	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 5959

FusionGeneSummary for CCHCR1_CDA

Fusion gene summary

Fusion gene information	Fusion gene name: CCHCR1_CDA
	Fusion gene ID: 5959
		Hgene	Tgene
	Gene symbol	CCHCR1	CDA
	Gene ID	54535	978
	Gene name	coiled-coil alpha-helical rod protein 1	cytidine deaminase
	Synonyms	C6orf18\|HCR\|SBP\|pg8	CDD
	Cytomap	6p21.33	1p36.12
	Type of gene	protein-coding	protein-coding
	Description	coiled-coil alpha-helical rod protein 1HCR (a-helix coiled-coil rod homologue)StAR-binding proteinalpha-helical coiled-coil rod proteinputative gene 8 protein	cytidine deaminasecytidine aminohydrolasecytosine nucleoside deaminasesmall cytidine deaminase
	Modification date	20180523	20180523
	UniProtAcc	Q8TD31	P32320
	Ensembl transtripts involved in fusion gene	ENST00000396268, ENST00000376266, ENST00000396263, ENST00000451521, ENST00000480060, ENST00000416163, ENST00000400351, ENST00000425620, ENST00000466904, ENST00000400352, ENST00000414614, ENST00000383341, ENST00000474554, ENST00000419528, ENST00000428677, ENST00000433804, ENST00000481855, ENST00000400412, ENST00000400406, ENST00000383527, ENST00000470755, ENST00000447252, ENST00000452333, ENST00000416392, ENST00000467461,	ENST00000375071, ENST00000461985,
Fusion gene scores	* DoF score	1 X 1 X 1=1	2 X 2 X 1=4
	# samples	1	2
	** MAII score	log2(1/1*10)=3.32192809488736	log2(2/4*10)=2.32192809488736
Context	PubMed: CCHCR1 [Title/Abstract] AND CDA [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CDA	GO:0009972	cytidine deamination	9596658
Tgene	CDA	GO:0030308	negative regulation of cell growth	9596658
Tgene	CDA	GO:0045980	negative regulation of nucleotide metabolic process	9596658
Tgene	CDA	GO:0051289	protein homotetramerization	9596658\|15689149

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BF901504	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000396268	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000396268	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000376266	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000376266	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000396263	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000396263	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000451521	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000451521	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000480060	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000480060	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000416163	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000416163	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000400351	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000400351	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000425620	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000425620	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000466904	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000466904	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000400352	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000400352	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000414614	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000414614	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000383341	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000383341	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000474554	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000474554	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000419528	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000419528	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000428677	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000428677	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000433804	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000433804	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000481855	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000481855	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000400412	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000400412	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000400406	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000400406	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000383527	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000383527	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000470755	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000470755	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000447252	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000447252	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000452333	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000452333	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000416392	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000416392	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000467461	ENST00000375071	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+
intron-intron	ENST00000467461	ENST00000461985	CCHCR1	chr6	2413749	+	CDA	chr1	20938233	+

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FusionProtFeatures for CCHCR1_CDA

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CCHCR1 Q8TD31	CDA P32320
	This enzyme scavenges exogenous and endogenous cytidineand 2'-deoxycytidine for UMP synthesis.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for CCHCR1_CDA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCHCR1_CDA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for CCHCR1_CDA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CCHCR1_CDA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CCHCR1	C0033578	Prostatic Neoplasms	1	CTD_human
Hgene	CCHCR1	C0236733	Amphetamine-Related Disorders	1	CTD_human
Tgene	CDA	C1458155	Mammary Neoplasms	2	CTD_human

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Fusion gene ID: 5959

FusionGeneSummary for CCHCR1_CDA

FusionProtFeatures for CCHCR1_CDA

FusionGeneSequence for CCHCR1_CDA

FusionGenePPI for CCHCR1_CDA

RelatedDrugs for CCHCR1_CDA

RelatedDiseases for CCHCR1_CDA