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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 5634

FusionGeneSummary for CASZ1_SLC9A1

check button Fusion gene summary
Fusion gene informationFusion gene name: CASZ1_SLC9A1
Fusion gene ID: 5634
HgeneTgene
Gene symbol

CASZ1

SLC9A1

Gene ID

54897

6548

Gene namecastor zinc finger 1solute carrier family 9 member A1
SynonymsCAS11|CST|SRG|ZNF693|dJ734G22.1APNH|LIKNS|NHE-1|NHE1|PPP1R143
Cytomap

1p36.22

1p36.11

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein castor homolog 1castor homolog 1, zinc fingercastor-related proteinsurvival-relatedzinc finger protein 693sodium/hydrogen exchanger 1Na(+)/H(+) exchanger 1Na-Li countertransporterprotein phosphatase 1, regulatory subunit 143solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive)solute carrier family 9 (sod
Modification date2018052320180527
UniProtAcc

Q86V15

P19634

Ensembl transtripts involved in fusion geneENST00000377022, ENST00000344008, 
ENST00000478728, 		ENST00000263980, 
ENST00000490329, ENST00000545949, 
ENST00000374086, 
Fusion gene scores* DoF score13 X 7 X 7=6374 X 5 X 3=60
# samples 155
** MAII scorelog2(15/637*10)=-2.08633087176042
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CASZ1 [Title/Abstract] AND SLC9A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCASZ1

GO:0045893

positive regulation of transcription, DNA-templated

27693370

TgeneSLC9A1

GO:0006883

cellular sodium ion homeostasis

24840010

TgeneSLC9A1

GO:0006885

regulation of pH

8901634

TgeneSLC9A1

GO:0010447

response to acidic pH

8901634

TgeneSLC9A1

GO:0045944

positive regulation of transcription by RNA polymerase II

22688515

TgeneSLC9A1

GO:0051453

regulation of intracellular pH

15035633|24840010

TgeneSLC9A1

GO:0070886

positive regulation of calcineurin-NFAT signaling cascade

22688515

TgeneSLC9A1

GO:0071468

cellular response to acidic pH

24840010

TgeneSLC9A1

GO:0098719

sodium ion import across plasma membrane

24840010

TgeneSLC9A1

GO:1902600

proton transmembrane transport

24840010


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPAADTCGA-3A-A9J0-01ACASZ1chr1

10753931

-SLC9A1chr1

27440777

-
TCGALDPAADTCGA-3A-A9J0-01ACASZ1chr1

10753931

-SLC9A1chr1

27436268

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000377022ENST00000263980CASZ1chr1

10753931

-SLC9A1chr1

27440777

-
5CDS-intronENST00000377022ENST00000490329CASZ1chr1

10753931

-SLC9A1chr1

27440777

-
5CDS-intronENST00000377022ENST00000545949CASZ1chr1

10753931

-SLC9A1chr1

27440777

-
5CDS-intronENST00000377022ENST00000374086CASZ1chr1

10753931

-SLC9A1chr1

27440777

-
In-frameENST00000344008ENST00000263980CASZ1chr1

10753931

-SLC9A1chr1

27440777

-
5CDS-intronENST00000344008ENST00000490329CASZ1chr1

10753931

-SLC9A1chr1

27440777

-
5CDS-intronENST00000344008ENST00000545949CASZ1chr1

10753931

-SLC9A1chr1

27440777

-
5CDS-intronENST00000344008ENST00000374086CASZ1chr1

10753931

-SLC9A1chr1

27440777

-
5UTR-3CDSENST00000478728ENST00000263980CASZ1chr1

10753931

-SLC9A1chr1

27440777

-
5UTR-intronENST00000478728ENST00000490329CASZ1chr1

10753931

-SLC9A1chr1

27440777

-
5UTR-intronENST00000478728ENST00000545949CASZ1chr1

10753931

-SLC9A1chr1

27440777

-
5UTR-intronENST00000478728ENST00000374086CASZ1chr1

10753931

-SLC9A1chr1

27440777

-
Frame-shiftENST00000377022ENST00000263980CASZ1chr1

10753931

-SLC9A1chr1

27436268

-
5CDS-intronENST00000377022ENST00000490329CASZ1chr1

10753931

-SLC9A1chr1

27436268

-
5CDS-5UTRENST00000377022ENST00000545949CASZ1chr1

10753931

-SLC9A1chr1

27436268

-
5CDS-5UTRENST00000377022ENST00000374086CASZ1chr1

10753931

-SLC9A1chr1

27436268

-
Frame-shiftENST00000344008ENST00000263980CASZ1chr1

10753931

-SLC9A1chr1

27436268

-
5CDS-intronENST00000344008ENST00000490329CASZ1chr1

10753931

-SLC9A1chr1

27436268

-
5CDS-5UTRENST00000344008ENST00000545949CASZ1chr1

10753931

-SLC9A1chr1

27436268

-
5CDS-5UTRENST00000344008ENST00000374086CASZ1chr1

10753931

-SLC9A1chr1

27436268

-
5UTR-3CDSENST00000478728ENST00000263980CASZ1chr1

10753931

-SLC9A1chr1

27436268

-
5UTR-intronENST00000478728ENST00000490329CASZ1chr1

10753931

-SLC9A1chr1

27436268

-
5UTR-5UTRENST00000478728ENST00000545949CASZ1chr1

10753931

-SLC9A1chr1

27436268

-
5UTR-5UTRENST00000478728ENST00000374086CASZ1chr1

10753931

-SLC9A1chr1

27436268

-

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FusionProtFeatures for CASZ1_SLC9A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CASZ1

Q86V15

SLC9A1

P19634

Involved in pH regulation to eliminate acids generatedby active metabolism or to counter adverse environmentalconditions. Major proton extruding system driven by the inwardsodium ion chemical gradient. Plays an important role in signaltransduction. {ECO:0000269|PubMed:11350981,ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:8901634}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012382_402117816IntramembraneName%3DH10
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05382_402117556IntramembraneName%3DH10
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012128_129117816Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012150_154117816Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012175_191117816Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012212_227117816Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012248_256117816Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012277_294117816Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012316_338117816Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012359_381117816Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012403_410117816Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012431_448117816Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012471_479117816Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012500_815117816Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05128_129117556Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05150_154117556Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05175_191117556Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05212_227117556Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05248_256117556Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05277_294117556Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05316_338117556Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05359_381117556Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05403_410117556Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05431_448117556Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05471_479117556Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05500_815117556Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012130_149117816TransmembraneHelical%3B Name%3DM3
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012155_174117816TransmembraneHelical%3B Name%3DM4
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012192_211117816TransmembraneHelical%3B Name%3DM5
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012228_247117816TransmembraneHelical%3B Name%3DM6
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012257_276117816TransmembraneHelical%3B Name%3DM7
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012295_315117816TransmembraneHelical%3B Name%3DM8
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012339_358117816TransmembraneHelical%3B Name%3DM9
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012411_430117816TransmembraneHelical%3B Name%3DM10
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012449_470117816TransmembraneHelical%3B Name%3DM11
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012480_499117816TransmembraneHelical%3B Name%3DM12
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05130_149117556TransmembraneHelical%3B Name%3DM3
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05155_174117556TransmembraneHelical%3B Name%3DM4
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05192_211117556TransmembraneHelical%3B Name%3DM5
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05228_247117556TransmembraneHelical%3B Name%3DM6
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05257_276117556TransmembraneHelical%3B Name%3DM7
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05295_315117556TransmembraneHelical%3B Name%3DM8
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05339_358117556TransmembraneHelical%3B Name%3DM9
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05411_430117556TransmembraneHelical%3B Name%3DM10
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05449_470117556TransmembraneHelical%3B Name%3DM11
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05480_499117556TransmembraneHelical%3B Name%3DM12

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-4161080_114351167Compositional biasNote=Pro-rich
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-4161635_167051167Compositional biasNote=Ala-rich
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-4161672_172951167Compositional biasNote=Glu-rich
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-4161691_171851167Compositional biasNote=Asp-rich
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-416384_41751167Compositional biasNote=Pro-rich
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-4211080_114351760Compositional biasNote=Pro-rich
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-4211635_167051760Compositional biasNote=Ala-rich
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-4211672_172951760Compositional biasNote=Glu-rich
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-4211691_171851760Compositional biasNote=Asp-rich
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-421384_41751760Compositional biasNote=Pro-rich
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-4161031_105551167Zinc fingerC2H2-type 4
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-4161300_132451167Zinc fingerC2H2-type 5
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-4161457_148151167Zinc fingerC2H2-type 6
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-4161515_153751167Zinc fingerC2H2-type 7
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-4161571_159551167Zinc fingerC2H2-type 8
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-416551_57551167Zinc fingerC2H2-type 1
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-416610_63451167Zinc fingerC2H2-type 2
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-416668_69251167Zinc fingerC2H2-type 3
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-4211031_105551760Zinc fingerC2H2-type 4
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-4211300_132451760Zinc fingerC2H2-type 5
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-4211457_148151760Zinc fingerC2H2-type 6
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-4211515_153751760Zinc fingerC2H2-type 7
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-4211571_159551760Zinc fingerC2H2-type 8
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-421551_57551760Zinc fingerC2H2-type 1
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-421610_63451760Zinc fingerC2H2-type 2
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-421668_69251760Zinc fingerC2H2-type 3
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-0121_12117816Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-01234_105117816Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-051_12117556Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-0534_105117556Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012106_127117816TransmembraneHelical%3B Name%3DM2
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-01213_33117816TransmembraneHelical%3B Name%3DM1
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05106_127117556TransmembraneHelical%3B Name%3DM2
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-0513_33117556TransmembraneHelical%3B Name%3DM1


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FusionGeneSequence for CASZ1_SLC9A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CASZ1_ENST00000377022_chr1_10753931_-_SLC9A1_ENST00000263980_chr1_27440777_-_704aa
MDLGTGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAF
FLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFANYEHVGIVDIF
LGFLSFFVVALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYF
LKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKK
HFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCL
IAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRH
TLVADPYEEAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITIDPASPQSPESVDLVNEELKGKVL

>In-frame_CASZ1_ENST00000344008_chr1_10753931_-_SLC9A1_ENST00000263980_chr1_27440777_-_704aa
MDLGTGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAF
FLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFANYEHVGIVDIF
LGFLSFFVVALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYF
LKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKK
HFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCL
IAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRH
TLVADPYEEAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITIDPASPQSPESVDLVNEELKGKVL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CASZ1_ENST00000377022_chr1_10753931_-_SLC9A1_ENST00000263980_chr1_27440777_-_2112nt
ATGGATCTTGGAACAGGTTTCCATGTGATCCCCACTATCTCAAGCATCGTCCCGGAGAGCTGCCTGCTGATCGTGGTGGGGCTGCTGGTG
GGGGGCCTGATCAAGGGTGTAGGCGAGACACCCCCCTTCCTGCAGTCCGACGTCTTCTTCCTCTTCCTGCTGCCGCCCATCATCCTGGAT
GCGGGCTACTTCCTGCCACTGCGGCAGTTCACAGAAAACCTGGGCACCATCCTGATCTTTGCCGTGGTGGGCACGCTGTGGAACGCCTTC
TTCCTGGGCGGCCTCATGTACGCCGTGTGCCTGGTGGGCGGTGAGCAGATCAACAACATCGGCCTCCTGGACAACCTGCTCTTCGGCAGC
ATCATCTCGGCCGTGGACCCCGTGGCGGTTCTGGCTGTCTTTGAGGAAATTCACATCAATGAGCTGCTGCACATCCTTGTTTTTGGGGAG
TCCTTGCTCAATGACGCCGTCACTGTGGTCCTGTATCACCTCTTTGAGGAGTTTGCCAACTACGAACACGTGGGCATCGTGGACATCTTC
CTCGGCTTCCTGAGCTTCTTCGTGGTGGCCCTGGGCGGGGTGCTTGTGGGCGTGGTCTACGGGGTCATCGCAGCCTTCACCTCCCGATTT
ACCTCCCACATCCGGGTCATCGAGCCGCTCTTCGTCTTCCTCTACAGCTACATGGCCTACTTGTCAGCCGAGCTCTTCCACCTGTCAGGC
ATCATGGCGCTCATAGCCTCAGGAGTGGTGATGCGCCCCTATGTGGAGGCCAACATCTCCCACAAGTCCCACACCACCATCAAATACTTC
CTGAAGATGTGGAGCAGCGTCAGCGAGACCCTCATCTTCATCTTCCTCGGCGTCTCCACGGTGGCCGGCTCCCACCACTGGAACTGGACC
TTCGTCATCAGCACCCTGCTCTTCTGCCTCATCGCCCGCGTGCTGGGGGTGCTGGGCCTGACCTGGTTCATCAACAAGTTCCGTATCGTG
AAGCTGACCCCCAAGGACCAGTTCATCATCGCCTATGGGGGCCTGCGAGGGGCCATCGCCTTCTCTCTGGGCTACCTCCTGGACAAGAAG
CACTTCCCCATGTGTGACCTGTTCCTCACTGCCATCATCACTGTCATCTTCTTCACCGTCTTTGTGCAGGGCATGACCATTCGGCCCCTG
GTAGACCTGTTGGCTGTGAAGAAAAAGCAAGAGACGAAGCGCTCCATCAACGAAGAGATCCACACACAGTTCCTGGACCACCTTCTGACA
GGCATCGAAGACATCTGTGGCCACTACGGTCACCACCACTGGAAGGACAAGCTCAACCGGTTTAATAAGAAATATGTGAAGAAGTGTCTG
ATAGCTGGCGAGCGCTCCAAGGAGCCCCAGCTCATTGCCTTCTACCACAAGATGGAGATGAAGCAGGCCATCGAGCTGGTGGAGAGCGGG
GGCATGGGCAAGATCCCCTCTGCCGTCTCCACCGTCTCCATGCAGAACATCCACCCCAAGTCCCTGCCTTCCGAGCGCATCCTGCCAGCA
CTGTCCAAGGACAAGGAGGAGGAGATCCGCAAAATCCTGAGGAACAACTTGCAGAAGACCAGGCAGCGGCTGCGGTCCTACAACAGACAC
ACGCTGGTGGCAGACCCCTACGAGGAAGCCTGGAACCAGATGCTGCTCCGGAGGCAGAAGGCCCGGCAGCTGGAGCAGAAGATCAACAAC
TACCTGACGGTGCCAGCCCACAAGCTGGACTCACCCACCATGTCTCGGGCCCGCATCGGCTCAGACCCACTGGCCTATGAGCCGAAGGAG
GACCTGCCTGTCATCACCATCGACCCGGCTTCCCCGCAGTCACCCGAGTCTGTGGACCTGGTGAATGAAGAGCTGAAGGGCAAAGTCTTA
GGGTTGAGCCGGGATCCTGCAAAGGTGGCTGAGGAGGACGAGGACGACGATGGGGGCATCATGATGCGGAGCAAGGAGACTTCGTCCCCA
GGAACCGACGATGTCTTCACCCCCGCGCCCAGTGACAGCCCCAGCTCCCAGAGGATACAGCGCTGCCTCAGTGACCCAGGCCCACACCCT

>In-frame_CASZ1_ENST00000344008_chr1_10753931_-_SLC9A1_ENST00000263980_chr1_27440777_-_2112nt
ATGGATCTTGGAACAGGTTTCCATGTGATCCCCACTATCTCAAGCATCGTCCCGGAGAGCTGCCTGCTGATCGTGGTGGGGCTGCTGGTG
GGGGGCCTGATCAAGGGTGTAGGCGAGACACCCCCCTTCCTGCAGTCCGACGTCTTCTTCCTCTTCCTGCTGCCGCCCATCATCCTGGAT
GCGGGCTACTTCCTGCCACTGCGGCAGTTCACAGAAAACCTGGGCACCATCCTGATCTTTGCCGTGGTGGGCACGCTGTGGAACGCCTTC
TTCCTGGGCGGCCTCATGTACGCCGTGTGCCTGGTGGGCGGTGAGCAGATCAACAACATCGGCCTCCTGGACAACCTGCTCTTCGGCAGC
ATCATCTCGGCCGTGGACCCCGTGGCGGTTCTGGCTGTCTTTGAGGAAATTCACATCAATGAGCTGCTGCACATCCTTGTTTTTGGGGAG
TCCTTGCTCAATGACGCCGTCACTGTGGTCCTGTATCACCTCTTTGAGGAGTTTGCCAACTACGAACACGTGGGCATCGTGGACATCTTC
CTCGGCTTCCTGAGCTTCTTCGTGGTGGCCCTGGGCGGGGTGCTTGTGGGCGTGGTCTACGGGGTCATCGCAGCCTTCACCTCCCGATTT
ACCTCCCACATCCGGGTCATCGAGCCGCTCTTCGTCTTCCTCTACAGCTACATGGCCTACTTGTCAGCCGAGCTCTTCCACCTGTCAGGC
ATCATGGCGCTCATAGCCTCAGGAGTGGTGATGCGCCCCTATGTGGAGGCCAACATCTCCCACAAGTCCCACACCACCATCAAATACTTC
CTGAAGATGTGGAGCAGCGTCAGCGAGACCCTCATCTTCATCTTCCTCGGCGTCTCCACGGTGGCCGGCTCCCACCACTGGAACTGGACC
TTCGTCATCAGCACCCTGCTCTTCTGCCTCATCGCCCGCGTGCTGGGGGTGCTGGGCCTGACCTGGTTCATCAACAAGTTCCGTATCGTG
AAGCTGACCCCCAAGGACCAGTTCATCATCGCCTATGGGGGCCTGCGAGGGGCCATCGCCTTCTCTCTGGGCTACCTCCTGGACAAGAAG
CACTTCCCCATGTGTGACCTGTTCCTCACTGCCATCATCACTGTCATCTTCTTCACCGTCTTTGTGCAGGGCATGACCATTCGGCCCCTG
GTAGACCTGTTGGCTGTGAAGAAAAAGCAAGAGACGAAGCGCTCCATCAACGAAGAGATCCACACACAGTTCCTGGACCACCTTCTGACA
GGCATCGAAGACATCTGTGGCCACTACGGTCACCACCACTGGAAGGACAAGCTCAACCGGTTTAATAAGAAATATGTGAAGAAGTGTCTG
ATAGCTGGCGAGCGCTCCAAGGAGCCCCAGCTCATTGCCTTCTACCACAAGATGGAGATGAAGCAGGCCATCGAGCTGGTGGAGAGCGGG
GGCATGGGCAAGATCCCCTCTGCCGTCTCCACCGTCTCCATGCAGAACATCCACCCCAAGTCCCTGCCTTCCGAGCGCATCCTGCCAGCA
CTGTCCAAGGACAAGGAGGAGGAGATCCGCAAAATCCTGAGGAACAACTTGCAGAAGACCAGGCAGCGGCTGCGGTCCTACAACAGACAC
ACGCTGGTGGCAGACCCCTACGAGGAAGCCTGGAACCAGATGCTGCTCCGGAGGCAGAAGGCCCGGCAGCTGGAGCAGAAGATCAACAAC
TACCTGACGGTGCCAGCCCACAAGCTGGACTCACCCACCATGTCTCGGGCCCGCATCGGCTCAGACCCACTGGCCTATGAGCCGAAGGAG
GACCTGCCTGTCATCACCATCGACCCGGCTTCCCCGCAGTCACCCGAGTCTGTGGACCTGGTGAATGAAGAGCTGAAGGGCAAAGTCTTA
GGGTTGAGCCGGGATCCTGCAAAGGTGGCTGAGGAGGACGAGGACGACGATGGGGGCATCATGATGCGGAGCAAGGAGACTTCGTCCCCA
GGAACCGACGATGTCTTCACCCCCGCGCCCAGTGACAGCCCCAGCTCCCAGAGGATACAGCGCTGCCTCAGTGACCCAGGCCCACACCCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_CASZ1_ENST00000377022_chr1_10753931_-_SLC9A1_ENST00000263980_chr1_27440777_-_3922nt
ATGCGCGCCCGCGGCGCTCCATCCCAAACACACACACATTTTTCCCCCGGACTTGGAAAGTCACCCAAAGCCGCCCCAAGTGCAGGCAAA
CAGACCTTGCTGACTGAAGGCAAAGACTCCTCCATCCCACCTGCCCTCCCAGCTGCCACGGCCATCGACCCCTCCTTTACAAGGGGCTCC
TGCAACTCCCCAGCAGCACGTGTTGGAATGGACTTCGGACCCTGGCCTCTTGGGATGCAAAGGATGAAGTGACACCCCCAGCTACATCCG
AGGAGGTTCTAGGACCTGCTACGAGAGTTTGGGACCAAGGAGAAGAGAATGGATCTTGGAACAGGTTTCCATGTGATCCCCACTATCTCA
AGCATCGTCCCGGAGAGCTGCCTGCTGATCGTGGTGGGGCTGCTGGTGGGGGGCCTGATCAAGGGTGTAGGCGAGACACCCCCCTTCCTG
CAGTCCGACGTCTTCTTCCTCTTCCTGCTGCCGCCCATCATCCTGGATGCGGGCTACTTCCTGCCACTGCGGCAGTTCACAGAAAACCTG
GGCACCATCCTGATCTTTGCCGTGGTGGGCACGCTGTGGAACGCCTTCTTCCTGGGCGGCCTCATGTACGCCGTGTGCCTGGTGGGCGGT
GAGCAGATCAACAACATCGGCCTCCTGGACAACCTGCTCTTCGGCAGCATCATCTCGGCCGTGGACCCCGTGGCGGTTCTGGCTGTCTTT
GAGGAAATTCACATCAATGAGCTGCTGCACATCCTTGTTTTTGGGGAGTCCTTGCTCAATGACGCCGTCACTGTGGTCCTGTATCACCTC
TTTGAGGAGTTTGCCAACTACGAACACGTGGGCATCGTGGACATCTTCCTCGGCTTCCTGAGCTTCTTCGTGGTGGCCCTGGGCGGGGTG
CTTGTGGGCGTGGTCTACGGGGTCATCGCAGCCTTCACCTCCCGATTTACCTCCCACATCCGGGTCATCGAGCCGCTCTTCGTCTTCCTC
TACAGCTACATGGCCTACTTGTCAGCCGAGCTCTTCCACCTGTCAGGCATCATGGCGCTCATAGCCTCAGGAGTGGTGATGCGCCCCTAT
GTGGAGGCCAACATCTCCCACAAGTCCCACACCACCATCAAATACTTCCTGAAGATGTGGAGCAGCGTCAGCGAGACCCTCATCTTCATC
TTCCTCGGCGTCTCCACGGTGGCCGGCTCCCACCACTGGAACTGGACCTTCGTCATCAGCACCCTGCTCTTCTGCCTCATCGCCCGCGTG
CTGGGGGTGCTGGGCCTGACCTGGTTCATCAACAAGTTCCGTATCGTGAAGCTGACCCCCAAGGACCAGTTCATCATCGCCTATGGGGGC
CTGCGAGGGGCCATCGCCTTCTCTCTGGGCTACCTCCTGGACAAGAAGCACTTCCCCATGTGTGACCTGTTCCTCACTGCCATCATCACT
GTCATCTTCTTCACCGTCTTTGTGCAGGGCATGACCATTCGGCCCCTGGTAGACCTGTTGGCTGTGAAGAAAAAGCAAGAGACGAAGCGC
TCCATCAACGAAGAGATCCACACACAGTTCCTGGACCACCTTCTGACAGGCATCGAAGACATCTGTGGCCACTACGGTCACCACCACTGG
AAGGACAAGCTCAACCGGTTTAATAAGAAATATGTGAAGAAGTGTCTGATAGCTGGCGAGCGCTCCAAGGAGCCCCAGCTCATTGCCTTC
TACCACAAGATGGAGATGAAGCAGGCCATCGAGCTGGTGGAGAGCGGGGGCATGGGCAAGATCCCCTCTGCCGTCTCCACCGTCTCCATG
CAGAACATCCACCCCAAGTCCCTGCCTTCCGAGCGCATCCTGCCAGCACTGTCCAAGGACAAGGAGGAGGAGATCCGCAAAATCCTGAGG
AACAACTTGCAGAAGACCAGGCAGCGGCTGCGGTCCTACAACAGACACACGCTGGTGGCAGACCCCTACGAGGAAGCCTGGAACCAGATG
CTGCTCCGGAGGCAGAAGGCCCGGCAGCTGGAGCAGAAGATCAACAACTACCTGACGGTGCCAGCCCACAAGCTGGACTCACCCACCATG
TCTCGGGCCCGCATCGGCTCAGACCCACTGGCCTATGAGCCGAAGGAGGACCTGCCTGTCATCACCATCGACCCGGCTTCCCCGCAGTCA
CCCGAGTCTGTGGACCTGGTGAATGAAGAGCTGAAGGGCAAAGTCTTAGGGTTGAGCCGGGATCCTGCAAAGGTGGCTGAGGAGGACGAG
GACGACGATGGGGGCATCATGATGCGGAGCAAGGAGACTTCGTCCCCAGGAACCGACGATGTCTTCACCCCCGCGCCCAGTGACAGCCCC
AGCTCCCAGAGGATACAGCGCTGCCTCAGTGACCCAGGCCCACACCCTGAGCCTGGGGAGGGAGAACCGTTCTTCCCCAAGGGGCAGTAA
CACCAGGGCCAGCAGGCAGCGCCTGTCCCCTCACAGACTCTTCCACCAGAGCAGGGGCTGCTGGGGGCTCCCCTTGCCCTTCCTGACCCG
GATTGGCCCTGCCCCTCCCCCTACCGCATGGCAGCTGGGCCCACAGCCCCCACCCCAGCACAGCTCCTCCCCTGCCGCCTCCCGGGAAGC
ATCCTCCCCACCAGAGCTGCCTCCCCAATCCATTTGGCAGAACTGCTGGGGCTGGTGAGGCCGGCCCTGCCCCTCCCTAGATCCAGGCTT
CTCCCGGACCTGGACTAGGGCCTCGGAGGCTCCTCCCTCTGCCTCATCCTCCTCCTCATTCAGACCAATCTTAGTTTCTAACCAAAGAGT
CTCTGGCTCAGCTGTGGTCCCACCCAGGAAGGGAGGGAGCTGAGGCCTCCCTTGAGTAGGCCCTGCTTTATCAGGGGACAAACCAGGGGT
ACCAGGCACATGGCTGGGGGAGGGACTGCTGACCCACCAAGGTCTCACACTCCTCCTGCCAGCTCTGTCACCCTGGCCACCACCCAACCT
GTCCTTACTCAGAGCTGCGGGCTGAGGGCATCTCTGAGTGTCTCTGCCTGGAGCAGGGGTGGTTTCTACGGTGACAGTGACGTGACTCAG
AGCTTTTCGAACTGTGCTCCCACGGGGACCACTGGGCCCCTCAGGGGAAGCTGCTAGGGGAAGGACTGGCCGTGGCTCCAGAATGTGCTG
CCTTTTTAAGTTTTGTTTGTTCACACTCCTATATATGATTGTTTGCACAGAGGGCGCTCCTGTTTTTAAAACATTTTGAAAACCCCTGGC
TGAACAGTGCTCTGCCTCTAACTCCCTCCTCACACTCCAGAATTACCCTTCCTCATCTGTGCCTGTCTGTCCAACCCCTCCCCCACGTCT
CTCTGCCTGCTGGGCTCTTAACTGTTGCTCGAAGACTGTGACATCAGAAGTAACTCCCACTCCTAATCAAGAGTCTCTCCAGCCTCACAG
ATGCTGGCCTCTTGGCACCTGCCTAGCTCTTGGGCCTGACCTCCAGTCCTGCTGGCCTGCTCTTACTTCCCCCACCCTGGGTTTGGCCCC
TGGAACCTTTCCCTTGTGTGTACCACACCCTGCCTGCTGTGGAGCCCATTGTGGAGGCGGTGGGGGGGAGAAGGCCTCCCCTGAGGATCC
CCTGTCCCCTGGGGCTGGTGGATTGGGCAGAATCCTGGGCCCCCAGAGACCTTTGCCCACACACACTCCTTCCCCTTGTCCCTGGGGCAC
TCCCCCAGGATTGTGCAATAGTCAGAGTGTCCCTTTTTGCAGGGGACTGGGCCATGGGTCCTCGGCCCATCTGTCCATCCTCCTCTCCAT
GCAAGTGCTGTTTGGGCAGGAGTCACCATGCAAGGGTGACATCGACAACCACGTACCAAGCCACCGCAGCTGCTGCCACTCTGCTGCCTG

>In-frame_CASZ1_ENST00000344008_chr1_10753931_-_SLC9A1_ENST00000263980_chr1_27440777_-_3924nt
GCATGCGCGCCCGCGGCGCTCCATCCCAAACACACACACATTTTTCCCCCGGACTTGGAAAGTCACCCAAAGCCGCCCCAAGTGCAGGCA
AACAGACCTTGCTGACTGAAGGCAAAGACTCCTCCATCCCACCTGCCCTCCCAGCTGCCACGGCCATCGACCCCTCCTTTACAAGGGGCT
CCTGCAACTCCCCAGCAGCACGTGTTGGAATGGACTTCGGACCCTGGCCTCTTGGGATGCAAAGGATGAAGTGACACCCCCAGCTACATC
CGAGGAGGTTCTAGGACCTGCTACGAGAGTTTGGGACCAAGGAGAAGAGAATGGATCTTGGAACAGGTTTCCATGTGATCCCCACTATCT
CAAGCATCGTCCCGGAGAGCTGCCTGCTGATCGTGGTGGGGCTGCTGGTGGGGGGCCTGATCAAGGGTGTAGGCGAGACACCCCCCTTCC
TGCAGTCCGACGTCTTCTTCCTCTTCCTGCTGCCGCCCATCATCCTGGATGCGGGCTACTTCCTGCCACTGCGGCAGTTCACAGAAAACC
TGGGCACCATCCTGATCTTTGCCGTGGTGGGCACGCTGTGGAACGCCTTCTTCCTGGGCGGCCTCATGTACGCCGTGTGCCTGGTGGGCG
GTGAGCAGATCAACAACATCGGCCTCCTGGACAACCTGCTCTTCGGCAGCATCATCTCGGCCGTGGACCCCGTGGCGGTTCTGGCTGTCT
TTGAGGAAATTCACATCAATGAGCTGCTGCACATCCTTGTTTTTGGGGAGTCCTTGCTCAATGACGCCGTCACTGTGGTCCTGTATCACC
TCTTTGAGGAGTTTGCCAACTACGAACACGTGGGCATCGTGGACATCTTCCTCGGCTTCCTGAGCTTCTTCGTGGTGGCCCTGGGCGGGG
TGCTTGTGGGCGTGGTCTACGGGGTCATCGCAGCCTTCACCTCCCGATTTACCTCCCACATCCGGGTCATCGAGCCGCTCTTCGTCTTCC
TCTACAGCTACATGGCCTACTTGTCAGCCGAGCTCTTCCACCTGTCAGGCATCATGGCGCTCATAGCCTCAGGAGTGGTGATGCGCCCCT
ATGTGGAGGCCAACATCTCCCACAAGTCCCACACCACCATCAAATACTTCCTGAAGATGTGGAGCAGCGTCAGCGAGACCCTCATCTTCA
TCTTCCTCGGCGTCTCCACGGTGGCCGGCTCCCACCACTGGAACTGGACCTTCGTCATCAGCACCCTGCTCTTCTGCCTCATCGCCCGCG
TGCTGGGGGTGCTGGGCCTGACCTGGTTCATCAACAAGTTCCGTATCGTGAAGCTGACCCCCAAGGACCAGTTCATCATCGCCTATGGGG
GCCTGCGAGGGGCCATCGCCTTCTCTCTGGGCTACCTCCTGGACAAGAAGCACTTCCCCATGTGTGACCTGTTCCTCACTGCCATCATCA
CTGTCATCTTCTTCACCGTCTTTGTGCAGGGCATGACCATTCGGCCCCTGGTAGACCTGTTGGCTGTGAAGAAAAAGCAAGAGACGAAGC
GCTCCATCAACGAAGAGATCCACACACAGTTCCTGGACCACCTTCTGACAGGCATCGAAGACATCTGTGGCCACTACGGTCACCACCACT
GGAAGGACAAGCTCAACCGGTTTAATAAGAAATATGTGAAGAAGTGTCTGATAGCTGGCGAGCGCTCCAAGGAGCCCCAGCTCATTGCCT
TCTACCACAAGATGGAGATGAAGCAGGCCATCGAGCTGGTGGAGAGCGGGGGCATGGGCAAGATCCCCTCTGCCGTCTCCACCGTCTCCA
TGCAGAACATCCACCCCAAGTCCCTGCCTTCCGAGCGCATCCTGCCAGCACTGTCCAAGGACAAGGAGGAGGAGATCCGCAAAATCCTGA
GGAACAACTTGCAGAAGACCAGGCAGCGGCTGCGGTCCTACAACAGACACACGCTGGTGGCAGACCCCTACGAGGAAGCCTGGAACCAGA
TGCTGCTCCGGAGGCAGAAGGCCCGGCAGCTGGAGCAGAAGATCAACAACTACCTGACGGTGCCAGCCCACAAGCTGGACTCACCCACCA
TGTCTCGGGCCCGCATCGGCTCAGACCCACTGGCCTATGAGCCGAAGGAGGACCTGCCTGTCATCACCATCGACCCGGCTTCCCCGCAGT
CACCCGAGTCTGTGGACCTGGTGAATGAAGAGCTGAAGGGCAAAGTCTTAGGGTTGAGCCGGGATCCTGCAAAGGTGGCTGAGGAGGACG
AGGACGACGATGGGGGCATCATGATGCGGAGCAAGGAGACTTCGTCCCCAGGAACCGACGATGTCTTCACCCCCGCGCCCAGTGACAGCC
CCAGCTCCCAGAGGATACAGCGCTGCCTCAGTGACCCAGGCCCACACCCTGAGCCTGGGGAGGGAGAACCGTTCTTCCCCAAGGGGCAGT
AACACCAGGGCCAGCAGGCAGCGCCTGTCCCCTCACAGACTCTTCCACCAGAGCAGGGGCTGCTGGGGGCTCCCCTTGCCCTTCCTGACC
CGGATTGGCCCTGCCCCTCCCCCTACCGCATGGCAGCTGGGCCCACAGCCCCCACCCCAGCACAGCTCCTCCCCTGCCGCCTCCCGGGAA
GCATCCTCCCCACCAGAGCTGCCTCCCCAATCCATTTGGCAGAACTGCTGGGGCTGGTGAGGCCGGCCCTGCCCCTCCCTAGATCCAGGC
TTCTCCCGGACCTGGACTAGGGCCTCGGAGGCTCCTCCCTCTGCCTCATCCTCCTCCTCATTCAGACCAATCTTAGTTTCTAACCAAAGA
GTCTCTGGCTCAGCTGTGGTCCCACCCAGGAAGGGAGGGAGCTGAGGCCTCCCTTGAGTAGGCCCTGCTTTATCAGGGGACAAACCAGGG
GTACCAGGCACATGGCTGGGGGAGGGACTGCTGACCCACCAAGGTCTCACACTCCTCCTGCCAGCTCTGTCACCCTGGCCACCACCCAAC
CTGTCCTTACTCAGAGCTGCGGGCTGAGGGCATCTCTGAGTGTCTCTGCCTGGAGCAGGGGTGGTTTCTACGGTGACAGTGACGTGACTC
AGAGCTTTTCGAACTGTGCTCCCACGGGGACCACTGGGCCCCTCAGGGGAAGCTGCTAGGGGAAGGACTGGCCGTGGCTCCAGAATGTGC
TGCCTTTTTAAGTTTTGTTTGTTCACACTCCTATATATGATTGTTTGCACAGAGGGCGCTCCTGTTTTTAAAACATTTTGAAAACCCCTG
GCTGAACAGTGCTCTGCCTCTAACTCCCTCCTCACACTCCAGAATTACCCTTCCTCATCTGTGCCTGTCTGTCCAACCCCTCCCCCACGT
CTCTCTGCCTGCTGGGCTCTTAACTGTTGCTCGAAGACTGTGACATCAGAAGTAACTCCCACTCCTAATCAAGAGTCTCTCCAGCCTCAC
AGATGCTGGCCTCTTGGCACCTGCCTAGCTCTTGGGCCTGACCTCCAGTCCTGCTGGCCTGCTCTTACTTCCCCCACCCTGGGTTTGGCC
CCTGGAACCTTTCCCTTGTGTGTACCACACCCTGCCTGCTGTGGAGCCCATTGTGGAGGCGGTGGGGGGGAGAAGGCCTCCCCTGAGGAT
CCCCTGTCCCCTGGGGCTGGTGGATTGGGCAGAATCCTGGGCCCCCAGAGACCTTTGCCCACACACACTCCTTCCCCTTGTCCCTGGGGC
ACTCCCCCAGGATTGTGCAATAGTCAGAGTGTCCCTTTTTGCAGGGGACTGGGCCATGGGTCCTCGGCCCATCTGTCCATCCTCCTCTCC
ATGCAAGTGCTGTTTGGGCAGGAGTCACCATGCAAGGGTGACATCGACAACCACGTACCAAGCCACCGCAGCTGCTGCCACTCTGCTGCC


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FusionGenePPI for CASZ1_SLC9A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CASZ1APP, EED, BAG4, BCAR3, ESR2, PALB2, PPM1D, PTPN1, RAF1, WT1, TEAD2, TRIM25SLC9A1MDFI, TESC, CALM1, CHP2, CHP1, CA2, MAP4K4, WNK1, NEDD4, ARRB1, DAXX, RPS6KA6, LYPD3, FAM189A2, PTGER3, LPAR1, MAP3K14, TCTN3, TMEM17, AP4S1, ROCK1, CDH1, IPPK, GALNT7, AOC3, FNDC5, SLCO6A1, CCDC107, PTGIR, SEMA7A, FUT1, SLC20A1, TCTN2, GALNT6, AKT1, HSPA4, HSP90AA1, ENO1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980-012516_539117816CHP2
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086-05516_539117556CHP2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CASZ1_SLC9A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSLC9A1P19634DB00594AmilorideSodium/hydrogen exchanger 1small moleculeapproved

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RelatedDiseases for CASZ1_SLC9A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSLC9A1C0004763Barrett Esophagus1CTD_human
TgeneSLC9A1C0007194Hypertrophic Cardiomyopathy1CTD_human
TgeneSLC9A1C0011853Diabetes Mellitus, Experimental1CTD_human
TgeneSLC9A1C0013604Edema1CTD_human
TgeneSLC9A1C0018801Heart failure1CTD_human
TgeneSLC9A1C0030193Pain1CTD_human
TgeneSLC9A1C0035126Reperfusion Injury1CTD_human
TgeneSLC9A1C0036982Shock, Hemorrhagic1CTD_human
TgeneSLC9A1C4225383LICHTENSTEIN-KNORR SYNDROME1ORPHANET;UNIPROT