	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 5620

FusionGeneSummary for CAST_CDHR3

Fusion gene summary

Fusion gene information	Fusion gene name: CAST_CDHR3
	Fusion gene ID: 5620
		Hgene	Tgene
	Gene symbol	CAST	CDHR3
	Gene ID	26059	222256
	Gene name	ELKS/RAB6-interacting/CAST family member 2	cadherin related family member 3
	Synonyms	CAST\|CAST1\|ELKSL\|SPBC110\|Spc110	CDH28
	Cytomap	3p14.3	7q22.3
	Type of gene	protein-coding	protein-coding
	Description	ERC protein 2CAZ-associated structural proteincytomatrix protein p110	cadherin-related family member 3cadherin-like protein 28
	Modification date	20180519	20180527
	UniProtAcc	P20810	Q6ZTQ4
	Ensembl transtripts involved in fusion gene	ENST00000338252, ENST00000508830, ENST00000359176, ENST00000395812, ENST00000325674, ENST00000395813, ENST00000510756, ENST00000508608, ENST00000341926, ENST00000511049, ENST00000309190, ENST00000509903, ENST00000511782, ENST00000504465, ENST00000348386, ENST00000508579, ENST00000515663,	ENST00000470188, ENST00000542731, ENST00000343407, ENST00000317716, ENST00000478080, ENST00000541203,
Fusion gene scores	* DoF score	5 X 7 X 3=105	2 X 1 X 2=4
	# samples	7	2
	** MAII score	log2(7/105*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/4*10)=2.32192809488736
Context	PubMed: CAST [Title/Abstract] AND CDHR3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LUAD	TCGA-75-7025-01A	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000338252	ENST00000470188	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
5CDS-intron	ENST00000338252	ENST00000542731	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
5CDS-intron	ENST00000338252	ENST00000343407	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
5CDS-intron	ENST00000338252	ENST00000317716	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
5CDS-intron	ENST00000338252	ENST00000478080	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
5CDS-intron	ENST00000338252	ENST00000541203	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000508830	ENST00000470188	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000508830	ENST00000542731	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000508830	ENST00000343407	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000508830	ENST00000317716	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000508830	ENST00000478080	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000508830	ENST00000541203	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000359176	ENST00000470188	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000359176	ENST00000542731	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000359176	ENST00000343407	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000359176	ENST00000317716	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000359176	ENST00000478080	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000359176	ENST00000541203	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000395812	ENST00000470188	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000395812	ENST00000542731	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000395812	ENST00000343407	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000395812	ENST00000317716	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000395812	ENST00000478080	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000395812	ENST00000541203	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000325674	ENST00000470188	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000325674	ENST00000542731	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000325674	ENST00000343407	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000325674	ENST00000317716	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000325674	ENST00000478080	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000325674	ENST00000541203	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000395813	ENST00000470188	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000395813	ENST00000542731	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000395813	ENST00000343407	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000395813	ENST00000317716	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000395813	ENST00000478080	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000395813	ENST00000541203	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000510756	ENST00000470188	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000510756	ENST00000542731	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000510756	ENST00000343407	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000510756	ENST00000317716	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000510756	ENST00000478080	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000510756	ENST00000541203	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000508608	ENST00000470188	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000508608	ENST00000542731	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000508608	ENST00000343407	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000508608	ENST00000317716	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000508608	ENST00000478080	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000508608	ENST00000541203	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000341926	ENST00000470188	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000341926	ENST00000542731	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000341926	ENST00000343407	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000341926	ENST00000317716	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000341926	ENST00000478080	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000341926	ENST00000541203	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000511049	ENST00000470188	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000511049	ENST00000542731	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000511049	ENST00000343407	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000511049	ENST00000317716	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000511049	ENST00000478080	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000511049	ENST00000541203	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000309190	ENST00000470188	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000309190	ENST00000542731	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000309190	ENST00000343407	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000309190	ENST00000317716	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000309190	ENST00000478080	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
3UTR-intron	ENST00000309190	ENST00000541203	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000509903	ENST00000470188	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000509903	ENST00000542731	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000509903	ENST00000343407	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000509903	ENST00000317716	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000509903	ENST00000478080	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000509903	ENST00000541203	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000511782	ENST00000470188	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000511782	ENST00000542731	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000511782	ENST00000343407	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000511782	ENST00000317716	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000511782	ENST00000478080	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000511782	ENST00000541203	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000504465	ENST00000470188	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000504465	ENST00000542731	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000504465	ENST00000343407	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000504465	ENST00000317716	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000504465	ENST00000478080	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000504465	ENST00000541203	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000348386	ENST00000470188	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000348386	ENST00000542731	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000348386	ENST00000343407	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000348386	ENST00000317716	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000348386	ENST00000478080	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000348386	ENST00000541203	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000508579	ENST00000470188	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000508579	ENST00000542731	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000508579	ENST00000343407	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000508579	ENST00000317716	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000508579	ENST00000478080	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000508579	ENST00000541203	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000515663	ENST00000470188	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000515663	ENST00000542731	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000515663	ENST00000343407	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000515663	ENST00000317716	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000515663	ENST00000478080	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+
intron-intron	ENST00000515663	ENST00000541203	CAST	chr5	96108937	+	CDHR3	chr7	105668108	+

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FusionProtFeatures for CAST_CDHR3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CAST P20810	CDHR3 Q6ZTQ4
	Cadherins are calcium-dependent cell adhesion proteins.They preferentially interact with themselves in a homophilicmanner in connecting cells; cadherins may thus contribute to thesorting of heterogeneous cell types. (Microbial infection) Acts as a receptor for rhinovirusC. {ECO:0000269\|PubMed:25848009}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for CAST_CDHR3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CAST_CDHR3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
CAST	CAPN1, KIAA0101, ELAVL1, PSIP1, COPS4, COPS5, CUL4A, EPB41L1, KIF5B, LRBA, PSMA6, PSMB3, PSMB5, PSMB7, RPP38, SART3, SMEK1, PSMA5, FNTB, CAPNS2, NUDC, CKB, CRK, LZIC, PPME1, BAG6, CDH1, CAPN8, MTUS2	CDHR3

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for CAST_CDHR3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Hgene	CAST	P20810	DB11638	Artenimol	Calpastatin	small molecule	approved\|investigational
Hgene	CAST	P20810	DB01373	Calcium	Calpastatin	small molecule	approved\|nutraceutical

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RelatedDiseases for CAST_CDHR3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CAST	C0027540	Necrosis	1	CTD_human
Hgene	CAST	C0162557	Liver Failure, Acute	1	CTD_human
Tgene	CDHR3	C0004096	Asthma	1	CTD_human

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Fusion gene ID: 5620

FusionGeneSummary for CAST_CDHR3

FusionProtFeatures for CAST_CDHR3

FusionGeneSequence for CAST_CDHR3

FusionGenePPI for CAST_CDHR3

RelatedDrugs for CAST_CDHR3

RelatedDiseases for CAST_CDHR3