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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5769

FusionGeneSummary for CCDC117_CCDC117

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC117_CCDC117
Fusion gene ID: 5769
HgeneTgene
Gene symbol

CCDC117

CCDC117

Gene ID

150275

150275

Gene namecoiled-coil domain containing 117coiled-coil domain containing 117
SynonymsdJ366L4.1dJ366L4.1
Cytomap

22q12.1

22q12.1

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 117coiled-coil domain-containing protein 117
Modification date2018051920180519
UniProtAcc

Q8IWD4

Q8IWD4

Ensembl transtripts involved in fusion geneENST00000249064, ENST00000448492, 
ENST00000421503, ENST00000443309, 
ENST00000249064, ENST00000448492, 
ENST00000421503, ENST00000443309, 
Fusion gene scores* DoF score7 X 7 X 4=1963 X 3 X 2=18
# samples 73
** MAII scorelog2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CCDC117 [Title/Abstract] AND CCDC117 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW238233CCDC117chr22

29184676

+CCDC117chr22

29185202

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000249064ENST00000249064CCDC117chr22

29184676

+CCDC117chr22

29185202

-
3UTR-intronENST00000249064ENST00000448492CCDC117chr22

29184676

+CCDC117chr22

29185202

-
3UTR-intronENST00000249064ENST00000421503CCDC117chr22

29184676

+CCDC117chr22

29185202

-
3UTR-intronENST00000249064ENST00000443309CCDC117chr22

29184676

+CCDC117chr22

29185202

-
intron-3UTRENST00000448492ENST00000249064CCDC117chr22

29184676

+CCDC117chr22

29185202

-
intron-intronENST00000448492ENST00000448492CCDC117chr22

29184676

+CCDC117chr22

29185202

-
intron-intronENST00000448492ENST00000421503CCDC117chr22

29184676

+CCDC117chr22

29185202

-
intron-intronENST00000448492ENST00000443309CCDC117chr22

29184676

+CCDC117chr22

29185202

-
intron-3UTRENST00000421503ENST00000249064CCDC117chr22

29184676

+CCDC117chr22

29185202

-
intron-intronENST00000421503ENST00000448492CCDC117chr22

29184676

+CCDC117chr22

29185202

-
intron-intronENST00000421503ENST00000421503CCDC117chr22

29184676

+CCDC117chr22

29185202

-
intron-intronENST00000421503ENST00000443309CCDC117chr22

29184676

+CCDC117chr22

29185202

-
intron-3UTRENST00000443309ENST00000249064CCDC117chr22

29184676

+CCDC117chr22

29185202

-
intron-intronENST00000443309ENST00000448492CCDC117chr22

29184676

+CCDC117chr22

29185202

-
intron-intronENST00000443309ENST00000421503CCDC117chr22

29184676

+CCDC117chr22

29185202

-
intron-intronENST00000443309ENST00000443309CCDC117chr22

29184676

+CCDC117chr22

29185202

-

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FusionProtFeatures for CCDC117_CCDC117


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCDC117

Q8IWD4

CCDC117

Q8IWD4


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCDC117_CCDC117


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCDC117_CCDC117


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCDC117_CCDC117


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCDC117_CCDC117


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource