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Fusion gene ID: 5893 |
FusionGeneSummary for CCDC6_LIPI |
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Fusion gene information | Fusion gene name: CCDC6_LIPI | Fusion gene ID: 5893 | Hgene | Tgene | Gene symbol | CCDC6 | LIPI | Gene ID | 8030 | 149998 |
Gene name | coiled-coil domain containing 6 | lipase I | |
Synonyms | D10S170|H4|PTC|TPC|TST1 | CT17|LPDL|PLA1C|PRED5|mPA-PLA1 beta | |
Cytomap | 10q21.2 | 21q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | coiled-coil domain-containing protein 6papillary thyroid carcinoma-encoded protein | lipase member ILPD lipasecancer/testis antigen 17lipase, member Imembrane-associated phosphatidic acid-selective phospholipase A1-beta | |
Modification date | 20180522 | 20180421 | |
UniProtAcc | Q16204 | Q6XZB0 | |
Ensembl transtripts involved in fusion gene | ENST00000263102, | ENST00000344577, ENST00000536861, | |
Fusion gene scores | * DoF score | 8 X 8 X 8=512 | 2 X 2 X 2=8 |
# samples | 43 | 2 | |
** MAII score | log2(43/512*10)=-0.25180715041054 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: CCDC6 [Title/Abstract] AND LIPI [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | LIPI | GO:0016042 | lipid catabolic process | 12963729 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-44-8117-01A | CCDC6 | chr10 | 61612311 | - | LIPI | chr21 | 15481401 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000263102 | ENST00000344577 | CCDC6 | chr10 | 61612311 | - | LIPI | chr21 | 15481401 | - |
In-frame | ENST00000263102 | ENST00000536861 | CCDC6 | chr10 | 61612311 | - | LIPI | chr21 | 15481401 | - |
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FusionProtFeatures for CCDC6_LIPI |
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Hgene | Tgene |
CCDC6 | LIPI |
Hydrolyzes specifically phosphatidic acid (PA) toproduce 2-acyl lysophosphatidic acid (LPA; a potent bioactivelipid mediator) and fatty acid. Does not hydrolyze otherphospholipids, like phosphatidylserine (PS), phosphatidylcholine(PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).{ECO:0000269|PubMed:12963729}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CCDC6_LIPI |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_CCDC6_ENST00000263102_chr10_61612311_-_LIPI_ENST00000536861_chr21_15481401_-_180aa MADSASESDTDGAGGNSSSSAAMQSSCSSTSGGGGGGGGGGGGGKSGGIVISPFRLEELTNRLASLQQENKVLKIELETYKLKCKALQEE NRDLRKASVTIQARAEQEEEFISNTLFKKIQALQKEKETLAVNYEKEEEFLTNELSRKLMQTTTLQVXYCTXRQRGSVSXSKHMYTKEHI |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_CCDC6_ENST00000263102_chr10_61612311_-_LIPI_ENST00000536861_chr21_15481401_-_541nt ATGGCGGACAGCGCCAGCGAGAGCGACACGGACGGGGCGGGGGGCAACAGCAGCAGCTCGGCCGCCATGCAGTCGTCCTGCTCGTCGACC TCGGGCGGCGGCGGTGGCGGCGGGGGAGGCGGCGGCGGTGGGAAGTCGGGGGGCATTGTCATCTCGCCGTTCCGCCTGGAGGAGCTCACC AACCGCCTGGCCTCGCTGCAGCAAGAGAACAAGGTGCTGAAGATAGAGCTGGAGACCTACAAACTGAAGTGCAAGGCACTGCAGGAGGAG AACCGCGACCTGCGCAAAGCCAGCGTGACCATCCAAGCCAGGGCTGAGCAGGAAGAAGAATTCATTAGTAACACTTTATTCAAGAAAATT CAGGCTTTGCAGAAGGAGAAAGAAACCCTTGCTGTAAATTATGAGAAAGAAGAAGAATTCCTCACTAATGAGCTCTCCAGAAAATTGATG CAGACCACCACTTTGCAGGTATAATATTGTACTTAAAGACAGAGAGGAAGTGTTTCTTAATCCAAACACATGTACACCAAAGAACACATA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_CCDC6_ENST00000263102_chr10_61612311_-_LIPI_ENST00000536861_chr21_15481401_-_953nt AGTGCAATACTGCCCAAGCCCGGGCGGGGTCTCTGTTCTCTGGCAGAGGAGGTCCCTTGGCAGCGGGAAGCGCCCTCTCTTTCTCTCGCC GCCGCTCCGAGTCTGCGCCCTGGTGCCAGGCGCTCAGCTCGGCGCTCCCCTGTGCTCGCCCGGCGCCCACTCATTCGCAGCCCGGCCTTC GTCGCCGCCGCCTCCCTGCTGCTCCTCCTCCTTTCCCCAGCCCGCCGCGGCCATGGCGGACAGCGCCAGCGAGAGCGACACGGACGGGGC GGGGGGCAACAGCAGCAGCTCGGCCGCCATGCAGTCGTCCTGCTCGTCGACCTCGGGCGGCGGCGGTGGCGGCGGGGGAGGCGGCGGCGG TGGGAAGTCGGGGGGCATTGTCATCTCGCCGTTCCGCCTGGAGGAGCTCACCAACCGCCTGGCCTCGCTGCAGCAAGAGAACAAGGTGCT GAAGATAGAGCTGGAGACCTACAAACTGAAGTGCAAGGCACTGCAGGAGGAGAACCGCGACCTGCGCAAAGCCAGCGTGACCATCCAAGC CAGGGCTGAGCAGGAAGAAGAATTCATTAGTAACACTTTATTCAAGAAAATTCAGGCTTTGCAGAAGGAGAAAGAAACCCTTGCTGTAAA TTATGAGAAAGAAGAAGAATTCCTCACTAATGAGCTCTCCAGAAAATTGATGCAGACCACCACTTTGCAGGTATAATATTGTACTTAAAG ACAGAGAGGAAGTGTTTCTTAATCCAAACACATGTACACCAAAGAACACATAAGATGCCTTCTTCCATCAAATGCACTTGCTTGTGAATT AATGGACTTGTAAATGAAACAATGCAATCAGTCTTTTATAATGCACTGTTCAATTTGAGATTCAAGTATTTCTATTTCTTGGAAAAAATT |
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FusionGenePPI for CCDC6_LIPI |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CCDC6 | PPP4C, USP7, CREB1, ATF2, PPP1CA, HDAC1, ELAVL1, CUL1, SKP1, FBXW7, CSNK2A1, YWHAB, BRCC3, SF3A1, CD2AP, GAPVD1, HNRNPR, NR3C1, PAAF1, PPP4R2, TRIM28, PPP2R1A, CEP170, PPP2CB, RASSF7, ZNF444, TCL1B, MAFF, DDI2, NUDC, SARS, SEPT2, NTRK1, XPO1, P4HB, PPP2CA, PPP4R1, POLG2, GSK3B, CCNB1, CDK1, MTMR7, CEP55, TRPC4AP, C1S, RALBP1, MTUS2, LZTS3, EXOC1, ZNF331, PDE4DIP, FBXO42, CCDC102A, SMEK2, SMEK1, TCP10L, PCBP3, APC, LPXN, ZNF445, NECAB1, RPTOR, TRIM25 | LIPI |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CCDC6_LIPI |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CCDC6_LIPI |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | LIPI | C0020480 | Hyperlipoproteinemia Type IV | 1 | CTD_human;UNIPROT |