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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5839

FusionGeneSummary for CCDC28A_WASF2

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC28A_WASF2
Fusion gene ID: 5839
HgeneTgene
Gene symbol

CCDC28A

WASF2

Gene ID

25901

10163

Gene namecoiled-coil domain containing 28AWAS protein family member 2
SynonymsC6orf80|CCRL1APIMD2|SCAR2|WASF4|WAVE2|dJ393P12.2
Cytomap

6q24.1

1p36.11

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 28Achemokine C-C motif receptor-like 1 adjacentwiskott-Aldrich syndrome protein family member 2WASP family Verprolin-homologous protein 2WASP family protein member 2WASP family protein member 4protein WAVE-2putative Wiskott-Aldrich syndrome protein family member 4suppressor of cyclic-AMP recepto
Modification date2018051920180522
UniProtAcc

Q8IWP9

Q9Y6W5

Ensembl transtripts involved in fusion geneENST00000332797, ENST00000430629, 
ENST00000536657, 
Fusion gene scores* DoF score3 X 3 X 3=274 X 3 X 3=36
# samples 54
** MAII scorelog2(5/27*10)=0.888968687611256
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CCDC28A [Title/Abstract] AND WASF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A1-A0SO-01ACCDC28Achr6

139097415

+WASF2chr1

27755443

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000332797ENST00000430629CCDC28Achr6

139097415

+WASF2chr1

27755443

-
5CDS-5UTRENST00000332797ENST00000536657CCDC28Achr6

139097415

+WASF2chr1

27755443

-

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FusionProtFeatures for CCDC28A_WASF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCDC28A

Q8IWP9

WASF2

Q9Y6W5

Downstream effector molecule involved in thetransmission of signals from tyrosine kinase receptors and smallGTPases to the actin cytoskeleton. Promotes formation of actinfilaments. Part of the WAVE complex that regulates lamellipodiaformation. The WAVE complex regulates actin filamentreorganization via its interaction with the Arp2/3 complex.{ECO:0000269|PubMed:10381382, ECO:0000269|PubMed:16275905}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCDC28A_WASF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCDC28A_WASF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CCDC28AELAVL1, SRPK2, ICA1, KIFC3, MYOG, TRIM54, KRTAP9-2, XPO1, CDC25A, CDC25B, EYA2, EYA3, PTPDC1WASF2ACTR3, BAIAP2, RYK, ITSN2, WASL, KLF16, YWHAQ, TCERG1, PRPF40A, APBB1, GAS7, POLD1, ZDHHC17, ABI3, ABI1, ABI2, ZNF511, NCK2, LHX4, CYFIP1, CYFIP2, NCKAP1, NTRK1, CEP19, TMEM17, TCF4, CDH1, TIMM50, NHSL2, AMZ1, CCDC53, CBLC, GJB7, HOMER3, CCDC27, EVL, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCDC28A_WASF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCDC28A_WASF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource