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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5977

FusionGeneSummary for CCNB1_CCDC84

check button Fusion gene summary
Fusion gene informationFusion gene name: CCNB1_CCDC84
Fusion gene ID: 5977
HgeneTgene
Gene symbol

CCNB1

CCDC84

Gene ID

891

338657

Gene namecyclin B1coiled-coil domain containing 84
SynonymsCCNBDLNB14
Cytomap

5q13.2

11q23.3

Type of geneprotein-codingprotein-coding
DescriptionG2/mitotic-specific cyclin-B1coiled-coil domain-containing protein 84
Modification date2018052320180519
UniProtAcc

P14635

Q86UT8

Ensembl transtripts involved in fusion geneENST00000256442, ENST00000334418, 
ENST00000580556, 
Fusion gene scores* DoF score3 X 3 X 1=92 X 2 X 1=4
# samples 42
** MAII scorelog2(4/9*10)=2.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/4*10)=2.32192809488736
Context

PubMed: CCNB1 [Title/Abstract] AND CCDC84 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCCNB1

GO:0010971

positive regulation of G2/M transition of mitotic cell cycle

24746669

HgeneCCNB1

GO:1905448

positive regulation of mitochondrial ATP synthesis coupled electron transport

24746669


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW855254CCNB1chr5

68470886

-CCDC84chr11

118869722

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000256442ENST00000334418CCNB1chr5

68470886

-CCDC84chr11

118869722

+
5CDS-intronENST00000256442ENST00000580556CCNB1chr5

68470886

-CCDC84chr11

118869722

+

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FusionProtFeatures for CCNB1_CCDC84


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCNB1

P14635

CCDC84

Q86UT8

Essential for the control of the cell cycle at the G2/M(mitosis) transition. {ECO:0000269|PubMed:17495531,ECO:0000269|PubMed:17495533}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCNB1_CCDC84


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCNB1_CCDC84


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCNB1_CCDC84


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCNB1_CCDC84


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCCNB1C0032460Polycystic Ovary Syndrome1CTD_human