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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5824

FusionGeneSummary for CCDC171_SARS

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC171_SARS
Fusion gene ID: 5824
HgeneTgene
Gene symbol

CCDC171

SARS

Gene ID

203238

54938

Gene namecoiled-coil domain containing 171seryl-tRNA synthetase 2, mitochondrial
SynonymsC9orf93|bA536D16.1|bA778P13.1SARS|SARSM|SERS|SYS|SerRS|SerRSmt|mtSerRS
Cytomap

9p22.3

19q13.2

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 171myosin tail domain containing proteinserine--tRNA ligase, mitochondrialmitochondrial seryl-tRNA synthetaseserine tRNA ligase 2, mitochondrialseryl-tRNA synthetase, mitochondrialseryl-tRNA(Ser/Sec) synthetase
Modification date2018051920180523
UniProtAcc

Q6TFL3

P49591

Ensembl transtripts involved in fusion geneENST00000297641, ENST00000380701, 
ENST00000535968, ENST00000486641, 
ENST00000234677, ENST00000369923, 
ENST00000468588, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 5 X 4=120
# samples 27
** MAII scorelog2(2/8*10)=1.32192809488736log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCDC171 [Title/Abstract] AND SARS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF378126CCDC171chr9

15764333

-SARSchr1

109780558

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000297641ENST00000234677CCDC171chr9

15764333

-SARSchr1

109780558

-
intron-3UTRENST00000297641ENST00000369923CCDC171chr9

15764333

-SARSchr1

109780558

-
intron-3UTRENST00000297641ENST00000468588CCDC171chr9

15764333

-SARSchr1

109780558

-
intron-3UTRENST00000380701ENST00000234677CCDC171chr9

15764333

-SARSchr1

109780558

-
intron-3UTRENST00000380701ENST00000369923CCDC171chr9

15764333

-SARSchr1

109780558

-
intron-3UTRENST00000380701ENST00000468588CCDC171chr9

15764333

-SARSchr1

109780558

-
intron-3UTRENST00000535968ENST00000234677CCDC171chr9

15764333

-SARSchr1

109780558

-
intron-3UTRENST00000535968ENST00000369923CCDC171chr9

15764333

-SARSchr1

109780558

-
intron-3UTRENST00000535968ENST00000468588CCDC171chr9

15764333

-SARSchr1

109780558

-
intron-3UTRENST00000486641ENST00000234677CCDC171chr9

15764333

-SARSchr1

109780558

-
intron-3UTRENST00000486641ENST00000369923CCDC171chr9

15764333

-SARSchr1

109780558

-
intron-3UTRENST00000486641ENST00000468588CCDC171chr9

15764333

-SARSchr1

109780558

-

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FusionProtFeatures for CCDC171_SARS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCDC171

Q6TFL3

SARS

P49591

Catalyzes the attachment of serine to tRNA(Ser) in atwo-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser)(PubMed:22353712, PubMed:24095058, PubMed:9431993,PubMed:26433229, PubMed:28236339). Is probably also able toaminoacylate tRNA(Sec) with serine, to form the misacylated tRNAL-seryl-tRNA(Sec), which will be further converted intoselenocysteinyl-tRNA(Sec) (PubMed:9431993, PubMed:26433229,PubMed:28236339). In the nucleus, binds to the VEGFA core promoterand prevents MYC binding and transcriptional activation by MYC(PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promotingdeacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibitsthe production of VEGFA and sprouting angiogenesis mediated byVEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000).{ECO:0000269|PubMed:19423847, ECO:0000269|PubMed:19423848,ECO:0000269|PubMed:22353712, ECO:0000269|PubMed:24095058,ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:26433229,ECO:0000269|PubMed:28236339, ECO:0000269|PubMed:9431993}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCDC171_SARS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCDC171_SARS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCDC171_SARS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCDC171_SARS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource