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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5908

FusionGeneSummary for CCDC80_PTPRC

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC80_PTPRC
Fusion gene ID: 5908
HgeneTgene
Gene symbol

CCDC80

PTPRC

Gene ID

151887

5788

Gene namecoiled-coil domain containing 80protein tyrosine phosphatase, receptor type C
SynonymsDRO1|SSG1|URB|okuribinB220|CD45|CD45R|GP180|L-CA|LCA|LY5|T200
Cytomap

3q13.2

1q31.3-q32.1

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 80down-regulated by oncogenes protein 1nuclear envelope protein okuribinsteroid sensitive gene 1up-regulated in BRS-3 deficient mouse homologreceptor-type tyrosine-protein phosphatase CCD45 antigenT200 glycoproteinT200 leukocyte common antigenprotein tyrosine phosphatase, receptor type, c polypeptide
Modification date2018051920180522
UniProtAcc

Q76M96

P08575

Ensembl transtripts involved in fusion geneENST00000206423, ENST00000439685, 
ENST00000475181, 
ENST00000352140, 
ENST00000594404, ENST00000367376, 
ENST00000442510, ENST00000348564, 
ENST00000598951, ENST00000367364, 
ENST00000413409, ENST00000391970, 
Fusion gene scores* DoF score6 X 7 X 2=844 X 4 X 2=32
# samples 75
** MAII scorelog2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/32*10)=0.643856189774725
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CCDC80 [Title/Abstract] AND PTPRC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePTPRC

GO:0006469

negative regulation of protein kinase activity

9197241

TgenePTPRC

GO:0050852

T cell receptor signaling pathway

10358156


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI587210CCDC80chr3

112324340

+PTPRCchr1

198719675

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000206423ENST00000352140CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-3CDSENST00000206423ENST00000594404CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-3CDSENST00000206423ENST00000367376CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-3CDSENST00000206423ENST00000442510CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-3CDSENST00000206423ENST00000348564CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-intronENST00000206423ENST00000598951CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-intronENST00000206423ENST00000367364CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-intronENST00000206423ENST00000413409CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-intronENST00000206423ENST00000391970CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-3CDSENST00000439685ENST00000352140CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-3CDSENST00000439685ENST00000594404CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-3CDSENST00000439685ENST00000367376CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-3CDSENST00000439685ENST00000442510CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-3CDSENST00000439685ENST00000348564CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-intronENST00000439685ENST00000598951CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-intronENST00000439685ENST00000367364CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-intronENST00000439685ENST00000413409CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-intronENST00000439685ENST00000391970CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-3CDSENST00000475181ENST00000352140CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-3CDSENST00000475181ENST00000594404CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-3CDSENST00000475181ENST00000367376CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-3CDSENST00000475181ENST00000442510CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-3CDSENST00000475181ENST00000348564CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-intronENST00000475181ENST00000598951CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-intronENST00000475181ENST00000367364CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-intronENST00000475181ENST00000413409CCDC80chr3

112324340

+PTPRCchr1

198719675

-
intron-intronENST00000475181ENST00000391970CCDC80chr3

112324340

+PTPRCchr1

198719675

-

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FusionProtFeatures for CCDC80_PTPRC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCDC80

Q76M96

PTPRC

P08575

Promotes cell adhesion and matrix assembly.{ECO:0000250}. Protein tyrosine-protein phosphatase required for T-cellactivation through the antigen receptor. Acts as a positiveregulator of T-cell coactivation upon binding to DPP4. The firstPTPase domain has enzymatic activity, while the second one seemsto affect the substrate specificity of the first one. Upon T-cellactivation, recruits and dephosphorylates SKAP1 and FYN.Dephosphorylates LYN, and thereby modulates LYN activity (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:11909961,ECO:0000269|PubMed:2845400}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCDC80_PTPRC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCDC80_PTPRC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCDC80_PTPRC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCDC80_PTPRC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCCDC80C0011615Dermatitis, Atopic1CTD_human
HgeneCCDC80C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgenePTPRCC0003873Rheumatoid Arthritis2CTD_human
TgenePTPRCC0023893Liver Cirrhosis, Experimental1CTD_human
TgenePTPRCC0033975Psychotic Disorders1PSYGENET
TgenePTPRCC0035309Retinal Diseases1CTD_human
TgenePTPRCC0349204Nonorganic psychosis1PSYGENET