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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5763

FusionGeneSummary for CCDC106_CD37

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC106_CD37
Fusion gene ID: 5763
HgeneTgene
Gene symbol

CCDC106

CD37

Gene ID

29903

951

Gene namecoiled-coil domain containing 106CD37 molecule
SynonymsHSU79303|ZNF581GP52-40|TSPAN26
Cytomap

19q13.42

19q13.33

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 106protein predicted by clone 23882leukocyte antigen CD37cell differentiation antigen 37leukocyte surface antigen CD37tetraspanin-26tspan-26
Modification date2018052220180523
UniProtAcc

Q9BWC9

P11049

Ensembl transtripts involved in fusion geneENST00000308964, ENST00000586790, 
ENST00000591578, ENST00000588740, 
ENST00000591241, 
ENST00000598095, 
ENST00000426897, ENST00000323906, 
ENST00000535669, ENST00000596426, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 3 X 4=48
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCDC106 [Title/Abstract] AND CD37 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A1-A0SQ-01ACCDC106chr19

56160950

+CD37chr19

49838971

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000308964ENST00000598095CCDC106chr19

56160950

+CD37chr19

49838971

+
5CDS-5UTRENST00000308964ENST00000426897CCDC106chr19

56160950

+CD37chr19

49838971

+
5CDS-5UTRENST00000308964ENST00000323906CCDC106chr19

56160950

+CD37chr19

49838971

+
5CDS-5UTRENST00000308964ENST00000535669CCDC106chr19

56160950

+CD37chr19

49838971

+
5CDS-3UTRENST00000308964ENST00000596426CCDC106chr19

56160950

+CD37chr19

49838971

+
5CDS-5UTRENST00000586790ENST00000598095CCDC106chr19

56160950

+CD37chr19

49838971

+
5CDS-5UTRENST00000586790ENST00000426897CCDC106chr19

56160950

+CD37chr19

49838971

+
5CDS-5UTRENST00000586790ENST00000323906CCDC106chr19

56160950

+CD37chr19

49838971

+
5CDS-5UTRENST00000586790ENST00000535669CCDC106chr19

56160950

+CD37chr19

49838971

+
5CDS-3UTRENST00000586790ENST00000596426CCDC106chr19

56160950

+CD37chr19

49838971

+
5CDS-5UTRENST00000591578ENST00000598095CCDC106chr19

56160950

+CD37chr19

49838971

+
5CDS-5UTRENST00000591578ENST00000426897CCDC106chr19

56160950

+CD37chr19

49838971

+
5CDS-5UTRENST00000591578ENST00000323906CCDC106chr19

56160950

+CD37chr19

49838971

+
5CDS-5UTRENST00000591578ENST00000535669CCDC106chr19

56160950

+CD37chr19

49838971

+
5CDS-3UTRENST00000591578ENST00000596426CCDC106chr19

56160950

+CD37chr19

49838971

+
5CDS-5UTRENST00000588740ENST00000598095CCDC106chr19

56160950

+CD37chr19

49838971

+
5CDS-5UTRENST00000588740ENST00000426897CCDC106chr19

56160950

+CD37chr19

49838971

+
5CDS-5UTRENST00000588740ENST00000323906CCDC106chr19

56160950

+CD37chr19

49838971

+
5CDS-5UTRENST00000588740ENST00000535669CCDC106chr19

56160950

+CD37chr19

49838971

+
5CDS-3UTRENST00000588740ENST00000596426CCDC106chr19

56160950

+CD37chr19

49838971

+
5CDS-5UTRENST00000591241ENST00000598095CCDC106chr19

56160950

+CD37chr19

49838971

+
5CDS-5UTRENST00000591241ENST00000426897CCDC106chr19

56160950

+CD37chr19

49838971

+
5CDS-5UTRENST00000591241ENST00000323906CCDC106chr19

56160950

+CD37chr19

49838971

+
5CDS-5UTRENST00000591241ENST00000535669CCDC106chr19

56160950

+CD37chr19

49838971

+
5CDS-3UTRENST00000591241ENST00000596426CCDC106chr19

56160950

+CD37chr19

49838971

+

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FusionProtFeatures for CCDC106_CD37


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCDC106

Q9BWC9

CD37

P11049

Promotes the degradation of p53/TP53 protein andinhibits its transactivity. {ECO:0000269|PubMed:20159018}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CCDC106_CD37


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CCDC106_CD37


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CCDC106ATF4, COPS6, KAT5, LRIF1, UTP14A, SETDB1, TP53, C14orf1, RBM48, CRMP1, EEF1G, APP, FAM9B, MAGEA10, TERF2IP, NEFM, TERF2, CAMK1CD37


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CCDC106_CD37


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CCDC106_CD37


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource