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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5651

FusionGeneSummary for CAV2_TES

check button Fusion gene summary
Fusion gene informationFusion gene name: CAV2_TES
Fusion gene ID: 5651
HgeneTgene
Gene symbol

CAV2

TES

Gene ID

858

26136

Gene namecaveolin 2testin LIM domain protein
SynonymsCAVTESS|TESS-2
Cytomap

7q31.2

7q31.2

Type of geneprotein-codingprotein-coding
Descriptioncaveolin-2caveolae protein, 20-kDcaveolin 2 isoform a and btestintestis derived transcript (3 LIM domains)
Modification date2018052320180522
UniProtAcc

P51636

Q9UGI8

Ensembl transtripts involved in fusion geneENST00000462876, ENST00000222693, 
ENST00000343213, ENST00000393480, 
ENST00000358204, ENST00000537767, 
ENST00000393481, ENST00000485009, 
Fusion gene scores* DoF score3 X 3 X 2=184 X 3 X 3=36
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CAV2 [Title/Abstract] AND TES [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCAV2

GO:0006906

vesicle fusion

12743374

HgeneCAV2

GO:0008286

insulin receptor signaling pathway

20455999

HgeneCAV2

GO:0016050

vesicle organization

12743374

HgeneCAV2

GO:0043410

positive regulation of MAPK cascade

20455999

HgeneCAV2

GO:0043547

positive regulation of GTPase activity

8552590

HgeneCAV2

GO:0048278

vesicle docking

12743374

HgeneCAV2

GO:0070836

caveola assembly

12743374


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDHNSCTCGA-CR-6478-01ACAV2chr7

116140501

+TESchr7

115889074

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000462876ENST00000358204CAV2chr7

116140501

+TESchr7

115889074

+
3UTR-intronENST00000462876ENST00000537767CAV2chr7

116140501

+TESchr7

115889074

+
3UTR-intronENST00000462876ENST00000393481CAV2chr7

116140501

+TESchr7

115889074

+
3UTR-3UTRENST00000462876ENST00000485009CAV2chr7

116140501

+TESchr7

115889074

+
In-frameENST00000222693ENST00000358204CAV2chr7

116140501

+TESchr7

115889074

+
5CDS-intronENST00000222693ENST00000537767CAV2chr7

116140501

+TESchr7

115889074

+
5CDS-intronENST00000222693ENST00000393481CAV2chr7

116140501

+TESchr7

115889074

+
5CDS-3UTRENST00000222693ENST00000485009CAV2chr7

116140501

+TESchr7

115889074

+
intron-3CDSENST00000343213ENST00000358204CAV2chr7

116140501

+TESchr7

115889074

+
intron-intronENST00000343213ENST00000537767CAV2chr7

116140501

+TESchr7

115889074

+
intron-intronENST00000343213ENST00000393481CAV2chr7

116140501

+TESchr7

115889074

+
intron-3UTRENST00000343213ENST00000485009CAV2chr7

116140501

+TESchr7

115889074

+
Frame-shiftENST00000393480ENST00000358204CAV2chr7

116140501

+TESchr7

115889074

+
5CDS-intronENST00000393480ENST00000537767CAV2chr7

116140501

+TESchr7

115889074

+
5CDS-intronENST00000393480ENST00000393481CAV2chr7

116140501

+TESchr7

115889074

+
5CDS-3UTRENST00000393480ENST00000485009CAV2chr7

116140501

+TESchr7

115889074

+

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FusionProtFeatures for CAV2_TES


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAV2

P51636

TES

Q9UGI8

May act as a scaffolding protein within caveolarmembranes. Interacts directly with G-protein alpha subunits andcan functionally regulate their activity. Acts as an accessoryprotein in conjunction with CAV1 in targeting to lipid rafts anddriving caveolae formation. The Ser-36 phosphorylated form has arole in modulating mitosis in endothelial cells. Positiveregulator of cellular mitogenesis of the MAPK signaling pathway.Required for the insulin-stimulated nuclear translocation andactivation of MAPK1 and STAT3, and the subsequent regulation ofcell cycle progression (By similarity). {ECO:0000250,ECO:0000269|PubMed:15504032, ECO:0000269|PubMed:18081315}. Scaffold protein that may play a role in cell adhesion,cell spreading and in the reorganization of the actincytoskeleton. Plays a role in the regulation of cellproliferation. May act as a tumor suppressor. Inhibits tumor cellgrowth. {ECO:0000269|PubMed:11420696, ECO:0000269|PubMed:12571287,ECO:0000269|PubMed:12695497}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CAV2_TES


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CAV2_ENST00000222693_chr7_116140501_+_TES_ENST00000358204_chr7_115889074_+_497aa
MGLETEKADVQLFMDDDSYSHHSGLEYADPEKFADSDQDRDPHRLNSHLKLGFEDVIAEPVTTHSFDKVWICSHALFEISKYVMYKFLTV
FLAIPLAFIAGILFATLSCLHIXKICRNCKCGQEEHDVLLSNEEDRKVGKLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVS
INTVTYEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEALGVGDVKLP
CEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNE
KLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CAV2_ENST00000222693_chr7_116140501_+_TES_ENST00000358204_chr7_115889074_+_1491nt
ATGGGGCTGGAGACGGAGAAGGCGGACGTACAGCTCTTCATGGACGACGACTCCTACAGCCACCACAGCGGCCTCGAGTACGCCGACCCC
GAGAAGTTCGCGGACTCGGACCAGGACCGGGATCCCCACCGGCTCAACTCGCATCTCAAGCTGGGCTTCGAGGATGTGATCGCAGAGCCG
GTGACTACGCACTCCTTTGACAAAGTGTGGATCTGCAGCCATGCCCTCTTTGAAATCAGCAAATACGTAATGTACAAGTTCCTGACGGTG
TTCCTGGCCATTCCCCTGGCCTTCATTGCGGGAATTCTCTTTGCCACCCTCAGCTGTCTGCACATCTGAAAAATATGTCGTAACTGCAAG
TGTGGCCAAGAAGAGCATGATGTCCTCTTGAGCAATGAAGAGGATCGAAAAGTGGGAAAACTTTTTGAAGACACCAAGTATACCACTCTG
ATTGCAAAACTAAAGTCAGATGGAATTCCCATGTATAAACGCAATGTTATGATATTGACGAATCCAGTTGCTGCCAAGAAGAATGTCTCC
ATCAATACAGTTACCTATGAGTGGGCTCCTCCTGTCCAGAATCAAGCATTGGCCAGGCAGTACATGCAGATGCTACCCAAGGAAAAGCAG
CCAGTAGCAGGCTCAGAGGGGGCACAGTACCGGAAGAAGCAGCTGGCAAAGCAGCTCCCTGCACATGACCAGGACCCTTCAAAGTGCCAT
GAGTTGTCTCCCAGAGAGGTGAAGGAGATGGAGCAGTTTGTGAAGAAATATAAGAGCGAAGCTCTGGGAGTAGGAGATGTCAAACTTCCC
TGTGAGATGGATGCCCAAGGCCCCAAACAAATGAACATTCCTGGAGGGGATAGAAGCACCCCAGCAGCAGTGGGGGCCATGGAGGACAAA
TCTGCTGAGCACAAAAGAACTCAATATTCCTGCTATTGCTGCAAACTGAGTATGAAAGAAGGTGACCCAGCCATCTATGCCGAAAGGGCT
GGCTATGATAAACTGTGGCACCCAGCTTGTTTTGTCTGCAGCACCTGCCATGAACTCCTGGTTGACATGATTTATTTTTGGAAGAATGAG
AAGCTATACTGTGGCAGACATTACTGTGACAGCGAGAAACCCCGATGTGCTGGCTGTGACGAGCTGATATTCAGCAATGAGTATACCCAG
GCAGAAAACCAGAATTGGCACCTGAAACACTTCTGCTGCTTTGACTGTGATAGCATTCTAGCTGGGGAGATATACGTGATGGTCAATGAC
AAGCCCGTGTGCAAGCCCTGCTATGTGAAGAATCACGCTGTGGTGTGTCAAGGATGCCACAATGCCATCGACCCAGAAGTGCAGCGGGTG
ACCTATAACAATTTCAGCTGGCATGCATCCACAGAGTGCTTTCTGTGCTCTTGCTGCAGCAAATGCCTCATTGGGCAGAAGTTCATGCCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_CAV2_ENST00000222693_chr7_116140501_+_TES_ENST00000358204_chr7_115889074_+_3184nt
CTCCCTCCAGGAAGGCCGTTGTCTTCCCTGGGACGACTTGCCAGCTCTGAGGCATGACAGTACGGGCCCCCAGAAGGGTGACCAGGAGGC
CCTCCTCGTCCCAGCTGCCGGCGTCGCCGCCCACTGCAGGGCCCGGGCTGTGACTCGTGGGGACGGTTCCCTGCGCCCCGGCGGGGGAGG
TGGGCGGGGAGGGGCGGCGGGGCGCCGGGGCGGGGCTCGGGACGGCCGGGCTGGGAGCTGGAGCCCACAGCGGGAAGCGGCCGCCGCCCG
GGCCTCGCAGGGCTAGGCGAGGCGAGGGGGGGCGGGGCCGGGCGCTACGGGAAGGGGAGGCCGCGCGGACCGGGAGCCGCACCGCGCCAG
CCGGGCTGCAGCGGCCGCGCACCAAGGCTGCGATGGGGCTGGAGACGGAGAAGGCGGACGTACAGCTCTTCATGGACGACGACTCCTACA
GCCACCACAGCGGCCTCGAGTACGCCGACCCCGAGAAGTTCGCGGACTCGGACCAGGACCGGGATCCCCACCGGCTCAACTCGCATCTCA
AGCTGGGCTTCGAGGATGTGATCGCAGAGCCGGTGACTACGCACTCCTTTGACAAAGTGTGGATCTGCAGCCATGCCCTCTTTGAAATCA
GCAAATACGTAATGTACAAGTTCCTGACGGTGTTCCTGGCCATTCCCCTGGCCTTCATTGCGGGAATTCTCTTTGCCACCCTCAGCTGTC
TGCACATCTGAAAAATATGTCGTAACTGCAAGTGTGGCCAAGAAGAGCATGATGTCCTCTTGAGCAATGAAGAGGATCGAAAAGTGGGAA
AACTTTTTGAAGACACCAAGTATACCACTCTGATTGCAAAACTAAAGTCAGATGGAATTCCCATGTATAAACGCAATGTTATGATATTGA
CGAATCCAGTTGCTGCCAAGAAGAATGTCTCCATCAATACAGTTACCTATGAGTGGGCTCCTCCTGTCCAGAATCAAGCATTGGCCAGGC
AGTACATGCAGATGCTACCCAAGGAAAAGCAGCCAGTAGCAGGCTCAGAGGGGGCACAGTACCGGAAGAAGCAGCTGGCAAAGCAGCTCC
CTGCACATGACCAGGACCCTTCAAAGTGCCATGAGTTGTCTCCCAGAGAGGTGAAGGAGATGGAGCAGTTTGTGAAGAAATATAAGAGCG
AAGCTCTGGGAGTAGGAGATGTCAAACTTCCCTGTGAGATGGATGCCCAAGGCCCCAAACAAATGAACATTCCTGGAGGGGATAGAAGCA
CCCCAGCAGCAGTGGGGGCCATGGAGGACAAATCTGCTGAGCACAAAAGAACTCAATATTCCTGCTATTGCTGCAAACTGAGTATGAAAG
AAGGTGACCCAGCCATCTATGCCGAAAGGGCTGGCTATGATAAACTGTGGCACCCAGCTTGTTTTGTCTGCAGCACCTGCCATGAACTCC
TGGTTGACATGATTTATTTTTGGAAGAATGAGAAGCTATACTGTGGCAGACATTACTGTGACAGCGAGAAACCCCGATGTGCTGGCTGTG
ACGAGCTGATATTCAGCAATGAGTATACCCAGGCAGAAAACCAGAATTGGCACCTGAAACACTTCTGCTGCTTTGACTGTGATAGCATTC
TAGCTGGGGAGATATACGTGATGGTCAATGACAAGCCCGTGTGCAAGCCCTGCTATGTGAAGAATCACGCTGTGGTGTGTCAAGGATGCC
ACAATGCCATCGACCCAGAAGTGCAGCGGGTGACCTATAACAATTTCAGCTGGCATGCATCCACAGAGTGCTTTCTGTGCTCTTGCTGCA
GCAAATGCCTCATTGGGCAGAAGTTCATGCCAGTAGAAGGGATGGTTTTCTGTTCAGTGGAATGTAAGAAGAGGATGTCTTAGGAGGAGG
GCACCCAGAAGTATCGAGCCATAGCTATCCAAAGTGGTCTGCATTTCTACTGTAAAATGCAATTTGAAAAAAATAAAACGCAAAAAAAGA
AACTGTAAAGGAAACCAAGAGATTTTGTTTAATTTTTTTGGCCATTTTTTCTTCATCAATTTTTTTTCGGTCTCAACTTTTAAACTTGGT
TTAAGCATTTGATTTGTAAAACAGTAAATAATTGTATCTTTCCATAGCTTTTCAAATGTGAAATCATTTTTGGAAGCTTGGATCTCATTA
AACTTCATGTCTCTATTCCATTTGTGCCACACACTTAAAAGTTAGTGTACTGAATGGAAAGATGAGCATTCCTAGTTCTACACTTCTTTT
TTCCCCCTCATGTGTAAAATGAAAAGAAAACTAAATTTGCCCTAATACCAAGGCGCTACGTTTATTGCCTCGTCTTATTCACTGACCTTT
GTAATGATACACAGTGAATTCTTTTTGACAAAGAGAAATGCAGTGTAGTATGCAGAGCTGCTGTTTTAATGCCTATGCATTTACTCTTTC
CTGATTTAGGCAGAGGTGGCATTTTCTTTATTGCATTTCTCTATTTTTTTAATGTACCCTACCTTCAGTATTCTCTTTGTAAGTTGGTGA
CTTGCATCTGTGGCCTTGAATATTTTATTATCACATGTGGCATAACAGTATCCACACTTTTTAGTTCTTTATTTTTTTTTTTTTATTTTG
AGCAATTCTCCTGCCTCAGCCTCCCAAATAGCTGGGATTACAGGTGCATGCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACA
GGTTTTCACCATGTTAGCCAGGCTGGTCTCAAACTCCTGACCTCAGATGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGT
GTGGGAGCCACCATGCCTGACCCACACACTTTTTACTTGTATAGATGATTTTTGGCTTGGACATAAAAGCCAAGCCACCCATTTGCTTTT
AATCCAAAGAACATGTATAGTTTTTGTACCCAGAGACTATGATTTATATTGATTGCACTTGCCTGCCATGATTTAGATAAGATTTTTTTT
GCATGGTTTTTATTCTTTCCTAATGGATCCTGTTTTATAATACTTCCAAGCCTGTCCATGGATATATCAAATGTCTTCACTTGTATATTT
TCATGGCTAGGTATTTCTAATGTTTATTCTTCCCTGTGTACTTCTACACATAGCTATGCACTATGAAAATTAAATGGAATGAATGATATG


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FusionGenePPI for CAV2_TES


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CAV2CAV1, PLD2, SRC, NCK1, RASA1, DNAJA1, MALL, KCNMA1, CSNK2A1, PTGS1, EGFRTESVASP, ACTA1, ENAH, ZYX, RAB8B, ARAP1, ELAVL1, SSSCA1, IGBP1, AHCYL1, THADA, ZPR1, SPTAN1, EVL, SOCS3, EPRS, HNRNPUL1, NAGK, OSGEP, RPRD1B, VPS25, MOV10, NXF1, ZSCAN32, NECAP2, KPTN, TNFAIP8L2, DNM1L, HSPB1, ITPA, RAB2A, SERPINB1, SCLT1, CDK2, FLNA, PPP1CB, IQGAP1, ATP6AP2, LIMA1, ANLN, MYO18A, CDH1, GORASP1, SNN, RNF135, FCGR2A, NFYA, RDH12, FGB, FSD1, SPRY2, UBE2A, PDHA1, PCK2, TES, IFIT1, DPM1, MYO10, AGPAT6, IFIT2, NR3C1, TOR1AIP2, DIAPH1, ITPRIP, TUBA4A, ACAA2, NAMPT, CALU, SOWAHC, TUBB4B, RANBP2, TUBB3, TRAFD1, COPB1, ARHGAP1, TUBB2A, PRKDC, AKAP8, RIN1, TIMM44, SH3BP4, DYNC1H1, COPG1, ERGIC2, OTULIN, RNF113A, TUBB4A, SCYL1, IKBKG, TUBB6, AVL9, ATP6V1H, NUP93, STAT1, PRKCA, SACM1L, TUBA1B, RAB3GAP2, TUBAL3, HK1, TUBA1C, LPCAT1, FHL3, TUBB, DIS3, STAT3, TTC37, SNX9, CUL4A, BAG6, CUL4B, TRAP1, AIFM1, TRIP13, UNC45A, RCN1, TUFM, ARCN1, AP2M1, FHL2, CRTAP, MAP2K3, SDF4, MAGED2, DNM2, EPHA2, SRP54, PC, CTTN, TKT, SPNS1, APP, ARMC6, CPS1, LAP3, COPA, PDCD6IP, MGEA5, ZC3HAV1, PDLIM5, SLC7A5, RAB3GAP1, DDX60, NAP1L4, PPP6R3, MYOF, PLAA, SLC1A5, CDK1, ANP32E, PML, MSH2, EIF2B4, RFC4, HSP90AB1, IPO7, TCP11L1, HUWE1, USP9X, ACSL3, SRPRB, SKIV2L, FAM207A, ASNS, GCN1L1, DCTN1, HGH1, SRP68, TRIM28, TRIM65, IPO4, PSMD3, TBC1D17, SLC3A2, GPI, CCBL2, ATG4B, ICAM1, COPG2, ALDH18A1, TGFB1I1, SEC16A, SUCLA2, GCDH, AHSA1, HK2, UBR4, SCD, SVIL, AFAP1, EIF3I, NEXN, LIMD2, CSRP1, DBN1, ACTBL2, AIF1L, CNN2, AKAP2, CNN3, CORO1C, MACF1, PPP1R18, CORO1B, MISP, ACTA2, FLNB, LPP, CALD1, PALM2, PALLD, PLEC, SPTBN1, LASP1, ACTB, UTRN, LMO7, TAGLN2, ACTN4, FLNC, CFL1, ARPC3, SH3BGRL3, TPM1, CAPZB, ACTN1, DBNL, RPS21, SH3BGRL, TNKS1BP1, FSCN1, MYL6, PDLIM7, CLTA, CLTC, KRT18, MYL9, CLTB, MYL12B, KIF27, ANXA3, CDC73, MYO1C, TFRC, HADHA, HAX1, CAD, ACP1, CYCS, PAF1, POTEF, FGF2, SQSTM1, DNAJA1, CCT7, ATP5E, CSRP2, IRF2BP2, CCDC50, VIM, CTNNB1, PPP1CA, KRT7, CTNNA1, CTNNA2, KRT17, DDX21, EBNA1BP2, NOLC1, KRT8, SF1, ERH, HIST1H1C, TLN1, HIST1H1E, HIST1H2BK, ATP5B, THRAP3, HN1L, HIST1H2AB


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CAV2_TES


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CAV2_TES


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCAV2C0003873Rheumatoid Arthritis1CTD_human
HgeneCAV2C0004238Atrial Fibrillation1CTD_human
HgeneCAV2C0017612Glaucoma, Open-Angle1CTD_human
HgeneCAV2C0033578Prostatic Neoplasms1CTD_human
TgeneTESC0017636Glioblastoma1CTD_human
TgeneTESC0023893Liver Cirrhosis, Experimental1CTD_human