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Fusion gene ID: 6031 |
FusionGeneSummary for CCNT1_LALBA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CCNT1_LALBA | Fusion gene ID: 6031 | Hgene | Tgene | Gene symbol | CCNT1 | LALBA | Gene ID | 904 | 3906 |
| Gene name | cyclin T1 | lactalbumin alpha | |
| Synonyms | CCNT|CYCT1|HIVE1 | LYZG | |
| Cytomap | 12q13.11-q13.12 | 12q13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cyclin-T1CDK9-associated C-type proteinMLLT10/CCNT1 fusioncyclin C-related proteinhuman immunodeficiency virus type 1 (HIV-1) expression (elevated) 1 | alpha-lactalbuminlactose synthase B proteinlysozyme Glysozyme-like protein 7 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O60563 | P00709 | |
| Ensembl transtripts involved in fusion gene | ENST00000261900, | ENST00000301046, ENST00000549817, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 2 X 2 X 2=8 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: CCNT1 [Title/Abstract] AND LALBA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CCNT1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 15563843 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-ZF-A9RM-01A | CCNT1 | chr12 | 49099551 | - | LALBA | chr12 | 48961800 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000261900 | ENST00000301046 | CCNT1 | chr12 | 49099551 | - | LALBA | chr12 | 48961800 | - |
| 5CDS-3UTR | ENST00000261900 | ENST00000549817 | CCNT1 | chr12 | 49099551 | - | LALBA | chr12 | 48961800 | - |
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FusionProtFeatures for CCNT1_LALBA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CCNT1 | LALBA |
| Regulatory subunit of the cyclin-dependent kinase pair(CDK9/cyclin-T1) complex, also called positive transcriptionelongation factor B (P-TEFb), which is proposed to facilitate thetransition from abortive to productive elongation byphosphorylating the CTD (carboxy-terminal domain) of the largesubunit of RNA polymerase II (RNA Pol II).{ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377}. (Microbial infection) In case of HIV or SIV infections,binds to the transactivation domain of the viral nucleartranscriptional activator, Tat, thereby increasing Tat's affinityfor the transactivating response RNA element (TAR RNA). Serves asan essential cofactor for Tat, by promoting RNA Pol II activation,allowing transcription of viral genes.{ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}. | Regulatory subunit of lactose synthase, changes thesubstrate specificity of galactosyltransferase in the mammarygland making glucose a good acceptor substrate for this enzyme.This enables LS to synthesize lactose, the major carbohydratecomponent of milk. In other tissues, galactosyltransferasetransfers galactose onto the N-acetylglucosamine of theoligosaccharide chains in glycoproteins. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CCNT1_LALBA |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CCNT1_LALBA |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CCNT1 | GRN, HEXIM1, NUFIP1, CDK9, MYC, MDFIC, AHR, PML, HTATSF1, PURA, AFF4, MYBL2, NCOA2, GRIPAP1, SUPT5H, BRD4, PGC, MEPCE, HNRNPA1, PMS1, AFF1, SNW1, MAX, MLLT3, KDM1B, WHSC1L1, MLLT1, KMT2A, TERF1, TERF2, TAF7, POLR2A, GTF2F1, UBE2A, LEO1, TAF1, TUBB4B, GNAI3, RPS9, C11orf58, TP53BP1, BARD1, CCNT1, ESR1, BRDT, DAB2, MED26, ELL2, SOX2, RN7SK, LARP7, KAT2B, TP73, TMEM150A, CACNG2, COMTD1, ELL3, CDK6, NTRK1, CTR9, AIRE, HEXIM2, PIP4K2A, H2AFY2, CTSE, CIITA, TRIM22 | LALBA | HIST2H3A, B4GALT1, HSPA8, CRYAB |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CCNT1_LALBA |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CCNT1_LALBA |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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