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Fusion gene ID: 5973 |
FusionGeneSummary for CCM2_PPIA |
Fusion gene summary |
Fusion gene information | Fusion gene name: CCM2_PPIA | Fusion gene ID: 5973 | Hgene | Tgene | Gene symbol | CCM2 | PPIA | Gene ID | 83605 | 5478 |
Gene name | CCM2 scaffold protein | peptidylprolyl isomerase A | |
Synonyms | C7orf22|OSM|PP10187 | CYPA|CYPH|HEL-S-69p | |
Cytomap | 7p13 | 7p13 | |
Type of gene | protein-coding | protein-coding | |
Description | cerebral cavernous malformations 2 proteinCCM2 scaffolding proteincerebral cavernous malformation 2malcaverninosmosensing scaffold for MEKK3 | peptidyl-prolyl cis-trans isomerase APPIase AT cell cyclophilincyclosporin A-binding proteinepididymis secretory sperm binding protein Li 69ppeptidylprolyl isomerase A (cyclophilin A)rotamase A | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9BSQ5 | P62937 | |
Ensembl transtripts involved in fusion gene | ENST00000461377, ENST00000258781, ENST00000544363, ENST00000541586, ENST00000475551, ENST00000381112, ENST00000474617, | ENST00000451562, ENST00000468812, ENST00000489459, ENST00000355968, ENST00000480603, | |
Fusion gene scores | * DoF score | 4 X 2 X 2=16 | 6 X 6 X 2=72 |
# samples | 5 | 7 | |
** MAII score | log2(5/16*10)=1.64385618977472 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CCM2 [Title/Abstract] AND PPIA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PPIA | GO:0000413 | protein peptidyl-prolyl isomerization | 14993672|20676357 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A7-A26G-01A | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
TCGA | LD | BRCA | TCGA-AR-A24O-01A | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000461377 | ENST00000451562 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
3UTR-3CDS | ENST00000461377 | ENST00000468812 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
3UTR-5UTR | ENST00000461377 | ENST00000489459 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
3UTR-5UTR | ENST00000461377 | ENST00000355968 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
3UTR-3UTR | ENST00000461377 | ENST00000480603 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
In-frame | ENST00000258781 | ENST00000451562 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
In-frame | ENST00000258781 | ENST00000468812 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
5CDS-5UTR | ENST00000258781 | ENST00000489459 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
5CDS-5UTR | ENST00000258781 | ENST00000355968 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
5CDS-3UTR | ENST00000258781 | ENST00000480603 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
In-frame | ENST00000544363 | ENST00000451562 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
In-frame | ENST00000544363 | ENST00000468812 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
5CDS-5UTR | ENST00000544363 | ENST00000489459 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
5CDS-5UTR | ENST00000544363 | ENST00000355968 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
5CDS-3UTR | ENST00000544363 | ENST00000480603 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
intron-3CDS | ENST00000541586 | ENST00000451562 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
intron-3CDS | ENST00000541586 | ENST00000468812 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
intron-5UTR | ENST00000541586 | ENST00000489459 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
intron-5UTR | ENST00000541586 | ENST00000355968 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
intron-3UTR | ENST00000541586 | ENST00000480603 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
In-frame | ENST00000475551 | ENST00000451562 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
In-frame | ENST00000475551 | ENST00000468812 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
5CDS-5UTR | ENST00000475551 | ENST00000489459 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
5CDS-5UTR | ENST00000475551 | ENST00000355968 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
5CDS-3UTR | ENST00000475551 | ENST00000480603 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
In-frame | ENST00000381112 | ENST00000451562 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
In-frame | ENST00000381112 | ENST00000468812 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
5CDS-5UTR | ENST00000381112 | ENST00000489459 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
5CDS-5UTR | ENST00000381112 | ENST00000355968 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
5CDS-3UTR | ENST00000381112 | ENST00000480603 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
In-frame | ENST00000474617 | ENST00000451562 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
In-frame | ENST00000474617 | ENST00000468812 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
5CDS-5UTR | ENST00000474617 | ENST00000489459 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
5CDS-5UTR | ENST00000474617 | ENST00000355968 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
5CDS-3UTR | ENST00000474617 | ENST00000480603 | CCM2 | chr7 | 45078025 | + | PPIA | chr7 | 44838846 | + |
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FusionProtFeatures for CCM2_PPIA |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
CCM2 | PPIA |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CCM2_PPIA |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_CCM2_ENST00000258781_chr7_45078025_+_PPIA_ENST00000451562_chr7_44838846_+_167aa MEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKLFADKVPKTAENFRALSTGEKG >In-frame_CCM2_ENST00000258781_chr7_45078025_+_PPIA_ENST00000468812_chr7_44838846_+_211aa MEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKLFADKVPKTAENFRALSTGEKG FGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEG >In-frame_CCM2_ENST00000544363_chr7_45078025_+_PPIA_ENST00000451562_chr7_44838846_+_167aa MEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKLFADKVPKTAENFRALSTGEKG >In-frame_CCM2_ENST00000544363_chr7_45078025_+_PPIA_ENST00000468812_chr7_44838846_+_211aa MEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKLFADKVPKTAENFRALSTGEKG FGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEG >In-frame_CCM2_ENST00000475551_chr7_45078025_+_PPIA_ENST00000451562_chr7_44838846_+_161aa MENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKLFADKVPKTAENFRALSTGEKGFGYKGS >In-frame_CCM2_ENST00000475551_chr7_45078025_+_PPIA_ENST00000468812_chr7_44838846_+_205aa MENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKLFADKVPKTAENFRALSTGEKGFGYKGS CFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEA >In-frame_CCM2_ENST00000381112_chr7_45078025_+_PPIA_ENST00000451562_chr7_44838846_+_188aa MHSSCRQRRNQNLSKEIPQTEFHTGYSMENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKL FADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFI >In-frame_CCM2_ENST00000381112_chr7_45078025_+_PPIA_ENST00000468812_chr7_44838846_+_232aa MHSSCRQRRNQNLSKEIPQTEFHTGYSMENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKL FADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFI >In-frame_CCM2_ENST00000474617_chr7_45078025_+_PPIA_ENST00000451562_chr7_44838846_+_161aa MENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKLFADKVPKTAENFRALSTGEKGFGYKGS >In-frame_CCM2_ENST00000474617_chr7_45078025_+_PPIA_ENST00000468812_chr7_44838846_+_205aa MENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKLFADKVPKTAENFRALSTGEKGFGYKGS CFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEA |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_CCM2_ENST00000258781_chr7_45078025_+_PPIA_ENST00000451562_chr7_44838846_+_501nt ATGGAAGAGGAGGGCAAGAAGGGCAAGAAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGAGATAAG AAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTGCTGAGC GACTATATTGAGAAGGAGGTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAGAAAGGA TTTGGTTATAAGGGTTCCTGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACTGGTGGC AAGTCCATCTATGGGGAGAAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCTGGACCC >In-frame_CCM2_ENST00000258781_chr7_45078025_+_PPIA_ENST00000468812_chr7_44838846_+_633nt ATGGAAGAGGAGGGCAAGAAGGGCAAGAAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGAGATAAG AAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTGCTGAGC GACTATATTGAGAAGGAGGTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAGAAAGGA TTTGGTTATAAGGGTTCCTGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACTGGTGGC AAGTCCATCTATGGGGAGAAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCTGGACCC AACACAAATGGTTCCCAGTTTTTCATCTGCACTGCCAAGACTGAGTGGTTGGATGGCAAGCATGTGGTGTTTGGCAAAGTGAAAGAAGGC ATGAATATTGTGGAGGCCATGGAGCGCTTTGGGTCCAGGAATGGCAAGACCAGCAAGAAGATCACCATTGCTGACTGTGGACAACTCGAA >In-frame_CCM2_ENST00000544363_chr7_45078025_+_PPIA_ENST00000451562_chr7_44838846_+_501nt ATGGAAGAGGAGGGCAAGAAGGGCAAGAAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGAGATAAG AAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTGCTGAGC GACTATATTGAGAAGGAGGTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAGAAAGGA TTTGGTTATAAGGGTTCCTGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACTGGTGGC AAGTCCATCTATGGGGAGAAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCTGGACCC >In-frame_CCM2_ENST00000544363_chr7_45078025_+_PPIA_ENST00000468812_chr7_44838846_+_633nt ATGGAAGAGGAGGGCAAGAAGGGCAAGAAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGAGATAAG AAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTGCTGAGC GACTATATTGAGAAGGAGGTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAGAAAGGA TTTGGTTATAAGGGTTCCTGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACTGGTGGC AAGTCCATCTATGGGGAGAAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCTGGACCC AACACAAATGGTTCCCAGTTTTTCATCTGCACTGCCAAGACTGAGTGGTTGGATGGCAAGCATGTGGTGTTTGGCAAAGTGAAAGAAGGC ATGAATATTGTGGAGGCCATGGAGCGCTTTGGGTCCAGGAATGGCAAGACCAGCAAGAAGATCACCATTGCTGACTGTGGACAACTCGAA >In-frame_CCM2_ENST00000475551_chr7_45078025_+_PPIA_ENST00000451562_chr7_44838846_+_483nt ATGGAGAATGAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTG ACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAG GTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCC TGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAG AAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAG >In-frame_CCM2_ENST00000475551_chr7_45078025_+_PPIA_ENST00000468812_chr7_44838846_+_615nt ATGGAGAATGAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTG ACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAG GTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCC TGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAG AAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAG TTTTTCATCTGCACTGCCAAGACTGAGTGGTTGGATGGCAAGCATGTGGTGTTTGGCAAAGTGAAAGAAGGCATGAATATTGTGGAGGCC >In-frame_CCM2_ENST00000381112_chr7_45078025_+_PPIA_ENST00000451562_chr7_44838846_+_564nt ATGCATAGTAGCTGTCGGCAGAGGAGGAACCAGAATCTCTCCAAAGAAATTCCTCAAACAGAATTTCACACAGGGTATTCCATGGAGAAT GAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGG CGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTG TTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCAC AGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAA GATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATC >In-frame_CCM2_ENST00000381112_chr7_45078025_+_PPIA_ENST00000468812_chr7_44838846_+_696nt ATGCATAGTAGCTGTCGGCAGAGGAGGAACCAGAATCTCTCCAAAGAAATTCCTCAAACAGAATTTCACACAGGGTATTCCATGGAGAAT GAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGG CGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTG TTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCAC AGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAA GATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATC TGCACTGCCAAGACTGAGTGGTTGGATGGCAAGCATGTGGTGTTTGGCAAAGTGAAAGAAGGCATGAATATTGTGGAGGCCATGGAGCGC >In-frame_CCM2_ENST00000474617_chr7_45078025_+_PPIA_ENST00000451562_chr7_44838846_+_483nt ATGGAGAATGAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTG ACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAG GTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCC TGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAG AAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAG >In-frame_CCM2_ENST00000474617_chr7_45078025_+_PPIA_ENST00000468812_chr7_44838846_+_615nt ATGGAGAATGAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTG ACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAG GTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCC TGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAG AAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAG TTTTTCATCTGCACTGCCAAGACTGAGTGGTTGGATGGCAAGCATGTGGTGTTTGGCAAAGTGAAAGAAGGCATGAATATTGTGGAGGCC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_CCM2_ENST00000258781_chr7_45078025_+_PPIA_ENST00000451562_chr7_44838846_+_783nt GGGGCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGC TGCTGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGC CTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCC CTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTG CAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAA TTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATG AGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCA CTGCCAAGACTGAGTGGTAAGGGTACAACATGGCACACTAACCACCTGACTAAATGAAAAGTTGCCCTGGGGGGAACGGAACAAACACTA >In-frame_CCM2_ENST00000258781_chr7_45078025_+_PPIA_ENST00000468812_chr7_44838846_+_2477nt GGGGCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGC TGCTGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGC CTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCC CTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTG CAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAA TTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATG AGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCA CTGCCAAGACTGAGTGGTTGGATGGCAAGCATGTGGTGTTTGGCAAAGTGAAAGAAGGCATGAATATTGTGGAGGCCATGGAGCGCTTTG GGTCCAGGAATGGCAAGACCAGCAAGAAGATCACCATTGCTGACTGTGGACAACTCGAATAAGTTTGACTTGTGTTTTATCTTAACCACC AGATCATTCCTTCTGTAGCTCAGGAGAGCACCCCTCCACCCCATTTGCTCGCAGTATCCTAGAATCTTTGTGCTCTCGCTGCAGTTCCCT TTGGGTTCCATGTTTTCCTTGTTCCCTCCCATGCCTAGCTGGATTGCAGAGTTAAGTTTATGATTATGAAATAAAAACTAAATAACAATT GTCCTCGTTTGAGTTAAGAGTGTTGATGTAGGCTTTATTTTAAGCAGTAATGGGTTACTTCTGAAACATCACTTGTTTGCTTAATTCTAC ACAGTACTTAGATTTTTTTTACTTTCCAGTCCCAGGAAGTGTCAATGTTTGTTGAGTGGAATATTGAAAATGTAGGCAGCAACTGGGCAT GGTGGCTCACTGTCTGTAATGTATTACCTGAGGCAGAAGACCACCTGAGGGTAGGAGTCAAGATCAGCCTGGGCAACATAGTGAGACGCT GTCTCTACAAAAAATAATTAGCCTGGCCTGGTGGTGCATGCCTAGTCCTAGCTGATCTGGAGGCTGACGTGGGAGGATTGCTTGAGCCTA GAGTGAGCTATTATCATGCCACTGTACAGCCTGGGTGTTCACAGATCTTGTGTCTCAAAGGTAGGCAGAGGCAGGAAAAGCAAGGAGCCA GAATTAAGAGGTTGGGTCAGTCTGCAGTGAGTTCATGCATTTAGAGGTGTTCTTCAAGATGACTAATGTCAAAAATTGAGACATCTGTTG CGGTTTTTTTTTTTTTTTTTTCCCCTGGAATGCAGTGGCGTGATCTCAGCTCACTGCAGCCTCCGCCTCCTGGGTTCAAGTGATTCTAGT GCCTCAGCCTCCTGAGTAGCTGGGATAATGGGCGTGTGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTATAGATGGGGTTTCATCAT TTTGACCAGGCTGGTCTCAAACTCTTGACCTCAGCTGATGCGCCTGCCTTGGCCTCCCAAACTGCTGAGATTACAGATGTGAGCCACCGC ACCCTACCTCATTTTCTGTAACAAAGCTAAGCTTGAACACTGTTGATGTTCTTGAGGGAAGCATATTGGGCTTTAGGCTGTAGGTCAAGT TTATACATCTTAATTATGGTGGAATTCCTATGTAGAGTCTAAAAAGCCAGGTACTTGGTGCTACAGTCAGTCTCCCTGCAGAGGGTTAAG GCGCAGACTACCTGCAGTGAGGAGGTACTGCTTGTAGCATATAGAGCCTCTCCCTAGCTTTGGTTATGGAGGCTTTGAGGTTTTGCAAAC CTGACCAATTTAAGCCATAAGATCTGGTCAAAGGGATACCCTTCCCACTAAGGACTTGGTTTCTCAGGAAATTATATGTACAGTGCTTGC TGGCAGTTAGATGTCAGGACAATCTAAGCTGAGAAAACCCCTTCTCTGCCCACCTTAACAGACCTCTAGGGTTCTTAACCCAGCAATCAA GTTTGCCTATCCTAGAGGTGGCGGATTTGATCATTTGGTGTGTTGGGCAATTTTTGTTTTACTGTCTGGTTCCTTCTGCGTGAATTACCA CCACCACCACTTGTGCATCTCAGTCTTGTGTGTTGTCTGGTTACGTATTCCCTGGGTGATACCATTCAATGTCTTAATGTACTTGTGGCT >In-frame_CCM2_ENST00000544363_chr7_45078025_+_PPIA_ENST00000451562_chr7_44838846_+_780nt GCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGCTGC TGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGCCTG GAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTC TGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTGCAG ACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAATTA TTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATGAGA ACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTG CCAAGACTGAGTGGTAAGGGTACAACATGGCACACTAACCACCTGACTAAATGAAAAGTTGCCCTGGGGGGAACGGAACAAACACTACTT >In-frame_CCM2_ENST00000544363_chr7_45078025_+_PPIA_ENST00000468812_chr7_44838846_+_2474nt GCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGCTGC TGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGCCTG GAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTC TGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTGCAG ACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAATTA TTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATGAGA ACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTG CCAAGACTGAGTGGTTGGATGGCAAGCATGTGGTGTTTGGCAAAGTGAAAGAAGGCATGAATATTGTGGAGGCCATGGAGCGCTTTGGGT CCAGGAATGGCAAGACCAGCAAGAAGATCACCATTGCTGACTGTGGACAACTCGAATAAGTTTGACTTGTGTTTTATCTTAACCACCAGA TCATTCCTTCTGTAGCTCAGGAGAGCACCCCTCCACCCCATTTGCTCGCAGTATCCTAGAATCTTTGTGCTCTCGCTGCAGTTCCCTTTG GGTTCCATGTTTTCCTTGTTCCCTCCCATGCCTAGCTGGATTGCAGAGTTAAGTTTATGATTATGAAATAAAAACTAAATAACAATTGTC CTCGTTTGAGTTAAGAGTGTTGATGTAGGCTTTATTTTAAGCAGTAATGGGTTACTTCTGAAACATCACTTGTTTGCTTAATTCTACACA GTACTTAGATTTTTTTTACTTTCCAGTCCCAGGAAGTGTCAATGTTTGTTGAGTGGAATATTGAAAATGTAGGCAGCAACTGGGCATGGT GGCTCACTGTCTGTAATGTATTACCTGAGGCAGAAGACCACCTGAGGGTAGGAGTCAAGATCAGCCTGGGCAACATAGTGAGACGCTGTC TCTACAAAAAATAATTAGCCTGGCCTGGTGGTGCATGCCTAGTCCTAGCTGATCTGGAGGCTGACGTGGGAGGATTGCTTGAGCCTAGAG TGAGCTATTATCATGCCACTGTACAGCCTGGGTGTTCACAGATCTTGTGTCTCAAAGGTAGGCAGAGGCAGGAAAAGCAAGGAGCCAGAA TTAAGAGGTTGGGTCAGTCTGCAGTGAGTTCATGCATTTAGAGGTGTTCTTCAAGATGACTAATGTCAAAAATTGAGACATCTGTTGCGG TTTTTTTTTTTTTTTTTTCCCCTGGAATGCAGTGGCGTGATCTCAGCTCACTGCAGCCTCCGCCTCCTGGGTTCAAGTGATTCTAGTGCC TCAGCCTCCTGAGTAGCTGGGATAATGGGCGTGTGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTATAGATGGGGTTTCATCATTTT GACCAGGCTGGTCTCAAACTCTTGACCTCAGCTGATGCGCCTGCCTTGGCCTCCCAAACTGCTGAGATTACAGATGTGAGCCACCGCACC CTACCTCATTTTCTGTAACAAAGCTAAGCTTGAACACTGTTGATGTTCTTGAGGGAAGCATATTGGGCTTTAGGCTGTAGGTCAAGTTTA TACATCTTAATTATGGTGGAATTCCTATGTAGAGTCTAAAAAGCCAGGTACTTGGTGCTACAGTCAGTCTCCCTGCAGAGGGTTAAGGCG CAGACTACCTGCAGTGAGGAGGTACTGCTTGTAGCATATAGAGCCTCTCCCTAGCTTTGGTTATGGAGGCTTTGAGGTTTTGCAAACCTG ACCAATTTAAGCCATAAGATCTGGTCAAAGGGATACCCTTCCCACTAAGGACTTGGTTTCTCAGGAAATTATATGTACAGTGCTTGCTGG CAGTTAGATGTCAGGACAATCTAAGCTGAGAAAACCCCTTCTCTGCCCACCTTAACAGACCTCTAGGGTTCTTAACCCAGCAATCAAGTT TGCCTATCCTAGAGGTGGCGGATTTGATCATTTGGTGTGTTGGGCAATTTTTGTTTTACTGTCTGGTTCCTTCTGCGTGAATTACCACCA CCACCACTTGTGCATCTCAGTCTTGTGTGTTGTCTGGTTACGTATTCCCTGGGTGATACCATTCAATGTCTTAATGTACTTGTGGCTCAG >In-frame_CCM2_ENST00000475551_chr7_45078025_+_PPIA_ENST00000451562_chr7_44838846_+_1376nt GAAGAAGTGAGCTTGGCCAGAGGCACGCTGTTTAATTTCAAAGTGCTGCTGACTCAAACTCATGAGTCCTGGAGGCAGGTAGAGGCACTT GTAGGCTGAGGACCCGTAGAGCCCGGTGTGCCCTGCCCAAGCCCCACCTGGGAATGGAGTTATCTCTGTAAAGATCTTGCTGCCTTTGAG CAAGCACTGCAAATGGGGTAACTGGAACAGCCTTGTCGCGTGTTTCCACCCTTCGTATGAGGCAGGTACCATGGGTCTTCACCAACAGCA CGGCCTGTTGTCTCCAGGAAATGGTAGCCCCTCACAGTGCTTTCTGTCTGCTTGTTTAGCTTTGGCATTTGAATGTGCAGAATGGTGGAC TTTGAAATTAATGTCCTTCTGTTGACTGCAGAATTTCTGCTGGAAATGCAGGGAGGCTGCTTGTGGGGTTCGCGTGCTGTGGGAAGTAGG GAAAATGAGCTGGTTTACTTTGTGTCTTTTTGTGCATGCAGACTGTTTGGATTTTGCCAACAGTTTCTGGGTGCTGCCTGCTTTTTAAAC TTTTAAAAAATTGTAAACAGCTTCAGTGGCTTTGCAGAAGGAAGCTGTGGTTTCTGGTCTTCCTGTTCAGTCATGTTTTTTTCAGAGGGA GGGCTAACATCTGGCCATATTTTTCAACAAATTCAGAAGTGAGTAGAGAATGCATAGTAGCTGTCGGCAGAGGAGGAACCAGAATCTCTC CAAAGAAATTCCTCAAACAGAATTTCACACAGGGTATTCCATGGAGAATGAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAA AGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGT CGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGC TCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCAC ACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTT GTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTGCCAAGACTGAGTGGTAAGGGTACAACATGGCACA CTAACCACCTGACTAAATGAAAAGTTGCCCTGGGGGGAACGGAACAAACACTACTTTTCTTCAACCTTTGCTTCCACAGACTTTTTCATC >In-frame_CCM2_ENST00000475551_chr7_45078025_+_PPIA_ENST00000468812_chr7_44838846_+_3070nt GAAGAAGTGAGCTTGGCCAGAGGCACGCTGTTTAATTTCAAAGTGCTGCTGACTCAAACTCATGAGTCCTGGAGGCAGGTAGAGGCACTT GTAGGCTGAGGACCCGTAGAGCCCGGTGTGCCCTGCCCAAGCCCCACCTGGGAATGGAGTTATCTCTGTAAAGATCTTGCTGCCTTTGAG CAAGCACTGCAAATGGGGTAACTGGAACAGCCTTGTCGCGTGTTTCCACCCTTCGTATGAGGCAGGTACCATGGGTCTTCACCAACAGCA CGGCCTGTTGTCTCCAGGAAATGGTAGCCCCTCACAGTGCTTTCTGTCTGCTTGTTTAGCTTTGGCATTTGAATGTGCAGAATGGTGGAC TTTGAAATTAATGTCCTTCTGTTGACTGCAGAATTTCTGCTGGAAATGCAGGGAGGCTGCTTGTGGGGTTCGCGTGCTGTGGGAAGTAGG GAAAATGAGCTGGTTTACTTTGTGTCTTTTTGTGCATGCAGACTGTTTGGATTTTGCCAACAGTTTCTGGGTGCTGCCTGCTTTTTAAAC TTTTAAAAAATTGTAAACAGCTTCAGTGGCTTTGCAGAAGGAAGCTGTGGTTTCTGGTCTTCCTGTTCAGTCATGTTTTTTTCAGAGGGA GGGCTAACATCTGGCCATATTTTTCAACAAATTCAGAAGTGAGTAGAGAATGCATAGTAGCTGTCGGCAGAGGAGGAACCAGAATCTCTC CAAAGAAATTCCTCAAACAGAATTTCACACAGGGTATTCCATGGAGAATGAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAA AGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGT CGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGC TCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCAC ACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTT GTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTGCCAAGACTGAGTGGTTGGATGGCAAGCATGTGGT GTTTGGCAAAGTGAAAGAAGGCATGAATATTGTGGAGGCCATGGAGCGCTTTGGGTCCAGGAATGGCAAGACCAGCAAGAAGATCACCAT TGCTGACTGTGGACAACTCGAATAAGTTTGACTTGTGTTTTATCTTAACCACCAGATCATTCCTTCTGTAGCTCAGGAGAGCACCCCTCC ACCCCATTTGCTCGCAGTATCCTAGAATCTTTGTGCTCTCGCTGCAGTTCCCTTTGGGTTCCATGTTTTCCTTGTTCCCTCCCATGCCTA GCTGGATTGCAGAGTTAAGTTTATGATTATGAAATAAAAACTAAATAACAATTGTCCTCGTTTGAGTTAAGAGTGTTGATGTAGGCTTTA TTTTAAGCAGTAATGGGTTACTTCTGAAACATCACTTGTTTGCTTAATTCTACACAGTACTTAGATTTTTTTTACTTTCCAGTCCCAGGA AGTGTCAATGTTTGTTGAGTGGAATATTGAAAATGTAGGCAGCAACTGGGCATGGTGGCTCACTGTCTGTAATGTATTACCTGAGGCAGA AGACCACCTGAGGGTAGGAGTCAAGATCAGCCTGGGCAACATAGTGAGACGCTGTCTCTACAAAAAATAATTAGCCTGGCCTGGTGGTGC ATGCCTAGTCCTAGCTGATCTGGAGGCTGACGTGGGAGGATTGCTTGAGCCTAGAGTGAGCTATTATCATGCCACTGTACAGCCTGGGTG TTCACAGATCTTGTGTCTCAAAGGTAGGCAGAGGCAGGAAAAGCAAGGAGCCAGAATTAAGAGGTTGGGTCAGTCTGCAGTGAGTTCATG CATTTAGAGGTGTTCTTCAAGATGACTAATGTCAAAAATTGAGACATCTGTTGCGGTTTTTTTTTTTTTTTTTTCCCCTGGAATGCAGTG GCGTGATCTCAGCTCACTGCAGCCTCCGCCTCCTGGGTTCAAGTGATTCTAGTGCCTCAGCCTCCTGAGTAGCTGGGATAATGGGCGTGT GCCACCATGCCCAGCTAATTTTTGTATTTTTAGTATAGATGGGGTTTCATCATTTTGACCAGGCTGGTCTCAAACTCTTGACCTCAGCTG ATGCGCCTGCCTTGGCCTCCCAAACTGCTGAGATTACAGATGTGAGCCACCGCACCCTACCTCATTTTCTGTAACAAAGCTAAGCTTGAA CACTGTTGATGTTCTTGAGGGAAGCATATTGGGCTTTAGGCTGTAGGTCAAGTTTATACATCTTAATTATGGTGGAATTCCTATGTAGAG TCTAAAAAGCCAGGTACTTGGTGCTACAGTCAGTCTCCCTGCAGAGGGTTAAGGCGCAGACTACCTGCAGTGAGGAGGTACTGCTTGTAG CATATAGAGCCTCTCCCTAGCTTTGGTTATGGAGGCTTTGAGGTTTTGCAAACCTGACCAATTTAAGCCATAAGATCTGGTCAAAGGGAT ACCCTTCCCACTAAGGACTTGGTTTCTCAGGAAATTATATGTACAGTGCTTGCTGGCAGTTAGATGTCAGGACAATCTAAGCTGAGAAAA CCCCTTCTCTGCCCACCTTAACAGACCTCTAGGGTTCTTAACCCAGCAATCAAGTTTGCCTATCCTAGAGGTGGCGGATTTGATCATTTG GTGTGTTGGGCAATTTTTGTTTTACTGTCTGGTTCCTTCTGCGTGAATTACCACCACCACCACTTGTGCATCTCAGTCTTGTGTGTTGTC TGGTTACGTATTCCCTGGGTGATACCATTCAATGTCTTAATGTACTTGTGGCTCAGACCTGAGTGCAAGGTGGAAATAAACATCAAACAT >In-frame_CCM2_ENST00000381112_chr7_45078025_+_PPIA_ENST00000451562_chr7_44838846_+_1376nt GAAGAAGTGAGCTTGGCCAGAGGCACGCTGTTTAATTTCAAAGTGCTGCTGACTCAAACTCATGAGTCCTGGAGGCAGGTAGAGGCACTT GTAGGCTGAGGACCCGTAGAGCCCGGTGTGCCCTGCCCAAGCCCCACCTGGGAATGGAGTTATCTCTGTAAAGATCTTGCTGCCTTTGAG CAAGCACTGCAAATGGGGTAACTGGAACAGCCTTGTCGCGTGTTTCCACCCTTCGTATGAGGCAGGTACCATGGGTCTTCACCAACAGCA CGGCCTGTTGTCTCCAGGAAATGGTAGCCCCTCACAGTGCTTTCTGTCTGCTTGTTTAGCTTTGGCATTTGAATGTGCAGAATGGTGGAC TTTGAAATTAATGTCCTTCTGTTGACTGCAGAATTTCTGCTGGAAATGCAGGGAGGCTGCTTGTGGGGTTCGCGTGCTGTGGGAAGTAGG GAAAATGAGCTGGTTTACTTTGTGTCTTTTTGTGCATGCAGACTGTTTGGATTTTGCCAACAGTTTCTGGGTGCTGCCTGCTTTTTAAAC TTTTAAAAAATTGTAAACAGCTTCAGTGGCTTTGCAGAAGGAAGCTGTGGTTTCTGGTCTTCCTGTTCAGTCATGTTTTTTTCAGAGGGA GGGCTAACATCTGGCCATATTTTTCAACAAATTCAGAAGTGAGTAGAGAATGCATAGTAGCTGTCGGCAGAGGAGGAACCAGAATCTCTC CAAAGAAATTCCTCAAACAGAATTTCACACAGGGTATTCCATGGAGAATGAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAA AGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGT CGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGC TCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCAC ACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTT GTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTGCCAAGACTGAGTGGTAAGGGTACAACATGGCACA CTAACCACCTGACTAAATGAAAAGTTGCCCTGGGGGGAACGGAACAAACACTACTTTTCTTCAACCTTTGCTTCCACAGACTTTTTCATC >In-frame_CCM2_ENST00000381112_chr7_45078025_+_PPIA_ENST00000468812_chr7_44838846_+_3070nt GAAGAAGTGAGCTTGGCCAGAGGCACGCTGTTTAATTTCAAAGTGCTGCTGACTCAAACTCATGAGTCCTGGAGGCAGGTAGAGGCACTT GTAGGCTGAGGACCCGTAGAGCCCGGTGTGCCCTGCCCAAGCCCCACCTGGGAATGGAGTTATCTCTGTAAAGATCTTGCTGCCTTTGAG CAAGCACTGCAAATGGGGTAACTGGAACAGCCTTGTCGCGTGTTTCCACCCTTCGTATGAGGCAGGTACCATGGGTCTTCACCAACAGCA CGGCCTGTTGTCTCCAGGAAATGGTAGCCCCTCACAGTGCTTTCTGTCTGCTTGTTTAGCTTTGGCATTTGAATGTGCAGAATGGTGGAC TTTGAAATTAATGTCCTTCTGTTGACTGCAGAATTTCTGCTGGAAATGCAGGGAGGCTGCTTGTGGGGTTCGCGTGCTGTGGGAAGTAGG GAAAATGAGCTGGTTTACTTTGTGTCTTTTTGTGCATGCAGACTGTTTGGATTTTGCCAACAGTTTCTGGGTGCTGCCTGCTTTTTAAAC TTTTAAAAAATTGTAAACAGCTTCAGTGGCTTTGCAGAAGGAAGCTGTGGTTTCTGGTCTTCCTGTTCAGTCATGTTTTTTTCAGAGGGA GGGCTAACATCTGGCCATATTTTTCAACAAATTCAGAAGTGAGTAGAGAATGCATAGTAGCTGTCGGCAGAGGAGGAACCAGAATCTCTC CAAAGAAATTCCTCAAACAGAATTTCACACAGGGTATTCCATGGAGAATGAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAA AGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGT CGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGC TCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCAC ACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTT GTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTGCCAAGACTGAGTGGTTGGATGGCAAGCATGTGGT GTTTGGCAAAGTGAAAGAAGGCATGAATATTGTGGAGGCCATGGAGCGCTTTGGGTCCAGGAATGGCAAGACCAGCAAGAAGATCACCAT TGCTGACTGTGGACAACTCGAATAAGTTTGACTTGTGTTTTATCTTAACCACCAGATCATTCCTTCTGTAGCTCAGGAGAGCACCCCTCC ACCCCATTTGCTCGCAGTATCCTAGAATCTTTGTGCTCTCGCTGCAGTTCCCTTTGGGTTCCATGTTTTCCTTGTTCCCTCCCATGCCTA GCTGGATTGCAGAGTTAAGTTTATGATTATGAAATAAAAACTAAATAACAATTGTCCTCGTTTGAGTTAAGAGTGTTGATGTAGGCTTTA TTTTAAGCAGTAATGGGTTACTTCTGAAACATCACTTGTTTGCTTAATTCTACACAGTACTTAGATTTTTTTTACTTTCCAGTCCCAGGA AGTGTCAATGTTTGTTGAGTGGAATATTGAAAATGTAGGCAGCAACTGGGCATGGTGGCTCACTGTCTGTAATGTATTACCTGAGGCAGA AGACCACCTGAGGGTAGGAGTCAAGATCAGCCTGGGCAACATAGTGAGACGCTGTCTCTACAAAAAATAATTAGCCTGGCCTGGTGGTGC ATGCCTAGTCCTAGCTGATCTGGAGGCTGACGTGGGAGGATTGCTTGAGCCTAGAGTGAGCTATTATCATGCCACTGTACAGCCTGGGTG TTCACAGATCTTGTGTCTCAAAGGTAGGCAGAGGCAGGAAAAGCAAGGAGCCAGAATTAAGAGGTTGGGTCAGTCTGCAGTGAGTTCATG CATTTAGAGGTGTTCTTCAAGATGACTAATGTCAAAAATTGAGACATCTGTTGCGGTTTTTTTTTTTTTTTTTTCCCCTGGAATGCAGTG GCGTGATCTCAGCTCACTGCAGCCTCCGCCTCCTGGGTTCAAGTGATTCTAGTGCCTCAGCCTCCTGAGTAGCTGGGATAATGGGCGTGT GCCACCATGCCCAGCTAATTTTTGTATTTTTAGTATAGATGGGGTTTCATCATTTTGACCAGGCTGGTCTCAAACTCTTGACCTCAGCTG ATGCGCCTGCCTTGGCCTCCCAAACTGCTGAGATTACAGATGTGAGCCACCGCACCCTACCTCATTTTCTGTAACAAAGCTAAGCTTGAA CACTGTTGATGTTCTTGAGGGAAGCATATTGGGCTTTAGGCTGTAGGTCAAGTTTATACATCTTAATTATGGTGGAATTCCTATGTAGAG TCTAAAAAGCCAGGTACTTGGTGCTACAGTCAGTCTCCCTGCAGAGGGTTAAGGCGCAGACTACCTGCAGTGAGGAGGTACTGCTTGTAG CATATAGAGCCTCTCCCTAGCTTTGGTTATGGAGGCTTTGAGGTTTTGCAAACCTGACCAATTTAAGCCATAAGATCTGGTCAAAGGGAT ACCCTTCCCACTAAGGACTTGGTTTCTCAGGAAATTATATGTACAGTGCTTGCTGGCAGTTAGATGTCAGGACAATCTAAGCTGAGAAAA CCCCTTCTCTGCCCACCTTAACAGACCTCTAGGGTTCTTAACCCAGCAATCAAGTTTGCCTATCCTAGAGGTGGCGGATTTGATCATTTG GTGTGTTGGGCAATTTTTGTTTTACTGTCTGGTTCCTTCTGCGTGAATTACCACCACCACCACTTGTGCATCTCAGTCTTGTGTGTTGTC TGGTTACGTATTCCCTGGGTGATACCATTCAATGTCTTAATGTACTTGTGGCTCAGACCTGAGTGCAAGGTGGAAATAAACATCAAACAT >In-frame_CCM2_ENST00000474617_chr7_45078025_+_PPIA_ENST00000451562_chr7_44838846_+_730nt ATATTTTTCAACAAATTCAGAAGTGAGTAGAGAATGCATAGTAGCTGTCGGCAGAGGAGGAACCAGAATCTCTCCAAAGAAATTCCTCAA ACAGAATTTCACACAGGGTATTCCATGGAGAATGAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGA GATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTG CTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAG AAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACT GGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCT GGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTGCCAAGACTGAGTGGTAAGGGTACAACATGGCACACTAACCACCTGACTAA ATGAAAAGTTGCCCTGGGGGGAACGGAACAAACACTACTTTTCTTCAACCTTTGCTTCCACAGACTTTTTCATCCCTAAGATACTAGAAG >In-frame_CCM2_ENST00000474617_chr7_45078025_+_PPIA_ENST00000468812_chr7_44838846_+_2424nt ATATTTTTCAACAAATTCAGAAGTGAGTAGAGAATGCATAGTAGCTGTCGGCAGAGGAGGAACCAGAATCTCTCCAAAGAAATTCCTCAA ACAGAATTTCACACAGGGTATTCCATGGAGAATGAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGA GATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTG CTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAG AAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACT GGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCT GGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTGCCAAGACTGAGTGGTTGGATGGCAAGCATGTGGTGTTTGGCAAAGTGAAA GAAGGCATGAATATTGTGGAGGCCATGGAGCGCTTTGGGTCCAGGAATGGCAAGACCAGCAAGAAGATCACCATTGCTGACTGTGGACAA CTCGAATAAGTTTGACTTGTGTTTTATCTTAACCACCAGATCATTCCTTCTGTAGCTCAGGAGAGCACCCCTCCACCCCATTTGCTCGCA GTATCCTAGAATCTTTGTGCTCTCGCTGCAGTTCCCTTTGGGTTCCATGTTTTCCTTGTTCCCTCCCATGCCTAGCTGGATTGCAGAGTT AAGTTTATGATTATGAAATAAAAACTAAATAACAATTGTCCTCGTTTGAGTTAAGAGTGTTGATGTAGGCTTTATTTTAAGCAGTAATGG GTTACTTCTGAAACATCACTTGTTTGCTTAATTCTACACAGTACTTAGATTTTTTTTACTTTCCAGTCCCAGGAAGTGTCAATGTTTGTT GAGTGGAATATTGAAAATGTAGGCAGCAACTGGGCATGGTGGCTCACTGTCTGTAATGTATTACCTGAGGCAGAAGACCACCTGAGGGTA GGAGTCAAGATCAGCCTGGGCAACATAGTGAGACGCTGTCTCTACAAAAAATAATTAGCCTGGCCTGGTGGTGCATGCCTAGTCCTAGCT GATCTGGAGGCTGACGTGGGAGGATTGCTTGAGCCTAGAGTGAGCTATTATCATGCCACTGTACAGCCTGGGTGTTCACAGATCTTGTGT CTCAAAGGTAGGCAGAGGCAGGAAAAGCAAGGAGCCAGAATTAAGAGGTTGGGTCAGTCTGCAGTGAGTTCATGCATTTAGAGGTGTTCT TCAAGATGACTAATGTCAAAAATTGAGACATCTGTTGCGGTTTTTTTTTTTTTTTTTTCCCCTGGAATGCAGTGGCGTGATCTCAGCTCA CTGCAGCCTCCGCCTCCTGGGTTCAAGTGATTCTAGTGCCTCAGCCTCCTGAGTAGCTGGGATAATGGGCGTGTGCCACCATGCCCAGCT AATTTTTGTATTTTTAGTATAGATGGGGTTTCATCATTTTGACCAGGCTGGTCTCAAACTCTTGACCTCAGCTGATGCGCCTGCCTTGGC CTCCCAAACTGCTGAGATTACAGATGTGAGCCACCGCACCCTACCTCATTTTCTGTAACAAAGCTAAGCTTGAACACTGTTGATGTTCTT GAGGGAAGCATATTGGGCTTTAGGCTGTAGGTCAAGTTTATACATCTTAATTATGGTGGAATTCCTATGTAGAGTCTAAAAAGCCAGGTA CTTGGTGCTACAGTCAGTCTCCCTGCAGAGGGTTAAGGCGCAGACTACCTGCAGTGAGGAGGTACTGCTTGTAGCATATAGAGCCTCTCC CTAGCTTTGGTTATGGAGGCTTTGAGGTTTTGCAAACCTGACCAATTTAAGCCATAAGATCTGGTCAAAGGGATACCCTTCCCACTAAGG ACTTGGTTTCTCAGGAAATTATATGTACAGTGCTTGCTGGCAGTTAGATGTCAGGACAATCTAAGCTGAGAAAACCCCTTCTCTGCCCAC CTTAACAGACCTCTAGGGTTCTTAACCCAGCAATCAAGTTTGCCTATCCTAGAGGTGGCGGATTTGATCATTTGGTGTGTTGGGCAATTT TTGTTTTACTGTCTGGTTCCTTCTGCGTGAATTACCACCACCACCACTTGTGCATCTCAGTCTTGTGTGTTGTCTGGTTACGTATTCCCT |
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FusionGenePPI for CCM2_PPIA |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CCM2 | POT1, SMURF1, SMURF2, SRPK2, TWIST2, VSTM2L, DOK4, KRIT1, ITGB1BP1, RAD21, UBE3D, AP1S2, DDX19B, STK26, TRIM25 | PPIA | PRR13, JAK2, PRLR, S100A8, PRSS23, PPP3R1, PPP3CA, ITK, YY1, H2AFX, POU5F1, HDAC5, PCNA, ELAVL1, ARRB2, HNRNPA1, CHMP4A, CUL3, CUL4B, CDK2, CUL1, COPS5, NEDD8, CD99, USP4, AKT1, APP, IGBP1, TAGLN2, CPLX1, ENO1, RPA2, SNX3, RAD23B, SOD1, PTMA, RB1, LIG4, PAXIP1, FN1, VCAM1, ITGA4, RAD52, TERT, ESR1, SRPK2, SRPK1, RPL23A, HUWE1, FUS, TCF4, LNX1, NOTCH3, CUL7, OBSL1, NTRK1, CBFB, CFL1, CRIP1, DDX46, HEATR5A, HSPE1, KYNU, LDHA, LDHB, PCK2, PEBP1, PIN1, PIR, PSMD4, RAB10, EWSR1, N4BP2L2, ANXA1, ANXA7, ALDH7A1, LYST, GART, MYH9, RAB5C, CSDE1, RBM4, STX3, UBE2N, MKNK1, BCL7B, DNM1L, ZER1, ATP5S, PKN3, EPB41L4B, COPS7B, DCAF15, TMEM189, MCM2, U2AF2, RC3H1, ERRFI1, DUSP28, DUSP4, DUSP9, COX15, DLST, HSD17B10, PARK7, SDHA, SOAT1, VDAC1, TRIM25, G3BP1 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CCM2_PPIA |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | PPIA | P62937 | DB11638 | Artenimol | Peptidyl-prolyl cis-trans isomerase A | small molecule | approved|investigational |
Tgene | PPIA | P62937 | DB00091 | Cyclosporine | Peptidyl-prolyl cis-trans isomerase A | small molecule | approved|investigational|vet_approved |
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RelatedDiseases for CCM2_PPIA |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CCM2 | C1864041 | CEREBRAL CAVERNOUS MALFORMATIONS 2 | 2 | CTD_human;UNIPROT |
Hgene | CCM2 | C0752160 | Hemangioma, Cavernous, Central Nervous System | 1 | CTD_human |
Tgene | PPIA | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Tgene | PPIA | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
Tgene | PPIA | C0026640 | Mouth Neoplasms | 1 | CTD_human |
Tgene | PPIA | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | PPIA | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | PPIA | C0038356 | Stomach Neoplasms | 1 | CTD_human |