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Fusion gene ID: 5936 |
FusionGeneSummary for CCDC91_NTSR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CCDC91_NTSR1 | Fusion gene ID: 5936 | Hgene | Tgene | Gene symbol | CCDC91 | NTSR1 | Gene ID | 55297 | 4923 |
| Gene name | coiled-coil domain containing 91 | neurotensin receptor 1 | |
| Synonyms | HSD8|p56 | NTR | |
| Cytomap | 12p11.22 | 20q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | coiled-coil domain-containing protein 91GGA-binding partnerp56 accessory protein | neurotensin receptor type 1NT-R-1NTR1NTRHhigh-affinity levocabastine-insensitive neurotensin receptorneurotensin receptor 1 (high affinity) | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q7Z6B0 | P30989 | |
| Ensembl transtripts involved in fusion gene | ENST00000539107, ENST00000545336, ENST00000381256, ENST00000381259, ENST00000540401, ENST00000306172, | ENST00000370501, ENST00000482259, | |
| Fusion gene scores | * DoF score | 11 X 8 X 7=616 | 3 X 1 X 3=9 |
| # samples | 11 | 3 | |
| ** MAII score | log2(11/616*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CCDC91 [Title/Abstract] AND NTSR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NTSR1 | GO:0007218 | neuropeptide signaling pathway | 21725197 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-05-4415-01A | CCDC91 | chr12 | 28544344 | + | NTSR1 | chr20 | 61386037 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000539107 | ENST00000370501 | CCDC91 | chr12 | 28544344 | + | NTSR1 | chr20 | 61386037 | + |
| intron-intron | ENST00000539107 | ENST00000482259 | CCDC91 | chr12 | 28544344 | + | NTSR1 | chr20 | 61386037 | + |
| In-frame | ENST00000545336 | ENST00000370501 | CCDC91 | chr12 | 28544344 | + | NTSR1 | chr20 | 61386037 | + |
| 5CDS-intron | ENST00000545336 | ENST00000482259 | CCDC91 | chr12 | 28544344 | + | NTSR1 | chr20 | 61386037 | + |
| intron-3CDS | ENST00000381256 | ENST00000370501 | CCDC91 | chr12 | 28544344 | + | NTSR1 | chr20 | 61386037 | + |
| intron-intron | ENST00000381256 | ENST00000482259 | CCDC91 | chr12 | 28544344 | + | NTSR1 | chr20 | 61386037 | + |
| In-frame | ENST00000381259 | ENST00000370501 | CCDC91 | chr12 | 28544344 | + | NTSR1 | chr20 | 61386037 | + |
| 5CDS-intron | ENST00000381259 | ENST00000482259 | CCDC91 | chr12 | 28544344 | + | NTSR1 | chr20 | 61386037 | + |
| 3UTR-3CDS | ENST00000540401 | ENST00000370501 | CCDC91 | chr12 | 28544344 | + | NTSR1 | chr20 | 61386037 | + |
| 3UTR-intron | ENST00000540401 | ENST00000482259 | CCDC91 | chr12 | 28544344 | + | NTSR1 | chr20 | 61386037 | + |
| In-frame | ENST00000306172 | ENST00000370501 | CCDC91 | chr12 | 28544344 | + | NTSR1 | chr20 | 61386037 | + |
| 5CDS-intron | ENST00000306172 | ENST00000482259 | CCDC91 | chr12 | 28544344 | + | NTSR1 | chr20 | 61386037 | + |
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FusionProtFeatures for CCDC91_NTSR1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CCDC91 | NTSR1 |
| Involved in the regulation of membrane traffic throughthe trans-Golgi network (TGN). Functions in close cooperation withthe GGAs in the sorting of hydrolases to lysosomes.{ECO:0000269|PubMed:17596511}. | G-protein coupled receptor for the tridecapeptideneurotensin (NTS) (PubMed:8381365, PubMed:21725197,PubMed:23140271). Signaling is effected via G proteins thatactivate a phosphatidylinositol-calcium second messenger system.Signaling leads to the activation of downstream MAP kinases andprotects cells against apoptosis (PubMed:21725197).{ECO:0000269|PubMed:21725197, ECO:0000269|PubMed:23140271,ECO:0000269|PubMed:8381365}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CCDC91_NTSR1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CCDC91_ENST00000545336_chr12_28544344_+_NTSR1_ENST00000370501_chr20_61386037_+_435aa MDDDDFGGFEAAETFDGGSGETQTTSPAIPWAAFPAVSGVHLSPSSPEIVLDRDHSSSIGCLSSDAIISSPENTHAANSIVSQTIPKAQI QQSTHTHLDISLFPLGLTDEKSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQE AISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQVNTFMSFIFPMVVISV LNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHY >In-frame_CCDC91_ENST00000381259_chr12_28544344_+_NTSR1_ENST00000370501_chr20_61386037_+_435aa MDDDDFGGFEAAETFDGGSGETQTTSPAIPWAAFPAVSGVHLSPSSPEIVLDRDHSSSIGCLSSDAIISSPENTHAANSIVSQTIPKAQI QQSTHTHLDISLFPLGLTDEKSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQE AISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQVNTFMSFIFPMVVISV LNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHY >In-frame_CCDC91_ENST00000306172_chr12_28544344_+_NTSR1_ENST00000370501_chr20_61386037_+_405aa MPMWNKVSGVHLSPSSPEIVLDRDHSSSIGCLSSDAIISSPENTHAANSIVSQTIPKAQIQQSTHTHLDISLFPLGLTDEKSNGTIALVD DSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEAL SIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHS TFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CCDC91_ENST00000545336_chr12_28544344_+_NTSR1_ENST00000370501_chr20_61386037_+_1305nt ATGGATGATGATGATTTTGGTGGTTTTGAGGCTGCGGAGACTTTTGATGGTGGAAGTGGTGAAACCCAAACAACATCTCCTGCTATTCCT TGGGCTGCCTTTCCTGCAGTATCTGGAGTCCATCTTTCACCATCTTCTCCTGAGATTGTACTGGACCGTGACCACTCTTCTTCCATTGGC TGCCTCTCTTCTGATGCCATTATTTCATCACCAGAGAATACACATGCAGCAAATAGCATTGTGAGTCAAACTATTCCAAAAGCACAGATT CAGCAATCAACACACACTCATCTGGATATCTCACTTTTTCCATTGGGTTTAACTGATGAAAAAAGTAATGGAACAATTGCCCTTGTGGAT GATTCTGAGGATCCTGGAGCCAATGTATCTAACATACAGCTTCAGCAAAAAATTTCAAGTCTGGAGATTAAACTCAAAGTATCTGAAGAA GAAAAACAGAGAATTAAACAGGATGTGGAATCATTGATGGAAAAGCATAATGTCTTAGAAAAAGGCTTTCTAAAAGAAAAAGAGCAAGAG GCCATTTCTTTTCAAGATAGATACAAAGAACTTCAGGAAAAACATAAACAAGAATTGGAAGACATGAGGAAAGCTGGTCACGAAGCCCTC AGCATTATTGTGGATGAATATAAGGCACTACTGCAGTCTTCAGTTAAGCAACAAGTAGAAGCTATTGAAAAACAGTACATTTCTGCAATT GAGAAACAGGCACACAAGTGTGAGGAGTTGCTAAATGCTCAGGTCAACACCTTCATGTCCTTCATATTCCCCATGGTGGTCATCTCGGTC CTGAACACCATCATCGCCAACAAGCTGACCGTCATGGTACGCCAGGCGGCCGAGCAGGGCCAAGTGTGCACGGTCGGGGGCGAGCACAGC ACATTCAGCATGGCCATCGAGCCTGGCAGGGTCCAGGCCCTGCGGCACGGCGTGCGCGTCCTACGTGCAGTGGTCATCGCCTTTGTGGTC TGCTGGCTGCCCTACCACGTGCGGCGCCTCATGTTCTGCTACATCTCGGATGAGCAGTGGACTCCGTTCCTCTATGACTTCTACCACTAC TTCTACATGGTGACCAACGCACTCTTCTACGTCAGCTCCACCATCAACCCCATCCTGTACAACCTCGTCTCTGCCAACTTCCGCCACATC TTCCTGGCCACACTGGCCTGCCTCTGCCCGGTGTGGCGGCGCAGGAGGAAGAGGCCAGCCTTCTCGAGGAAGGCCGACAGCGTGTCCAGC >In-frame_CCDC91_ENST00000381259_chr12_28544344_+_NTSR1_ENST00000370501_chr20_61386037_+_1305nt ATGGATGATGATGATTTTGGTGGTTTTGAGGCTGCGGAGACTTTTGATGGTGGAAGTGGTGAAACCCAAACAACATCTCCTGCTATTCCT TGGGCTGCCTTTCCTGCAGTATCTGGAGTCCATCTTTCACCATCTTCTCCTGAGATTGTACTGGACCGTGACCACTCTTCTTCCATTGGC TGCCTCTCTTCTGATGCCATTATTTCATCACCAGAGAATACACATGCAGCAAATAGCATTGTGAGTCAAACTATTCCAAAAGCACAGATT CAGCAATCAACACACACTCATCTGGATATCTCACTTTTTCCATTGGGTTTAACTGATGAAAAAAGTAATGGAACAATTGCCCTTGTGGAT GATTCTGAGGATCCTGGAGCCAATGTATCTAACATACAGCTTCAGCAAAAAATTTCAAGTCTGGAGATTAAACTCAAAGTATCTGAAGAA GAAAAACAGAGAATTAAACAGGATGTGGAATCATTGATGGAAAAGCATAATGTCTTAGAAAAAGGCTTTCTAAAAGAAAAAGAGCAAGAG GCCATTTCTTTTCAAGATAGATACAAAGAACTTCAGGAAAAACATAAACAAGAATTGGAAGACATGAGGAAAGCTGGTCACGAAGCCCTC AGCATTATTGTGGATGAATATAAGGCACTACTGCAGTCTTCAGTTAAGCAACAAGTAGAAGCTATTGAAAAACAGTACATTTCTGCAATT GAGAAACAGGCACACAAGTGTGAGGAGTTGCTAAATGCTCAGGTCAACACCTTCATGTCCTTCATATTCCCCATGGTGGTCATCTCGGTC CTGAACACCATCATCGCCAACAAGCTGACCGTCATGGTACGCCAGGCGGCCGAGCAGGGCCAAGTGTGCACGGTCGGGGGCGAGCACAGC ACATTCAGCATGGCCATCGAGCCTGGCAGGGTCCAGGCCCTGCGGCACGGCGTGCGCGTCCTACGTGCAGTGGTCATCGCCTTTGTGGTC TGCTGGCTGCCCTACCACGTGCGGCGCCTCATGTTCTGCTACATCTCGGATGAGCAGTGGACTCCGTTCCTCTATGACTTCTACCACTAC TTCTACATGGTGACCAACGCACTCTTCTACGTCAGCTCCACCATCAACCCCATCCTGTACAACCTCGTCTCTGCCAACTTCCGCCACATC TTCCTGGCCACACTGGCCTGCCTCTGCCCGGTGTGGCGGCGCAGGAGGAAGAGGCCAGCCTTCTCGAGGAAGGCCGACAGCGTGTCCAGC >In-frame_CCDC91_ENST00000306172_chr12_28544344_+_NTSR1_ENST00000370501_chr20_61386037_+_1215nt ATGCCAATGTGGAATAAAGTATCTGGAGTCCATCTTTCACCATCTTCTCCTGAGATTGTACTGGACCGTGACCACTCTTCTTCCATTGGC TGCCTCTCTTCTGATGCCATTATTTCATCACCAGAGAATACACATGCAGCAAATAGCATTGTGAGTCAAACTATTCCAAAAGCACAGATT CAGCAATCAACACACACTCATCTGGATATCTCACTTTTTCCATTGGGTTTAACTGATGAAAAAAGTAATGGAACAATTGCCCTTGTGGAT GATTCTGAGGATCCTGGAGCCAATGTATCTAACATACAGCTTCAGCAAAAAATTTCAAGTCTGGAGATTAAACTCAAAGTATCTGAAGAA GAAAAACAGAGAATTAAACAGGATGTGGAATCATTGATGGAAAAGCATAATGTCTTAGAAAAAGGCTTTCTAAAAGAAAAAGAGCAAGAG GCCATTTCTTTTCAAGATAGATACAAAGAACTTCAGGAAAAACATAAACAAGAATTGGAAGACATGAGGAAAGCTGGTCACGAAGCCCTC AGCATTATTGTGGATGAATATAAGGCACTACTGCAGTCTTCAGTTAAGCAACAAGTAGAAGCTATTGAAAAACAGTACATTTCTGCAATT GAGAAACAGGCACACAAGTGTGAGGAGTTGCTAAATGCTCAGGTCAACACCTTCATGTCCTTCATATTCCCCATGGTGGTCATCTCGGTC CTGAACACCATCATCGCCAACAAGCTGACCGTCATGGTACGCCAGGCGGCCGAGCAGGGCCAAGTGTGCACGGTCGGGGGCGAGCACAGC ACATTCAGCATGGCCATCGAGCCTGGCAGGGTCCAGGCCCTGCGGCACGGCGTGCGCGTCCTACGTGCAGTGGTCATCGCCTTTGTGGTC TGCTGGCTGCCCTACCACGTGCGGCGCCTCATGTTCTGCTACATCTCGGATGAGCAGTGGACTCCGTTCCTCTATGACTTCTACCACTAC TTCTACATGGTGACCAACGCACTCTTCTACGTCAGCTCCACCATCAACCCCATCCTGTACAACCTCGTCTCTGCCAACTTCCGCCACATC TTCCTGGCCACACTGGCCTGCCTCTGCCCGGTGTGGCGGCGCAGGAGGAAGAGGCCAGCCTTCTCGAGGAAGGCCGACAGCGTGTCCAGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CCDC91_ENST00000545336_chr12_28544344_+_NTSR1_ENST00000370501_chr20_61386037_+_4228nt TTCCGGGGGCAGAGGTGTTCGAAGCCGGGTGGTGCGTGGGCTACCCCAACCTGTGTGGCTGGGCCGCGGTCTCCCCTCAAGGGCCTGGGG CCGTGCCTCGGGTGTACGCGTAGGGGTCTGTGTGCTGGGGGTGGCTCACCGGGCAGCGTGGGTGAGCGGCGCAGCGGCGGCAGCGGAGAG CGAGAGAGGGGAGCAGGCTTCTAACCCTCCTTTATGTGACTCAGAGAAAGGAGACCTCATTCCAAGTTCCAGGATTAATTCTGATGAAAG TATTCTGTCTCATGCATCTAATACTTTACTTGTGAATGAAGATTCATTATGAGGTGCTATACGTGGATGACCTGCTTAGTTTTAATTTTT GGAGAAATACATTTTATAAAACATTTTCATCAGATTGCTAAAATTGTGCCACTTGAAGAATGGATGATGATGATTTTGGTGGTTTTGAGG CTGCGGAGACTTTTGATGGTGGAAGTGGTGAAACCCAAACAACATCTCCTGCTATTCCTTGGGCTGCCTTTCCTGCAGTATCTGGAGTCC ATCTTTCACCATCTTCTCCTGAGATTGTACTGGACCGTGACCACTCTTCTTCCATTGGCTGCCTCTCTTCTGATGCCATTATTTCATCAC CAGAGAATACACATGCAGCAAATAGCATTGTGAGTCAAACTATTCCAAAAGCACAGATTCAGCAATCAACACACACTCATCTGGATATCT CACTTTTTCCATTGGGTTTAACTGATGAAAAAAGTAATGGAACAATTGCCCTTGTGGATGATTCTGAGGATCCTGGAGCCAATGTATCTA ACATACAGCTTCAGCAAAAAATTTCAAGTCTGGAGATTAAACTCAAAGTATCTGAAGAAGAAAAACAGAGAATTAAACAGGATGTGGAAT CATTGATGGAAAAGCATAATGTCTTAGAAAAAGGCTTTCTAAAAGAAAAAGAGCAAGAGGCCATTTCTTTTCAAGATAGATACAAAGAAC TTCAGGAAAAACATAAACAAGAATTGGAAGACATGAGGAAAGCTGGTCACGAAGCCCTCAGCATTATTGTGGATGAATATAAGGCACTAC TGCAGTCTTCAGTTAAGCAACAAGTAGAAGCTATTGAAAAACAGTACATTTCTGCAATTGAGAAACAGGCACACAAGTGTGAGGAGTTGC TAAATGCTCAGGTCAACACCTTCATGTCCTTCATATTCCCCATGGTGGTCATCTCGGTCCTGAACACCATCATCGCCAACAAGCTGACCG TCATGGTACGCCAGGCGGCCGAGCAGGGCCAAGTGTGCACGGTCGGGGGCGAGCACAGCACATTCAGCATGGCCATCGAGCCTGGCAGGG TCCAGGCCCTGCGGCACGGCGTGCGCGTCCTACGTGCAGTGGTCATCGCCTTTGTGGTCTGCTGGCTGCCCTACCACGTGCGGCGCCTCA TGTTCTGCTACATCTCGGATGAGCAGTGGACTCCGTTCCTCTATGACTTCTACCACTACTTCTACATGGTGACCAACGCACTCTTCTACG TCAGCTCCACCATCAACCCCATCCTGTACAACCTCGTCTCTGCCAACTTCCGCCACATCTTCCTGGCCACACTGGCCTGCCTCTGCCCGG TGTGGCGGCGCAGGAGGAAGAGGCCAGCCTTCTCGAGGAAGGCCGACAGCGTGTCCAGCAACCACACCCTCTCCAGCAATGCCACCCGCG AGACGCTGTACTAGGCTGTGCGCCCCGGAACGTGTCCAGGAGGAGCCTGGCCATGGGTCCTTGCCCCCGACAGACAGAGCAGCCCCCACC CGGGAGCCTTGATGGGGGTCAGGCAGAGGCCAGCCTGCACTGGAGTCTGAGGCCTGGGACCCCCCCCTCCCACCCCCTAACCCATGTTTC TCATTAGTGTCTCCCGGGCCTGTCCCCAACTCCTCCCCACCCCTCCCCCATCTCCTCTTTGAAAGCCAGAACAAGAGAGCGCTCCTCTCC CAGATAGGAAAAGGGCCTCTAACAAGGAGAAATTAGTGTGCGGCAAAAGGCAGTTTTCTTTGTTCTCAGACTAATGGATGGTTCCAGAGA AGGAAATGAAAGGTGCTGGGTGGGGCCGGGCCTCCGGCGGCCCGGCTGCTGTTCCCATGTCCACATCTCTGAGGCCTGCACCCCCTCTGT CTAGCTCGGGGAGTCCAGCCCCAGTCCCGCAGGCTCCGTGGCTTTGGGCCTCACGTGCAGACCCTGCCATGCAGACCCATGCCCCCCTCC CCCAGGCAGCTCCAAGAAAGCTCCCTGACTCGCCCCTTCAGGCCTGGCAAGCTGGGGGCCCATCGCCGTGGGGAGTCCCTCCCACCACCC TCGCCGCAGGCAGCTGCAGCCCCCAGAGGGGACCACAAGCCCAAAAAGGACAAAAATGGGCTGGCCTGGAATGGCCCAGACCCCAGCCTC CCCTCCTCCCTCCCATCCTCACCCAGGCCAAGGCCCAGGGGCTCTGCCAGGACACCACATGGGAGGGGGCTCAGGCCTCAGCCTCAAGAT CTTCAGCTGTGGCCTCTCGGGCTCGGCAGAAGGGACGCCGGATCAGGGGCCTGGTCTCCAGCACCTGCCCGAGTGGCCGTGGCCAGGATG GGGTGCGCATTCCGTGTGCTTTGCTTGTGGCTGTGCAGGCTGAGGTCTGGAGCCAGGCCCAGAGCTGGCTTCAGGGTGGGGCCTTGAGAA GGGGAATGTGGGACAGGGGCGATGGTGCCTGGTCTCTGAGTAAGATGCCAGGTCCCAGGAACTCAGGCTTCAGGTGAGAAGGAGCGGTGT GTCCAGGCACCGCTGGCCGGCAGCCCTGGGCTGAGGCACAGACTCATTTGTCACCTTCTGGCGGCGGCAGCCCTGGCCCCGGCCTCCAAG CAGTTGAAAAAGCTGGCGCCTCCTTGGTCTCTAGGATCCAGGCTCCACAGAGCACATGACTAGCCAGGCCCCTGGCTTAAGAAGGTCGCC TAAGCCTAAGAGAAGACAGTCCCAGGAGAAGCTGGCCGGGACCAGCCAGGAGCTGGGAGCCACAGGAAGCAAAAGTCAGCCTTTTCTTCA AGGGATTTCCCTGTCTCAGAGCAGCCTTTGCCCCAGGGAAATGGGCTCTGGGCTGGCTGCCTGCACCGGCCATGTCGACCCAGGACCCGG ACACCTGGTCTTGGGCTGTGTTCAGCCACTTTGCCTTCTCTGGACTCAGTTTCCCCGTCTGAGAAATGAGAGTCGAATGCTACAGTATCT GCAGTCGCTTGGATCTGGCTGTTGAGTTGACGGGTTCCTTGAACCCCACAAAATCCCTCTCCAACCACAGGACCCTTCGGCTCACCAAGA ACAGGGCCCAGGGGAGTCAGGCCTATTCGCTGCACTTCCTGCCAAACTTTGCCCCCACAAGCCTGGTCATCAGCCAGGCAGCCCTCCCAG TGCCCAAGGGCCACCAACCCCAGGGAAACAGGGCCAGCACAGAGGGGCCTTCCTCCCCCACAGAGCCCCCATGACATAGTCTGCTCTGGG CGGAAGAGCTTTGCTGCCAGCCAGGGATGTCCAGAGGTCAGTGCAGCCCCTACCCCTGCTCAGGAGTGGGCTCAGAGTCTAGCAAATGCT AAGGCCCCTCAGGCTGGGCTCTGAACGAGGACCTGGACTCAGAGCCAGACAGGGCAGCCTCAGACCCTTCTCTGGGGCTCCTGGACCTTG GGCCATAATTTCTGAGCCTCGGTTTCCCCATCTAAGGAACAGATGTGGTCGTTCCGCCCTCTCAGCTGGATGAGACTGTCCTGGAGGATC CACCCCGGAACAGACAGAATGGTGTCTCTCAGGATGGTGCTCTGAGAGAGGGCAGAGTGGATGCCCCACTGCCCTAGACCCTCGGTAGAC GTGGGGTCTCTGGGGCGGGGTCTGTGGCTGTGACTGAAGTCGGCTTTTCCCGTTGATGTCTTGATGCTCCTATCTGTGCACTTACCGTAG GTAGGGACACGTGTCCACGCACCACAGACACACCCACGACACCTGATCTCGTATCACTAGCTTGCGGCCAGGTCATGATGTGGCCCCGGA AGCTGGCCCTGCGTGCCATGAGTGCGTCGGTCATGGAGTCCGGAGCCCCTGAGCCGGCCCCTGGTGACGGCACAGCCCTCACAGCTCAAA >In-frame_CCDC91_ENST00000381259_chr12_28544344_+_NTSR1_ENST00000370501_chr20_61386037_+_3825nt AGGTGCCACTTGAAGAATGGATGATGATGATTTTGGTGGTTTTGAGGCTGCGGAGACTTTTGATGGTGGAAGTGGTGAAACCCAAACAAC ATCTCCTGCTATTCCTTGGGCTGCCTTTCCTGCAGTATCTGGAGTCCATCTTTCACCATCTTCTCCTGAGATTGTACTGGACCGTGACCA CTCTTCTTCCATTGGCTGCCTCTCTTCTGATGCCATTATTTCATCACCAGAGAATACACATGCAGCAAATAGCATTGTGAGTCAAACTAT TCCAAAAGCACAGATTCAGCAATCAACACACACTCATCTGGATATCTCACTTTTTCCATTGGGTTTAACTGATGAAAAAAGTAATGGAAC AATTGCCCTTGTGGATGATTCTGAGGATCCTGGAGCCAATGTATCTAACATACAGCTTCAGCAAAAAATTTCAAGTCTGGAGATTAAACT CAAAGTATCTGAAGAAGAAAAACAGAGAATTAAACAGGATGTGGAATCATTGATGGAAAAGCATAATGTCTTAGAAAAAGGCTTTCTAAA AGAAAAAGAGCAAGAGGCCATTTCTTTTCAAGATAGATACAAAGAACTTCAGGAAAAACATAAACAAGAATTGGAAGACATGAGGAAAGC TGGTCACGAAGCCCTCAGCATTATTGTGGATGAATATAAGGCACTACTGCAGTCTTCAGTTAAGCAACAAGTAGAAGCTATTGAAAAACA GTACATTTCTGCAATTGAGAAACAGGCACACAAGTGTGAGGAGTTGCTAAATGCTCAGGTCAACACCTTCATGTCCTTCATATTCCCCAT GGTGGTCATCTCGGTCCTGAACACCATCATCGCCAACAAGCTGACCGTCATGGTACGCCAGGCGGCCGAGCAGGGCCAAGTGTGCACGGT CGGGGGCGAGCACAGCACATTCAGCATGGCCATCGAGCCTGGCAGGGTCCAGGCCCTGCGGCACGGCGTGCGCGTCCTACGTGCAGTGGT CATCGCCTTTGTGGTCTGCTGGCTGCCCTACCACGTGCGGCGCCTCATGTTCTGCTACATCTCGGATGAGCAGTGGACTCCGTTCCTCTA TGACTTCTACCACTACTTCTACATGGTGACCAACGCACTCTTCTACGTCAGCTCCACCATCAACCCCATCCTGTACAACCTCGTCTCTGC CAACTTCCGCCACATCTTCCTGGCCACACTGGCCTGCCTCTGCCCGGTGTGGCGGCGCAGGAGGAAGAGGCCAGCCTTCTCGAGGAAGGC CGACAGCGTGTCCAGCAACCACACCCTCTCCAGCAATGCCACCCGCGAGACGCTGTACTAGGCTGTGCGCCCCGGAACGTGTCCAGGAGG AGCCTGGCCATGGGTCCTTGCCCCCGACAGACAGAGCAGCCCCCACCCGGGAGCCTTGATGGGGGTCAGGCAGAGGCCAGCCTGCACTGG AGTCTGAGGCCTGGGACCCCCCCCTCCCACCCCCTAACCCATGTTTCTCATTAGTGTCTCCCGGGCCTGTCCCCAACTCCTCCCCACCCC TCCCCCATCTCCTCTTTGAAAGCCAGAACAAGAGAGCGCTCCTCTCCCAGATAGGAAAAGGGCCTCTAACAAGGAGAAATTAGTGTGCGG CAAAAGGCAGTTTTCTTTGTTCTCAGACTAATGGATGGTTCCAGAGAAGGAAATGAAAGGTGCTGGGTGGGGCCGGGCCTCCGGCGGCCC GGCTGCTGTTCCCATGTCCACATCTCTGAGGCCTGCACCCCCTCTGTCTAGCTCGGGGAGTCCAGCCCCAGTCCCGCAGGCTCCGTGGCT TTGGGCCTCACGTGCAGACCCTGCCATGCAGACCCATGCCCCCCTCCCCCAGGCAGCTCCAAGAAAGCTCCCTGACTCGCCCCTTCAGGC CTGGCAAGCTGGGGGCCCATCGCCGTGGGGAGTCCCTCCCACCACCCTCGCCGCAGGCAGCTGCAGCCCCCAGAGGGGACCACAAGCCCA AAAAGGACAAAAATGGGCTGGCCTGGAATGGCCCAGACCCCAGCCTCCCCTCCTCCCTCCCATCCTCACCCAGGCCAAGGCCCAGGGGCT CTGCCAGGACACCACATGGGAGGGGGCTCAGGCCTCAGCCTCAAGATCTTCAGCTGTGGCCTCTCGGGCTCGGCAGAAGGGACGCCGGAT CAGGGGCCTGGTCTCCAGCACCTGCCCGAGTGGCCGTGGCCAGGATGGGGTGCGCATTCCGTGTGCTTTGCTTGTGGCTGTGCAGGCTGA GGTCTGGAGCCAGGCCCAGAGCTGGCTTCAGGGTGGGGCCTTGAGAAGGGGAATGTGGGACAGGGGCGATGGTGCCTGGTCTCTGAGTAA GATGCCAGGTCCCAGGAACTCAGGCTTCAGGTGAGAAGGAGCGGTGTGTCCAGGCACCGCTGGCCGGCAGCCCTGGGCTGAGGCACAGAC TCATTTGTCACCTTCTGGCGGCGGCAGCCCTGGCCCCGGCCTCCAAGCAGTTGAAAAAGCTGGCGCCTCCTTGGTCTCTAGGATCCAGGC TCCACAGAGCACATGACTAGCCAGGCCCCTGGCTTAAGAAGGTCGCCTAAGCCTAAGAGAAGACAGTCCCAGGAGAAGCTGGCCGGGACC AGCCAGGAGCTGGGAGCCACAGGAAGCAAAAGTCAGCCTTTTCTTCAAGGGATTTCCCTGTCTCAGAGCAGCCTTTGCCCCAGGGAAATG GGCTCTGGGCTGGCTGCCTGCACCGGCCATGTCGACCCAGGACCCGGACACCTGGTCTTGGGCTGTGTTCAGCCACTTTGCCTTCTCTGG ACTCAGTTTCCCCGTCTGAGAAATGAGAGTCGAATGCTACAGTATCTGCAGTCGCTTGGATCTGGCTGTTGAGTTGACGGGTTCCTTGAA CCCCACAAAATCCCTCTCCAACCACAGGACCCTTCGGCTCACCAAGAACAGGGCCCAGGGGAGTCAGGCCTATTCGCTGCACTTCCTGCC AAACTTTGCCCCCACAAGCCTGGTCATCAGCCAGGCAGCCCTCCCAGTGCCCAAGGGCCACCAACCCCAGGGAAACAGGGCCAGCACAGA GGGGCCTTCCTCCCCCACAGAGCCCCCATGACATAGTCTGCTCTGGGCGGAAGAGCTTTGCTGCCAGCCAGGGATGTCCAGAGGTCAGTG CAGCCCCTACCCCTGCTCAGGAGTGGGCTCAGAGTCTAGCAAATGCTAAGGCCCCTCAGGCTGGGCTCTGAACGAGGACCTGGACTCAGA GCCAGACAGGGCAGCCTCAGACCCTTCTCTGGGGCTCCTGGACCTTGGGCCATAATTTCTGAGCCTCGGTTTCCCCATCTAAGGAACAGA TGTGGTCGTTCCGCCCTCTCAGCTGGATGAGACTGTCCTGGAGGATCCACCCCGGAACAGACAGAATGGTGTCTCTCAGGATGGTGCTCT GAGAGAGGGCAGAGTGGATGCCCCACTGCCCTAGACCCTCGGTAGACGTGGGGTCTCTGGGGCGGGGTCTGTGGCTGTGACTGAAGTCGG CTTTTCCCGTTGATGTCTTGATGCTCCTATCTGTGCACTTACCGTAGGTAGGGACACGTGTCCACGCACCACAGACACACCCACGACACC TGATCTCGTATCACTAGCTTGCGGCCAGGTCATGATGTGGCCCCGGAAGCTGGCCCTGCGTGCCATGAGTGCGTCGGTCATGGAGTCCGG AGCCCCTGAGCCGGCCCCTGGTGACGGCACAGCCCTCACAGCTCAAACGCCCACCCCCACTCCCACCATCTGCAGGTGGTGAAAACAAAC >In-frame_CCDC91_ENST00000306172_chr12_28544344_+_NTSR1_ENST00000370501_chr20_61386037_+_3719nt ATGCCAATGTGGAATAAAGTATCTGGAGTCCATCTTTCACCATCTTCTCCTGAGATTGTACTGGACCGTGACCACTCTTCTTCCATTGGC TGCCTCTCTTCTGATGCCATTATTTCATCACCAGAGAATACACATGCAGCAAATAGCATTGTGAGTCAAACTATTCCAAAAGCACAGATT CAGCAATCAACACACACTCATCTGGATATCTCACTTTTTCCATTGGGTTTAACTGATGAAAAAAGTAATGGAACAATTGCCCTTGTGGAT GATTCTGAGGATCCTGGAGCCAATGTATCTAACATACAGCTTCAGCAAAAAATTTCAAGTCTGGAGATTAAACTCAAAGTATCTGAAGAA GAAAAACAGAGAATTAAACAGGATGTGGAATCATTGATGGAAAAGCATAATGTCTTAGAAAAAGGCTTTCTAAAAGAAAAAGAGCAAGAG GCCATTTCTTTTCAAGATAGATACAAAGAACTTCAGGAAAAACATAAACAAGAATTGGAAGACATGAGGAAAGCTGGTCACGAAGCCCTC AGCATTATTGTGGATGAATATAAGGCACTACTGCAGTCTTCAGTTAAGCAACAAGTAGAAGCTATTGAAAAACAGTACATTTCTGCAATT GAGAAACAGGCACACAAGTGTGAGGAGTTGCTAAATGCTCAGGTCAACACCTTCATGTCCTTCATATTCCCCATGGTGGTCATCTCGGTC CTGAACACCATCATCGCCAACAAGCTGACCGTCATGGTACGCCAGGCGGCCGAGCAGGGCCAAGTGTGCACGGTCGGGGGCGAGCACAGC ACATTCAGCATGGCCATCGAGCCTGGCAGGGTCCAGGCCCTGCGGCACGGCGTGCGCGTCCTACGTGCAGTGGTCATCGCCTTTGTGGTC TGCTGGCTGCCCTACCACGTGCGGCGCCTCATGTTCTGCTACATCTCGGATGAGCAGTGGACTCCGTTCCTCTATGACTTCTACCACTAC TTCTACATGGTGACCAACGCACTCTTCTACGTCAGCTCCACCATCAACCCCATCCTGTACAACCTCGTCTCTGCCAACTTCCGCCACATC TTCCTGGCCACACTGGCCTGCCTCTGCCCGGTGTGGCGGCGCAGGAGGAAGAGGCCAGCCTTCTCGAGGAAGGCCGACAGCGTGTCCAGC AACCACACCCTCTCCAGCAATGCCACCCGCGAGACGCTGTACTAGGCTGTGCGCCCCGGAACGTGTCCAGGAGGAGCCTGGCCATGGGTC CTTGCCCCCGACAGACAGAGCAGCCCCCACCCGGGAGCCTTGATGGGGGTCAGGCAGAGGCCAGCCTGCACTGGAGTCTGAGGCCTGGGA CCCCCCCCTCCCACCCCCTAACCCATGTTTCTCATTAGTGTCTCCCGGGCCTGTCCCCAACTCCTCCCCACCCCTCCCCCATCTCCTCTT TGAAAGCCAGAACAAGAGAGCGCTCCTCTCCCAGATAGGAAAAGGGCCTCTAACAAGGAGAAATTAGTGTGCGGCAAAAGGCAGTTTTCT TTGTTCTCAGACTAATGGATGGTTCCAGAGAAGGAAATGAAAGGTGCTGGGTGGGGCCGGGCCTCCGGCGGCCCGGCTGCTGTTCCCATG TCCACATCTCTGAGGCCTGCACCCCCTCTGTCTAGCTCGGGGAGTCCAGCCCCAGTCCCGCAGGCTCCGTGGCTTTGGGCCTCACGTGCA GACCCTGCCATGCAGACCCATGCCCCCCTCCCCCAGGCAGCTCCAAGAAAGCTCCCTGACTCGCCCCTTCAGGCCTGGCAAGCTGGGGGC CCATCGCCGTGGGGAGTCCCTCCCACCACCCTCGCCGCAGGCAGCTGCAGCCCCCAGAGGGGACCACAAGCCCAAAAAGGACAAAAATGG GCTGGCCTGGAATGGCCCAGACCCCAGCCTCCCCTCCTCCCTCCCATCCTCACCCAGGCCAAGGCCCAGGGGCTCTGCCAGGACACCACA TGGGAGGGGGCTCAGGCCTCAGCCTCAAGATCTTCAGCTGTGGCCTCTCGGGCTCGGCAGAAGGGACGCCGGATCAGGGGCCTGGTCTCC AGCACCTGCCCGAGTGGCCGTGGCCAGGATGGGGTGCGCATTCCGTGTGCTTTGCTTGTGGCTGTGCAGGCTGAGGTCTGGAGCCAGGCC CAGAGCTGGCTTCAGGGTGGGGCCTTGAGAAGGGGAATGTGGGACAGGGGCGATGGTGCCTGGTCTCTGAGTAAGATGCCAGGTCCCAGG AACTCAGGCTTCAGGTGAGAAGGAGCGGTGTGTCCAGGCACCGCTGGCCGGCAGCCCTGGGCTGAGGCACAGACTCATTTGTCACCTTCT GGCGGCGGCAGCCCTGGCCCCGGCCTCCAAGCAGTTGAAAAAGCTGGCGCCTCCTTGGTCTCTAGGATCCAGGCTCCACAGAGCACATGA CTAGCCAGGCCCCTGGCTTAAGAAGGTCGCCTAAGCCTAAGAGAAGACAGTCCCAGGAGAAGCTGGCCGGGACCAGCCAGGAGCTGGGAG CCACAGGAAGCAAAAGTCAGCCTTTTCTTCAAGGGATTTCCCTGTCTCAGAGCAGCCTTTGCCCCAGGGAAATGGGCTCTGGGCTGGCTG CCTGCACCGGCCATGTCGACCCAGGACCCGGACACCTGGTCTTGGGCTGTGTTCAGCCACTTTGCCTTCTCTGGACTCAGTTTCCCCGTC TGAGAAATGAGAGTCGAATGCTACAGTATCTGCAGTCGCTTGGATCTGGCTGTTGAGTTGACGGGTTCCTTGAACCCCACAAAATCCCTC TCCAACCACAGGACCCTTCGGCTCACCAAGAACAGGGCCCAGGGGAGTCAGGCCTATTCGCTGCACTTCCTGCCAAACTTTGCCCCCACA AGCCTGGTCATCAGCCAGGCAGCCCTCCCAGTGCCCAAGGGCCACCAACCCCAGGGAAACAGGGCCAGCACAGAGGGGCCTTCCTCCCCC ACAGAGCCCCCATGACATAGTCTGCTCTGGGCGGAAGAGCTTTGCTGCCAGCCAGGGATGTCCAGAGGTCAGTGCAGCCCCTACCCCTGC TCAGGAGTGGGCTCAGAGTCTAGCAAATGCTAAGGCCCCTCAGGCTGGGCTCTGAACGAGGACCTGGACTCAGAGCCAGACAGGGCAGCC TCAGACCCTTCTCTGGGGCTCCTGGACCTTGGGCCATAATTTCTGAGCCTCGGTTTCCCCATCTAAGGAACAGATGTGGTCGTTCCGCCC TCTCAGCTGGATGAGACTGTCCTGGAGGATCCACCCCGGAACAGACAGAATGGTGTCTCTCAGGATGGTGCTCTGAGAGAGGGCAGAGTG GATGCCCCACTGCCCTAGACCCTCGGTAGACGTGGGGTCTCTGGGGCGGGGTCTGTGGCTGTGACTGAAGTCGGCTTTTCCCGTTGATGT CTTGATGCTCCTATCTGTGCACTTACCGTAGGTAGGGACACGTGTCCACGCACCACAGACACACCCACGACACCTGATCTCGTATCACTA GCTTGCGGCCAGGTCATGATGTGGCCCCGGAAGCTGGCCCTGCGTGCCATGAGTGCGTCGGTCATGGAGTCCGGAGCCCCTGAGCCGGCC CCTGGTGACGGCACAGCCCTCACAGCTCAAACGCCCACCCCCACTCCCACCATCTGCAGGTGGTGAAAACAAACCCCGTGTATCTCTCAA |
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FusionGenePPI for CCDC91_NTSR1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CCDC91 | TESC, EWSR1, GGA1, GGA2, CCDC91, ECT2, MVK, ANGPTL3, STARD7, C10orf88, CCDC102A, PES1 | NTSR1 | NTS |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CCDC91_NTSR1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CCDC91_NTSR1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CCDC91 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| Tgene | NTSR1 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Tgene | NTSR1 | C0030193 | Pain | 1 | CTD_human |
| Tgene | NTSR1 | C0036341 | Schizophrenia | 1 | CTD_human |
| Tgene | NTSR1 | C0525045 | Mood Disorders | 1 | PSYGENET |
| Tgene | NTSR1 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
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