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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5705

FusionGeneSummary for CBWD2_RPL28

check button Fusion gene summary
Fusion gene informationFusion gene name: CBWD2_RPL28
Fusion gene ID: 5705
HgeneTgene
Gene symbol

CBWD2

RPL28

Gene ID

150472

6158

Gene nameCOBW domain containing 2ribosomal protein L28
Synonyms-L28
Cytomap

2q14.1

19q13.42

Type of geneprotein-codingprotein-coding
DescriptionCOBW domain-containing protein 2cobalamin synthase W domain-containing protein 2cobalamin synthetase W domain-containing protein 260S ribosomal protein L28large ribosomal subunit protein eL28
Modification date2018051920180525
UniProtAcc

Q8IUF1

P46779

Ensembl transtripts involved in fusion geneENST00000259199, ENST00000416503, 
ENST00000433343, 		ENST00000344063, 
ENST00000431533, ENST00000428193, 
ENST00000558815, ENST00000560583, 
ENST00000560055, ENST00000559463, 
ENST00000558131, ENST00000558752, 
ENST00000458349, 
Fusion gene scores* DoF score2 X 2 X 2=88 X 8 X 4=256
# samples 511
** MAII scorelog2(5/8*10)=2.64385618977472log2(11/256*10)=-1.21864028647534
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CBWD2 [Title/Abstract] AND RPL28 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ648662CBWD2chr2

114223370

+RPL28chr19

55899743

-
ChiTaRS3.1BQ645838CBWD2chr2

114223370

+RPL28chr19

55899743

-
ChiTaRS3.1BQ646046CBWD2chr2

114223370

+RPL28chr19

55899743

-
ChiTaRS3.1BQ649823CBWD2chr2

114223370

+RPL28chr19

55899743

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000259199ENST00000344063CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-intronENST00000259199ENST00000431533CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-intronENST00000259199ENST00000428193CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-intronENST00000259199ENST00000558815CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-3UTRENST00000259199ENST00000560583CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-intronENST00000259199ENST00000560055CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-intronENST00000259199ENST00000559463CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-intronENST00000259199ENST00000558131CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-intronENST00000259199ENST00000558752CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-intronENST00000259199ENST00000458349CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-3UTRENST00000416503ENST00000344063CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-intronENST00000416503ENST00000431533CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-intronENST00000416503ENST00000428193CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-intronENST00000416503ENST00000558815CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-3UTRENST00000416503ENST00000560583CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-intronENST00000416503ENST00000560055CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-intronENST00000416503ENST00000559463CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-intronENST00000416503ENST00000558131CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-intronENST00000416503ENST00000558752CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-intronENST00000416503ENST00000458349CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-3UTRENST00000433343ENST00000344063CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-intronENST00000433343ENST00000431533CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-intronENST00000433343ENST00000428193CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-intronENST00000433343ENST00000558815CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-3UTRENST00000433343ENST00000560583CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-intronENST00000433343ENST00000560055CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-intronENST00000433343ENST00000559463CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-intronENST00000433343ENST00000558131CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-intronENST00000433343ENST00000558752CBWD2chr2

114223370

+RPL28chr19

55899743

-
intron-intronENST00000433343ENST00000458349CBWD2chr2

114223370

+RPL28chr19

55899743

-

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FusionProtFeatures for CBWD2_RPL28


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CBWD2

Q8IUF1

RPL28

P46779


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CBWD2_RPL28


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CBWD2_RPL28


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CBWD2_RPL28


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CBWD2_RPL28


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRPL28C0043094Weight Gain1CTD_human