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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6015

FusionGeneSummary for CCNG1_SLCO6A1

check button Fusion gene summary
Fusion gene informationFusion gene name: CCNG1_SLCO6A1
Fusion gene ID: 6015
HgeneTgene
Gene symbol

CCNG1

SLCO6A1

Gene ID

900

133482

Gene namecyclin G1solute carrier organic anion transporter family member 6A1
SynonymsCCNGCT48|GST|OATP-I|OATP6A1|OATPY
Cytomap

5q34

5q21.1

Type of geneprotein-codingprotein-coding
Descriptioncyclin-G1cyclin-Gsolute carrier organic anion transporter family member 6A1cancer/testis antigen 48gonad-specific transporterorganic anion-transporting polypeptide Isolute carrier family 21 member 19testicular tissue protein Li 174testis-specific organic anion trans
Modification date2018052320180523
UniProtAcc

P51959

Q86UG4

Ensembl transtripts involved in fusion geneENST00000512163, ENST00000393929, 
ENST00000340828, ENST00000511683, 
ENST00000510664, ENST00000504553, 
ENST00000509425, 
ENST00000506729, 
ENST00000379807, ENST00000389019, 
ENST00000513675, ENST00000379810, 
ENST00000514551, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 2 X 4=40
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/40*10)=0
Context

PubMed: CCNG1 [Title/Abstract] AND SLCO6A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVACCTCGA-OR-A5JS-01ACCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000512163ENST00000506729CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
intron-3CDSENST00000512163ENST00000379807CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
intron-3CDSENST00000512163ENST00000389019CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
intron-3CDSENST00000512163ENST00000513675CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
intron-3CDSENST00000512163ENST00000379810CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
intron-intronENST00000512163ENST00000514551CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
3UTR-3CDSENST00000393929ENST00000506729CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
3UTR-3CDSENST00000393929ENST00000379807CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
3UTR-3CDSENST00000393929ENST00000389019CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
3UTR-3CDSENST00000393929ENST00000513675CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
3UTR-3CDSENST00000393929ENST00000379810CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
3UTR-intronENST00000393929ENST00000514551CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
3UTR-3CDSENST00000340828ENST00000506729CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
3UTR-3CDSENST00000340828ENST00000379807CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
3UTR-3CDSENST00000340828ENST00000389019CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
3UTR-3CDSENST00000340828ENST00000513675CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
3UTR-3CDSENST00000340828ENST00000379810CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
3UTR-intronENST00000340828ENST00000514551CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
intron-3CDSENST00000511683ENST00000506729CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
intron-3CDSENST00000511683ENST00000379807CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
intron-3CDSENST00000511683ENST00000389019CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
intron-3CDSENST00000511683ENST00000513675CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
intron-3CDSENST00000511683ENST00000379810CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
intron-intronENST00000511683ENST00000514551CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
intron-3CDSENST00000510664ENST00000506729CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
intron-3CDSENST00000510664ENST00000379807CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
intron-3CDSENST00000510664ENST00000389019CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
intron-3CDSENST00000510664ENST00000513675CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
intron-3CDSENST00000510664ENST00000379810CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
intron-intronENST00000510664ENST00000514551CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
intron-3CDSENST00000504553ENST00000506729CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
intron-3CDSENST00000504553ENST00000379807CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
intron-3CDSENST00000504553ENST00000389019CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
intron-3CDSENST00000504553ENST00000513675CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
intron-3CDSENST00000504553ENST00000379810CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
intron-intronENST00000504553ENST00000514551CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
3UTR-3CDSENST00000509425ENST00000506729CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
3UTR-3CDSENST00000509425ENST00000379807CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
3UTR-3CDSENST00000509425ENST00000389019CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
3UTR-3CDSENST00000509425ENST00000513675CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
3UTR-3CDSENST00000509425ENST00000379810CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-
3UTR-intronENST00000509425ENST00000514551CCNG1chr5

162871487

+SLCO6A1chr5

101709198

-

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FusionProtFeatures for CCNG1_SLCO6A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCNG1

P51959

SLCO6A1

Q86UG4

May play a role in growth regulation. Is associated withG2/M phase arrest in response to DNA damage. May be anintermediate by which p53 mediates its role as an inhibitor ofcellular proliferation (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCNG1_SLCO6A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCNG1_SLCO6A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CCNG1TP53, MDM2, CDKN2A, GAK, PPP2R4, TP73, CDK2, APP, TNIP1, SHKBP1, GRN, LTBP3, NFATC4, TFAP2C, PLEKHA4, PNMA1, RBPMS, TFIP11, PAK7, HMBOX1, LZTS2, KRT40, SPERT, KRTAP10-7, MOV10, NXF1, CPSF4L, ZZEF1, CUL4B, CUL4A, HECTD3, PPP2R5D, PPP2R5E, PPP2R5C, LARP1B, DDB1, UBR4, TRIM25, LMNASLCO6A1LAPTM4B, RNASE7, SLC9A1, CTSH, HAL, CPA4, PTPN1, ASAH1, EDA, TTYH3, PSMD11, TGM1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCNG1_SLCO6A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCNG1_SLCO6A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCCNG1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCCNG1C0024121Lung Neoplasms1CTD_human