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Fusion gene ID: 5587 |
FusionGeneSummary for CASKIN2_PDE2A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CASKIN2_PDE2A | Fusion gene ID: 5587 | Hgene | Tgene | Gene symbol | CASKIN2 | PDE2A | Gene ID | 57513 | 5138 |
| Gene name | CASK interacting protein 2 | phosphodiesterase 2A | |
| Synonyms | ANKS5B | CGS-PDE|PDE2A1|PED2A4|cGSPDE | |
| Cytomap | 17q25.1 | 11q13.4 | |
| Type of gene | protein-coding | protein-coding | |
| Description | caskin-2 | cGMP-dependent 3',5'-cyclic phosphodiesterasecGMP-stimulated phosphodiesterase 1cGMP-stimulated phosphodiesterase 2cGMP-stimulated phosphodiesterase 4cyclic GMP-stimulated phosphodiesterasephosphodiesterase 2A, cGMP-stimulated | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8WXE0 | O00408 | |
| Ensembl transtripts involved in fusion gene | ENST00000321617, ENST00000433559, ENST00000581870, | ENST00000334456, ENST00000376450, ENST00000444035, ENST00000544570, ENST00000418754, ENST00000540345, ENST00000540380, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 9 X 5 X 6=270 |
| # samples | 2 | 9 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(9/270*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CASKIN2 [Title/Abstract] AND PDE2A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PDE2A | GO:0000122 | negative regulation of transcription by RNA polymerase II | 17329248 |
| Tgene | PDE2A | GO:0006198 | cAMP catabolic process | 15938621|17704206 |
| Tgene | PDE2A | GO:0033159 | negative regulation of protein import into nucleus, translocation | 17329248 |
| Tgene | PDE2A | GO:0036006 | cellular response to macrophage colony-stimulating factor stimulus | 14687666 |
| Tgene | PDE2A | GO:0043951 | negative regulation of cAMP-mediated signaling | 17329248 |
| Tgene | PDE2A | GO:0046069 | cGMP catabolic process | 15938621|19828435 |
| Tgene | PDE2A | GO:0071320 | cellular response to cAMP | 17329248 |
| Tgene | PDE2A | GO:0071321 | cellular response to cGMP | 17704206|19828435 |
| Tgene | PDE2A | GO:1904613 | cellular response to 2,3,7,8-tetrachlorodibenzodioxine | 17329248 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-YL-A8SF-01A | CASKIN2 | chr17 | 73509792 | - | PDE2A | chr11 | 72353370 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000321617 | ENST00000334456 | CASKIN2 | chr17 | 73509792 | - | PDE2A | chr11 | 72353370 | - |
| In-frame | ENST00000321617 | ENST00000376450 | CASKIN2 | chr17 | 73509792 | - | PDE2A | chr11 | 72353370 | - |
| Frame-shift | ENST00000321617 | ENST00000444035 | CASKIN2 | chr17 | 73509792 | - | PDE2A | chr11 | 72353370 | - |
| In-frame | ENST00000321617 | ENST00000544570 | CASKIN2 | chr17 | 73509792 | - | PDE2A | chr11 | 72353370 | - |
| Frame-shift | ENST00000321617 | ENST00000418754 | CASKIN2 | chr17 | 73509792 | - | PDE2A | chr11 | 72353370 | - |
| Frame-shift | ENST00000321617 | ENST00000540345 | CASKIN2 | chr17 | 73509792 | - | PDE2A | chr11 | 72353370 | - |
| 5CDS-intron | ENST00000321617 | ENST00000540380 | CASKIN2 | chr17 | 73509792 | - | PDE2A | chr11 | 72353370 | - |
| intron-3CDS | ENST00000433559 | ENST00000334456 | CASKIN2 | chr17 | 73509792 | - | PDE2A | chr11 | 72353370 | - |
| intron-3CDS | ENST00000433559 | ENST00000376450 | CASKIN2 | chr17 | 73509792 | - | PDE2A | chr11 | 72353370 | - |
| intron-3CDS | ENST00000433559 | ENST00000444035 | CASKIN2 | chr17 | 73509792 | - | PDE2A | chr11 | 72353370 | - |
| intron-3CDS | ENST00000433559 | ENST00000544570 | CASKIN2 | chr17 | 73509792 | - | PDE2A | chr11 | 72353370 | - |
| intron-3CDS | ENST00000433559 | ENST00000418754 | CASKIN2 | chr17 | 73509792 | - | PDE2A | chr11 | 72353370 | - |
| intron-3CDS | ENST00000433559 | ENST00000540345 | CASKIN2 | chr17 | 73509792 | - | PDE2A | chr11 | 72353370 | - |
| intron-intron | ENST00000433559 | ENST00000540380 | CASKIN2 | chr17 | 73509792 | - | PDE2A | chr11 | 72353370 | - |
| Frame-shift | ENST00000581870 | ENST00000334456 | CASKIN2 | chr17 | 73509792 | - | PDE2A | chr11 | 72353370 | - |
| In-frame | ENST00000581870 | ENST00000376450 | CASKIN2 | chr17 | 73509792 | - | PDE2A | chr11 | 72353370 | - |
| Frame-shift | ENST00000581870 | ENST00000444035 | CASKIN2 | chr17 | 73509792 | - | PDE2A | chr11 | 72353370 | - |
| In-frame | ENST00000581870 | ENST00000544570 | CASKIN2 | chr17 | 73509792 | - | PDE2A | chr11 | 72353370 | - |
| Frame-shift | ENST00000581870 | ENST00000418754 | CASKIN2 | chr17 | 73509792 | - | PDE2A | chr11 | 72353370 | - |
| Frame-shift | ENST00000581870 | ENST00000540345 | CASKIN2 | chr17 | 73509792 | - | PDE2A | chr11 | 72353370 | - |
| 5CDS-intron | ENST00000581870 | ENST00000540380 | CASKIN2 | chr17 | 73509792 | - | PDE2A | chr11 | 72353370 | - |
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FusionProtFeatures for CASKIN2_PDE2A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CASKIN2 | PDE2A |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CASKIN2_PDE2A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CASKIN2_ENST00000321617_chr17_73509792_-_PDE2A_ENST00000376450_chr11_72353370_-_31aa >In-frame_CASKIN2_ENST00000321617_chr17_73509792_-_PDE2A_ENST00000544570_chr11_72353370_-_31aa >In-frame_CASKIN2_ENST00000581870_chr17_73509792_-_PDE2A_ENST00000376450_chr11_72353370_-_31aa >In-frame_CASKIN2_ENST00000581870_chr17_73509792_-_PDE2A_ENST00000544570_chr11_72353370_-_31aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CASKIN2_ENST00000321617_chr17_73509792_-_PDE2A_ENST00000376450_chr11_72353370_-_94nt ATGGGTCGTGAACAGGACCTGATCCTCGCCGTCAAGAATGGAGATGTGACCGGTGTGCAGAAACTGGTGGCGAAGGTCAAGGCCACAAAG >In-frame_CASKIN2_ENST00000321617_chr17_73509792_-_PDE2A_ENST00000544570_chr11_72353370_-_94nt ATGGGTCGTGAACAGGACCTGATCCTCGCCGTCAAGAATGGAGATGTGACCGGTGTGCAGAAACTGGTGGCGAAGGTCAAGGCCACAAAG >In-frame_CASKIN2_ENST00000581870_chr17_73509792_-_PDE2A_ENST00000376450_chr11_72353370_-_94nt ATGGGTCGTGAACAGGACCTGATCCTCGCCGTCAAGAATGGAGATGTGACCGGTGTGCAGAAACTGGTGGCGAAGGTCAAGGCCACAAAG >In-frame_CASKIN2_ENST00000581870_chr17_73509792_-_PDE2A_ENST00000544570_chr11_72353370_-_94nt ATGGGTCGTGAACAGGACCTGATCCTCGCCGTCAAGAATGGAGATGTGACCGGTGTGCAGAAACTGGTGGCGAAGGTCAAGGCCACAAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CASKIN2_ENST00000321617_chr17_73509792_-_PDE2A_ENST00000376450_chr11_72353370_-_2728nt GACGGTCCCTCCGTTCCCGATCCGGCGGGAGGGAGGGGGGAGGGGCGGGATTTCCTGCGGGAGGCGCCGAGCCGGCCTTGGAAAAGGAGA AGGAGAAAGGGGGGCAGGGGGGAGTGGGAGCCACCGTCCTGAGTGCCAGGGACCGAGCAGGGCCAGCCGGACCCCGGCGGGCGGCCGGGA GAGAGCCCTGAGACCAGTGCACCGCTGCTGCCTGAGGCCCAAGGGAATGCTGGCTGCTCTCTGGGTGGGCACTGGTGTTCCACAGCCAAG CCGGGAAGATTGGTGTGCCCAGTCCCAGCCCATCCTGGAGCTGTCGGAAGCCACAAGCTGATATCCATCCAGATTTCCATGTAGCCTTCA CCCCCTCAAAGATTAGCTTTCCTTCGTGTGGTGGCAGTTCACGGAGCACCTTTGGGAGTATCCCTCAGTACCTGACGAGGAGCCCACTGC CTGGGACACCTGACTTGCTCCCCCGGAACCGGGAGCCCTCCAAGGGGCTGTGGCATGGCGCCCTGACGCCCCAGCTTGGACCCGTTGCCT GCCTTTGCCCTGGACTCCTGAGTGTAGAGCTCAGCCCAGGAGCCAGTATGGGTCGTGAACAGGACCTGATCCTCGCCGTCAAGAATGGAG ATGTGACCGGTGTGCAGAAACTGGTGGCGAAGGTCAAGGCCACAAAGACAAGACGCGCTGACCGAGCGCAGCGGCCGGGCCGGCGGGCGG GCGGGCGGCTGCGAGCATGGTCCTGGTGCTGCACCACATCCTCATCGCTGTTGTCCAATTCCTCAGGCGGGGCCAGCAGGTCTTCCTCAA GCCGGACGAGCCGCCGCCGCCGCCGCAGCCATGCGCCGACAGCCTGCAGGACGCCTTGCTGAGTCTGGGCTCTGTCATCGACATTTCAGG CCTGCAACGTGCTGTCAAGGAGGCCCTGTCAGCTGTGCTCCCCCGAGTGGAAACTGTCTACACCTACCTACTGGATGGTGAGTCCCAGCT GGTGTGTGAGGACCCCCCACATGAGCTGCCCCAGGAGGGGAAAGTCCGGTTCACCGACGAGGACGAGCATGTGATCCAGCACTGCTTCCA CTACACCAGCACCGTGCTCACCAGCACCCTGGCCTTCCAGAAGGAACAGAAACTCAAGTGTGAGTGCCAGGCTCTTCTCCAAGTGGCAAA GAACCTCTTCACCCACCTGGATGACGTCTCTGTCCTGCTCCAGGAGATCATCACGGAGGCCAGAAACCTCAGCAACGCAGAGATCTGCTC TGTGTTCCTGCTGGATCAGAATGAGCTGGTGGCCAAGGTGTTCGACGGGGGCGTGGTGGATGATGAGAGCTATGAGATCCGCATCCCGGC CGATCAGGGCATCGCGGGACACGTGGCGACCACGGGCCAGATCCTGAACATCCCTGACGCATATGCCCATCCGCTTTTCTACCGCGGCGT GGACGACAGCACCGGCTTCCGCACGCGCAACATCCTCTGCTTCCCCATCAAGAACGAGAACCAGGAGGTCATCGGTGTGGCCGAGCTGGT GAACAAGATCAATGGGCCATGGTTCAGCAAGTTCGACGAGGACCTGGCGACGGCCTTCTCCATCTACTGCGGCATCAGCATCGCCCATTC TCTCCTATACAAAAAAGTGAATGAGGCTCAGTATCGCAGCCACCTGGCCAATGAGATGATGATGTACCACATGAAGGTCTCCGATGATGA GTATACCAAACTTCTCCATGATGGGATCCAGCCTGTGGCTGCCATTGACTCCAATTTTGCAAGTTTCACCTATACCCCTCGTTCCCTGCC CGAGGATGACACGTCCATGGCCATCCTGAGCATGCTGCAGGACATGAATTTCATCAACAACTACAAAATTGACTGCCCGACCCTGGCCCG GTTCTGTTTGATGGTGAAGAAGGGCTACCGGGATCCCCCCTACCACAACTGGATGCACGCCTTTTCTGTCTCCCACTTCTGCTACCTGCT CTACAAGAACCTGGAGCTCACCAACTACCTCGAGGACATCGAGATCTTTGCCTTGTTTATTTCCTGCATGTGTCATGACCTGGACCACAG AGGCACAAACAACTCTTTCCAGGTGGCCTCGAAATCTGTGCTGGCTGCGCTCTACAGCTCTGAGGGCTCCGTCATGGAGAGGCACCACTT TGCTCAGGCCATCGCCATCCTCAACACCCACGGCTGCAACATCTTTGATCATTTCTCCCGGAAGGACTATCAGCGCATGCTGGATCTGAT GCGGGACATCATCTTGGCCACAGACCTGGCCCACCATCTCCGCATCTTCAAGGACCTCCAGAAGATGGCTGAGGTGGGCTACGACCGAAA CAACAAGCAGCACCACAGACTTCTCCTCTGCCTCCTCATGACCTCCTGTGACCTCTCTGACCAGACCAAGGGCTGGAAGACTACGAGAAA GATCGCGGAGCTGATCTACAAAGAATTCTTCTCCCAGGGAGACCTGGAGAAGGCCATGGGCAACAGGCCGATGGAGATGATGGACCGGGA GAAGGCCTATATCCCTGAGCTGCAAATCAGCTTCATGGAGCACATTGCAATGCCCATCTACAAGCAGACGGCTAATCCACATGGTCTTCG TCCTTGACGTCGTTTTACAAGAAAACAATGGGGCTGGTTTTGCTTCCCCGTGCATGATTTACTCTTAGAGATGATTCAGAGGTCACTTCA >In-frame_CASKIN2_ENST00000321617_chr17_73509792_-_PDE2A_ENST00000544570_chr11_72353370_-_3504nt GACGGTCCCTCCGTTCCCGATCCGGCGGGAGGGAGGGGGGAGGGGCGGGATTTCCTGCGGGAGGCGCCGAGCCGGCCTTGGAAAAGGAGA AGGAGAAAGGGGGGCAGGGGGGAGTGGGAGCCACCGTCCTGAGTGCCAGGGACCGAGCAGGGCCAGCCGGACCCCGGCGGGCGGCCGGGA GAGAGCCCTGAGACCAGTGCACCGCTGCTGCCTGAGGCCCAAGGGAATGCTGGCTGCTCTCTGGGTGGGCACTGGTGTTCCACAGCCAAG CCGGGAAGATTGGTGTGCCCAGTCCCAGCCCATCCTGGAGCTGTCGGAAGCCACAAGCTGATATCCATCCAGATTTCCATGTAGCCTTCA CCCCCTCAAAGATTAGCTTTCCTTCGTGTGGTGGCAGTTCACGGAGCACCTTTGGGAGTATCCCTCAGTACCTGACGAGGAGCCCACTGC CTGGGACACCTGACTTGCTCCCCCGGAACCGGGAGCCCTCCAAGGGGCTGTGGCATGGCGCCCTGACGCCCCAGCTTGGACCCGTTGCCT GCCTTTGCCCTGGACTCCTGAGTGTAGAGCTCAGCCCAGGAGCCAGTATGGGTCGTGAACAGGACCTGATCCTCGCCGTCAAGAATGGAG ATGTGACCGGTGTGCAGAAACTGGTGGCGAAGGTCAAGGCCACAAAGACAAACTCGGGCGGACCAGGCGAAGCTGTCGCGGACGCGCTGA CCGAGCGCAGCGGCCGGGCCGGCGGGCGGGCGGGCGGCTGCGAGCATGGTCCTGGTGCTGCACCACATCCTCATCGCTGTTGTCCAATTC CTCAGGCGGGGCCAGCAGGTCTTCCTCAAGCCGGACGAGCCGCCGCCGCCGCCGCAGCCATGCGCCGACAGCCTGCAGGACGCCTTGCTG AGTCTGGGCTCTGTCATCGACATTTCAGGCCTGCAACGTGCTGTCAAGGAGGCCCTGTCAGCTGTGCTCCCCCGAGTGGAAACTGTCTAC ACCTACCTACTGGATGGTGAGTCCCAGCTGGTGTGTGAGGACCCCCCACATGAGCTGCCCCAGGAGGGGAAAGTCCGGGAGGCTATCATC TCCCAGAAGCGGCTGGGCTGCAATGGGCTGGGCTTCTCAGACCTGCCAGGGAAGCCCTTGGCCAGGCTGGTGGCTCCACTGGCTCCTGAT ACCCAAGTGCTGGTCATGCCGCTAGCGGACAAGGAGGCTGGGGCCGTGGCAGCTGTCATCTTGGTGCACTGTGGCCAGCTGAGTGATAAT GAGGAATGGAGCCTGCAGGCGGTGGAGAAGCATACCCTGGTCGCCCTGCGGAGGGTGCAGGTCCTGCAGCAGCGCGGGCCCAGGGAGGCT CCCCGAGCCGTCCAGAACCCCCCGGAGGGGACGGCGGAAGACCAGAAGGGCGGGGCGGCGTACACCGACCGCGACCGCAAGATCCTCCAA CTGTGCGGGGAACTCTACGACCTGGATGCCTCTTCCCTGCAGCTCAAAGTGCTCCAATACCTGCAGCAGGAGACCCGGGCATCCCGCTGC TGCCTCCTGCTGGTGTCGGAGGACAATCTCCAGCTTTCTTGCAAGGTCATCGGAGACAAAGTGCTCGGGGAAGAGGTCAGCTTTCCCTTG ACAGGATGCCTGGGCCAGGTGGTGGAAGACAAGAAGTCCATCCAGCTGAAGGACCTCACCTCCGAGGATGTACAACAGCTGCAGAGCATG TTGGGCTGTGAGCTGCAGGCCATGCTCTGTGTCCCTGTCATCAGCCGGGCCACTGACCAGGTGGTGGCCTTGGCCTGCGCCTTCAACAAG CTAGAAGGAGACTTGTTCACCGACGAGGACGAGCATGTGATCCAGCACTGCTTCCACTACACCAGCACCGTGCTCACCAGCACCCTGGCC TTCCAGAAGGAACAGAAACTCAAGTGTGAGTGCCAGGCTCTTCTCCAAGTGGCAAAGAACCTCTTCACCCACCTGGATGACGTCTCTGTC CTGCTCCAGGAGATCATCACGGAGGCCAGAAACCTCAGCAACGCAGAGATCTGCTCTGTGTTCCTGCTGGATCAGAATGAGCTGGTGGCC AAGGTGTTCGACGGGGGCGTGGTGGATGATGAGAGCTATGAGATCCGCATCCCGGCCGATCAGGGCATCGCGGGACACGTGGCGACCACG GGCCAGATCCTGAACATCCCTGACGCATATGCCCATCCGCTTTTCTACCGCGGCGTGGACGACAGCACCGGCTTCCGCACGCGCAACATC CTCTGCTTCCCCATCAAGAACGAGAACCAGGAGGTCATCGGTGTGGCCGAGCTGGTGAACAAGATCAATGGGCCATGGTTCAGCAAGTTC GACGAGGACCTGGCGACGGCCTTCTCCATCTACTGCGGCATCAGCATCGCCCATTCTCTCCTATACAAAAAAGTGAATGAGGCTCAGTAT CGCAGCCACCTGGCCAATGAGATGATGATGTACCACATGAAGGTCTCCGATGATGAGTATACCAAACTTCTCCATGATGGGATCCAGCCT GTGGCTGCCATTGACTCCAATTTTGCAAGTTTCACCTATACCCCTCGTTCCCTGCCCGAGGATGACACGTCCATGGCCATCCTGAGCATG CTGCAGGACATGAATTTCATCAACAACTACAAAATTGACTGCCCGACCCTGGCCCGGTTCTGTTTGATGGTGAAGAAGGGCTACCGGGAT CCCCCCTACCACAACTGGATGCACGCCTTTTCTGTCTCCCACTTCTGCTACCTGCTCTACAAGAACCTGGAGCTCACCAACTACCTCGAG GACATCGAGATCTTTGCCTTGTTTATTTCCTGCATGTGTCATGACCTGGACCACAGAGGCACAAACAACTCTTTCCAGGTGGCCTCGAAA TCTGTGCTGGCTGCGCTCTACAGCTCTGAGGGCTCCGTCATGGAGAGGCACCACTTTGCTCAGGCCATCGCCATCCTCAACACCCACGGC TGCAACATCTTTGATCATTTCTCCCGGAAGGACTATCAGCGCATGCTGGATCTGATGCGGGACATCATCTTGGCCACAGACCTGGCCCAC CATCTCCGCATCTTCAAGGACCTCCAGAAGATGGCTGAGGTGGGCTACGACCGAAACAACAAGCAGCACCACAGACTTCTCCTCTGCCTC CTCATGACCTCCTGTGACCTCTCTGACCAGACCAAGGGCTGGAAGACTACGAGAAAGATCGCGGAGCTGATCTACAAAGAATTCTTCTCC CAGGGAGACCTGGAGAAGGCCATGGGCAACAGGCCGATGGAGATGATGGACCGGGAGAAGGCCTATATCCCTGAGCTGCAAATCAGCTTC ATGGAGCACATTGCAATGCCCATCTACAAGCAGACGGCTAATCCACATGGTCTTCGTCCTTGACGTCGTTTTACAAGAAAACAATGGGGC >In-frame_CASKIN2_ENST00000581870_chr17_73509792_-_PDE2A_ENST00000376450_chr11_72353370_-_2585nt CGAGCAGGGCCAGCCGGACCCCGGCGGGCGGCCGGGAGAGAGCCCTGAGACCAGTGCACCGCTGCTGCCTGAGGCCCAAGGGAATGCTGG CTGCTCTCTGGGTGGGCACTGGTGTTCCACAGCCAAGCCGGGAAGATTGGTGTGCCCAGTCCCAGCCCATCCTGGAGCTGTCGGAAGCCA CAAGCTGATATCCATCCAGATTTCCATGTAGCCTTCACCCCCTCAAAGATTAGCTTTCCTTCGTGTGGTGGCAGTTCACGGAGCACCTTT GGGAGTATCCCTCAGTACCTGACGAGGAGCCCACTGCCTGGGACACCTGACTTGCTCCCCCGGAACCGGGAGCCCTCCAAGGGGCTGTGG CATGGCGCCCTGACGCCCCAGCTTGGACCCGTTGCCTGCCTTTGCCCTGGACTCCTGAGTGTAGAGCTCAGCCCAGGAGCCAGTATGGGT CGTGAACAGGACCTGATCCTCGCCGTCAAGAATGGAGATGTGACCGGTGTGCAGAAACTGGTGGCGAAGGTCAAGGCCACAAAGACAAGA CGCGCTGACCGAGCGCAGCGGCCGGGCCGGCGGGCGGGCGGGCGGCTGCGAGCATGGTCCTGGTGCTGCACCACATCCTCATCGCTGTTG TCCAATTCCTCAGGCGGGGCCAGCAGGTCTTCCTCAAGCCGGACGAGCCGCCGCCGCCGCCGCAGCCATGCGCCGACAGCCTGCAGGACG CCTTGCTGAGTCTGGGCTCTGTCATCGACATTTCAGGCCTGCAACGTGCTGTCAAGGAGGCCCTGTCAGCTGTGCTCCCCCGAGTGGAAA CTGTCTACACCTACCTACTGGATGGTGAGTCCCAGCTGGTGTGTGAGGACCCCCCACATGAGCTGCCCCAGGAGGGGAAAGTCCGGTTCA CCGACGAGGACGAGCATGTGATCCAGCACTGCTTCCACTACACCAGCACCGTGCTCACCAGCACCCTGGCCTTCCAGAAGGAACAGAAAC TCAAGTGTGAGTGCCAGGCTCTTCTCCAAGTGGCAAAGAACCTCTTCACCCACCTGGATGACGTCTCTGTCCTGCTCCAGGAGATCATCA CGGAGGCCAGAAACCTCAGCAACGCAGAGATCTGCTCTGTGTTCCTGCTGGATCAGAATGAGCTGGTGGCCAAGGTGTTCGACGGGGGCG TGGTGGATGATGAGAGCTATGAGATCCGCATCCCGGCCGATCAGGGCATCGCGGGACACGTGGCGACCACGGGCCAGATCCTGAACATCC CTGACGCATATGCCCATCCGCTTTTCTACCGCGGCGTGGACGACAGCACCGGCTTCCGCACGCGCAACATCCTCTGCTTCCCCATCAAGA ACGAGAACCAGGAGGTCATCGGTGTGGCCGAGCTGGTGAACAAGATCAATGGGCCATGGTTCAGCAAGTTCGACGAGGACCTGGCGACGG CCTTCTCCATCTACTGCGGCATCAGCATCGCCCATTCTCTCCTATACAAAAAAGTGAATGAGGCTCAGTATCGCAGCCACCTGGCCAATG AGATGATGATGTACCACATGAAGGTCTCCGATGATGAGTATACCAAACTTCTCCATGATGGGATCCAGCCTGTGGCTGCCATTGACTCCA ATTTTGCAAGTTTCACCTATACCCCTCGTTCCCTGCCCGAGGATGACACGTCCATGGCCATCCTGAGCATGCTGCAGGACATGAATTTCA TCAACAACTACAAAATTGACTGCCCGACCCTGGCCCGGTTCTGTTTGATGGTGAAGAAGGGCTACCGGGATCCCCCCTACCACAACTGGA TGCACGCCTTTTCTGTCTCCCACTTCTGCTACCTGCTCTACAAGAACCTGGAGCTCACCAACTACCTCGAGGACATCGAGATCTTTGCCT TGTTTATTTCCTGCATGTGTCATGACCTGGACCACAGAGGCACAAACAACTCTTTCCAGGTGGCCTCGAAATCTGTGCTGGCTGCGCTCT ACAGCTCTGAGGGCTCCGTCATGGAGAGGCACCACTTTGCTCAGGCCATCGCCATCCTCAACACCCACGGCTGCAACATCTTTGATCATT TCTCCCGGAAGGACTATCAGCGCATGCTGGATCTGATGCGGGACATCATCTTGGCCACAGACCTGGCCCACCATCTCCGCATCTTCAAGG ACCTCCAGAAGATGGCTGAGGTGGGCTACGACCGAAACAACAAGCAGCACCACAGACTTCTCCTCTGCCTCCTCATGACCTCCTGTGACC TCTCTGACCAGACCAAGGGCTGGAAGACTACGAGAAAGATCGCGGAGCTGATCTACAAAGAATTCTTCTCCCAGGGAGACCTGGAGAAGG CCATGGGCAACAGGCCGATGGAGATGATGGACCGGGAGAAGGCCTATATCCCTGAGCTGCAAATCAGCTTCATGGAGCACATTGCAATGC CCATCTACAAGCAGACGGCTAATCCACATGGTCTTCGTCCTTGACGTCGTTTTACAAGAAAACAATGGGGCTGGTTTTGCTTCCCCGTGC >In-frame_CASKIN2_ENST00000581870_chr17_73509792_-_PDE2A_ENST00000544570_chr11_72353370_-_3361nt CGAGCAGGGCCAGCCGGACCCCGGCGGGCGGCCGGGAGAGAGCCCTGAGACCAGTGCACCGCTGCTGCCTGAGGCCCAAGGGAATGCTGG CTGCTCTCTGGGTGGGCACTGGTGTTCCACAGCCAAGCCGGGAAGATTGGTGTGCCCAGTCCCAGCCCATCCTGGAGCTGTCGGAAGCCA CAAGCTGATATCCATCCAGATTTCCATGTAGCCTTCACCCCCTCAAAGATTAGCTTTCCTTCGTGTGGTGGCAGTTCACGGAGCACCTTT GGGAGTATCCCTCAGTACCTGACGAGGAGCCCACTGCCTGGGACACCTGACTTGCTCCCCCGGAACCGGGAGCCCTCCAAGGGGCTGTGG CATGGCGCCCTGACGCCCCAGCTTGGACCCGTTGCCTGCCTTTGCCCTGGACTCCTGAGTGTAGAGCTCAGCCCAGGAGCCAGTATGGGT CGTGAACAGGACCTGATCCTCGCCGTCAAGAATGGAGATGTGACCGGTGTGCAGAAACTGGTGGCGAAGGTCAAGGCCACAAAGACAAAC TCGGGCGGACCAGGCGAAGCTGTCGCGGACGCGCTGACCGAGCGCAGCGGCCGGGCCGGCGGGCGGGCGGGCGGCTGCGAGCATGGTCCT GGTGCTGCACCACATCCTCATCGCTGTTGTCCAATTCCTCAGGCGGGGCCAGCAGGTCTTCCTCAAGCCGGACGAGCCGCCGCCGCCGCC GCAGCCATGCGCCGACAGCCTGCAGGACGCCTTGCTGAGTCTGGGCTCTGTCATCGACATTTCAGGCCTGCAACGTGCTGTCAAGGAGGC CCTGTCAGCTGTGCTCCCCCGAGTGGAAACTGTCTACACCTACCTACTGGATGGTGAGTCCCAGCTGGTGTGTGAGGACCCCCCACATGA GCTGCCCCAGGAGGGGAAAGTCCGGGAGGCTATCATCTCCCAGAAGCGGCTGGGCTGCAATGGGCTGGGCTTCTCAGACCTGCCAGGGAA GCCCTTGGCCAGGCTGGTGGCTCCACTGGCTCCTGATACCCAAGTGCTGGTCATGCCGCTAGCGGACAAGGAGGCTGGGGCCGTGGCAGC TGTCATCTTGGTGCACTGTGGCCAGCTGAGTGATAATGAGGAATGGAGCCTGCAGGCGGTGGAGAAGCATACCCTGGTCGCCCTGCGGAG GGTGCAGGTCCTGCAGCAGCGCGGGCCCAGGGAGGCTCCCCGAGCCGTCCAGAACCCCCCGGAGGGGACGGCGGAAGACCAGAAGGGCGG GGCGGCGTACACCGACCGCGACCGCAAGATCCTCCAACTGTGCGGGGAACTCTACGACCTGGATGCCTCTTCCCTGCAGCTCAAAGTGCT CCAATACCTGCAGCAGGAGACCCGGGCATCCCGCTGCTGCCTCCTGCTGGTGTCGGAGGACAATCTCCAGCTTTCTTGCAAGGTCATCGG AGACAAAGTGCTCGGGGAAGAGGTCAGCTTTCCCTTGACAGGATGCCTGGGCCAGGTGGTGGAAGACAAGAAGTCCATCCAGCTGAAGGA CCTCACCTCCGAGGATGTACAACAGCTGCAGAGCATGTTGGGCTGTGAGCTGCAGGCCATGCTCTGTGTCCCTGTCATCAGCCGGGCCAC TGACCAGGTGGTGGCCTTGGCCTGCGCCTTCAACAAGCTAGAAGGAGACTTGTTCACCGACGAGGACGAGCATGTGATCCAGCACTGCTT CCACTACACCAGCACCGTGCTCACCAGCACCCTGGCCTTCCAGAAGGAACAGAAACTCAAGTGTGAGTGCCAGGCTCTTCTCCAAGTGGC AAAGAACCTCTTCACCCACCTGGATGACGTCTCTGTCCTGCTCCAGGAGATCATCACGGAGGCCAGAAACCTCAGCAACGCAGAGATCTG CTCTGTGTTCCTGCTGGATCAGAATGAGCTGGTGGCCAAGGTGTTCGACGGGGGCGTGGTGGATGATGAGAGCTATGAGATCCGCATCCC GGCCGATCAGGGCATCGCGGGACACGTGGCGACCACGGGCCAGATCCTGAACATCCCTGACGCATATGCCCATCCGCTTTTCTACCGCGG CGTGGACGACAGCACCGGCTTCCGCACGCGCAACATCCTCTGCTTCCCCATCAAGAACGAGAACCAGGAGGTCATCGGTGTGGCCGAGCT GGTGAACAAGATCAATGGGCCATGGTTCAGCAAGTTCGACGAGGACCTGGCGACGGCCTTCTCCATCTACTGCGGCATCAGCATCGCCCA TTCTCTCCTATACAAAAAAGTGAATGAGGCTCAGTATCGCAGCCACCTGGCCAATGAGATGATGATGTACCACATGAAGGTCTCCGATGA TGAGTATACCAAACTTCTCCATGATGGGATCCAGCCTGTGGCTGCCATTGACTCCAATTTTGCAAGTTTCACCTATACCCCTCGTTCCCT GCCCGAGGATGACACGTCCATGGCCATCCTGAGCATGCTGCAGGACATGAATTTCATCAACAACTACAAAATTGACTGCCCGACCCTGGC CCGGTTCTGTTTGATGGTGAAGAAGGGCTACCGGGATCCCCCCTACCACAACTGGATGCACGCCTTTTCTGTCTCCCACTTCTGCTACCT GCTCTACAAGAACCTGGAGCTCACCAACTACCTCGAGGACATCGAGATCTTTGCCTTGTTTATTTCCTGCATGTGTCATGACCTGGACCA CAGAGGCACAAACAACTCTTTCCAGGTGGCCTCGAAATCTGTGCTGGCTGCGCTCTACAGCTCTGAGGGCTCCGTCATGGAGAGGCACCA CTTTGCTCAGGCCATCGCCATCCTCAACACCCACGGCTGCAACATCTTTGATCATTTCTCCCGGAAGGACTATCAGCGCATGCTGGATCT GATGCGGGACATCATCTTGGCCACAGACCTGGCCCACCATCTCCGCATCTTCAAGGACCTCCAGAAGATGGCTGAGGTGGGCTACGACCG AAACAACAAGCAGCACCACAGACTTCTCCTCTGCCTCCTCATGACCTCCTGTGACCTCTCTGACCAGACCAAGGGCTGGAAGACTACGAG AAAGATCGCGGAGCTGATCTACAAAGAATTCTTCTCCCAGGGAGACCTGGAGAAGGCCATGGGCAACAGGCCGATGGAGATGATGGACCG GGAGAAGGCCTATATCCCTGAGCTGCAAATCAGCTTCATGGAGCACATTGCAATGCCCATCTACAAGCAGACGGCTAATCCACATGGTCT TCGTCCTTGACGTCGTTTTACAAGAAAACAATGGGGCTGGTTTTGCTTCCCCGTGCATGATTTACTCTTAGAGATGATTCAGAGGTCACT |
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FusionGenePPI for CASKIN2_PDE2A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CASKIN2 | SH3KBP1, NCK2, CDH1, PTPRG, PTPRS, ABI2, P4HA3 | PDE2A | MOV10, NXF1, NUFIP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CASKIN2_PDE2A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | PDE2A | O00408 | DB08811 | Tofisopam | cGMP-dependent 3',5'-cyclic phosphodiesterase | small molecule | approved |
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RelatedDiseases for CASKIN2_PDE2A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PDE2A | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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