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Fusion gene ID: 5899 |
FusionGeneSummary for CCDC6_UBE2D1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CCDC6_UBE2D1 | Fusion gene ID: 5899 | Hgene | Tgene | Gene symbol | CCDC6 | UBE2D1 | Gene ID | 8030 | 7321 |
| Gene name | coiled-coil domain containing 6 | ubiquitin conjugating enzyme E2 D1 | |
| Synonyms | D10S170|H4|PTC|TPC|TST1 | E2(17)KB1|SFT|UBC4/5|UBCH5|UBCH5A | |
| Cytomap | 10q21.2 | 10q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | coiled-coil domain-containing protein 6papillary thyroid carcinoma-encoded protein | ubiquitin-conjugating enzyme E2 D1(E3-independent) E2 ubiquitin-conjugating enzyme D1E2 ubiquitin-conjugating enzyme D1UBC4/5 homologstimulator of Fe transportubiquitin carrier protein D1ubiquitin conjugating enzyme E2D 1ubiquitin-conjugating enzym | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q16204 | P51668 | |
| Ensembl transtripts involved in fusion gene | ENST00000263102, | ENST00000373910, | |
| Fusion gene scores | * DoF score | 8 X 8 X 8=512 | 3 X 2 X 3=18 |
| # samples | 43 | 3 | |
| ** MAII score | log2(43/512*10)=-0.25180715041054 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CCDC6 [Title/Abstract] AND UBE2D1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | UBE2D1 | GO:0000209 | protein polyubiquitination | 15247280|16275645 |
| Tgene | UBE2D1 | GO:0006511 | ubiquitin-dependent protein catabolic process | 16275645 |
| Tgene | UBE2D1 | GO:0031398 | positive regulation of protein ubiquitination | 16275645 |
| Tgene | UBE2D1 | GO:0070936 | protein K48-linked ubiquitination | 20061386 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AO-A0J6-01A | CCDC6 | chr10 | 61665880 | - | UBE2D1 | chr10 | 60121098 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000263102 | ENST00000373910 | CCDC6 | chr10 | 61665880 | - | UBE2D1 | chr10 | 60121098 | + |
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FusionProtFeatures for CCDC6_UBE2D1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CCDC6 | UBE2D1 |
| Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins (PubMed:22496338). In vitrocatalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386).Mediates the selective degradation of short-lived and abnormalproteins. Functions in the E6/E6-AP-induced ubiquitination ofp53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitinationof STUB1, TRAF6 and TRIM63/MURF1 (PubMed:18042044,PubMed:18359941). Ubiquitinates STUB1-associated HSP90AB1 in vitro(PubMed:18042044). Lacks inherent specificity for any particularlysine residue of ubiquitin (PubMed:18042044). Essential for viralactivation of IRF3 (PubMed:19854139). Mediates polyubiquitinationof CYP3A4 (PubMed:19103148). {ECO:0000269|PubMed:18042044,ECO:0000269|PubMed:18359941, ECO:0000269|PubMed:19103148,ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20061386,ECO:0000269|PubMed:22496338}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CCDC6 | chr10:61665880 | chr10:60121098 | ENST00000263102 | - | 1 | 9 | 17_20 | 101 | 475 | Compositional bias | Note=Poly-Ser |
| Hgene | CCDC6 | chr10:61665880 | chr10:60121098 | ENST00000263102 | - | 1 | 9 | 32_44 | 101 | 475 | Compositional bias | Note=Poly-Gly |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CCDC6 | chr10:61665880 | chr10:60121098 | ENST00000263102 | - | 1 | 9 | 253_332 | 101 | 475 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CCDC6 | chr10:61665880 | chr10:60121098 | ENST00000263102 | - | 1 | 9 | 53_237 | 101 | 475 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CCDC6 | chr10:61665880 | chr10:60121098 | ENST00000263102 | - | 1 | 9 | 440_448 | 101 | 475 | Compositional bias | Note=Poly-Pro |
| Hgene | >CCDC6 | chr10:61665880 | chr10:60121098 | ENST00000263102 | - | 1 | 9 | 442_451 | 101 | 475 | Motif | SH3-binding |
| Hgene | >CCDC6 | chr10:61665880 | chr10:60121098 | ENST00000263102 | - | 1 | 9 | 106_235 | 101 | 475 | Region | Note=5 X 29 AA tandem repeats |
| Hgene | >CCDC6 | chr10:61665880 | chr10:60121098 | ENST00000263102 | - | 1 | 9 | 106_134 | 101 | 475 | Repeat | Note=1 |
| Hgene | >CCDC6 | chr10:61665880 | chr10:60121098 | ENST00000263102 | - | 1 | 9 | 135_163 | 101 | 475 | Repeat | Note=2 |
| Hgene | >CCDC6 | chr10:61665880 | chr10:60121098 | ENST00000263102 | - | 1 | 9 | 164_192 | 101 | 475 | Repeat | Note=3 |
| Hgene | >CCDC6 | chr10:61665880 | chr10:60121098 | ENST00000263102 | - | 1 | 9 | 193_206 | 101 | 475 | Repeat | Note=4%3B approximate |
| Hgene | >CCDC6 | chr10:61665880 | chr10:60121098 | ENST00000263102 | - | 1 | 9 | 207_235 | 101 | 475 | Repeat | Note=5 |
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FusionGeneSequence for CCDC6_UBE2D1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CCDC6_ENST00000263102_chr10_61665880_-_UBE2D1_ENST00000373910_chr10_60121098_+_241aa MADSASESDTDGAGGNSSSSAAMQSSCSSTSGGGGGGGGGGGGGKSGGIVISPFRLEELTNRLASLQQENKVLKIELETYKLKCKALQEE NRDLRKASVTIELSDLQRDPPAHCSAGPVGDDLFHWQATIMGPPDSAYQGGVFFLTVHFPTDYPFKPPKIAFTTKIYHPNINSNGSICLD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CCDC6_ENST00000263102_chr10_61665880_-_UBE2D1_ENST00000373910_chr10_60121098_+_723nt ATGGCGGACAGCGCCAGCGAGAGCGACACGGACGGGGCGGGGGGCAACAGCAGCAGCTCGGCCGCCATGCAGTCGTCCTGCTCGTCGACC TCGGGCGGCGGCGGTGGCGGCGGGGGAGGCGGCGGCGGTGGGAAGTCGGGGGGCATTGTCATCTCGCCGTTCCGCCTGGAGGAGCTCACC AACCGCCTGGCCTCGCTGCAGCAAGAGAACAAGGTGCTGAAGATAGAGCTGGAGACCTACAAACTGAAGTGCAAGGCACTGCAGGAGGAG AACCGCGACCTGCGCAAAGCCAGCGTGACCATCGAATTGAGTGATCTACAGCGCGATCCACCTGCTCACTGTTCAGCTGGACCTGTGGGA GATGACTTGTTCCACTGGCAAGCCACTATTATGGGGCCTCCTGATAGCGCATATCAAGGTGGAGTCTTCTTTCTCACTGTACATTTTCCG ACAGATTATCCTTTTAAACCACCAAAGATTGCTTTCACAACAAAAATTTACCATCCAAACATAAACAGTAATGGAAGTATTTGTCTCGAT ATTCTGAGGTCACAATGGTCACCAGCTCTGACTGTATCAAAAGTTTTATTGTCCATATGTTCTCTACTTTGTGATCCTAATCCAGATGAC CCCTTAGTACCAGATATTGCACAAATCTATAAATCAGACAAAGAAAAATACAACAGACATGCAAGAGAATGGACTCAGAAATATGCAATG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CCDC6_ENST00000263102_chr10_61665880_-_UBE2D1_ENST00000373910_chr10_60121098_+_2943nt AGTGCAATACTGCCCAAGCCCGGGCGGGGTCTCTGTTCTCTGGCAGAGGAGGTCCCTTGGCAGCGGGAAGCGCCCTCTCTTTCTCTCGCC GCCGCTCCGAGTCTGCGCCCTGGTGCCAGGCGCTCAGCTCGGCGCTCCCCTGTGCTCGCCCGGCGCCCACTCATTCGCAGCCCGGCCTTC GTCGCCGCCGCCTCCCTGCTGCTCCTCCTCCTTTCCCCAGCCCGCCGCGGCCATGGCGGACAGCGCCAGCGAGAGCGACACGGACGGGGC GGGGGGCAACAGCAGCAGCTCGGCCGCCATGCAGTCGTCCTGCTCGTCGACCTCGGGCGGCGGCGGTGGCGGCGGGGGAGGCGGCGGCGG TGGGAAGTCGGGGGGCATTGTCATCTCGCCGTTCCGCCTGGAGGAGCTCACCAACCGCCTGGCCTCGCTGCAGCAAGAGAACAAGGTGCT GAAGATAGAGCTGGAGACCTACAAACTGAAGTGCAAGGCACTGCAGGAGGAGAACCGCGACCTGCGCAAAGCCAGCGTGACCATCGAATT GAGTGATCTACAGCGCGATCCACCTGCTCACTGTTCAGCTGGACCTGTGGGAGATGACTTGTTCCACTGGCAAGCCACTATTATGGGGCC TCCTGATAGCGCATATCAAGGTGGAGTCTTCTTTCTCACTGTACATTTTCCGACAGATTATCCTTTTAAACCACCAAAGATTGCTTTCAC AACAAAAATTTACCATCCAAACATAAACAGTAATGGAAGTATTTGTCTCGATATTCTGAGGTCACAATGGTCACCAGCTCTGACTGTATC AAAAGTTTTATTGTCCATATGTTCTCTACTTTGTGATCCTAATCCAGATGACCCCTTAGTACCAGATATTGCACAAATCTATAAATCAGA CAAAGAAAAATACAACAGACATGCAAGAGAATGGACTCAGAAATATGCAATGTAAAAATCAAAAACATTTTCATATATACCAGAGTACTG TAAAATCTAGGTTTTTTTCAACATTAGCAGTAAATTGAGCACTGTTTACTGTTTCATTGTACCATGAAACCATTTGATTTTTACCCATTT TAAATGTGTTTCTGAAGCAAGACAAAACAAACTTCCAAAAATACCCTTAAGACTGTGATGAGAGCATTTATCATTTTGTATGCATTGAGA AAGACATTTATTATGGTTTTTAAGATACTTGGACATCTGCATCTTCAGCTTACAAGATCTACAATGCAGCTGAAAAGCAACCAAATTATT TTTTGCTGAAACTAGATGTTTTTACATGAGAAATACTGTATGTGTTGTCTAAGATGTCAGTTTTATAAATCTGTATTCAGATTTCATTCT TTGTTAGCTCACTTTATAATTTGTATTTTTTTACTGTATAGACTAAATATATTCTATTTACATGTATGTCAACTCATTACTTTTTTCCTG TGAACAGTATTGAAAAACCCCAACGGCTGATAATTAAGTGAATTAACTGTGTCTCCCTTGTCTTAGGATATTCTGTAGATTGATTGCAGA TTTCTTAAATCTGAAATGATCTTTACACTGTAATTCTCAGCATACTGATTATGGAGAAACACTTGTTTTGATTTTGTTATACTTGACTTA ACTTTATTGCAATGTGAATTAATTGCACTGCTAAGTAGGAAGATGTGTAACTTTTATTTGTTGCTATTCACATTTGAATTTTTTCCTGTA TAGGCAATATTATATTGACACCTTTTACAGATCTTACTGTAGCTTTTTCCATATAAATAAAATGCTTTTTCTACTATTTGTCTTGATTAC TTAAAAAAATAAAAATATAAGTAAGGATCAAAACTCTAAAATTTTGCATGAAAATTACATCCAAATTGTGAAAATCAGATCTATTTTGTT TGCCATTAGTCACCATTAGTTATATAAATTTTATTGTTTTAGGTTAGTATCTCTTTACTAAATTGTCAGTCTATAAGATAATATATGTTG ATCCCTTGCTGTAGAGGAGAATTTAGAGTAATTTGGGGTTTGTCTTGGATTATATCTAAATGGATTATTTGTTAAAAGTACTGAAATGAG TATAAGGCAGTATCACCCATCCAAAAGAAAGGTCTTTATAGACCTGCACAGTCACTAGATTAATTCATTAAAATGCCCCCACCCTGATGT AATTGACATTACATTTCTTAACATTTTAAAATCTAGAATTTCTAAAATGGAATTTAATGCCATCACAATTTGAAAAACTTTTTTTTTTTT TTTACTATAGAAGTTACAAAGGAAGTTCTAAAATTATGCCTCCCTCTGTTTTTATAAGTTGCCATCGAAAAGTGATTTAAATAAGCAGGT TATCTTTATAGATTTTAAAGAAAACTAGAAAGTTTTAATGTTTTAACTTGGGGAAAAATACATCTCTTTAATGTTTAGCATGCTTGTCAA CCTTGAGTGAGTGTCATTTTTAAGAACAGTTGTAGCCCTTCTGATTATTGCAGTAGCTGTAGAAGTATGTAAGAATATGTGATGGGTGTA GTCATTAGCAAAGCATTTAAATCACTTGAGTATTTTGTCATGGTTCATTATTATTAAAGCACAAAATAACCTATTGTTAGAAAATATGTG TTTTTATAAATGAATGTAAAATAATTAAATGAATTGTGAAATGGATGTTTAAGAAAATATAGGCTTAAAAAGTAAATCTATAAAATGATG TCTTAAAACAGCCATATCATGAAAAATTCTACTTAGCTATATTATTATAAGCTACATTTGCCCTGAATTTGAACACTCAACATCACTAGA TTTAAATATTTAGTATATTTTGATAGTAAAGGGTTTTGTTTCTTGAATATCTTCACTTTAAACAAAAAAAAAAAACAACTTTCATTTGTG |
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FusionGenePPI for CCDC6_UBE2D1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CCDC6 | PPP4C, USP7, CREB1, ATF2, PPP1CA, HDAC1, ELAVL1, CUL1, SKP1, FBXW7, CSNK2A1, YWHAB, BRCC3, SF3A1, CD2AP, GAPVD1, HNRNPR, NR3C1, PAAF1, PPP4R2, TRIM28, PPP2R1A, CEP170, PPP2CB, RASSF7, ZNF444, TCL1B, MAFF, DDI2, NUDC, SARS, SEPT2, NTRK1, XPO1, P4HB, PPP2CA, PPP4R1, POLG2, GSK3B, CCNB1, CDK1, MTMR7, CEP55, TRPC4AP, C1S, RALBP1, MTUS2, LZTS3, EXOC1, ZNF331, PDE4DIP, FBXO42, CCDC102A, SMEK2, SMEK1, TCP10L, PCBP3, APC, LPXN, ZNF445, NECAB1, RPTOR, TRIM25 | UBE2D1 | TRIM39, RNF126, BARD1, BRCA1, BRE, BRCC3, DTX3L, RNF2, MDM4, SIAH1, UBE3A, TOPORS, NFKBIA, CBL, STUB1, DDX58, STAM2, EPS15, POLM, POLL, HDAC6, UBASH3B, UFM1, AMFR, MUL1, CADPS2, DTX1, UBE4A, RNF103, RNF181, MAP3K1, MIB1, PJA2, RFWD3, RNF11, RNF111, RNF13, RNF130, RNF150, RNF165, RNF167, RNF25, RNF43, RNF4, RNF115, ZNRF1, ZNRF2, ZNRF4, XIAP, RNF125, UBOX5, RNF5, DTX3, RNF14, RNF114, TRIM8, DZIP3, MID1, MKRN3, TRIM27, RNF10, RNF166, RNF185, TRIM43, TRAF6, BIRC8, BFAR, TRAF7, RING1, RLIM, LRSAM1, CHFR, ARIH2, MGRN1, TRIM55, RNF38, RNF7, TRIM17, TRIM2, TRIM25, TRIM26, TRIM31, TRIM35, TRIM5, BIRC2, BIRC3, MDM2, CUL2, BIRC7, BTRC, MYLIP, OTUB1, MKNK1, GSK3B, C7orf25, TAF1D, ANXA1, CDKN1A, TNNT1, SIRT6, HSD17B10, NR1H2, ANXA7, TSC22D1, GADD45A, FOS, MID2, TRIM10, TRIM11, TRIM50, TRIM7, TRIM37, TRIM38, TRIM45, TRIM32, UBA1, HIF1A, RELA, CTNNB1, TBL1X, TBL1XR1, UBE2D1, UBE3C, RNF8, RBX1, FZR1, RNF31, ASB2, SMURF2, TOM1, BIRC6, CRYAB, KAT2B, CNOT4, TRIM28, TRIM23, UHRF2, ANAPC11, TRAF2, VHL, NEDD4, TRIM21, TRIP12, HUWE1, RABGEF1, ARIH1, HERC5, RNF182, KLHL9, KLHL13, FBXO2, KDM2B, SKP1, TRAIP, NEDD4L, HERC3, TRIM63, NEURL1, RNF122, SH3RF1, RNF128, MARCH5, SIAH2, PELI1, ASB9, CDK7, PSMB7, UBE2D2, ZPR1, USP9X, SSSCA1, UTRN, ATP6V1F, UBXN7, USP34, ZFYVE19, UBL7, AHCYL1, UBE4B, WDR4, UBE2B, UBQLN1, IGBP1, UNK, UBR5, UPP1, TTLL12, YAP1, TKT, WDR1, SH3BGRL2, NBN, RFWD2, SIVA1, AREL1, KLHL2, UBTD1, MARCH1, MARCH2, MARCH4, MARCH8, ASB4, UBR1, CAND1, CAND2, CBLC, UBA6, MARCH7, RNF6, TNFAIP3, NHLRC1, CUL3, FAF2, RNF146, RNF26, RFFL, EP300, CREBBP, DTL, MKRN2, DTX2, BRMS1, RCHY1, UBC, RBCK1, DYRK2, TMEM129, CYP3A4, PTEN, KRAS, FBXL2, ITCH, SMURF1, WWP1, WWP2, HECW1, MCM2, SPOP, CDC5L, RNF168, F12, KCTD17, TRIM3, RAG1, TRIM69, HERC2, F3, NQO1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CCDC6_UBE2D1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CCDC6_UBE2D1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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