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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5898

FusionGeneSummary for CCDC6_SLC16A9

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC6_SLC16A9
Fusion gene ID: 5898
HgeneTgene
Gene symbol

CCDC6

SLC16A9

Gene ID

8030

220963

Gene namecoiled-coil domain containing 6solute carrier family 16 member 9
SynonymsD10S170|H4|PTC|TPC|TST1C10orf36|MCT9
Cytomap

10q21.2

10q21.2

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 6papillary thyroid carcinoma-encoded proteinmonocarboxylate transporter 9MCT 9monocarboxylic acid transporter 9solute carrier family 16 (monocarboxylic acid transporters), member 9
Modification date2018052220180523
UniProtAcc

Q16204

Q7RTY1

Ensembl transtripts involved in fusion geneENST00000263102, ENST00000395347, 
ENST00000395348, ENST00000490066, 
Fusion gene scores* DoF score8 X 8 X 8=5123 X 4 X 3=36
# samples 433
** MAII scorelog2(43/512*10)=-0.25180715041054
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/36*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCDC6 [Title/Abstract] AND SLC16A9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-50-5936-01ACCDC6chr10

61554231

-SLC16A9chr10

61444085

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000263102ENST00000395347CCDC6chr10

61554231

-SLC16A9chr10

61444085

-
5CDS-5UTRENST00000263102ENST00000395348CCDC6chr10

61554231

-SLC16A9chr10

61444085

-
5CDS-5UTRENST00000263102ENST00000490066CCDC6chr10

61554231

-SLC16A9chr10

61444085

-

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FusionProtFeatures for CCDC6_SLC16A9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCDC6

Q16204

SLC16A9

Q7RTY1

Proton-linked monocarboxylate transporter. May catalyzethe transport of monocarboxylates across the plasma membrane.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCDC6_SLC16A9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCDC6_SLC16A9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CCDC6PPP4C, USP7, CREB1, ATF2, PPP1CA, HDAC1, ELAVL1, CUL1, SKP1, FBXW7, CSNK2A1, YWHAB, BRCC3, SF3A1, CD2AP, GAPVD1, HNRNPR, NR3C1, PAAF1, PPP4R2, TRIM28, PPP2R1A, CEP170, PPP2CB, RASSF7, ZNF444, TCL1B, MAFF, DDI2, NUDC, SARS, SEPT2, NTRK1, XPO1, P4HB, PPP2CA, PPP4R1, POLG2, GSK3B, CCNB1, CDK1, MTMR7, CEP55, TRPC4AP, C1S, RALBP1, MTUS2, LZTS3, EXOC1, ZNF331, PDE4DIP, FBXO42, CCDC102A, SMEK2, SMEK1, TCP10L, PCBP3, APC, LPXN, ZNF445, NECAB1, RPTOR, TRIM25SLC16A9EIF4A2, MRPL11, KLC4, NXF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCDC6_SLC16A9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCDC6_SLC16A9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource