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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6004

FusionGeneSummary for CCND3_PPP2R5D

check button Fusion gene summary
Fusion gene informationFusion gene name: CCND3_PPP2R5D
Fusion gene ID: 6004
HgeneTgene
Gene symbol

CCND3

PPP2R5D

Gene ID

896

5528

Gene namecyclin D3protein phosphatase 2 regulatory subunit B'delta
Synonyms-B56D|B56delta|MRD35
Cytomap

6p21.1

6p21.1

Type of geneprotein-codingprotein-coding
DescriptionG1/S-specific cyclin-D3D3-type cyclinserine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoformPP2A, B subunit, B' delta isoformPP2A, B subunit, B56 delta isoformPP2A, B subunit, PR61 delta isoformPP2A, B subunit, R5 delta isoformSerine/threonine protein phosphatase
Modification date2018052320180523
UniProtAcc

P30281

Q14738

Ensembl transtripts involved in fusion geneENST00000511642, ENST00000415497, 
ENST00000372988, ENST00000510503, 
ENST00000511686, ENST00000372991, 
ENST00000372987, ENST00000414200, 
ENST00000485511, ENST00000394110, 
ENST00000472118, ENST00000461010, 
Fusion gene scores* DoF score10 X 2 X 10=2004 X 2 X 2=16
# samples 143
** MAII scorelog2(14/200*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/16*10)=0.906890595608518
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CCND3 [Title/Abstract] AND PPP2R5D [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCCND3

GO:0001934

positive regulation of protein phosphorylation

8114739

HgeneCCND3

GO:0045737

positive regulation of cyclin-dependent protein serine/threonine kinase activity

8114739

TgenePPP2R5D

GO:0006470

protein dephosphorylation

24157919


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-13-1505-01ACCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000511642ENST00000485511CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
intron-3CDSENST00000511642ENST00000394110CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
intron-3CDSENST00000511642ENST00000472118CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
intron-intronENST00000511642ENST00000461010CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
5UTR-3CDSENST00000415497ENST00000485511CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
5UTR-3CDSENST00000415497ENST00000394110CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
5UTR-3CDSENST00000415497ENST00000472118CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
5UTR-intronENST00000415497ENST00000461010CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
5UTR-3CDSENST00000372988ENST00000485511CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
5UTR-3CDSENST00000372988ENST00000394110CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
5UTR-3CDSENST00000372988ENST00000472118CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
5UTR-intronENST00000372988ENST00000461010CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
5UTR-3CDSENST00000510503ENST00000485511CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
5UTR-3CDSENST00000510503ENST00000394110CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
5UTR-3CDSENST00000510503ENST00000472118CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
5UTR-intronENST00000510503ENST00000461010CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
5UTR-3CDSENST00000511686ENST00000485511CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
5UTR-3CDSENST00000511686ENST00000394110CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
5UTR-3CDSENST00000511686ENST00000472118CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
5UTR-intronENST00000511686ENST00000461010CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
intron-3CDSENST00000372991ENST00000485511CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
intron-3CDSENST00000372991ENST00000394110CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
intron-3CDSENST00000372991ENST00000472118CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
intron-intronENST00000372991ENST00000461010CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
intron-3CDSENST00000372987ENST00000485511CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
intron-3CDSENST00000372987ENST00000394110CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
intron-3CDSENST00000372987ENST00000472118CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
intron-intronENST00000372987ENST00000461010CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
intron-3CDSENST00000414200ENST00000485511CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
intron-3CDSENST00000414200ENST00000394110CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
intron-3CDSENST00000414200ENST00000472118CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+
intron-intronENST00000414200ENST00000461010CCND3chr6

42016239

-PPP2R5Dchr6

42957349

+

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FusionProtFeatures for CCND3_PPP2R5D


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCND3

P30281

PPP2R5D

Q14738

Regulatory component of the cyclin D3-CDK4 (DC) complexthat phosphorylates and inhibits members of the retinoblastoma(RB) protein family including RB1 and regulates the cell-cycleduring G(1)/S transition. Phosphorylation of RB1 allowsdissociation of the transcription factor E2F from the RB/E2Fcomplex and the subsequent transcription of E2F target genes whichare responsible for the progression through the G(1) phase.Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4complexes are major integrators of various mitogenenic andantimitogenic signals. Also substrate for SMAD3, phosphorylatingSMAD3 in a cell-cycle-dependent manner and repressing itstranscriptional activity. Component of the ternary complex, cyclinD3/CDK4/CDKN1B, required for nuclear translocation and activity ofthe cyclin D-CDK4 complex. {ECO:0000269|PubMed:15358120}. The B regulatory subunit might modulate substrateselectivity and catalytic activity, and also might direct thelocalization of the catalytic enzyme to a particular subcellularcompartment.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCND3_PPP2R5D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCND3_PPP2R5D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CCND3EIF3K, DTNBP1, EFEMP2, MAF1, CDKN1B, CDKN1A, CDK4, MCM10, AKAP8, RB1, ATP5C1, CDK6, RBX1, TSC2, NPDC1, PCNA, CDK11B, CRABP2, RARA, CASP2, NCOA2, CDK2, PPP1CA, PPP1CB, PPP1CC, APP, RBL2, POLD1, CDK14, SIL1, FAS, MYB, ETV1, GC, NME1, MAPK6, VDR, ATF5, CDK5, TFIP11, POLR3GL, CDK1, ZNF2, CLU, CDKN1C, CDKN2C, KLK5, CREBBP, AREG, STAP1PPP2R5DHAND2, PPFIA1, HAND1, ARL2, PPP4C, PPP2CA, PPP2R1A, PPP2CB, PPP2R1B, CHEK2, GSK3B, SOX2, YWHAB, ARPC2, NIF3L1, ARPC1B, DHPS, FEN1, GOPC, HECTD1, LPP, PRDX1, PRDX2, RANGAP1, RPA2, SH3GLB1, TPD52L2, USHBP1, FSD2, CLOCK, CSNK2B, DEC1, RORC, CRY2, CRY1, CSNK1E, BCAT1, DNASE2B, PPME1, FAM43A, WNT3A, PON2, CCNG1, DNAAF5, LARS, PFDN5, PPP2R2A, PPP2R2D, PPP2R5A, TTC27, PTPRF, RRM2, XPO6, NTRK1, CTR9, CCHCR1, CCDC61, DUSP19, PRR14, CCNG2, CELA3A, RAPGEF5, USP47, FBXL3, YBEY, BTBD6, RPS27, GPR37, PDDC1, BMP7, PPP1CA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCND3_PPP2R5D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCND3_PPP2R5D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePPP2R5DC4225354MENTAL RETARDATION, AUTOSOMAL DOMINANT 351ORPHANET;UNIPROT