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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5714

FusionGeneSummary for CBX4_DBI

check button Fusion gene summary
Fusion gene informationFusion gene name: CBX4_DBI
Fusion gene ID: 5714
HgeneTgene
Gene symbol

CBX4

DBI

Gene ID

8535

1622

Gene namechromobox 4diazepam binding inhibitor, acyl-CoA binding protein
SynonymsNBP16|PC2ACBD1|ACBP|CCK-RP|EP
Cytomap

17q25.3

2q14.2

Type of geneprotein-codingprotein-coding
DescriptionE3 SUMO-protein ligase CBX4NS5ATP1-binding protein 16Pc class 2 homologchromobox homolog 4 (Pc class homolog, Drosophila)chromobox protein homolog 4chromobox-like protein 4polycomb 2 homologacyl-CoA-binding proteinGABA receptor modulatoracyl coenzyme A binding proteinacyl-Coenzyme A binding domain containing 1cholecystokinin-releasing peptide, trypsin-sensitivediazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein
Modification date2018052220180519
UniProtAcc

O00257

P07108

Ensembl transtripts involved in fusion geneENST00000269397, ENST00000448310, 
ENST00000355857, ENST00000535617, 
ENST00000535757, ENST00000409094, 
ENST00000311521, ENST00000460901, 
ENST00000542275, ENST00000393103, 
Fusion gene scores* DoF score3 X 2 X 3=184 X 4 X 1=16
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CBX4 [Title/Abstract] AND DBI [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCBX4

GO:0045892

negative regulation of transcription, DNA-templated

18567530

TgeneDBI

GO:0018345

protein palmitoylation

21079819

TgeneDBI

GO:0036151

phosphatidylcholine acyl-chain remodeling

21079819


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AV752007CBX4chr17

77812419

-DBIchr2

120124581

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000269397ENST00000355857CBX4chr17

77812419

-DBIchr2

120124581

+
intron-5UTRENST00000269397ENST00000535617CBX4chr17

77812419

-DBIchr2

120124581

+
intron-5UTRENST00000269397ENST00000535757CBX4chr17

77812419

-DBIchr2

120124581

+
intron-5UTRENST00000269397ENST00000409094CBX4chr17

77812419

-DBIchr2

120124581

+
intron-intronENST00000269397ENST00000311521CBX4chr17

77812419

-DBIchr2

120124581

+
intron-intronENST00000269397ENST00000460901CBX4chr17

77812419

-DBIchr2

120124581

+
intron-intronENST00000269397ENST00000542275CBX4chr17

77812419

-DBIchr2

120124581

+
intron-intronENST00000269397ENST00000393103CBX4chr17

77812419

-DBIchr2

120124581

+
intron-5UTRENST00000448310ENST00000355857CBX4chr17

77812419

-DBIchr2

120124581

+
intron-5UTRENST00000448310ENST00000535617CBX4chr17

77812419

-DBIchr2

120124581

+
intron-5UTRENST00000448310ENST00000535757CBX4chr17

77812419

-DBIchr2

120124581

+
intron-5UTRENST00000448310ENST00000409094CBX4chr17

77812419

-DBIchr2

120124581

+
intron-intronENST00000448310ENST00000311521CBX4chr17

77812419

-DBIchr2

120124581

+
intron-intronENST00000448310ENST00000460901CBX4chr17

77812419

-DBIchr2

120124581

+
intron-intronENST00000448310ENST00000542275CBX4chr17

77812419

-DBIchr2

120124581

+
intron-intronENST00000448310ENST00000393103CBX4chr17

77812419

-DBIchr2

120124581

+

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FusionProtFeatures for CBX4_DBI


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CBX4

O00257

DBI

P07108

E3 SUMO-protein ligase which facilitates SUMO1conjugation by UBE2I (PubMed:12679040). Involved in thesumoylation of HNRNPK, a p53/TP53 transcriptional coactivator,hence indirectly regulates p53/TP53 transcriptional activationresulting in p21/CDKN1A expression. Monosumoylates ZNF131(PubMed:22825850). {ECO:0000269|PubMed:12679040,ECO:0000269|PubMed:22825850}. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain thetranscriptionally repressive state of many genes, including Hoxgenes, throughout development (PubMed:12167701, PubMed:19636380,PubMed:21282530). PcG PRC1 complex acts via chromatin remodelingand modification of histones; it mediates monoubiquitination ofhistone H2A 'Lys-119', rendering chromatin heritably changed inits expressibility (PubMed:12167701, PubMed:19636380,PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9'(H3K9me3) (By similarity). Plays a role in the lineagedifferentiation of the germ layers in embryonic development (Bysimilarity). {ECO:0000250|UniProtKB:O55187,ECO:0000269|PubMed:12167701, ECO:0000269|PubMed:19636380,ECO:0000269|PubMed:21282530}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CBX4_DBI


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CBX4_DBI


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CBX4_DBI


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CBX4_DBI


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDBIC0024667Animal Mammary Neoplasms1CTD_human
TgeneDBIC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneDBIC0033975Psychotic Disorders1PSYGENET
TgeneDBIC0036341Schizophrenia1PSYGENET