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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5838

FusionGeneSummary for CCDC28A_IL22RA2

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC28A_IL22RA2
Fusion gene ID: 5838
HgeneTgene
Gene symbol

CCDC28A

IL22RA2

Gene ID

25901

116379

Gene namecoiled-coil domain containing 28Ainterleukin 22 receptor subunit alpha 2
SynonymsC6orf80|CCRL1APCRF2-10|CRF2-S1|CRF2X|IL-22BP|IL-22R-alpha-2|IL-22RA2|ZCYTOR16
Cytomap

6q24.1

6q23.3

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 28Achemokine C-C motif receptor-like 1 adjacentinterleukin-22 receptor subunit alpha-2cytokine receptor class-II member 10cytokine receptor family type 2, soluble 1interleukin 22 receptor, alpha 2interleukin 22-binding protein
Modification date2018051920180523
UniProtAcc

Q8IWP9

Q969J5

Ensembl transtripts involved in fusion geneENST00000332797, ENST00000339602, 
ENST00000296980, ENST00000349184, 
Fusion gene scores* DoF score3 X 3 X 3=271 X 2 X 1=2
# samples 53
** MAII scorelog2(5/27*10)=0.888968687611256
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/2*10)=3.90689059560852
Context

PubMed: CCDC28A [Title/Abstract] AND IL22RA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1KC819276CCDC28Achr6

139101122

+IL22RA2chr6

137482952

-
ChiTaRS3.1KC819274CCDC28Achr6

139101122

+IL22RA2chr6

137482952

-
ChiTaRS3.1KC819275CCDC28Achr6

139101124

+IL22RA2chr6

137484017

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000332797ENST00000339602CCDC28Achr6

139101122

+IL22RA2chr6

137482952

-
5CDS-5UTRENST00000332797ENST00000296980CCDC28Achr6

139101122

+IL22RA2chr6

137482952

-
5CDS-5UTRENST00000332797ENST00000349184CCDC28Achr6

139101122

+IL22RA2chr6

137482952

-
5CDS-intronENST00000332797ENST00000339602CCDC28Achr6

139101124

+IL22RA2chr6

137484017

-
5CDS-intronENST00000332797ENST00000296980CCDC28Achr6

139101124

+IL22RA2chr6

137484017

-
5CDS-intronENST00000332797ENST00000349184CCDC28Achr6

139101124

+IL22RA2chr6

137484017

-

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FusionProtFeatures for CCDC28A_IL22RA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCDC28A

Q8IWP9

IL22RA2

Q969J5

Isoform 2 is a receptor for IL22. Binds to IL22,prevents interaction with the functional IL-22R complex and blocksthe activity of IL22 (in vitro). May play an important role as anIL22 antagonist in the regulation of inflammatory responses. Isoform 1 may play a role in establishing andmaintaining successful pregnancy.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCDC28A_IL22RA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCDC28A_IL22RA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CCDC28AELAVL1, SRPK2, ICA1, KIFC3, MYOG, TRIM54, KRTAP9-2, XPO1, CDC25A, CDC25B, EYA2, EYA3, PTPDC1IL22RA2IL22, TBC1D31


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCDC28A_IL22RA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCDC28A_IL22RA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource