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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5636

FusionGeneSummary for CASZ1_SRM

check button Fusion gene summary
Fusion gene informationFusion gene name: CASZ1_SRM
Fusion gene ID: 5636
HgeneTgene
Gene symbol

CASZ1

SRM

Gene ID

54897

6723

Gene namecastor zinc finger 1spermidine synthase
SynonymsCAS11|CST|SRG|ZNF693|dJ734G22.1PAPT|SPDSY|SPS1|SRML1
Cytomap

1p36.22

1p36.22

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein castor homolog 1castor homolog 1, zinc fingercastor-related proteinsurvival-relatedzinc finger protein 693spermidine synthaseputrescine aminopropyltransferasespermidine synthase-1
Modification date2018052320180523
UniProtAcc

Q86V15

P19623

Ensembl transtripts involved in fusion geneENST00000377022, ENST00000344008, 
ENST00000478728, 
ENST00000376957, 
Fusion gene scores* DoF score13 X 7 X 7=6373 X 2 X 3=18
# samples 153
** MAII scorelog2(15/637*10)=-2.08633087176042
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CASZ1 [Title/Abstract] AND SRM [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCASZ1

GO:0045893

positive regulation of transcription, DNA-templated

27693370

TgeneSRM

GO:0008295

spermidine biosynthetic process

17585781


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-C8-A12Q-01ACASZ1chr1

10753931

-SRMchr1

11119402

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000377022ENST00000376957CASZ1chr1

10753931

-SRMchr1

11119402

-
Frame-shiftENST00000344008ENST00000376957CASZ1chr1

10753931

-SRMchr1

11119402

-
5UTR-3CDSENST00000478728ENST00000376957CASZ1chr1

10753931

-SRMchr1

11119402

-

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FusionProtFeatures for CASZ1_SRM


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CASZ1

Q86V15

SRM

P19623

Catalyzes the production of spermidine from putrescineand decarboxylated S-adenosylmethionine (dcSAM). Has a strongpreference for putrescine as substrate, and has very low activitytowards 1,3-diaminopropane. Has extremely low activity towardsspermidine. {ECO:0000269|PubMed:17585781}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CASZ1_SRM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CASZ1_SRM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CASZ1APP, EED, BAG4, BCAR3, ESR2, PALB2, PPM1D, PTPN1, RAF1, WT1, TEAD2, TRIM25SRMDMWD, DDA1, TERF1, NT5DC1, VCAM1, FN1, ITGA4, SOX12, MOV10, NXF1, ABCE1, CRK, HK2, AARSD1, PTGES3L-AARSD1, GOLPH3, RPRD1B, TIPRL, NTRK1, CRY2, DUSP1, DUSP19, DUSP28, DUSP4, DUSP6, DUSP9, EFHC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CASZ1_SRM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CASZ1_SRM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource