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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5953

FusionGeneSummary for CCDC97_GTF2A2

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC97_GTF2A2
Fusion gene ID: 5953
HgeneTgene
Gene symbol

CCDC97

GTF2A2

Gene ID

90324

2958

Gene namecoiled-coil domain containing 97general transcription factor IIA subunit 2
Synonyms-HsT18745|T18745|TF2A2|TFIIA|TFIIA-12|TFIIA-gamma|TFIIAS
Cytomap

19q13.2

15q22.2

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 97transcription initiation factor IIA subunit 2TFIIA gamma subunitTFIIA p12 subunitgeneral transcription factor IIA 2general transcription factor IIA, 2, 12kDatranscription initiation factor IIA gamma chain
Modification date2018052320180523
UniProtAcc

Q96F63

P52657

Ensembl transtripts involved in fusion geneENST00000269967, ENST00000396060, 
ENST00000267869, ENST00000396064, 
ENST00000396063, ENST00000396061, 
ENST00000484743, 
Fusion gene scores* DoF score4 X 3 X 3=362 X 2 X 1=4
# samples 42
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/4*10)=2.32192809488736
Context

PubMed: CCDC97 [Title/Abstract] AND GTF2A2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGTF2A2

GO:0006366

transcription by RNA polymerase II

7724559|7958900|8626665

TgeneGTF2A2

GO:0045944

positive regulation of transcription by RNA polymerase II

7958899

TgeneGTF2A2

GO:0051091

positive regulation of DNA binding transcription factor activity

8626665

TgeneGTF2A2

GO:0051123

RNA polymerase II transcriptional preinitiation complex assembly

7958899|8626665


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-49-6743-01ACCDC97chr19

41816261

+GTF2A2chr15

59944525

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000269967ENST00000396060CCDC97chr19

41816261

+GTF2A2chr15

59944525

-
5CDS-intronENST00000269967ENST00000267869CCDC97chr19

41816261

+GTF2A2chr15

59944525

-
5CDS-5UTRENST00000269967ENST00000396064CCDC97chr19

41816261

+GTF2A2chr15

59944525

-
5CDS-5UTRENST00000269967ENST00000396063CCDC97chr19

41816261

+GTF2A2chr15

59944525

-
5CDS-5UTRENST00000269967ENST00000396061CCDC97chr19

41816261

+GTF2A2chr15

59944525

-
5CDS-5UTRENST00000269967ENST00000484743CCDC97chr19

41816261

+GTF2A2chr15

59944525

-

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FusionProtFeatures for CCDC97_GTF2A2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCDC97

Q96F63

GTF2A2

P52657

TFIIA is a component of the transcription machinery ofRNA polymerase II and plays an important role in transcriptionalactivation. TFIIA in a complex with TBP mediates transcriptionalactivity. {ECO:0000269|PubMed:11030333}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCDC97_GTF2A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCDC97_GTF2A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CCDC97MAPK14, SRPK2, APBB1, MOV10, NXF1, ZRSR2, COPA, SF3B1, SF3B6, SF3B3, SF3B5, TIGD6, PAXIP1, TTC33, SF3A2, SF3A3, SF3A1, CIZ1, ATF1, SF3B4, PIP5K1A, SF3B2, JUNGTF2A2TBPL1, TBP, TAF4, GTF2A1, TERF1, TERF2, GTF2A2, POLR2A, PTPN11


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCDC97_GTF2A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCDC97_GTF2A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource