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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5921

FusionGeneSummary for CCDC88C_C14orf159

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC88C_C14orf159
Fusion gene ID: 5921
HgeneTgene
Gene symbol

CCDC88C

C14orf159

Gene ID

440193

Gene namecoiled-coil domain containing 88C
SynonymsDAPLE|HKRP2|KIAA1509|SCA40
Cytomap

14q32.11-q32.12

Type of geneprotein-coding
Descriptionprotein DapleDvl-associating protein with a high frequency of leucine residueshook-related protein 2spinocerebellar ataxia 40
Modification date20180523
UniProtAcc

Q9P219

Ensembl transtripts involved in fusion geneENST00000389857, ENST00000331194, 
ENST00000389856, ENST00000553403, 
ENST00000554165, 
ENST00000298858, 
ENST00000520328, ENST00000256324, 
ENST00000521077, ENST00000518665, 
ENST00000518868, ENST00000519019, 
ENST00000523816, ENST00000525393, 
ENST00000428926, ENST00000522322, 
ENST00000523771, ENST00000412671, 
ENST00000517877, ENST00000523576, 
Fusion gene scores* DoF score4 X 4 X 3=484 X 4 X 4=64
# samples 64
** MAII scorelog2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCDC88C [Title/Abstract] AND C14orf159 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-UY-A9PE-01ACCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000389857ENST00000298858CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
5CDS-intronENST00000389857ENST00000520328CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
5CDS-intronENST00000389857ENST00000256324CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
5CDS-intronENST00000389857ENST00000521077CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
5CDS-intronENST00000389857ENST00000518665CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
5CDS-intronENST00000389857ENST00000518868CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
5CDS-intronENST00000389857ENST00000519019CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
5CDS-intronENST00000389857ENST00000523816CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
5CDS-intronENST00000389857ENST00000525393CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
5CDS-intronENST00000389857ENST00000428926CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
5CDS-intronENST00000389857ENST00000522322CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
5CDS-intronENST00000389857ENST00000523771CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
5CDS-intronENST00000389857ENST00000412671CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
5CDS-intronENST00000389857ENST00000517877CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
5CDS-intronENST00000389857ENST00000523576CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000331194ENST00000298858CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000331194ENST00000520328CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000331194ENST00000256324CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000331194ENST00000521077CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000331194ENST00000518665CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000331194ENST00000518868CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000331194ENST00000519019CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000331194ENST00000523816CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000331194ENST00000525393CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000331194ENST00000428926CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000331194ENST00000522322CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000331194ENST00000523771CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000331194ENST00000412671CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000331194ENST00000517877CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000331194ENST00000523576CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000389856ENST00000298858CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000389856ENST00000520328CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000389856ENST00000256324CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000389856ENST00000521077CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000389856ENST00000518665CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000389856ENST00000518868CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000389856ENST00000519019CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000389856ENST00000523816CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000389856ENST00000525393CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000389856ENST00000428926CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000389856ENST00000522322CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000389856ENST00000523771CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000389856ENST00000412671CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000389856ENST00000517877CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000389856ENST00000523576CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000553403ENST00000298858CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000553403ENST00000520328CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000553403ENST00000256324CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000553403ENST00000521077CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000553403ENST00000518665CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000553403ENST00000518868CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000553403ENST00000519019CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000553403ENST00000523816CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000553403ENST00000525393CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000553403ENST00000428926CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000553403ENST00000522322CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000553403ENST00000523771CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000553403ENST00000412671CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000553403ENST00000517877CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000553403ENST00000523576CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000554165ENST00000298858CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000554165ENST00000520328CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000554165ENST00000256324CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000554165ENST00000521077CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000554165ENST00000518665CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000554165ENST00000518868CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000554165ENST00000519019CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000554165ENST00000523816CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000554165ENST00000525393CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000554165ENST00000428926CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000554165ENST00000522322CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000554165ENST00000523771CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000554165ENST00000412671CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000554165ENST00000517877CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+
intron-intronENST00000554165ENST00000523576CCDC88Cchr14

91760517

-C14orf159chr14

91681749

+

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FusionProtFeatures for CCDC88C_C14orf159


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCDC88C

Q9P219

C14orf159

Negative regulator of the canonical Wnt signalingpathway, acting downstream of DVL to inhibit CTNNB1/Beta-cateninstabilization (By similarity). May also activate the JNK signalingpathway (PubMed:25062847). {ECO:0000250|UniProtKB:Q6VGS5,ECO:0000269|PubMed:25062847}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCDC88C_C14orf159


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCDC88C_C14orf159


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CCDC88CMAPK8, ITSN2, APP, SMURF1, BAG3, LATS2, GNAI3, MCM7, WHSC1, KATNA1, WDFY1, RNASE7, ALDH1L1C14orf159APP, PSMA3, C14orf159, MSRB2, BOLA3, C17orf89, SLC25A6, PAK7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCDC88C_C14orf159


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCDC88C_C14orf159


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource