	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 5611

FusionGeneSummary for CASP8_CFLAR

Fusion gene summary

Fusion gene information	Fusion gene name: CASP8_CFLAR
	Fusion gene ID: 5611
		Hgene	Tgene
	Gene symbol	CASP8	CFLAR
	Gene ID	841	8837
	Gene name	caspase 8	CASP8 and FADD like apoptosis regulator
	Synonyms	ALPS2B\|CAP4\|Casp-8\|FLICE\|MACH\|MCH5	CASH\|CASP8AP1\|CLARP\|Casper\|FLAME\|FLAME-1\|FLAME1\|FLIP\|I-FLICE\|MRIT\|c-FLIP\|c-FLIPL\|c-FLIPR\|c-FLIPS
	Cytomap	2q33.1	2q33.1
	Type of gene	protein-coding	protein-coding
	Description	caspase-8FADD-homologous ICE/CED-3-like proteaseFADD-like ICEICE-like apoptotic protease 5MACH-alpha-1/2/3 proteinMACH-beta-1/2/3/4 proteinMORT1-associated ced-3 homologapoptotic cysteine proteaseapoptotic protease Mch-5caspase 8, apoptosis-relat	CASP8 and FADD-like apoptosis regulatorFADD-like antiapoptotic molecule 1MACH-related inducer of toxicitycaspase homologcaspase-eight-related proteincaspase-like apoptosis regulatory proteincaspase-related inducer of apoptosiscellular FLICE-like in
	Modification date	20180523	20180523
	UniProtAcc	Q14790	O15519
	Ensembl transtripts involved in fusion gene	ENST00000392259, ENST00000392266, ENST00000264274, ENST00000432109, ENST00000264275, ENST00000392258, ENST00000490682, ENST00000358485, ENST00000323492,	ENST00000309955, ENST00000443227, ENST00000341222, ENST00000340870, ENST00000355558, ENST00000341582, ENST00000342795, ENST00000395148, ENST00000423241, ENST00000490965, ENST00000440180, ENST00000457277, ENST00000494258, ENST00000479953,
Fusion gene scores	* DoF score	8 X 4 X 10=320	9 X 6 X 6=324
	# samples	10	10
	** MAII score	log2(10/320*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/324*10)=-1.6959938131099 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CASP8 [Title/Abstract] AND CFLAR [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CASP8	GO:0006508	proteolysis	12888622
Hgene	CASP8	GO:0036462	TRAIL-activated apoptotic signaling pathway	21785459
Hgene	CASP8	GO:0045862	positive regulation of proteolysis	18387192
Hgene	CASP8	GO:0097191	extrinsic apoptotic signaling pathway	21785459
Hgene	CASP8	GO:0097202	activation of cysteine-type endopeptidase activity	18387192
Tgene	CFLAR	GO:0060544	regulation of necroptotic process	21737330
Tgene	CFLAR	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	26582200
Tgene	CFLAR	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	9208847

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	SKCM	TCGA-WE-A8K4-01A	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
TCGA	RV	STAD	TCGA-BR-8361-01A	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-5UTR	ENST00000392259	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392259	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392259	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392259	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392259	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392259	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392266	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392266	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392266	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392266	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392266	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264274	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264274	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264274	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264274	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264274	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000432109	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000432109	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000432109	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000432109	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000432109	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264275	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264275	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264275	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264275	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264275	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392258	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392258	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392258	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392258	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392258	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-intron	ENST00000490682	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-intron	ENST00000490682	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-intron	ENST00000490682	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-intron	ENST00000490682	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-intron	ENST00000490682	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000358485	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000358485	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000358485	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000358485	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000358485	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000323492	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000323492	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000323492	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000323492	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000323492	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+

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FusionProtFeatures for CASP8_CFLAR

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CASP8 Q14790	CFLAR O15519

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for CASP8_CFLAR

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CASP8_CFLAR

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
CASP8	TNFRSF10B, FADD, FASLG, BID, EZR, FAS, MAPK8, MSN, CASP10, RHOA, ARHGDIA, TNFRSF1A, RALBP1, TRADD, TRAF1, TRAF2, BIRC2, CFLAR, CASP8, CHD3, TFCP2, VIM, BCAP31, TNFRSF10A, APAF1, NR1H4, NOD1, PEA15, BCL2, HIP1, IFT57, CASP6, CASP3, CASP7, CASP9, CASP2, BCL2L1, XIAP, RIPK1, MAP3K14, CHUK, IKBKB, NOL3, DEDD2, DEDD, CASP4, CASP1, CASP8AP2, CASP14, TNFAIP3, HDAC7, FAF1, RALGDS, NLRC4, PTEN, KHDRBS1, MAP1LC3B, USP2, TSC22D3, MAP1LC3A, SQSTM1, TNFSF10, SORBS1, CEBPB, TRAF6, COPS6, CLIP3, BIRC6, BFAR, RNF34, MAPK1, TOPORS, TP53, LRRK2, FIS1, UBC, CUL3, CARD11, PARK7, RIPK3, RB1, PLA2G4B, PRKCI, SNRPD3, PDIA6, PLIN4, GZMB, HECTD3, CRYAB, TNF, PRDX6, BAX, ERLIN2, TICAM1, BIRC3, ATG4D, PARP1, AGR3, ANGPTL4, ATAD2, BAP1, BEX1, BLID, CASC3, CDH13, EPSTI1, ERRFI1, GLCE, GREB1, IL13RA2, IL24, KLK5, KLK9, LYPD3, PRDM14, PSMC3IP, S100A14, SCGB2A2, SERPINB5, ST14, PRSS50, VPS45, WHSC1L1, ATP1A3, BCL2L10, CNBP, HBP1, QDPR, SOX2, UMPS, YBX1, BLM, GMNN, MLKL, TLR3, OPTN, RYBP, CHEK1, CDK9, MTOR, VHL, CDKN1B, SERPINB9, MAPK14	CFLAR	SF3B3, DOK2, CASP8, CASP10, RIPK2, FADD, FAS, CASP3, TRAF1, TRAF2, CFLAR, TNFRSF10A, TNFRSF10B, NOD1, TRAF3, RIPK1, RAF1, BCL2L1, DEDD2, DEDD, MAP3K14, NOL3, TP53, ITCH, XRCC6, TNFSF10, ATG3, CBLB, DAXX, FASLG, STUB1, HSP90AA1, SPATS1, SMAD3, GSN, TICAM1, PLIN5, REV3L, USP8

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for CASP8_CFLAR

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CASP8_CFLAR

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CASP8	C1458155	Mammary Neoplasms	3	CTD_human
Hgene	CASP8	C0014859	Esophageal Neoplasms	2	CTD_human
Hgene	CASP8	C0025202	melanoma	2	CTD_human
Hgene	CASP8	C0001418	Adenocarcinoma	1	CTD_human
Hgene	CASP8	C0005586	Bipolar Disorder	1	PSYGENET
Hgene	CASP8	C0007131	Non-Small Cell Lung Carcinoma	1	CTD_human
Hgene	CASP8	C0007873	Uterine Cervical Neoplasm	1	CTD_human
Hgene	CASP8	C0009404	Colorectal Neoplasms	1	CTD_human
Hgene	CASP8	C0011616	Contact Dermatitis	1	CTD_human
Hgene	CASP8	C0011860	Diabetes Mellitus, Non-Insulin-Dependent	1	CTD_human
Hgene	CASP8	C0013604	Edema	1	CTD_human
Hgene	CASP8	C0024121	Lung Neoplasms	1	CTD_human
Hgene	CASP8	C0027055	Myocardial Reperfusion Injury	1	CTD_human
Hgene	CASP8	C0035126	Reperfusion Injury	1	CTD_human
Hgene	CASP8	C0037286	Skin Neoplasms	1	CTD_human
Hgene	CASP8	C0038220	Status Epilepticus	1	CTD_human
Hgene	CASP8	C0038356	Stomach Neoplasms	1	CTD_human
Hgene	CASP8	C0162820	Dermatitis, Allergic Contact	1	CTD_human
Hgene	CASP8	C0950124	Papillomavirus Infections	1	CTD_human
Hgene	CASP8	C1168401	Squamous cell carcinoma of the head and neck	1	CTD_human
Hgene	CASP8	C1846545	Autoimmune Lymphoproliferative Syndrome Type 2B	1	ORPHANET;UNIPROT
Hgene	CASP8	C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	1	CTD_human
Hgene	CASP8	C2937358	Cerebral Hemorrhage	1	CTD_human
Tgene	CFLAR	C0019829	Hodgkin Disease	1	CTD_human
Tgene	CFLAR	C0023418	leukemia	1	CTD_human
Tgene	CFLAR	C0030297	Pancreatic Neoplasm	1	CTD_human
Tgene	CFLAR	C1955906	Lymphoma, Extranodal NK-T-Cell	1	CTD_human
Tgene	CFLAR	C3463824	MYELODYSPLASTIC SYNDROME	1	CTD_human

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Fusion gene ID: 5611

FusionGeneSummary for CASP8_CFLAR

FusionProtFeatures for CASP8_CFLAR

FusionGeneSequence for CASP8_CFLAR

FusionGenePPI for CASP8_CFLAR

RelatedDrugs for CASP8_CFLAR

RelatedDiseases for CASP8_CFLAR