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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5604

FusionGeneSummary for CASP7_LRRC27

check button Fusion gene summary
Fusion gene informationFusion gene name: CASP7_LRRC27
Fusion gene ID: 5604
HgeneTgene
Gene symbol

CASP7

LRRC27

Gene ID

840

80313

Gene namecaspase 7leucine rich repeat containing 27
SynonymsCASP-7|CMH-1|ICE-LAP3|LICE2|MCH3-
Cytomap

10q25.3

10q26.3

Type of geneprotein-codingprotein-coding
Descriptioncaspase-7ICE-like apoptotic protease 3apoptotic protease MCH-3caspase 7, apoptosis-related cysteine peptidasecaspase 7, apoptosis-related cysteine proteaseleucine-rich repeat-containing protein 27testicular tissue protein Li 108
Modification date2018052320180523
UniProtAcc

P55210

Q9C0I9

Ensembl transtripts involved in fusion geneENST00000369331, ENST00000369321, 
ENST00000345633, ENST00000369318, 
ENST00000369315, ENST00000452490, 
ENST00000468790, 
ENST00000368615, 
ENST00000392638, ENST00000344079, 
ENST00000356571, ENST00000368614, 
ENST00000368613, ENST00000368612, 
ENST00000368610, ENST00000432555, 
ENST00000475747, 
Fusion gene scores* DoF score5 X 3 X 4=604 X 4 X 6=96
# samples 56
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CASP7 [Title/Abstract] AND LRRC27 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCASP7

GO:0006508

proteolysis

12888622

HgeneCASP7

GO:0006915

apoptotic process

17464193


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-TP-A8TT-01ACASP7chr10

115439737

+LRRC27chr10

134165111

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000369331ENST00000368615CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-3CDSENST00000369331ENST00000392638CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-3CDSENST00000369331ENST00000344079CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-intronENST00000369331ENST00000356571CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-intronENST00000369331ENST00000368614CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-intronENST00000369331ENST00000368613CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-intronENST00000369331ENST00000368612CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-intronENST00000369331ENST00000368610CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-intronENST00000369331ENST00000432555CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-3UTRENST00000369331ENST00000475747CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-3CDSENST00000369321ENST00000368615CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-3CDSENST00000369321ENST00000392638CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-3CDSENST00000369321ENST00000344079CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-intronENST00000369321ENST00000356571CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-intronENST00000369321ENST00000368614CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-intronENST00000369321ENST00000368613CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-intronENST00000369321ENST00000368612CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-intronENST00000369321ENST00000368610CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-intronENST00000369321ENST00000432555CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-3UTRENST00000369321ENST00000475747CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-3CDSENST00000345633ENST00000368615CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-3CDSENST00000345633ENST00000392638CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-3CDSENST00000345633ENST00000344079CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-intronENST00000345633ENST00000356571CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-intronENST00000345633ENST00000368614CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-intronENST00000345633ENST00000368613CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-intronENST00000345633ENST00000368612CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-intronENST00000345633ENST00000368610CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-intronENST00000345633ENST00000432555CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-3UTRENST00000345633ENST00000475747CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-3CDSENST00000369318ENST00000368615CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-3CDSENST00000369318ENST00000392638CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-3CDSENST00000369318ENST00000344079CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-intronENST00000369318ENST00000356571CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-intronENST00000369318ENST00000368614CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-intronENST00000369318ENST00000368613CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-intronENST00000369318ENST00000368612CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-intronENST00000369318ENST00000368610CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-intronENST00000369318ENST00000432555CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-3UTRENST00000369318ENST00000475747CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-3CDSENST00000369315ENST00000368615CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-3CDSENST00000369315ENST00000392638CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-3CDSENST00000369315ENST00000344079CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-intronENST00000369315ENST00000356571CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-intronENST00000369315ENST00000368614CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-intronENST00000369315ENST00000368613CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-intronENST00000369315ENST00000368612CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-intronENST00000369315ENST00000368610CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-intronENST00000369315ENST00000432555CASP7chr10

115439737

+LRRC27chr10

134165111

+
5UTR-3UTRENST00000369315ENST00000475747CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-3CDSENST00000452490ENST00000368615CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-3CDSENST00000452490ENST00000392638CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-3CDSENST00000452490ENST00000344079CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-intronENST00000452490ENST00000356571CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-intronENST00000452490ENST00000368614CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-intronENST00000452490ENST00000368613CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-intronENST00000452490ENST00000368612CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-intronENST00000452490ENST00000368610CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-intronENST00000452490ENST00000432555CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-3UTRENST00000452490ENST00000475747CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-3CDSENST00000468790ENST00000368615CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-3CDSENST00000468790ENST00000392638CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-3CDSENST00000468790ENST00000344079CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-intronENST00000468790ENST00000356571CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-intronENST00000468790ENST00000368614CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-intronENST00000468790ENST00000368613CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-intronENST00000468790ENST00000368612CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-intronENST00000468790ENST00000368610CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-intronENST00000468790ENST00000432555CASP7chr10

115439737

+LRRC27chr10

134165111

+
intron-3UTRENST00000468790ENST00000475747CASP7chr10

115439737

+LRRC27chr10

134165111

+

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FusionProtFeatures for CASP7_LRRC27


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CASP7

P55210

LRRC27

Q9C0I9


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CASP7_LRRC27


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CASP7_LRRC27


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CASP7HSPA5, CASP2, BIRC7, BIRC5, XIAP, CASP8, BIRC3, BIRC2, CASP10, TNFRSF1A, BIRC6, TERF1, COPS6, SP1, CCT2, VCP, RB1, PLA2G4B, PARP1, CLSPN, PTGES3, ARHGDIA, VIM, SPTAN1, STAT1, DFFA, ROCK1, CASP3, CASP7, CASP9, GZMB, CAPN1, CNDP2, EEF2, GNS, PEPD, CTSA, EIF4H, GBP2, GINS2, MVD, RPS6KA1, CRYAB, BAX, SAT1, FBXW11LRRC27HMOX1, MCM8, SCRIB, IFT52, LRRC40, POLA2, WDR19, BBS7, PJA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CASP7_LRRC27


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CASP7_LRRC27


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCASP7C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneCASP7C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCASP7C0027055Myocardial Reperfusion Injury1CTD_human
HgeneCASP7C0042900Vitiligo1CTD_human
HgeneCASP7C1458155Mammary Neoplasms1CTD_human