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Fusion gene ID: 6013 |
FusionGeneSummary for CCNF_NPW |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CCNF_NPW | Fusion gene ID: 6013 | Hgene | Tgene | Gene symbol | CCNF | NPW | Gene ID | 899 | 283869 |
| Gene name | cyclin F | neuropeptide W | |
| Synonyms | FBX1|FBXO1 | L8|L8C|PPL8|PPNPW | |
| Cytomap | 16p13.3 | 16p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cyclin-FF-box only protein 1G2/mitotic-specific cyclin-F | neuropeptide WhPPL8prepro-neuropeptide Wpreproprotein L8 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P41002 | Q8N729 | |
| Ensembl transtripts involved in fusion gene | ENST00000397066, | ENST00000329610, ENST00000566435, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 2 X 2 X 2=8 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: CCNF [Title/Abstract] AND NPW [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CCNF | GO:0010826 | negative regulation of centrosome duplication | 20596027 |
| Hgene | CCNF | GO:0016567 | protein ubiquitination | 20596027 |
| Hgene | CCNF | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 20596027 |
| Tgene | NPW | GO:0007186 | G-protein coupled receptor signaling pathway | 12401809 |
| Tgene | NPW | GO:0007631 | feeding behavior | 12959997 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCEC | TCGA-A5-A2K2-01A | CCNF | chr16 | 2507017 | + | NPW | chr16 | 2070534 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000397066 | ENST00000329610 | CCNF | chr16 | 2507017 | + | NPW | chr16 | 2070534 | + |
| Frame-shift | ENST00000397066 | ENST00000566435 | CCNF | chr16 | 2507017 | + | NPW | chr16 | 2070534 | + |
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FusionProtFeatures for CCNF_NPW |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CCNF | NPW |
| Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediatesthe ubiquitination and subsequent proteasomal degradation of CP110during G2 phase, thereby acting as an inhibitor of centrosomereduplication. {ECO:0000269|PubMed:20596027}. | Plays a regulatory role in the organization ofneuroendocrine signals accessing the anterior pituitary gland.Stimulates water drinking and food intake. May play a role in thehypothalamic response to stress (By similarity). NPW23 activatesGPR7 and GPR8 more efficiently than NPW30. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CCNF_NPW |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CCNF_NPW |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CCNF | CDK1, CCNB1, CCP110, PSMA6, SKP1, RRM2, CUL1, RBX1, NUSAP1, SCYL1, MYBL2, CDC6, SLBP, TRIM25, FZR1, CDC20, AKT1 | NPW | NPBWR1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CCNF_NPW |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CCNF_NPW |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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