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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6096

FusionGeneSummary for CCT3_HVCN1

check button Fusion gene summary
Fusion gene informationFusion gene name: CCT3_HVCN1
Fusion gene ID: 6096
HgeneTgene
Gene symbol

CCT3

HVCN1

Gene ID

7203

84329

Gene namechaperonin containing TCP1 subunit 3hydrogen voltage gated channel 1
SynonymsCCT-gamma|CCTG|PIG48|TCP-1-gamma|TRIC5HV1|VSOP
Cytomap

1q22

12q24.11

Type of geneprotein-codingprotein-coding
DescriptionT-complex protein 1 subunit gammaT-complex protein 1, gamma subunitTCP1 (t-complex-1) ring complex, polypeptide 5chaperonin containing TCP1, subunit 3 (gamma)hTRiC5voltage-gated hydrogen channel 1voltage sensor domain-only protein
Modification date2018052320180519
UniProtAcc

P49368

Q96D96

Ensembl transtripts involved in fusion geneENST00000295688, ENST00000368259, 
ENST00000368261, ENST00000472765, 
ENST00000368256, 
ENST00000548312, 
ENST00000242607, ENST00000356742, 
ENST00000439744, 
Fusion gene scores* DoF score16 X 10 X 9=14404 X 4 X 3=48
# samples 174
** MAII scorelog2(17/1440*10)=-3.08246216019197
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCT3 [Title/Abstract] AND HVCN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHVCN1

GO:0010043

response to zinc ion

16554753

TgeneHVCN1

GO:0071294

cellular response to zinc ion

22020278

TgeneHVCN1

GO:0071467

cellular response to pH

22020278

TgeneHVCN1

GO:1902600

proton transmembrane transport

22020278


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA748732CCT3chr1

156280436

+HVCN1chr12

111091636

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000295688ENST00000548312CCT3chr1

156280436

+HVCN1chr12

111091636

+
intron-intronENST00000295688ENST00000242607CCT3chr1

156280436

+HVCN1chr12

111091636

+
intron-intronENST00000295688ENST00000356742CCT3chr1

156280436

+HVCN1chr12

111091636

+
intron-intronENST00000295688ENST00000439744CCT3chr1

156280436

+HVCN1chr12

111091636

+
intron-intronENST00000368259ENST00000548312CCT3chr1

156280436

+HVCN1chr12

111091636

+
intron-intronENST00000368259ENST00000242607CCT3chr1

156280436

+HVCN1chr12

111091636

+
intron-intronENST00000368259ENST00000356742CCT3chr1

156280436

+HVCN1chr12

111091636

+
intron-intronENST00000368259ENST00000439744CCT3chr1

156280436

+HVCN1chr12

111091636

+
intron-intronENST00000368261ENST00000548312CCT3chr1

156280436

+HVCN1chr12

111091636

+
intron-intronENST00000368261ENST00000242607CCT3chr1

156280436

+HVCN1chr12

111091636

+
intron-intronENST00000368261ENST00000356742CCT3chr1

156280436

+HVCN1chr12

111091636

+
intron-intronENST00000368261ENST00000439744CCT3chr1

156280436

+HVCN1chr12

111091636

+
intron-intronENST00000472765ENST00000548312CCT3chr1

156280436

+HVCN1chr12

111091636

+
intron-intronENST00000472765ENST00000242607CCT3chr1

156280436

+HVCN1chr12

111091636

+
intron-intronENST00000472765ENST00000356742CCT3chr1

156280436

+HVCN1chr12

111091636

+
intron-intronENST00000472765ENST00000439744CCT3chr1

156280436

+HVCN1chr12

111091636

+
intron-intronENST00000368256ENST00000548312CCT3chr1

156280436

+HVCN1chr12

111091636

+
intron-intronENST00000368256ENST00000242607CCT3chr1

156280436

+HVCN1chr12

111091636

+
intron-intronENST00000368256ENST00000356742CCT3chr1

156280436

+HVCN1chr12

111091636

+
intron-intronENST00000368256ENST00000439744CCT3chr1

156280436

+HVCN1chr12

111091636

+

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FusionProtFeatures for CCT3_HVCN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCT3

P49368

HVCN1

Q96D96

Molecular chaperone; assists the folding of proteinsupon ATP hydrolysis. As part of the BBS/CCT complex may play arole in the assembly of BBSome, a complex involved in ciliogenesisregulating transports vesicles to the cilia. Known to play a role,in vitro, in the folding of actin and tubulin.{ECO:0000269|PubMed:20080638}. Mediates the voltage-dependent proton permeability ofexcitable membranes. Forms a proton-selective channel throughwhich protons may pass in accordance with their electrochemicalgradient. Proton efflux, accompanied by membrane depolarization,facilitates acute production of reactive oxygen species inphagocytosis. {ECO:0000269|PubMed:16554753,ECO:0000269|PubMed:20037153, ECO:0000269|PubMed:22020278}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCT3_HVCN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCT3_HVCN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCT3_HVCN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCCT3P49368DB11638ArtenimolT-complex protein 1 subunit gammasmall moleculeapproved|investigational

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RelatedDiseases for CCT3_HVCN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCCT3C0019693HIV Infections1CTD_human