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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5797

FusionGeneSummary for CCDC142_LAMA2

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC142_LAMA2
Fusion gene ID: 5797
HgeneTgene
Gene symbol

CCDC142

LAMA2

Gene ID

84865

3908

Gene namecoiled-coil domain containing 142laminin subunit alpha 2
Synonyms-LAMM
Cytomap

2p13.1

6q22.33

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 142laminin subunit alpha-2laminin M chainlaminin, alpha 2laminin-12 subunit alphalaminin-2 subunit alphalaminin-4 subunit alphamerosin heavy chainmutant laminin subunit alpha 2
Modification date2018032920180522
UniProtAcc

Q17RM4

P24043

Ensembl transtripts involved in fusion geneENST00000393965, ENST00000290418, 
ENST00000471713, 
ENST00000421865, 
ENST00000498257, 
Fusion gene scores* DoF score2 X 2 X 2=810 X 9 X 6=540
# samples 29
** MAII scorelog2(2/8*10)=1.32192809488736log2(9/540*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCDC142 [Title/Abstract] AND LAMA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1T06308CCDC142chr2

74709387

-LAMA2chr6

129813607

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000393965ENST00000421865CCDC142chr2

74709387

-LAMA2chr6

129813607

-
intron-3UTRENST00000393965ENST00000498257CCDC142chr2

74709387

-LAMA2chr6

129813607

-
intron-3CDSENST00000290418ENST00000421865CCDC142chr2

74709387

-LAMA2chr6

129813607

-
intron-3UTRENST00000290418ENST00000498257CCDC142chr2

74709387

-LAMA2chr6

129813607

-
intron-3CDSENST00000471713ENST00000421865CCDC142chr2

74709387

-LAMA2chr6

129813607

-
intron-3UTRENST00000471713ENST00000498257CCDC142chr2

74709387

-LAMA2chr6

129813607

-

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FusionProtFeatures for CCDC142_LAMA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCDC142

Q17RM4

LAMA2

P24043

Binding to cells via a high affinity receptor, lamininis thought to mediate the attachment, migration and organizationof cells into tissues during embryonic development by interactingwith other extracellular matrix components.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCDC142_LAMA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCDC142_LAMA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCDC142_LAMA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCDC142_LAMA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLAMA2C1263858Muscular dystrophy congenital, merosin negative3CTD_human;ORPHANET;UNIPROT
TgeneLAMA2C0026850Muscular Dystrophy2CTD_human;HPO
TgeneLAMA2C0036341Schizophrenia2CTD_human
TgeneLAMA2C0005695Bladder Neoplasm1CTD_human
TgeneLAMA2C0027092Myopia1CTD_human