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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5819

FusionGeneSummary for CCDC158_MSRB3

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC158_MSRB3
Fusion gene ID: 5819
HgeneTgene
Gene symbol

CCDC158

MSRB3

Gene ID

339965

253827

Gene namecoiled-coil domain containing 158methionine sulfoxide reductase B3
Synonyms-DFNB74
Cytomap

4q21.1

12q14.3

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 158methionine-R-sulfoxide reductase B3methionine-R-sulfoxide reductase B3, mitochondrial
Modification date2018051920180523
UniProtAcc

Q5M9N0

Q8IXL7

Ensembl transtripts involved in fusion geneENST00000504868, ENST00000388914, 
ENST00000434846, 
ENST00000355192, 
ENST00000308259, ENST00000540804, 
ENST00000535664, ENST00000538725, 
Fusion gene scores* DoF score1 X 1 X 1=111 X 6 X 6=396
# samples 110
** MAII scorelog2(1/1*10)=3.32192809488736log2(10/396*10)=-1.98550043030488
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCDC158 [Title/Abstract] AND MSRB3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMSRB3

GO:0030091

protein repair

14699060


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-3C-AAAU-01ACCDC158chr4

77288447

-MSRB3chr12

65847508

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000504868ENST00000355192CCDC158chr4

77288447

-MSRB3chr12

65847508

+
intron-3CDSENST00000504868ENST00000308259CCDC158chr4

77288447

-MSRB3chr12

65847508

+
intron-3CDSENST00000504868ENST00000540804CCDC158chr4

77288447

-MSRB3chr12

65847508

+
intron-3CDSENST00000504868ENST00000535664CCDC158chr4

77288447

-MSRB3chr12

65847508

+
intron-intronENST00000504868ENST00000538725CCDC158chr4

77288447

-MSRB3chr12

65847508

+
Frame-shiftENST00000388914ENST00000355192CCDC158chr4

77288447

-MSRB3chr12

65847508

+
Frame-shiftENST00000388914ENST00000308259CCDC158chr4

77288447

-MSRB3chr12

65847508

+
Frame-shiftENST00000388914ENST00000540804CCDC158chr4

77288447

-MSRB3chr12

65847508

+
Frame-shiftENST00000388914ENST00000535664CCDC158chr4

77288447

-MSRB3chr12

65847508

+
5CDS-intronENST00000388914ENST00000538725CCDC158chr4

77288447

-MSRB3chr12

65847508

+
intron-3CDSENST00000434846ENST00000355192CCDC158chr4

77288447

-MSRB3chr12

65847508

+
intron-3CDSENST00000434846ENST00000308259CCDC158chr4

77288447

-MSRB3chr12

65847508

+
intron-3CDSENST00000434846ENST00000540804CCDC158chr4

77288447

-MSRB3chr12

65847508

+
intron-3CDSENST00000434846ENST00000535664CCDC158chr4

77288447

-MSRB3chr12

65847508

+
intron-intronENST00000434846ENST00000538725CCDC158chr4

77288447

-MSRB3chr12

65847508

+

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FusionProtFeatures for CCDC158_MSRB3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCDC158

Q5M9N0

MSRB3

Q8IXL7

Catalyzes the reduction of free and protein-boundmethionine sulfoxide to methionine. Isoform 2 is essential forhearing. {ECO:0000269|PubMed:14699060,ECO:0000269|PubMed:21185009}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCDC158_MSRB3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCDC158_MSRB3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CCDC158FCHSD2, GPSM1, SH3GLB2, CCDC101, NAGK, CBX2, CBX4, CBX6, C1orf216, MYCBP2, SCGB2A1MSRB3GOLGA2, TCF4, TRIP6, PRDM4, MOV10, NXF1, AZIN1, GAPDH, MAPK8IP2, LNX2, KLHL7, RBP4, SPOP, DCUN1D4, C1QL1, BTBD9, STIM2, IFNA21


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCDC158_MSRB3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCDC158_MSRB3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMSRB3C1384666hearing impairment1CTD_human
TgeneMSRB3C2239351DEAFNESS, AUTOSOMAL RECESSIVE 741CTD_human;UNIPROT