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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5606

FusionGeneSummary for CASP7_UQCRB

check button Fusion gene summary
Fusion gene informationFusion gene name: CASP7_UQCRB
Fusion gene ID: 5606
HgeneTgene
Gene symbol

CASP7

UQCRB

Gene ID

840

7381

Gene namecaspase 7ubiquinol-cytochrome c reductase binding protein
SynonymsCASP-7|CMH-1|ICE-LAP3|LICE2|MCH3MC3DN3|QCR7|QP-C|QPC|UQBC|UQBP|UQCR6|UQPC
Cytomap

10q25.3

8q22.1

Type of geneprotein-codingprotein-coding
Descriptioncaspase-7ICE-like apoptotic protease 3apoptotic protease MCH-3caspase 7, apoptosis-related cysteine peptidasecaspase 7, apoptosis-related cysteine proteasecytochrome b-c1 complex subunit 7complex III subunit 7complex III subunit VIImitochondrial ubiquinone-binding proteinubiquinol-cytochrome c reductase complex 14 kDa proteinubiquinol-cytochrome c reductase, complex III subunit VI
Modification date2018052320180523
UniProtAcc

P55210

P14927

Ensembl transtripts involved in fusion geneENST00000369331, ENST00000369321, 
ENST00000345633, ENST00000369318, 
ENST00000369315, ENST00000452490, 
ENST00000468790, 		ENST00000287022, 
ENST00000517523, ENST00000518406, 
ENST00000523920, 
Fusion gene scores* DoF score5 X 3 X 4=603 X 2 X 2=12
# samples 54
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CASP7 [Title/Abstract] AND UQCRB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCASP7

GO:0006508

proteolysis

12888622

HgeneCASP7

GO:0006915

apoptotic process

17464193


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-R6-A8W8-01BCASP7chr10

115490446

+UQCRBchr8

97247765

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000369331ENST00000287022CASP7chr10

115490446

+UQCRBchr8

97247765

-
3UTR-intronENST00000369331ENST00000517523CASP7chr10

115490446

+UQCRBchr8

97247765

-
3UTR-intronENST00000369331ENST00000518406CASP7chr10

115490446

+UQCRBchr8

97247765

-
3UTR-5UTRENST00000369331ENST00000523920CASP7chr10

115490446

+UQCRBchr8

97247765

-
3UTR-5UTRENST00000369321ENST00000287022CASP7chr10

115490446

+UQCRBchr8

97247765

-
3UTR-intronENST00000369321ENST00000517523CASP7chr10

115490446

+UQCRBchr8

97247765

-
3UTR-intronENST00000369321ENST00000518406CASP7chr10

115490446

+UQCRBchr8

97247765

-
3UTR-5UTRENST00000369321ENST00000523920CASP7chr10

115490446

+UQCRBchr8

97247765

-
3UTR-5UTRENST00000345633ENST00000287022CASP7chr10

115490446

+UQCRBchr8

97247765

-
3UTR-intronENST00000345633ENST00000517523CASP7chr10

115490446

+UQCRBchr8

97247765

-
3UTR-intronENST00000345633ENST00000518406CASP7chr10

115490446

+UQCRBchr8

97247765

-
3UTR-5UTRENST00000345633ENST00000523920CASP7chr10

115490446

+UQCRBchr8

97247765

-
3UTR-5UTRENST00000369318ENST00000287022CASP7chr10

115490446

+UQCRBchr8

97247765

-
3UTR-intronENST00000369318ENST00000517523CASP7chr10

115490446

+UQCRBchr8

97247765

-
3UTR-intronENST00000369318ENST00000518406CASP7chr10

115490446

+UQCRBchr8

97247765

-
3UTR-5UTRENST00000369318ENST00000523920CASP7chr10

115490446

+UQCRBchr8

97247765

-
3UTR-5UTRENST00000369315ENST00000287022CASP7chr10

115490446

+UQCRBchr8

97247765

-
3UTR-intronENST00000369315ENST00000517523CASP7chr10

115490446

+UQCRBchr8

97247765

-
3UTR-intronENST00000369315ENST00000518406CASP7chr10

115490446

+UQCRBchr8

97247765

-
3UTR-5UTRENST00000369315ENST00000523920CASP7chr10

115490446

+UQCRBchr8

97247765

-
intron-5UTRENST00000452490ENST00000287022CASP7chr10

115490446

+UQCRBchr8

97247765

-
intron-intronENST00000452490ENST00000517523CASP7chr10

115490446

+UQCRBchr8

97247765

-
intron-intronENST00000452490ENST00000518406CASP7chr10

115490446

+UQCRBchr8

97247765

-
intron-5UTRENST00000452490ENST00000523920CASP7chr10

115490446

+UQCRBchr8

97247765

-
intron-5UTRENST00000468790ENST00000287022CASP7chr10

115490446

+UQCRBchr8

97247765

-
intron-intronENST00000468790ENST00000517523CASP7chr10

115490446

+UQCRBchr8

97247765

-
intron-intronENST00000468790ENST00000518406CASP7chr10

115490446

+UQCRBchr8

97247765

-
intron-5UTRENST00000468790ENST00000523920CASP7chr10

115490446

+UQCRBchr8

97247765

-

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FusionProtFeatures for CASP7_UQCRB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CASP7

P55210

UQCRB

P14927

This is a component of the ubiquinol-cytochrome creductase complex (complex III or cytochrome b-c1 complex), whichis part of the mitochondrial respiratory chain. This component isinvolved in redox-linked proton pumping.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CASP7_UQCRB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CASP7_UQCRB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CASP7HSPA5, CASP2, BIRC7, BIRC5, XIAP, CASP8, BIRC3, BIRC2, CASP10, TNFRSF1A, BIRC6, TERF1, COPS6, SP1, CCT2, VCP, RB1, PLA2G4B, PARP1, CLSPN, PTGES3, ARHGDIA, VIM, SPTAN1, STAT1, DFFA, ROCK1, CASP3, CASP7, CASP9, GZMB, CAPN1, CNDP2, EEF2, GNS, PEPD, CTSA, EIF4H, GBP2, GINS2, MVD, RPS6KA1, CRYAB, BAX, SAT1, FBXW11UQCRBMAGEA4, MAGEA1, ATP5F1, NDUFS4, UQCRFS1, NDUFB11, SDHA, NDUFB8, COX5A, RPS10, RPL9, RPL23, RPL11, TIMM10, RPL14, RPS2, ACAT1, ALDH1B1, MYL12A, RPS16, RPL6, SLC25A17, CEP76, ACCS, CYC1, UQCRC2, COX7A2L, MYO18A, UHRF1, S100A10, PRKCA, UQCRC1, CYTB, RABL6, UQCR10, UQCRH, COX1, COX6B1, UQCRQ, HSPB1, DDOST, NDUFA12, NDUFA8, NDUFV1, ATP1B1, ATP1B3, COX4I1, NDUFA10, NDUFS1, SDHB, VAPA, VDAC1, NDUFA11, NDUFS3, NDUFA4, PTPMT1, CISD3, C15orf48, APOOL, ACTBL2, TJP1, ACTB


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CASP7_UQCRB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CASP7_UQCRB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCASP7C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneCASP7C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCASP7C0027055Myocardial Reperfusion Injury1CTD_human
HgeneCASP7C0042900Vitiligo1CTD_human
HgeneCASP7C1458155Mammary Neoplasms1CTD_human