST00000601291	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000434343	ENST00000377139	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000434343	ENST00000597198	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000434343	ENST00000593922	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000434343	ENST00000600022	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000434343	ENST00000599223	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000434343	ENST00000596765	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000434343	ENST00000599144	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000434343	ENST00000598808	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000434343	ENST00000377135	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000434343	ENST00000442265	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000451613	ENST00000599680	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000451613	ENST00000309877	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000451613	ENST00000600911	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000451613	ENST00000596822	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000451613	ENST00000601291	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000451613	ENST00000377139	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000451613	ENST00000597198	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000451613	ENST00000593922	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000451613	ENST00000600022	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000451613	ENST00000599223	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000451613	ENST00000596765	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000451613	ENST00000599144	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000451613	ENST00000598808	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000451613	ENST00000377135	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000451613	ENST00000442265	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000602986	ENST00000599680	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000602986	ENST00000309877	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000602986	ENST00000600911	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000602986	ENST00000596822	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000602986	ENST00000601291	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000602986	ENST00000377139	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000602986	ENST00000597198	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000602986	ENST00000593922	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000602986	ENST00000600022	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000602986	ENST00000599223	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000602986	ENST00000596765	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000602986	ENST00000599144	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000602986	ENST00000598808	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000602986	ENST00000377135	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000602986	ENST00000442265	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000502617	ENST00000599680	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000502617	ENST00000309877	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000502617	ENST00000600911	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000502617	ENST00000596822	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000502617	ENST00000601291	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000502617	ENST00000377139	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000502617	ENST00000597198	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000502617	ENST00000593922	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000502617	ENST00000600022	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000502617	ENST00000599223	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000502617	ENST00000596765	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000502617	ENST00000599144	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000502617	ENST00000598808	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000502617	ENST00000377135	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000502617	ENST00000442265	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000510762	ENST00000599680	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000510762	ENST00000309877	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000510762	ENST00000600911	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000510762	ENST00000596822	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000510762	ENST00000601291	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000510762	ENST00000377139	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000510762	ENST00000597198	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000510762	ENST00000593922	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000510762	ENST00000600022	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000510762	ENST00000599223	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000510762	ENST00000596765	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000510762	ENST00000599144	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000510762	ENST00000598808	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000510762	ENST00000377135	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+
intron-intron	ENST00000510762	ENST00000442265	AASDH	chr4	57204721	+	IRF3	chr19	50165205	+

Top

FusionProtFeatures for AASDH_IRF3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AASDH Q4L235	IRF3 Q14653
	Key transcriptional regulator of type I interferon(IFN)-dependent immune responses which plays a critical role inthe innate immune response against DNA and RNA viruses. Regulatesthe transcription of type I IFN genes (IFN-alpha and IFN-beta) andIFN-stimulated genes (ISG) by binding to an interferon-stimulatedresponse element (ISRE) in their promoters. Acts as a more potentactivator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA)gene and plays a critical role in both the early and late phasesof the IFNA/B gene induction. Found in an inactive form in thecytoplasm of uninfected cells and following viral infection,double-stranded RNA (dsRNA), or toll-like receptor (TLR)signaling, is phosphorylated by IKBKE and TBK1 kinases. Thisinduces a conformational change, leading to its dimerization andnuclear localization and association with CREB binding protein(CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex whichactivates the transcription of the type I IFN and ISG genes. Canactivate distinct gene expression programs in macrophages and caninduce significant apoptosis in primary macrophages.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

FusionGeneSequence for AASDH_IRF3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for AASDH_IRF3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

RelatedDrugs for AASDH_IRF3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for AASDH_IRF3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	IRF3	C4225294	HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 7	1	UNIPROT

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 61

FusionGeneSummary for AASDH_IRF3

FusionProtFeatures for AASDH_IRF3

FusionGeneSequence for AASDH_IRF3

FusionGenePPI for AASDH_IRF3

RelatedDrugs for AASDH_IRF3

RelatedDiseases for AASDH_IRF3