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Fusion gene ID: 6091 |
FusionGeneSummary for CCT3_ARHGEF11 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CCT3_ARHGEF11 | Fusion gene ID: 6091 | Hgene | Tgene | Gene symbol | CCT3 | ARHGEF11 | Gene ID | 7203 | 9826 |
| Gene name | chaperonin containing TCP1 subunit 3 | Rho guanine nucleotide exchange factor 11 | |
| Synonyms | CCT-gamma|CCTG|PIG48|TCP-1-gamma|TRIC5 | GTRAP48|PDZ-RHOGEF | |
| Cytomap | 1q22 | 1q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | T-complex protein 1 subunit gammaT-complex protein 1, gamma subunitTCP1 (t-complex-1) ring complex, polypeptide 5chaperonin containing TCP1, subunit 3 (gamma)hTRiC5 | rho guanine nucleotide exchange factor 11Rho guanine exchange factor (GEF) 11Rho guanine nucleotide exchange factor (GEF) 11RhoA-specific guanine nucleotide exchange factorRhoGEF glutamate transport modulatorglutamate transporter EAAT4-associated pro | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P49368 | O15085 | |
| Ensembl transtripts involved in fusion gene | ENST00000295688, ENST00000368259, ENST00000368261, ENST00000472765, ENST00000368256, | ENST00000368194, ENST00000487682, ENST00000361409, ENST00000315174, | |
| Fusion gene scores | * DoF score | 16 X 10 X 9=1440 | 4 X 4 X 4=64 |
| # samples | 17 | 4 | |
| ** MAII score | log2(17/1440*10)=-3.08246216019197 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CCT3 [Title/Abstract] AND ARHGEF11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ARHGEF11 | GO:0007186 | G-protein coupled receptor signaling pathway | 15755723 |
| Tgene | ARHGEF11 | GO:0007266 | Rho protein signal transduction | 10026210 |
| Tgene | ARHGEF11 | GO:0045893 | positive regulation of transcription, DNA-templated | 10026210 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | OV | TCGA-13-A5FT-01A | CCT3 | chr1 | 156304504 | - | ARHGEF11 | chr1 | 156931567 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000295688 | ENST00000368194 | CCT3 | chr1 | 156304504 | - | ARHGEF11 | chr1 | 156931567 | - |
| 5CDS-intron | ENST00000295688 | ENST00000487682 | CCT3 | chr1 | 156304504 | - | ARHGEF11 | chr1 | 156931567 | - |
| 5CDS-intron | ENST00000295688 | ENST00000361409 | CCT3 | chr1 | 156304504 | - | ARHGEF11 | chr1 | 156931567 | - |
| 5CDS-intron | ENST00000295688 | ENST00000315174 | CCT3 | chr1 | 156304504 | - | ARHGEF11 | chr1 | 156931567 | - |
| intron-3CDS | ENST00000368259 | ENST00000368194 | CCT3 | chr1 | 156304504 | - | ARHGEF11 | chr1 | 156931567 | - |
| intron-intron | ENST00000368259 | ENST00000487682 | CCT3 | chr1 | 156304504 | - | ARHGEF11 | chr1 | 156931567 | - |
| intron-intron | ENST00000368259 | ENST00000361409 | CCT3 | chr1 | 156304504 | - | ARHGEF11 | chr1 | 156931567 | - |
| intron-intron | ENST00000368259 | ENST00000315174 | CCT3 | chr1 | 156304504 | - | ARHGEF11 | chr1 | 156931567 | - |
| Frame-shift | ENST00000368261 | ENST00000368194 | CCT3 | chr1 | 156304504 | - | ARHGEF11 | chr1 | 156931567 | - |
| 5CDS-intron | ENST00000368261 | ENST00000487682 | CCT3 | chr1 | 156304504 | - | ARHGEF11 | chr1 | 156931567 | - |
| 5CDS-intron | ENST00000368261 | ENST00000361409 | CCT3 | chr1 | 156304504 | - | ARHGEF11 | chr1 | 156931567 | - |
| 5CDS-intron | ENST00000368261 | ENST00000315174 | CCT3 | chr1 | 156304504 | - | ARHGEF11 | chr1 | 156931567 | - |
| In-frame | ENST00000472765 | ENST00000368194 | CCT3 | chr1 | 156304504 | - | ARHGEF11 | chr1 | 156931567 | - |
| 5CDS-intron | ENST00000472765 | ENST00000487682 | CCT3 | chr1 | 156304504 | - | ARHGEF11 | chr1 | 156931567 | - |
| 5CDS-intron | ENST00000472765 | ENST00000361409 | CCT3 | chr1 | 156304504 | - | ARHGEF11 | chr1 | 156931567 | - |
| 5CDS-intron | ENST00000472765 | ENST00000315174 | CCT3 | chr1 | 156304504 | - | ARHGEF11 | chr1 | 156931567 | - |
| 5UTR-3CDS | ENST00000368256 | ENST00000368194 | CCT3 | chr1 | 156304504 | - | ARHGEF11 | chr1 | 156931567 | - |
| 5UTR-intron | ENST00000368256 | ENST00000487682 | CCT3 | chr1 | 156304504 | - | ARHGEF11 | chr1 | 156931567 | - |
| 5UTR-intron | ENST00000368256 | ENST00000361409 | CCT3 | chr1 | 156304504 | - | ARHGEF11 | chr1 | 156931567 | - |
| 5UTR-intron | ENST00000368256 | ENST00000315174 | CCT3 | chr1 | 156304504 | - | ARHGEF11 | chr1 | 156931567 | - |
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FusionProtFeatures for CCT3_ARHGEF11 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CCT3 | ARHGEF11 |
| Molecular chaperone; assists the folding of proteinsupon ATP hydrolysis. As part of the BBS/CCT complex may play arole in the assembly of BBSome, a complex involved in ciliogenesisregulating transports vesicles to the cilia. Known to play a role,in vitro, in the folding of actin and tubulin.{ECO:0000269|PubMed:20080638}. | May play a role in the regulation of RhoA GTPase byguanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13).Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPaseand may act as GTPase-activating protein (GAP) for GNA12 andGNA13. Involved in neurotrophin-induced neurite outgrowth.{ECO:0000269|PubMed:21670212}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ARHGEF11 | chr1:156304504 | chr1:156931567 | ENST00000361409 | - | 11 | 40 | 444_470 | 340 | 1523 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >ARHGEF11 | chr1:156304504 | chr1:156931567 | ENST00000368194 | - | 12 | 41 | 444_470 | 380 | 1563 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >ARHGEF11 | chr1:156304504 | chr1:156931567 | ENST00000361409 | - | 11 | 40 | 1094_1099 | 340 | 1523 | Compositional bias | Note=Poly-Pro |
| Tgene | >ARHGEF11 | chr1:156304504 | chr1:156931567 | ENST00000368194 | - | 12 | 41 | 1094_1099 | 380 | 1563 | Compositional bias | Note=Poly-Pro |
| Tgene | >ARHGEF11 | chr1:156304504 | chr1:156931567 | ENST00000361409 | - | 11 | 40 | 734_923 | 340 | 1523 | Domain | DH |
| Tgene | >ARHGEF11 | chr1:156304504 | chr1:156931567 | ENST00000361409 | - | 11 | 40 | 965_1079 | 340 | 1523 | Domain | PH |
| Tgene | >ARHGEF11 | chr1:156304504 | chr1:156931567 | ENST00000368194 | - | 12 | 41 | 734_923 | 380 | 1563 | Domain | DH |
| Tgene | >ARHGEF11 | chr1:156304504 | chr1:156931567 | ENST00000368194 | - | 12 | 41 | 965_1079 | 380 | 1563 | Domain | PH |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ARHGEF11 | chr1:156304504 | chr1:156931567 | ENST00000361409 | - | 11 | 40 | 306_486 | 340 | 1523 | Domain | RGSL |
| Tgene | ARHGEF11 | chr1:156304504 | chr1:156931567 | ENST00000361409 | - | 11 | 40 | 47_126 | 340 | 1523 | Domain | PDZ |
| Tgene | ARHGEF11 | chr1:156304504 | chr1:156931567 | ENST00000368194 | - | 12 | 41 | 306_486 | 380 | 1563 | Domain | RGSL |
| Tgene | ARHGEF11 | chr1:156304504 | chr1:156931567 | ENST00000368194 | - | 12 | 41 | 47_126 | 380 | 1563 | Domain | PDZ |
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FusionGeneSequence for CCT3_ARHGEF11 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CCT3_ENST00000295688_chr1_156304504_-_ARHGEF11_ENST00000368194_chr1_156931567_-_1252aa MMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILRELFYLCAEVYQQASPKDSRSLG KDIWNIFLEKNAPLRVKIPEMLQAEIDSRLRNSEDARGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLDGDPLRERQVAE KQLAALGDILSKYEEDRSAPMDFALNTYMSHAGIRLREARPSNTAEKAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIG KPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFENNQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLKGREEMKRSRKAENVP RSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVG KDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISD LMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTS EHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLED LLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNA TRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQGKHQVLLEDPEQEGSAEEEELGVLPCPSTSL DGENRGIRTRNPIHLAFPGPLFMEGLADSALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGGE GDNTQLAGLEGERPEQEDMGLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGYKVVRKAEVAGSKVVPALPESGQSEPGPPEVE GGTKATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPDSLPAGQTEPQPQLQGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLKD >In-frame_CCT3_ENST00000472765_chr1_156304504_-_ARHGEF11_ENST00000368194_chr1_156931567_-_1207aa MMKMLLDPMGGIVMTNDGNAILRELFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIPEMLQAEIDSRLRNSEDARGVLCEAQE AAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLDGDPLRERQVAEKQLAALGDILSKYEEDRSAPMDFALNTYMSHAGIRLREARPSNTA EKAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFENNQQYDAPEPGTQ RLSTGSFPEDLLESDSSRSEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMG RRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKK ENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLF MQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALE RASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSV ATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEP EELPGGTGSQQRVQGKHQVLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADSALEDVENLRHLILWSL LPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDMGLCSLEHLPPRTRNSGIWESPELDRN LAEDASSTEAAGGYKVVRKAEVAGSKVVPALPESGQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPDSLPAGQTEP QPQLQGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLKDMELAHRELLKSLGGESSGGTTPVGSFHTEAARWTDGSLSPPAKEP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CCT3_ENST00000295688_chr1_156304504_-_ARHGEF11_ENST00000368194_chr1_156931567_-_3756nt ATGATGGGCCATCGTCCAGTGCTCGTGCTCAGCCAGAACACAAAGCGTGAATCCGGAAGAAAAGTTCAATCTGGAAACATCAATGCTGCC AAGACTATTGCAGATATCATCCGAACATGTTTGGGACCCAAGTCCATGATGAAGATGCTTTTGGACCCAATGGGAGGCATTGTGATGACC AATGATGGCAATGCCATTCTTCGAGAGCTTTTTTACCTGTGTGCAGAAGTTTATCAGCAGGCAAGCCCCAAGGATTCCCGAAGCTTGGGG AAAGACATCTGGAATATTTTCCTGGAGAAAAATGCGCCTCTGAGAGTGAAGATCCCTGAGATGCTACAGGCTGAAATTGACTCGCGCCTG CGGAACAGCGAAGATGCCCGTGGTGTTCTCTGTGAAGCTCAAGAGGCAGCCATGCCTGAGATCCAAGAGCAGATCCACGACTACAGAACG AAGCGCACACTGGGGCTGGGCAGCCTGTATGGTGAAAATGACCTGCTGGACCTGGATGGGGACCCTCTCCGAGAGCGCCAAGTGGCTGAG AAGCAGCTGGCTGCCCTTGGAGATATTTTGTCCAAGTATGAGGAAGACAGGAGCGCCCCCATGGACTTCGCCCTCAATACCTACATGAGC CATGCTGGGATCCGTCTTCGAGAGGCACGACCTTCCAACACAGCTGAAAAGGCCCAGTCTGCTCCTGACAAGGACAAGTGGCTACCGTTC TTCCCTAAGACCAAGAAGAGCAGCAATTCCAAGAAAGAAAAGGATGCCTTGGAGGACAAGAAGCGAAACCCTATCCTCAAATACATTGGG AAGCCCAAAAGCTCTTCTCAAAGCACATTTCATATTCCCTTGTCCCCTGTGGAAGTCAAACCAGGCAATGTGAGGAACATCATTCAGCAC TTTGAGAACAACCAGCAGTATGATGCCCCAGAACCTGGGACACAACGACTCTCGACCGGAAGCTTTCCTGAGGACCTGCTGGAGAGTGAC AGTTCACGCTCAGAGATTCGCCTGGGCCGCTCTGAAAGCCTCAAGGGCCGGGAAGAGATGAAACGGTCTCGAAAGGCAGAGAACGTGCCC CGCTCTCGCAGTGATGTTGACATGGATGCTGCTGCGGAGGCTACTCGCCTGCACCAGTCAGCCTCGTCCTCTACCTCCAGCCTCTCCACC AGGTCTCTTGAGAACCCAACCCCTCCATTCACTCCCAAAATGGGCCGCAGGAGCATTGAGTCCCCCAGTTTGGGGTTCTGCACAGATACC CTCCTTCCCCACCTCCTAGAGGATGATCTGGGCCAGCTGTCTGACCTGGAGCCAGAGCCAGATGCCCAAAATTGGCAGCATACAGTGGGC AAGGATGTGGTGGCTGGGCTAACCCAGCGGGAGATTGACCGGCAAGAGGTCATCAATGAGCTGTTTGTGACTGAAGCTTCCCACCTGCGC ACACTCCGGGTCCTGGACCTGATCTTCTACCAGCGAATGAAGAAGGAGAACCTGATGCCCCGGGAGGAGCTGGCCCGGCTCTTCCCGAAC CTGCCTGAACTCATAGAGATTCACAATTCCTGGTGTGAAGCCATGAAGAAGCTCCGGGAGGAAGGCCCCATCATCAAAGAGATCAGTGAC CTCATGCTGGCCCGGTTTGATGGCCCTGCCCGAGAGGAACTCCAGCAAGTGGCTGCACAGTTCTGTTCCTATCAGTCAATAGCCCTAGAG CTAATCAAGACCAAGCAACGCAAGGAGAGTCGATTCCAGCTCTTCATGCAGGAGGCTGAGAGCCACCCTCAGTGTCGGCGGCTGCAGCTG AGAGACCTCATCATCTCTGAGATGCAGCGGCTCACCAAGTACCCGCTGCTGCTGGAGAGCATCATCAAGCACACAGAGGGTGGCACCTCT GAGCATGAGAAGCTGTGCCGGGCCCGGGACCAGTGCCGGGAGATTCTCAAGTATGTGAATGAAGCGGTAAAACAAACAGAGAACCGCCAC CGTTTAGAGGGCTACCAGAAACGCCTGGATGCCACCGCCCTGGAGAGGGCCAGCAACCCCCTGGCAGCAGAGTTCAAGAGCCTGGATCTT ACAACCAGAAAAATGATCCATGAGGGACCCCTGACCTGGAGGATCAGCAAGGATAAGACCTTGGACCTCCACGTGCTGCTGCTGGAGGAC CTCCTAGTGCTGCTACAGAAACAGGATGAGAAGCTATTGCTGAAGTGCCACAGCAAGACTGCTGTGGGCTCCTCAGACAGCAAGCAGACC TTCAGCCCCGTGCTCAAGCTCAATGCTGTGCTCATCCGCTCTGTGGCCACAGATAAACGGGCCTTCTTCATCATCTGCACCTCCAAGCTG GGCCCACCCCAGATCTATGAGCTGGTTGCATTGACGTCATCAGACAAGAACACATGGATGGAGCTCTTAGAAGAGGCCGTGCGGAATGCC ACCAGGCACCCCGGAGCTGCCCCAATGCCCGTCCATCCTCCACCCCCAGGTCCCCGGGAGCCAGCCCAGCAGGGCCCCACACCCAGCAGG GTAGAACTGGATGACTCAGACGTGTTCCATGGTGAACCTGAACCTGAGGAGCTGCCTGGAGGCACTGGGTCCCAGCAGAGGGTCCAAGGG AAGCACCAGGTCCTGCTAGAGGACCCTGAGCAGGAGGGCAGTGCAGAGGAAGAGGAACTGGGTGTCCTGCCTTGCCCTTCCACATCCCTG GATGGAGAGAACAGGGGCATCAGGACAAGGAACCCCATCCACTTGGCCTTCCCAGGCCCTCTGTTCATGGAAGGGCTCGCTGACTCCGCT CTGGAAGATGTGGAGAACCTGCGACATCTGATCCTGTGGAGCCTGCTGCCAGGTCACACCATGGAAACTCAGGCTGCCCAGGAGCCCGAG GACGACCTGACACCCACACCTTCTGTCATCAGCGTCACCTCTCACCCCTGGGACCCAGGCTCCCCAGGGCAAGCACCCCCTGGGGGTGAA GGGGACAACACCCAGCTTGCAGGGCTGGAGGGGGAACGGCCAGAGCAGGAAGACATGGGTCTCTGTTCTCTGGAACACCTACCCCCAAGG ACCAGAAATTCTGGGATATGGGAGTCTCCAGAACTGGACAGGAATCTGGCTGAAGATGCTTCAAGCACAGAGGCAGCAGGAGGTTACAAA GTTGTGAGAAAAGCTGAGGTGGCAGGCAGCAAGGTTGTCCCTGCACTACCAGAGAGTGGCCAGTCAGAGCCTGGGCCACCTGAAGTGGAA GGCGGAACAAAGGCTACGGGGAACTGCTTTTATGTCAGCATGCCATCAGGACCCCCGGACTCAAGCACCGACCACTCAGAGGCACCCATG AGCCCCCCTCAGCCTGACAGCCTCCCTGCAGGGCAGACAGAGCCTCAGCCTCAGCTGCAGGGAGGCAACGATGATCCAAGACGCCCCAGC CGCTCTCCTCCAAGCCTGGCCCTCAGGGACGTGGGCATGATCTTCCATACCATTGAGCAGCTCACTCTCAAGCTCAACAGGCTCAAGGAT ATGGAGCTGGCCCACAGAGAGCTGCTCAAGTCCCTTGGGGGAGAGTCATCTGGTGGCACCACGCCTGTGGGCAGTTTCCACACAGAAGCA GCTAGATGGACAGATGGCTCCCTCTCACCTCCCGCTAAGGAGCCCCTAGCTTCTGACTCCAGGAACAGCCATGAACTGGGGCCCTGCCCT >In-frame_CCT3_ENST00000472765_chr1_156304504_-_ARHGEF11_ENST00000368194_chr1_156931567_-_3621nt ATGATGAAGATGCTTTTGGACCCAATGGGAGGCATTGTGATGACCAATGATGGCAATGCCATTCTTCGAGAGCTTTTTTACCTGTGTGCA GAAGTTTATCAGCAGGCAAGCCCCAAGGATTCCCGAAGCTTGGGGAAAGACATCTGGAATATTTTCCTGGAGAAAAATGCGCCTCTGAGA GTGAAGATCCCTGAGATGCTACAGGCTGAAATTGACTCGCGCCTGCGGAACAGCGAAGATGCCCGTGGTGTTCTCTGTGAAGCTCAAGAG GCAGCCATGCCTGAGATCCAAGAGCAGATCCACGACTACAGAACGAAGCGCACACTGGGGCTGGGCAGCCTGTATGGTGAAAATGACCTG CTGGACCTGGATGGGGACCCTCTCCGAGAGCGCCAAGTGGCTGAGAAGCAGCTGGCTGCCCTTGGAGATATTTTGTCCAAGTATGAGGAA GACAGGAGCGCCCCCATGGACTTCGCCCTCAATACCTACATGAGCCATGCTGGGATCCGTCTTCGAGAGGCACGACCTTCCAACACAGCT GAAAAGGCCCAGTCTGCTCCTGACAAGGACAAGTGGCTACCGTTCTTCCCTAAGACCAAGAAGAGCAGCAATTCCAAGAAAGAAAAGGAT GCCTTGGAGGACAAGAAGCGAAACCCTATCCTCAAATACATTGGGAAGCCCAAAAGCTCTTCTCAAAGCACATTTCATATTCCCTTGTCC CCTGTGGAAGTCAAACCAGGCAATGTGAGGAACATCATTCAGCACTTTGAGAACAACCAGCAGTATGATGCCCCAGAACCTGGGACACAA CGACTCTCGACCGGAAGCTTTCCTGAGGACCTGCTGGAGAGTGACAGTTCACGCTCAGAGATTCGCCTGGGCCGCTCTGAAAGCCTCAAG GGCCGGGAAGAGATGAAACGGTCTCGAAAGGCAGAGAACGTGCCCCGCTCTCGCAGTGATGTTGACATGGATGCTGCTGCGGAGGCTACT CGCCTGCACCAGTCAGCCTCGTCCTCTACCTCCAGCCTCTCCACCAGGTCTCTTGAGAACCCAACCCCTCCATTCACTCCCAAAATGGGC CGCAGGAGCATTGAGTCCCCCAGTTTGGGGTTCTGCACAGATACCCTCCTTCCCCACCTCCTAGAGGATGATCTGGGCCAGCTGTCTGAC CTGGAGCCAGAGCCAGATGCCCAAAATTGGCAGCATACAGTGGGCAAGGATGTGGTGGCTGGGCTAACCCAGCGGGAGATTGACCGGCAA GAGGTCATCAATGAGCTGTTTGTGACTGAAGCTTCCCACCTGCGCACACTCCGGGTCCTGGACCTGATCTTCTACCAGCGAATGAAGAAG GAGAACCTGATGCCCCGGGAGGAGCTGGCCCGGCTCTTCCCGAACCTGCCTGAACTCATAGAGATTCACAATTCCTGGTGTGAAGCCATG AAGAAGCTCCGGGAGGAAGGCCCCATCATCAAAGAGATCAGTGACCTCATGCTGGCCCGGTTTGATGGCCCTGCCCGAGAGGAACTCCAG CAAGTGGCTGCACAGTTCTGTTCCTATCAGTCAATAGCCCTAGAGCTAATCAAGACCAAGCAACGCAAGGAGAGTCGATTCCAGCTCTTC ATGCAGGAGGCTGAGAGCCACCCTCAGTGTCGGCGGCTGCAGCTGAGAGACCTCATCATCTCTGAGATGCAGCGGCTCACCAAGTACCCG CTGCTGCTGGAGAGCATCATCAAGCACACAGAGGGTGGCACCTCTGAGCATGAGAAGCTGTGCCGGGCCCGGGACCAGTGCCGGGAGATT CTCAAGTATGTGAATGAAGCGGTAAAACAAACAGAGAACCGCCACCGTTTAGAGGGCTACCAGAAACGCCTGGATGCCACCGCCCTGGAG AGGGCCAGCAACCCCCTGGCAGCAGAGTTCAAGAGCCTGGATCTTACAACCAGAAAAATGATCCATGAGGGACCCCTGACCTGGAGGATC AGCAAGGATAAGACCTTGGACCTCCACGTGCTGCTGCTGGAGGACCTCCTAGTGCTGCTACAGAAACAGGATGAGAAGCTATTGCTGAAG TGCCACAGCAAGACTGCTGTGGGCTCCTCAGACAGCAAGCAGACCTTCAGCCCCGTGCTCAAGCTCAATGCTGTGCTCATCCGCTCTGTG GCCACAGATAAACGGGCCTTCTTCATCATCTGCACCTCCAAGCTGGGCCCACCCCAGATCTATGAGCTGGTTGCATTGACGTCATCAGAC AAGAACACATGGATGGAGCTCTTAGAAGAGGCCGTGCGGAATGCCACCAGGCACCCCGGAGCTGCCCCAATGCCCGTCCATCCTCCACCC CCAGGTCCCCGGGAGCCAGCCCAGCAGGGCCCCACACCCAGCAGGGTAGAACTGGATGACTCAGACGTGTTCCATGGTGAACCTGAACCT GAGGAGCTGCCTGGAGGCACTGGGTCCCAGCAGAGGGTCCAAGGGAAGCACCAGGTCCTGCTAGAGGACCCTGAGCAGGAGGGCAGTGCA GAGGAAGAGGAACTGGGTGTCCTGCCTTGCCCTTCCACATCCCTGGATGGAGAGAACAGGGGCATCAGGACAAGGAACCCCATCCACTTG GCCTTCCCAGGCCCTCTGTTCATGGAAGGGCTCGCTGACTCCGCTCTGGAAGATGTGGAGAACCTGCGACATCTGATCCTGTGGAGCCTG CTGCCAGGTCACACCATGGAAACTCAGGCTGCCCAGGAGCCCGAGGACGACCTGACACCCACACCTTCTGTCATCAGCGTCACCTCTCAC CCCTGGGACCCAGGCTCCCCAGGGCAAGCACCCCCTGGGGGTGAAGGGGACAACACCCAGCTTGCAGGGCTGGAGGGGGAACGGCCAGAG CAGGAAGACATGGGTCTCTGTTCTCTGGAACACCTACCCCCAAGGACCAGAAATTCTGGGATATGGGAGTCTCCAGAACTGGACAGGAAT CTGGCTGAAGATGCTTCAAGCACAGAGGCAGCAGGAGGTTACAAAGTTGTGAGAAAAGCTGAGGTGGCAGGCAGCAAGGTTGTCCCTGCA CTACCAGAGAGTGGCCAGTCAGAGCCTGGGCCACCTGAAGTGGAAGGCGGAACAAAGGCTACGGGGAACTGCTTTTATGTCAGCATGCCA TCAGGACCCCCGGACTCAAGCACCGACCACTCAGAGGCACCCATGAGCCCCCCTCAGCCTGACAGCCTCCCTGCAGGGCAGACAGAGCCT CAGCCTCAGCTGCAGGGAGGCAACGATGATCCAAGACGCCCCAGCCGCTCTCCTCCAAGCCTGGCCCTCAGGGACGTGGGCATGATCTTC CATACCATTGAGCAGCTCACTCTCAAGCTCAACAGGCTCAAGGATATGGAGCTGGCCCACAGAGAGCTGCTCAAGTCCCTTGGGGGAGAG TCATCTGGTGGCACCACGCCTGTGGGCAGTTTCCACACAGAAGCAGCTAGATGGACAGATGGCTCCCTCTCACCTCCCGCTAAGGAGCCC CTAGCTTCTGACTCCAGGAACAGCCATGAACTGGGGCCCTGCCCTGAGGATGGCTCTGACGCCCCCCTGGAAGACAGCACAGCAGACGCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CCT3_ENST00000295688_chr1_156304504_-_ARHGEF11_ENST00000368194_chr1_156931567_-_5197nt ACTGCGCAAGCGCCTGTGCCCTCCCAGTGCCTTCGTCGTGCGCTCTCTGTCTAACTTGTCTGGCCGTTCTTGCGTAGGGGGCGGGACTAA GGCTGTCAATTGGTCTGTTTTTGTGCCGATCAATGAGATGGGTGCGGTGATTGGCGACTACCTTGAGAGTAGCGGGTTGAGGTGTAAGCC CTGAGGAGGCAGCGTTTTCTGGGCTTCTGTCTGGTTCTCTCTCTCCAGAAGGTTCTGCCGGTTCCCCCAGCTCTGGGTACCCGGCTCTGC ATCGCGTCGCCATGATGGGCCATCGTCCAGTGCTCGTGCTCAGCCAGAACACAAAGCGTGAATCCGGAAGAAAAGTTCAATCTGGAAACA TCAATGCTGCCAAGACTATTGCAGATATCATCCGAACATGTTTGGGACCCAAGTCCATGATGAAGATGCTTTTGGACCCAATGGGAGGCA TTGTGATGACCAATGATGGCAATGCCATTCTTCGAGAGCTTTTTTACCTGTGTGCAGAAGTTTATCAGCAGGCAAGCCCCAAGGATTCCC GAAGCTTGGGGAAAGACATCTGGAATATTTTCCTGGAGAAAAATGCGCCTCTGAGAGTGAAGATCCCTGAGATGCTACAGGCTGAAATTG ACTCGCGCCTGCGGAACAGCGAAGATGCCCGTGGTGTTCTCTGTGAAGCTCAAGAGGCAGCCATGCCTGAGATCCAAGAGCAGATCCACG ACTACAGAACGAAGCGCACACTGGGGCTGGGCAGCCTGTATGGTGAAAATGACCTGCTGGACCTGGATGGGGACCCTCTCCGAGAGCGCC AAGTGGCTGAGAAGCAGCTGGCTGCCCTTGGAGATATTTTGTCCAAGTATGAGGAAGACAGGAGCGCCCCCATGGACTTCGCCCTCAATA CCTACATGAGCCATGCTGGGATCCGTCTTCGAGAGGCACGACCTTCCAACACAGCTGAAAAGGCCCAGTCTGCTCCTGACAAGGACAAGT GGCTACCGTTCTTCCCTAAGACCAAGAAGAGCAGCAATTCCAAGAAAGAAAAGGATGCCTTGGAGGACAAGAAGCGAAACCCTATCCTCA AATACATTGGGAAGCCCAAAAGCTCTTCTCAAAGCACATTTCATATTCCCTTGTCCCCTGTGGAAGTCAAACCAGGCAATGTGAGGAACA TCATTCAGCACTTTGAGAACAACCAGCAGTATGATGCCCCAGAACCTGGGACACAACGACTCTCGACCGGAAGCTTTCCTGAGGACCTGC TGGAGAGTGACAGTTCACGCTCAGAGATTCGCCTGGGCCGCTCTGAAAGCCTCAAGGGCCGGGAAGAGATGAAACGGTCTCGAAAGGCAG AGAACGTGCCCCGCTCTCGCAGTGATGTTGACATGGATGCTGCTGCGGAGGCTACTCGCCTGCACCAGTCAGCCTCGTCCTCTACCTCCA GCCTCTCCACCAGGTCTCTTGAGAACCCAACCCCTCCATTCACTCCCAAAATGGGCCGCAGGAGCATTGAGTCCCCCAGTTTGGGGTTCT GCACAGATACCCTCCTTCCCCACCTCCTAGAGGATGATCTGGGCCAGCTGTCTGACCTGGAGCCAGAGCCAGATGCCCAAAATTGGCAGC ATACAGTGGGCAAGGATGTGGTGGCTGGGCTAACCCAGCGGGAGATTGACCGGCAAGAGGTCATCAATGAGCTGTTTGTGACTGAAGCTT CCCACCTGCGCACACTCCGGGTCCTGGACCTGATCTTCTACCAGCGAATGAAGAAGGAGAACCTGATGCCCCGGGAGGAGCTGGCCCGGC TCTTCCCGAACCTGCCTGAACTCATAGAGATTCACAATTCCTGGTGTGAAGCCATGAAGAAGCTCCGGGAGGAAGGCCCCATCATCAAAG AGATCAGTGACCTCATGCTGGCCCGGTTTGATGGCCCTGCCCGAGAGGAACTCCAGCAAGTGGCTGCACAGTTCTGTTCCTATCAGTCAA TAGCCCTAGAGCTAATCAAGACCAAGCAACGCAAGGAGAGTCGATTCCAGCTCTTCATGCAGGAGGCTGAGAGCCACCCTCAGTGTCGGC GGCTGCAGCTGAGAGACCTCATCATCTCTGAGATGCAGCGGCTCACCAAGTACCCGCTGCTGCTGGAGAGCATCATCAAGCACACAGAGG GTGGCACCTCTGAGCATGAGAAGCTGTGCCGGGCCCGGGACCAGTGCCGGGAGATTCTCAAGTATGTGAATGAAGCGGTAAAACAAACAG AGAACCGCCACCGTTTAGAGGGCTACCAGAAACGCCTGGATGCCACCGCCCTGGAGAGGGCCAGCAACCCCCTGGCAGCAGAGTTCAAGA GCCTGGATCTTACAACCAGAAAAATGATCCATGAGGGACCCCTGACCTGGAGGATCAGCAAGGATAAGACCTTGGACCTCCACGTGCTGC TGCTGGAGGACCTCCTAGTGCTGCTACAGAAACAGGATGAGAAGCTATTGCTGAAGTGCCACAGCAAGACTGCTGTGGGCTCCTCAGACA GCAAGCAGACCTTCAGCCCCGTGCTCAAGCTCAATGCTGTGCTCATCCGCTCTGTGGCCACAGATAAACGGGCCTTCTTCATCATCTGCA CCTCCAAGCTGGGCCCACCCCAGATCTATGAGCTGGTTGCATTGACGTCATCAGACAAGAACACATGGATGGAGCTCTTAGAAGAGGCCG TGCGGAATGCCACCAGGCACCCCGGAGCTGCCCCAATGCCCGTCCATCCTCCACCCCCAGGTCCCCGGGAGCCAGCCCAGCAGGGCCCCA CACCCAGCAGGGTAGAACTGGATGACTCAGACGTGTTCCATGGTGAACCTGAACCTGAGGAGCTGCCTGGAGGCACTGGGTCCCAGCAGA GGGTCCAAGGGAAGCACCAGGTCCTGCTAGAGGACCCTGAGCAGGAGGGCAGTGCAGAGGAAGAGGAACTGGGTGTCCTGCCTTGCCCTT CCACATCCCTGGATGGAGAGAACAGGGGCATCAGGACAAGGAACCCCATCCACTTGGCCTTCCCAGGCCCTCTGTTCATGGAAGGGCTCG CTGACTCCGCTCTGGAAGATGTGGAGAACCTGCGACATCTGATCCTGTGGAGCCTGCTGCCAGGTCACACCATGGAAACTCAGGCTGCCC AGGAGCCCGAGGACGACCTGACACCCACACCTTCTGTCATCAGCGTCACCTCTCACCCCTGGGACCCAGGCTCCCCAGGGCAAGCACCCC CTGGGGGTGAAGGGGACAACACCCAGCTTGCAGGGCTGGAGGGGGAACGGCCAGAGCAGGAAGACATGGGTCTCTGTTCTCTGGAACACC TACCCCCAAGGACCAGAAATTCTGGGATATGGGAGTCTCCAGAACTGGACAGGAATCTGGCTGAAGATGCTTCAAGCACAGAGGCAGCAG GAGGTTACAAAGTTGTGAGAAAAGCTGAGGTGGCAGGCAGCAAGGTTGTCCCTGCACTACCAGAGAGTGGCCAGTCAGAGCCTGGGCCAC CTGAAGTGGAAGGCGGAACAAAGGCTACGGGGAACTGCTTTTATGTCAGCATGCCATCAGGACCCCCGGACTCAAGCACCGACCACTCAG AGGCACCCATGAGCCCCCCTCAGCCTGACAGCCTCCCTGCAGGGCAGACAGAGCCTCAGCCTCAGCTGCAGGGAGGCAACGATGATCCAA GACGCCCCAGCCGCTCTCCTCCAAGCCTGGCCCTCAGGGACGTGGGCATGATCTTCCATACCATTGAGCAGCTCACTCTCAAGCTCAACA GGCTCAAGGATATGGAGCTGGCCCACAGAGAGCTGCTCAAGTCCCTTGGGGGAGAGTCATCTGGTGGCACCACGCCTGTGGGCAGTTTCC ACACAGAAGCAGCTAGATGGACAGATGGCTCCCTCTCACCTCCCGCTAAGGAGCCCCTAGCTTCTGACTCCAGGAACAGCCATGAACTGG GGCCCTGCCCTGAGGATGGCTCTGACGCCCCCCTGGAAGACAGCACAGCAGACGCAGCCGCGTCACCAGGACCATAACCGTACAAACCAC CAAATCCTCTGCGTCCCCACTCCTCCTTCAGGGACTGGCCTGAGACCGGGGCACAGGGTAGGGGGGATCCCAACACTCCTCCCTGTGGAG GAGGCAGTTAGGGAAACTAGGATCCAGCCAAGGCCCGGGGGGAGACCCGCATGTTGCTTGGTCTGCTCAAGTCGGAGTCAGGTTTCAGTG TCTTTTCCCTCCCTTAGCCCAACCCTCCAAGGCCTCATGTCTCCTAAGCATGCTGACTGCATCCGAAAGGCCCCCACTCACCATGGTCTG CCCTCACCCCACATATGTGTGTACACGCGCACGCCTGTATGTGCGCTGCCCTCAGACATGCAAGTGAAAGGAGGAGGCTTCTGTGTAAAT GCACTTTCTTCCTCCCCTCTTTCTCCATAAGACCCCAGGCAGAGGTGGGTGCCTCCCCTCCCCTCTTTGTCACTTTGGTTTCCTATAAAT ATGTATGTATCGTATGTGCATCTTTGCTATTGTAAATAACTTTGACCTTTTTTGTTCCTGTTCCTGAAGTGCTGGAGGCAGTTATGGAAG GAGCTGCTTAGGGAAGAGGGGTTTCACTTGTATCTCCTTAGTTAACAACCCAGTTCCAGGATCGAGCCTAAAGCGGGAGCCAGGCCTGAG TGTTCCTGTCCCTGTGAGTGGGAAGGTCTTCTGGCTCCCCATCCCACCTGGCTCCAGAGCCTGCCCTCCACAGCTTGCTGCCAAGCTACT CCCTCCCTCCCTGGACTTCTCATCTTCACAAGATGGGGATCATGGGGGTTTCTTACCCCACCTATGTCCCCCTCTTCCCCACCCTGTCCC TGTAGAAAACCAGTGAAGCAGGTACGGAGCTGAGGACTGGGCCCCAGGAGGTGGGGACAGGGGTCTGAATGCCGAGTCCCTGAATTCACC CAGGACCATCCAAGGGGCCACCGCAGCATTGGCCCCATCACCACGTCCTCACCCAACTCTCCCTGATGAATAGAATATACACACTGTGCT AGGTGTATATATACATATATATATATATAAATATATATATAATATATAAAATATAGATATGGAAATGACTGTTCTGCTGTTAAGATAATG >In-frame_CCT3_ENST00000472765_chr1_156304504_-_ARHGEF11_ENST00000368194_chr1_156931567_-_5102nt GTCTGGTTCTCTCTCTCCAGAAGGTTCTGCCGGTTCCCCCAGCTCTGGGTACCCGGCTCTGCATCGCGTCGCCATGATGGGCCATCGTCC AGTGCTCGTGCTCATTAGGTCTAGCTTTATATTCTTGGCCCATCCCTTAGTAGCGGTAATTTAAATGTTTCAATCTGTATTACGGAGTTA ACAGTATTTCCTAGTAGAATTGTGAGAATTAAATGAGGCCAGAACACAAAGCGTGAATCCGGAAGAAAAGTTCAATCTGGAAACATCAAT GCTGCCAAGACTATTGCAGATATCATCCGAACATGTTTGGGACCCAAGTCCATGATGAAGATGCTTTTGGACCCAATGGGAGGCATTGTG ATGACCAATGATGGCAATGCCATTCTTCGAGAGCTTTTTTACCTGTGTGCAGAAGTTTATCAGCAGGCAAGCCCCAAGGATTCCCGAAGC TTGGGGAAAGACATCTGGAATATTTTCCTGGAGAAAAATGCGCCTCTGAGAGTGAAGATCCCTGAGATGCTACAGGCTGAAATTGACTCG CGCCTGCGGAACAGCGAAGATGCCCGTGGTGTTCTCTGTGAAGCTCAAGAGGCAGCCATGCCTGAGATCCAAGAGCAGATCCACGACTAC AGAACGAAGCGCACACTGGGGCTGGGCAGCCTGTATGGTGAAAATGACCTGCTGGACCTGGATGGGGACCCTCTCCGAGAGCGCCAAGTG GCTGAGAAGCAGCTGGCTGCCCTTGGAGATATTTTGTCCAAGTATGAGGAAGACAGGAGCGCCCCCATGGACTTCGCCCTCAATACCTAC ATGAGCCATGCTGGGATCCGTCTTCGAGAGGCACGACCTTCCAACACAGCTGAAAAGGCCCAGTCTGCTCCTGACAAGGACAAGTGGCTA CCGTTCTTCCCTAAGACCAAGAAGAGCAGCAATTCCAAGAAAGAAAAGGATGCCTTGGAGGACAAGAAGCGAAACCCTATCCTCAAATAC ATTGGGAAGCCCAAAAGCTCTTCTCAAAGCACATTTCATATTCCCTTGTCCCCTGTGGAAGTCAAACCAGGCAATGTGAGGAACATCATT CAGCACTTTGAGAACAACCAGCAGTATGATGCCCCAGAACCTGGGACACAACGACTCTCGACCGGAAGCTTTCCTGAGGACCTGCTGGAG AGTGACAGTTCACGCTCAGAGATTCGCCTGGGCCGCTCTGAAAGCCTCAAGGGCCGGGAAGAGATGAAACGGTCTCGAAAGGCAGAGAAC GTGCCCCGCTCTCGCAGTGATGTTGACATGGATGCTGCTGCGGAGGCTACTCGCCTGCACCAGTCAGCCTCGTCCTCTACCTCCAGCCTC TCCACCAGGTCTCTTGAGAACCCAACCCCTCCATTCACTCCCAAAATGGGCCGCAGGAGCATTGAGTCCCCCAGTTTGGGGTTCTGCACA GATACCCTCCTTCCCCACCTCCTAGAGGATGATCTGGGCCAGCTGTCTGACCTGGAGCCAGAGCCAGATGCCCAAAATTGGCAGCATACA GTGGGCAAGGATGTGGTGGCTGGGCTAACCCAGCGGGAGATTGACCGGCAAGAGGTCATCAATGAGCTGTTTGTGACTGAAGCTTCCCAC CTGCGCACACTCCGGGTCCTGGACCTGATCTTCTACCAGCGAATGAAGAAGGAGAACCTGATGCCCCGGGAGGAGCTGGCCCGGCTCTTC CCGAACCTGCCTGAACTCATAGAGATTCACAATTCCTGGTGTGAAGCCATGAAGAAGCTCCGGGAGGAAGGCCCCATCATCAAAGAGATC AGTGACCTCATGCTGGCCCGGTTTGATGGCCCTGCCCGAGAGGAACTCCAGCAAGTGGCTGCACAGTTCTGTTCCTATCAGTCAATAGCC CTAGAGCTAATCAAGACCAAGCAACGCAAGGAGAGTCGATTCCAGCTCTTCATGCAGGAGGCTGAGAGCCACCCTCAGTGTCGGCGGCTG CAGCTGAGAGACCTCATCATCTCTGAGATGCAGCGGCTCACCAAGTACCCGCTGCTGCTGGAGAGCATCATCAAGCACACAGAGGGTGGC ACCTCTGAGCATGAGAAGCTGTGCCGGGCCCGGGACCAGTGCCGGGAGATTCTCAAGTATGTGAATGAAGCGGTAAAACAAACAGAGAAC CGCCACCGTTTAGAGGGCTACCAGAAACGCCTGGATGCCACCGCCCTGGAGAGGGCCAGCAACCCCCTGGCAGCAGAGTTCAAGAGCCTG GATCTTACAACCAGAAAAATGATCCATGAGGGACCCCTGACCTGGAGGATCAGCAAGGATAAGACCTTGGACCTCCACGTGCTGCTGCTG GAGGACCTCCTAGTGCTGCTACAGAAACAGGATGAGAAGCTATTGCTGAAGTGCCACAGCAAGACTGCTGTGGGCTCCTCAGACAGCAAG CAGACCTTCAGCCCCGTGCTCAAGCTCAATGCTGTGCTCATCCGCTCTGTGGCCACAGATAAACGGGCCTTCTTCATCATCTGCACCTCC AAGCTGGGCCCACCCCAGATCTATGAGCTGGTTGCATTGACGTCATCAGACAAGAACACATGGATGGAGCTCTTAGAAGAGGCCGTGCGG AATGCCACCAGGCACCCCGGAGCTGCCCCAATGCCCGTCCATCCTCCACCCCCAGGTCCCCGGGAGCCAGCCCAGCAGGGCCCCACACCC AGCAGGGTAGAACTGGATGACTCAGACGTGTTCCATGGTGAACCTGAACCTGAGGAGCTGCCTGGAGGCACTGGGTCCCAGCAGAGGGTC CAAGGGAAGCACCAGGTCCTGCTAGAGGACCCTGAGCAGGAGGGCAGTGCAGAGGAAGAGGAACTGGGTGTCCTGCCTTGCCCTTCCACA TCCCTGGATGGAGAGAACAGGGGCATCAGGACAAGGAACCCCATCCACTTGGCCTTCCCAGGCCCTCTGTTCATGGAAGGGCTCGCTGAC TCCGCTCTGGAAGATGTGGAGAACCTGCGACATCTGATCCTGTGGAGCCTGCTGCCAGGTCACACCATGGAAACTCAGGCTGCCCAGGAG CCCGAGGACGACCTGACACCCACACCTTCTGTCATCAGCGTCACCTCTCACCCCTGGGACCCAGGCTCCCCAGGGCAAGCACCCCCTGGG GGTGAAGGGGACAACACCCAGCTTGCAGGGCTGGAGGGGGAACGGCCAGAGCAGGAAGACATGGGTCTCTGTTCTCTGGAACACCTACCC CCAAGGACCAGAAATTCTGGGATATGGGAGTCTCCAGAACTGGACAGGAATCTGGCTGAAGATGCTTCAAGCACAGAGGCAGCAGGAGGT TACAAAGTTGTGAGAAAAGCTGAGGTGGCAGGCAGCAAGGTTGTCCCTGCACTACCAGAGAGTGGCCAGTCAGAGCCTGGGCCACCTGAA GTGGAAGGCGGAACAAAGGCTACGGGGAACTGCTTTTATGTCAGCATGCCATCAGGACCCCCGGACTCAAGCACCGACCACTCAGAGGCA CCCATGAGCCCCCCTCAGCCTGACAGCCTCCCTGCAGGGCAGACAGAGCCTCAGCCTCAGCTGCAGGGAGGCAACGATGATCCAAGACGC CCCAGCCGCTCTCCTCCAAGCCTGGCCCTCAGGGACGTGGGCATGATCTTCCATACCATTGAGCAGCTCACTCTCAAGCTCAACAGGCTC AAGGATATGGAGCTGGCCCACAGAGAGCTGCTCAAGTCCCTTGGGGGAGAGTCATCTGGTGGCACCACGCCTGTGGGCAGTTTCCACACA GAAGCAGCTAGATGGACAGATGGCTCCCTCTCACCTCCCGCTAAGGAGCCCCTAGCTTCTGACTCCAGGAACAGCCATGAACTGGGGCCC TGCCCTGAGGATGGCTCTGACGCCCCCCTGGAAGACAGCACAGCAGACGCAGCCGCGTCACCAGGACCATAACCGTACAAACCACCAAAT CCTCTGCGTCCCCACTCCTCCTTCAGGGACTGGCCTGAGACCGGGGCACAGGGTAGGGGGGATCCCAACACTCCTCCCTGTGGAGGAGGC AGTTAGGGAAACTAGGATCCAGCCAAGGCCCGGGGGGAGACCCGCATGTTGCTTGGTCTGCTCAAGTCGGAGTCAGGTTTCAGTGTCTTT TCCCTCCCTTAGCCCAACCCTCCAAGGCCTCATGTCTCCTAAGCATGCTGACTGCATCCGAAAGGCCCCCACTCACCATGGTCTGCCCTC ACCCCACATATGTGTGTACACGCGCACGCCTGTATGTGCGCTGCCCTCAGACATGCAAGTGAAAGGAGGAGGCTTCTGTGTAAATGCACT TTCTTCCTCCCCTCTTTCTCCATAAGACCCCAGGCAGAGGTGGGTGCCTCCCCTCCCCTCTTTGTCACTTTGGTTTCCTATAAATATGTA TGTATCGTATGTGCATCTTTGCTATTGTAAATAACTTTGACCTTTTTTGTTCCTGTTCCTGAAGTGCTGGAGGCAGTTATGGAAGGAGCT GCTTAGGGAAGAGGGGTTTCACTTGTATCTCCTTAGTTAACAACCCAGTTCCAGGATCGAGCCTAAAGCGGGAGCCAGGCCTGAGTGTTC CTGTCCCTGTGAGTGGGAAGGTCTTCTGGCTCCCCATCCCACCTGGCTCCAGAGCCTGCCCTCCACAGCTTGCTGCCAAGCTACTCCCTC CCTCCCTGGACTTCTCATCTTCACAAGATGGGGATCATGGGGGTTTCTTACCCCACCTATGTCCCCCTCTTCCCCACCCTGTCCCTGTAG AAAACCAGTGAAGCAGGTACGGAGCTGAGGACTGGGCCCCAGGAGGTGGGGACAGGGGTCTGAATGCCGAGTCCCTGAATTCACCCAGGA CCATCCAAGGGGCCACCGCAGCATTGGCCCCATCACCACGTCCTCACCCAACTCTCCCTGATGAATAGAATATACACACTGTGCTAGGTG TATATATACATATATATATATATAAATATATATATAATATATAAAATATAGATATGGAAATGACTGTTCTGCTGTTAAGATAATGTATAC |
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FusionGenePPI for CCT3_ARHGEF11 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CCT3 | SSSCA1, FANCA, RAF1, EIF2B2, PAFAH1B2, PPP4C, CTTNBP2, MOB4, PPP2CA, STK24, STRN, STRN3, PPP2CB, PPP2R2C, IGBP1, TCP1, CDK9, RFWD2, ATG16L1, MAPK6, VHL, WDR82, UBC, MYC, PPP2R2A, PPP2R2B, PPP2R2D, PPP2R4, AGO3, HDAC5, PSMA3, FBXW8, RAD21, SH3BP4, VAV2, SIRT7, ISG15, PSMA2, CUL3, CDK2, XRCC6, INPPL1, UBASH3B, GRB2, EPS15, FBXO6, PACRG, CCT2, CCT5, CCT7, CCT8, CCT6A, CCT4, CCT6B, MARS, PSMA6, PSMA5, NOTCH1, VCP, FN1, VCAM1, ATF2, PEX14, NOS2, CAMKMT, FAM86B2, METTL18, METTL20, METTL21B, METTL21C, METTL23, ITGA4, CFTR, PAN2, CD81, IGSF8, ICAM1, HDAC3, HDAC11, HDAC6, FBXW4, PARK2, ACACA, COPA, EEF1G, LRRC47, PPP4R2, VARS, TRIM28, CDK5, ILK, CDC20, LGALS3BP, NEDD1, TP53, TUBG1, HUWE1, FUS, MIPOL1, CUL7, OBSL1, CCDC8, SUZ12, RNF2, BMI1, CDK13, IKBKE, IRAK1, JAK3, MAPK8, PRKY, PTK6, SGK2, TSSK6, TYK2, WDR76, POC1A, NXF5, TXNDC9, FYCO1, WDR37, WDR83, DCAF5, WDR92, PEX7, GNB5, TSSC1, DDB2, TUBB2B, ACTR1B, SEC31B, TUBAL3, ACTL6A, PNPLA1, TTLL3, TUBA3C, TUBA3E, C17orf102, RPS6KB2, LGALS3, DCAF7, AMBRA1, ARF1, CAD, CANX, CLTC, DNAJA1, DNAJA4, EHD2, ETFA, GTF2I, HSPE1, LDHA, LDHB, PDCL3, PSMC2, SLC25A3, SUCLG2, WARS, CYP27A1, HSP90B1, KPNA4, MCM7, PC, RPN1, STOM, UQCRC2, NTRK1, BTRC, B9D1, MKS1, CETN2, AHSA1, GBA, HDAC1, PDK3, DNAJC7, XRCC3, NSMAF, NIPSNAP1, PRPF4, ACTR2, WRAP53, RFWD3, KIF21A, SEH1L, TUBA1C, ARMC6, GAN, SKI, FBXW7, MCM2, SNW1, CDC5L, ERRFI1, TTC27, CDC73, ZNF746, PPM1J, TUBD1, DCAF12, DTL, WDR70, DCAF13, JMJD4, KLHL33, KDM4B, DCAF10, KLHDC8A, KLHL8, WDR77, WDR46, RAP2C, DCAF4, DNAI2, BUB3, WDR86, ODF1, KLHDC8B, DCAF11, WDTC1, TUBG2, GNB1L, METAP2, DCAF8, ACTR3B, TBL1Y, THOC3, PDCL, WDR34, UTP18, GNB2, GANAB, SMOX, HCFC2, WDR5B, C4orf26, C1orf127, ACTR3, NOL10, MLST8, POC1B, ACTBL2, MAPK15, P4HA2, C11orf70, KLHDC2, CDK11A, TTLL9, STRADB, RPE65, PNPLA5, TUBA1B, DCAF12L2, C11orf54, RBM3, CYLD, TRIM25, G3BP1, BRCA1 | ARHGEF11 | PLXNB3, PLXNB1, PLXNB2, RHOA, GNA13, GNA12, CDC42, ELAVL1, ARRB2, GSK3A, GSK3B, TRMT61A, PAK4, NTRK1, ARAP2, RFXANK, PAK7, RHOC, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CCT3_ARHGEF11 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | CCT3 | P49368 | DB11638 | Artenimol | T-complex protein 1 subunit gamma | small molecule | approved|investigational |
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RelatedDiseases for CCT3_ARHGEF11 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CCT3 | C0019693 | HIV Infections | 1 | CTD_human |
| Tgene | ARHGEF11 | C0036341 | Schizophrenia | 2 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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