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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6041

FusionGeneSummary for CCNY_ANK3

check button Fusion gene summary
Fusion gene informationFusion gene name: CCNY_ANK3
Fusion gene ID: 6041
HgeneTgene
Gene symbol

CCNY

ANK3

Gene ID

219771

288

Gene namecyclin Yankyrin 3
SynonymsC10orf9|CBCP1|CCNX|CFP1ANKYRIN-G|MRT37
Cytomap

10p11.21

10q21.2

Type of geneprotein-codingprotein-coding
Descriptioncyclin-Ycyc-Ycyclin box protein 1cyclin fold protein 1cyclin-Xcyclin-box carrying protein 1ankyrin-3ankyrin 3, node of Ranvier (ankyrin G)
Modification date2018052320180523
UniProtAcc

Q8ND76

Q12955

Ensembl transtripts involved in fusion geneENST00000374706, ENST00000265375, 
ENST00000339497, ENST00000374704, 
ENST00000492478, 		ENST00000280772, 
ENST00000373827, ENST00000355288, 
ENST00000503366, ENST00000510382, 
ENST00000460468, 
Fusion gene scores* DoF score16 X 8 X 9=115212 X 16 X 9=1728
# samples 1818
** MAII scorelog2(18/1152*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1728*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCNY [Title/Abstract] AND ANK3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCCNY

GO:0000086

G2/M transition of mitotic cell cycle

20059949

HgeneCCNY

GO:0045737

positive regulation of cyclin-dependent protein serine/threonine kinase activity

19524571|20059949

HgeneCCNY

GO:0060828

regulation of canonical Wnt signaling pathway

20059949


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-FD-A3SP-01ACCNYchr10

35626135

+ANK3chr10

61874089

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000374706ENST00000280772CCNYchr10

35626135

+ANK3chr10

61874089

-
intron-3CDSENST00000374706ENST00000373827CCNYchr10

35626135

+ANK3chr10

61874089

-
intron-3CDSENST00000374706ENST00000355288CCNYchr10

35626135

+ANK3chr10

61874089

-
intron-3CDSENST00000374706ENST00000503366CCNYchr10

35626135

+ANK3chr10

61874089

-
intron-intronENST00000374706ENST00000510382CCNYchr10

35626135

+ANK3chr10

61874089

-
intron-intronENST00000374706ENST00000460468CCNYchr10

35626135

+ANK3chr10

61874089

-
5UTR-3CDSENST00000265375ENST00000280772CCNYchr10

35626135

+ANK3chr10

61874089

-
5UTR-3CDSENST00000265375ENST00000373827CCNYchr10

35626135

+ANK3chr10

61874089

-
5UTR-3CDSENST00000265375ENST00000355288CCNYchr10

35626135

+ANK3chr10

61874089

-
5UTR-3CDSENST00000265375ENST00000503366CCNYchr10

35626135

+ANK3chr10

61874089

-
5UTR-intronENST00000265375ENST00000510382CCNYchr10

35626135

+ANK3chr10

61874089

-
5UTR-intronENST00000265375ENST00000460468CCNYchr10

35626135

+ANK3chr10

61874089

-
Frame-shiftENST00000339497ENST00000280772CCNYchr10

35626135

+ANK3chr10

61874089

-
Frame-shiftENST00000339497ENST00000373827CCNYchr10

35626135

+ANK3chr10

61874089

-
Frame-shiftENST00000339497ENST00000355288CCNYchr10

35626135

+ANK3chr10

61874089

-
Frame-shiftENST00000339497ENST00000503366CCNYchr10

35626135

+ANK3chr10

61874089

-
5CDS-intronENST00000339497ENST00000510382CCNYchr10

35626135

+ANK3chr10

61874089

-
5CDS-intronENST00000339497ENST00000460468CCNYchr10

35626135

+ANK3chr10

61874089

-
Frame-shiftENST00000374704ENST00000280772CCNYchr10

35626135

+ANK3chr10

61874089

-
Frame-shiftENST00000374704ENST00000373827CCNYchr10

35626135

+ANK3chr10

61874089

-
Frame-shiftENST00000374704ENST00000355288CCNYchr10

35626135

+ANK3chr10

61874089

-
Frame-shiftENST00000374704ENST00000503366CCNYchr10

35626135

+ANK3chr10

61874089

-
5CDS-intronENST00000374704ENST00000510382CCNYchr10

35626135

+ANK3chr10

61874089

-
5CDS-intronENST00000374704ENST00000460468CCNYchr10

35626135

+ANK3chr10

61874089

-
3UTR-3CDSENST00000492478ENST00000280772CCNYchr10

35626135

+ANK3chr10

61874089

-
3UTR-3CDSENST00000492478ENST00000373827CCNYchr10

35626135

+ANK3chr10

61874089

-
3UTR-3CDSENST00000492478ENST00000355288CCNYchr10

35626135

+ANK3chr10

61874089

-
3UTR-3CDSENST00000492478ENST00000503366CCNYchr10

35626135

+ANK3chr10

61874089

-
3UTR-intronENST00000492478ENST00000510382CCNYchr10

35626135

+ANK3chr10

61874089

-
3UTR-intronENST00000492478ENST00000460468CCNYchr10

35626135

+ANK3chr10

61874089

-

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FusionProtFeatures for CCNY_ANK3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCNY

Q8ND76

ANK3

Q12955


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCNY_ANK3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCNY_ANK3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CCNYELAVL1, CDK14, CUL1, ABCE1, HOXB5, FYTTD1, TMEM185A, CCNL2, CYP51A1, CCNYL1, GJB7, KIFAP3, GPR141, SDC1, CDK16ANK3KCNC1, SPTBN4, TIAM1, MAPK6, SMAD3, SMAD2, RNF2, DOK4, PALM2, C16orf70, SCN1B, SRPK2, TMEM17, KIF11, PCNA, MCM2, CDH1, CTDSPL, RAPGEF5, CHL1, MAPK8IP1, FEZ1, HIF1AN, UXS1, PWP1, NEXN, LILRB3, PROSER2, ARHGAP22, USP15, SPAG9, MCM4, MCM6, EPS15L1, IVNS1ABP, GTF3C4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCNY_ANK3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCNY_ANK3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCCNYC0009324Ulcerative Colitis1CTD_human
HgeneCCNYC0010346Crohn Disease1CTD_human
TgeneANK3C0005586Bipolar Disorder7CTD_human;PSYGENET
TgeneANK3C0036341Schizophrenia3PSYGENET
TgeneANK3C0033975Psychotic Disorders2PSYGENET
TgeneANK3C0525045Mood Disorders2PSYGENET
TgeneANK3C0033300Progeria1CTD_human
TgeneANK3C0038220Status Epilepticus1CTD_human
TgeneANK3C0178417Anhedonia1PSYGENET
TgeneANK3C0349204Nonorganic psychosis1PSYGENET