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Fusion gene ID: 5893 |
FusionGeneSummary for CCDC6_LIPI |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CCDC6_LIPI | Fusion gene ID: 5893 | Hgene | Tgene | Gene symbol | CCDC6 | LIPI | Gene ID | 8030 | 149998 |
| Gene name | coiled-coil domain containing 6 | lipase I | |
| Synonyms | D10S170|H4|PTC|TPC|TST1 | CT17|LPDL|PLA1C|PRED5|mPA-PLA1 beta | |
| Cytomap | 10q21.2 | 21q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | coiled-coil domain-containing protein 6papillary thyroid carcinoma-encoded protein | lipase member ILPD lipasecancer/testis antigen 17lipase, member Imembrane-associated phosphatidic acid-selective phospholipase A1-beta | |
| Modification date | 20180522 | 20180421 | |
| UniProtAcc | Q16204 | Q6XZB0 | |
| Ensembl transtripts involved in fusion gene | ENST00000263102, | ENST00000344577, ENST00000536861, | |
| Fusion gene scores | * DoF score | 8 X 8 X 8=512 | 2 X 2 X 2=8 |
| # samples | 43 | 2 | |
| ** MAII score | log2(43/512*10)=-0.25180715041054 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: CCDC6 [Title/Abstract] AND LIPI [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | LIPI | GO:0016042 | lipid catabolic process | 12963729 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-44-8117-01A | CCDC6 | chr10 | 61612311 | - | LIPI | chr21 | 15481401 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000263102 | ENST00000344577 | CCDC6 | chr10 | 61612311 | - | LIPI | chr21 | 15481401 | - |
| In-frame | ENST00000263102 | ENST00000536861 | CCDC6 | chr10 | 61612311 | - | LIPI | chr21 | 15481401 | - |
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FusionProtFeatures for CCDC6_LIPI |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CCDC6 | LIPI |
| Hydrolyzes specifically phosphatidic acid (PA) toproduce 2-acyl lysophosphatidic acid (LPA; a potent bioactivelipid mediator) and fatty acid. Does not hydrolyze otherphospholipids, like phosphatidylserine (PS), phosphatidylcholine(PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).{ECO:0000269|PubMed:12963729}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CCDC6_LIPI |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CCDC6_ENST00000263102_chr10_61612311_-_LIPI_ENST00000536861_chr21_15481401_-_180aa MADSASESDTDGAGGNSSSSAAMQSSCSSTSGGGGGGGGGGGGGKSGGIVISPFRLEELTNRLASLQQENKVLKIELETYKLKCKALQEE NRDLRKASVTIQARAEQEEEFISNTLFKKIQALQKEKETLAVNYEKEEEFLTNELSRKLMQTTTLQVXYCTXRQRGSVSXSKHMYTKEHI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CCDC6_ENST00000263102_chr10_61612311_-_LIPI_ENST00000536861_chr21_15481401_-_541nt ATGGCGGACAGCGCCAGCGAGAGCGACACGGACGGGGCGGGGGGCAACAGCAGCAGCTCGGCCGCCATGCAGTCGTCCTGCTCGTCGACC TCGGGCGGCGGCGGTGGCGGCGGGGGAGGCGGCGGCGGTGGGAAGTCGGGGGGCATTGTCATCTCGCCGTTCCGCCTGGAGGAGCTCACC AACCGCCTGGCCTCGCTGCAGCAAGAGAACAAGGTGCTGAAGATAGAGCTGGAGACCTACAAACTGAAGTGCAAGGCACTGCAGGAGGAG AACCGCGACCTGCGCAAAGCCAGCGTGACCATCCAAGCCAGGGCTGAGCAGGAAGAAGAATTCATTAGTAACACTTTATTCAAGAAAATT CAGGCTTTGCAGAAGGAGAAAGAAACCCTTGCTGTAAATTATGAGAAAGAAGAAGAATTCCTCACTAATGAGCTCTCCAGAAAATTGATG CAGACCACCACTTTGCAGGTATAATATTGTACTTAAAGACAGAGAGGAAGTGTTTCTTAATCCAAACACATGTACACCAAAGAACACATA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CCDC6_ENST00000263102_chr10_61612311_-_LIPI_ENST00000536861_chr21_15481401_-_953nt AGTGCAATACTGCCCAAGCCCGGGCGGGGTCTCTGTTCTCTGGCAGAGGAGGTCCCTTGGCAGCGGGAAGCGCCCTCTCTTTCTCTCGCC GCCGCTCCGAGTCTGCGCCCTGGTGCCAGGCGCTCAGCTCGGCGCTCCCCTGTGCTCGCCCGGCGCCCACTCATTCGCAGCCCGGCCTTC GTCGCCGCCGCCTCCCTGCTGCTCCTCCTCCTTTCCCCAGCCCGCCGCGGCCATGGCGGACAGCGCCAGCGAGAGCGACACGGACGGGGC GGGGGGCAACAGCAGCAGCTCGGCCGCCATGCAGTCGTCCTGCTCGTCGACCTCGGGCGGCGGCGGTGGCGGCGGGGGAGGCGGCGGCGG TGGGAAGTCGGGGGGCATTGTCATCTCGCCGTTCCGCCTGGAGGAGCTCACCAACCGCCTGGCCTCGCTGCAGCAAGAGAACAAGGTGCT GAAGATAGAGCTGGAGACCTACAAACTGAAGTGCAAGGCACTGCAGGAGGAGAACCGCGACCTGCGCAAAGCCAGCGTGACCATCCAAGC CAGGGCTGAGCAGGAAGAAGAATTCATTAGTAACACTTTATTCAAGAAAATTCAGGCTTTGCAGAAGGAGAAAGAAACCCTTGCTGTAAA TTATGAGAAAGAAGAAGAATTCCTCACTAATGAGCTCTCCAGAAAATTGATGCAGACCACCACTTTGCAGGTATAATATTGTACTTAAAG ACAGAGAGGAAGTGTTTCTTAATCCAAACACATGTACACCAAAGAACACATAAGATGCCTTCTTCCATCAAATGCACTTGCTTGTGAATT AATGGACTTGTAAATGAAACAATGCAATCAGTCTTTTATAATGCACTGTTCAATTTGAGATTCAAGTATTTCTATTTCTTGGAAAAAATT |
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FusionGenePPI for CCDC6_LIPI |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CCDC6 | PPP4C, USP7, CREB1, ATF2, PPP1CA, HDAC1, ELAVL1, CUL1, SKP1, FBXW7, CSNK2A1, YWHAB, BRCC3, SF3A1, CD2AP, GAPVD1, HNRNPR, NR3C1, PAAF1, PPP4R2, TRIM28, PPP2R1A, CEP170, PPP2CB, RASSF7, ZNF444, TCL1B, MAFF, DDI2, NUDC, SARS, SEPT2, NTRK1, XPO1, P4HB, PPP2CA, PPP4R1, POLG2, GSK3B, CCNB1, CDK1, MTMR7, CEP55, TRPC4AP, C1S, RALBP1, MTUS2, LZTS3, EXOC1, ZNF331, PDE4DIP, FBXO42, CCDC102A, SMEK2, SMEK1, TCP10L, PCBP3, APC, LPXN, ZNF445, NECAB1, RPTOR, TRIM25 | LIPI |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CCDC6_LIPI |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CCDC6_LIPI |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | LIPI | C0020480 | Hyperlipoproteinemia Type IV | 1 | CTD_human;UNIPROT |
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