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Fusion gene ID: 5969 |
FusionGeneSummary for CCL8_ARL8B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CCL8_ARL8B | Fusion gene ID: 5969 | Hgene | Tgene | Gene symbol | CCL8 | ARL8B | Gene ID | 6355 | 55207 |
| Gene name | C-C motif chemokine ligand 8 | ADP ribosylation factor like GTPase 8B | |
| Synonyms | HC14|MCP-2|MCP2|SCYA10|SCYA8 | ARL10C|Gie1 | |
| Cytomap | 17q12 | 3p26.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | C-C motif chemokine 8chemokine (C-C motif) ligand 8monocyte chemoattractant protein 2monocyte chemotactic protein 2small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2)small-inducible cytokine A8 | ADP-ribosylation factor-like protein 8BADP-ribosylation factor-like 10CADP-ribosylation factor-like 8BADP-ribosylation factor-like protein 10Cnovel small G protein indispensable for equal chromosome segregation 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P80075 | Q9NVJ2 | |
| Ensembl transtripts involved in fusion gene | ENST00000394620, | ENST00000256496, ENST00000419534, ENST00000468010, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 5 X 2=50 |
| # samples | 1 | 5 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/50*10)=0 | |
| Context | PubMed: CCL8 [Title/Abstract] AND ARL8B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CCL8 | GO:0006816 | calcium ion transport | 10734056 |
| Hgene | CCL8 | GO:0006874 | cellular calcium ion homeostasis | 10734056 |
| Hgene | CCL8 | GO:0006887 | exocytosis | 10734056 |
| Hgene | CCL8 | GO:0007267 | cell-cell signaling | 10734056 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI493177 | CCL8 | chr17 | 32648295 | - | ARL8B | chr3 | 5221315 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000394620 | ENST00000256496 | CCL8 | chr17 | 32648295 | - | ARL8B | chr3 | 5221315 | - |
| 3UTR-3UTR | ENST00000394620 | ENST00000419534 | CCL8 | chr17 | 32648295 | - | ARL8B | chr3 | 5221315 | - |
| 3UTR-intron | ENST00000394620 | ENST00000468010 | CCL8 | chr17 | 32648295 | - | ARL8B | chr3 | 5221315 | - |
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FusionProtFeatures for CCL8_ARL8B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CCL8 | ARL8B |
| Chemotactic factor that attracts monocytes, lymphocytes,basophils and eosinophils. May play a role in neoplasia andinflammatory host responses. This protein can bind heparin. Theprocessed form MCP-2(6-76) does not show monocyte chemotacticactivity, but inhibits the chemotactic effect most predominantlyof CCL7, and also of CCL2 and CCL5 and CCL8.{ECO:0000269|PubMed:9558113}. | May play a role in lysosome motility (PubMed:16537643,PubMed:25898167). May play a role in chromosome segregation(PubMed:15331635). {ECO:0000269|PubMed:15331635,ECO:0000269|PubMed:16537643, ECO:0000269|PubMed:25898167}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CCL8_ARL8B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CCL8_ARL8B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CCL8_ARL8B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CCL8_ARL8B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CCL8 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| Hgene | CCL8 | C0020517 | Hypersensitivity | 1 | CTD_human |
| Hgene | CCL8 | C0021400 | Influenza | 1 | CTD_human |
| Hgene | CCL8 | C0032285 | Pneumonia | 1 | CTD_human |
| Hgene | CCL8 | C0035228 | Respiratory Hypersensitivity | 1 | CTD_human |
| Hgene | CCL8 | C1619692 | Nephrogenic Fibrosing Dermopathy | 1 | CTD_human |
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