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Fusion gene ID: 5583 |
FusionGeneSummary for CASC4_TGM5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CASC4_TGM5 | Fusion gene ID: 5583 | Hgene | Tgene | Gene symbol | CASC4 | TGM5 | Gene ID | 113201 | 9333 |
| Gene name | cancer susceptibility 4 | transglutaminase 5 | |
| Synonyms | H63 | PSS2|TGASE5|TGASEX|TGM6|TGMX|TGX | |
| Cytomap | 15q15.3 | 15q15.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein CASC4cancer susceptibility candidate 4cancer susceptibility candidate gene 4 proteingene associated with HER-2/neu overexpression | protein-glutamine gamma-glutamyltransferase 5TG(X)TGase XTGase-5transglutaminase Vtransglutaminase X | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q6P4E1 | O43548 | |
| Ensembl transtripts involved in fusion gene | ENST00000299957, ENST00000360824, ENST00000345795, ENST00000429162, | ENST00000220420, ENST00000349114, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 2 X 3 X 3=18 |
| # samples | 6 | 3 | |
| ** MAII score | log2(6/64*10)=-0.0931094043914815 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CASC4 [Title/Abstract] AND TGM5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-BH-A0E6-01A | CASC4 | chr15 | 44630515 | + | TGM5 | chr15 | 43533188 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000299957 | ENST00000220420 | CASC4 | chr15 | 44630515 | + | TGM5 | chr15 | 43533188 | - |
| In-frame | ENST00000299957 | ENST00000349114 | CASC4 | chr15 | 44630515 | + | TGM5 | chr15 | 43533188 | - |
| 3UTR-3CDS | ENST00000360824 | ENST00000220420 | CASC4 | chr15 | 44630515 | + | TGM5 | chr15 | 43533188 | - |
| 3UTR-3CDS | ENST00000360824 | ENST00000349114 | CASC4 | chr15 | 44630515 | + | TGM5 | chr15 | 43533188 | - |
| In-frame | ENST00000345795 | ENST00000220420 | CASC4 | chr15 | 44630515 | + | TGM5 | chr15 | 43533188 | - |
| In-frame | ENST00000345795 | ENST00000349114 | CASC4 | chr15 | 44630515 | + | TGM5 | chr15 | 43533188 | - |
| intron-3CDS | ENST00000429162 | ENST00000220420 | CASC4 | chr15 | 44630515 | + | TGM5 | chr15 | 43533188 | - |
| intron-3CDS | ENST00000429162 | ENST00000349114 | CASC4 | chr15 | 44630515 | + | TGM5 | chr15 | 43533188 | - |
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FusionProtFeatures for CASC4_TGM5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CASC4 | TGM5 |
| Catalyzes the cross-linking of proteins and theconjugation of polyamines to proteins. Contributes to theformation of the cornified cell envelope of keratinocytes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CASC4 | chr15:44630515 | chr15:43533188 | ENST00000299957 | + | 6 | 10 | 35_198 | 267 | 437 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CASC4 | chr15:44630515 | chr15:43533188 | ENST00000345795 | + | 6 | 9 | 35_198 | 267 | 381 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CASC4 | chr15:44630515 | chr15:43533188 | ENST00000360824 | + | 5 | 8 | 35_198 | 237 | 802 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CASC4 | chr15:44630515 | chr15:43533188 | ENST00000299957 | + | 6 | 10 | 1_14 | 267 | 437 | Topological domain | Cytoplasmic |
| Hgene | CASC4 | chr15:44630515 | chr15:43533188 | ENST00000345795 | + | 6 | 9 | 1_14 | 267 | 381 | Topological domain | Cytoplasmic |
| Hgene | CASC4 | chr15:44630515 | chr15:43533188 | ENST00000360824 | + | 5 | 8 | 1_14 | 237 | 802 | Topological domain | Cytoplasmic |
| Hgene | CASC4 | chr15:44630515 | chr15:43533188 | ENST00000299957 | + | 6 | 10 | 15_35 | 267 | 437 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Hgene | CASC4 | chr15:44630515 | chr15:43533188 | ENST00000345795 | + | 6 | 9 | 15_35 | 267 | 381 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Hgene | CASC4 | chr15:44630515 | chr15:43533188 | ENST00000360824 | + | 5 | 8 | 15_35 | 237 | 802 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CASC4 | chr15:44630515 | chr15:43533188 | ENST00000299957 | + | 6 | 10 | 36_433 | 267 | 437 | Topological domain | Lumenal |
| Hgene | >CASC4 | chr15:44630515 | chr15:43533188 | ENST00000345795 | + | 6 | 9 | 36_433 | 267 | 381 | Topological domain | Lumenal |
| Hgene | >CASC4 | chr15:44630515 | chr15:43533188 | ENST00000360824 | + | 5 | 8 | 36_433 | 237 | 802 | Topological domain | Lumenal |
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FusionGeneSequence for CASC4_TGM5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CASC4_ENST00000299957_chr15_44630515_+_TGM5_ENST00000220420_chr15_43533188_-_701aa MVGFGANRRAGRLPSLVLVVLLVVIVVLAFNYWSISSRHVLLQEEVAELQGQVQRTEVARGRLEKRNSDLLLLVDTHKKQIDQKEADYGR LSSRLQAREGLGKRCEDDKVKLQNNISYQMADIHHLKEQLAELRQEFLRQEDQLQDYRKNNTYLVKRLEYESFQCGQQMKELRAQHEENI KKLADQFLEEQKQETQKIQSNDGKELDINNQVVPKNIPKVAENVADKNEEPSSNHIPHGKEQIKRGGDAGMPGIEENDLAKVDDLPPVMR CLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRA IKEGEVDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDTSSVGNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFH GSQRGAELQPSRPTSLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQ DTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQV >In-frame_CASC4_ENST00000299957_chr15_44630515_+_TGM5_ENST00000349114_chr15_43533188_-_701aa MVGFGANRRAGRLPSLVLVVLLVVIVVLAFNYWSISSRHVLLQEEVAELQGQVQRTEVARGRLEKRNSDLLLLVDTHKKQIDQKEADYGR LSSRLQAREGLGKRCEDDKVKLQNNISYQMADIHHLKEQLAELRQEFLRQEDQLQDYRKNNTYLVKRLEYESFQCGQQMKELRAQHEENI KKLADQFLEEQKQETQKIQSNDGKELDINNQVVPKNIPKVAENVADKNEEPSSNHIPHGKEQIKRGGDAGMPGIEENDLAKVDDLPPVMR CLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRA IKEGEVDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDTSSVGNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFH GSQRGAELQPSRPTSLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQ DTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQV >In-frame_CASC4_ENST00000345795_chr15_44630515_+_TGM5_ENST00000220420_chr15_43533188_-_701aa MVGFGANRRAGRLPSLVLVVLLVVIVVLAFNYWSISSRHVLLQEEVAELQGQVQRTEVARGRLEKRNSDLLLLVDTHKKQIDQKEADYGR LSSRLQAREGLGKRCEDDKVKLQNNISYQMADIHHLKEQLAELRQEFLRQEDQLQDYRKNNTYLVKRLEYESFQCGQQMKELRAQHEENI KKLADQFLEEQKQETQKIQSNDGKELDINNQVVPKNIPKVAENVADKNEEPSSNHIPHGKEQIKRGGDAGMPGIEENDLAKVDDLPPVMR CLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRA IKEGEVDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDTSSVGNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFH GSQRGAELQPSRPTSLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQ DTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQV >In-frame_CASC4_ENST00000345795_chr15_44630515_+_TGM5_ENST00000349114_chr15_43533188_-_701aa MVGFGANRRAGRLPSLVLVVLLVVIVVLAFNYWSISSRHVLLQEEVAELQGQVQRTEVARGRLEKRNSDLLLLVDTHKKQIDQKEADYGR LSSRLQAREGLGKRCEDDKVKLQNNISYQMADIHHLKEQLAELRQEFLRQEDQLQDYRKNNTYLVKRLEYESFQCGQQMKELRAQHEENI KKLADQFLEEQKQETQKIQSNDGKELDINNQVVPKNIPKVAENVADKNEEPSSNHIPHGKEQIKRGGDAGMPGIEENDLAKVDDLPPVMR CLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRA IKEGEVDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDTSSVGNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFH GSQRGAELQPSRPTSLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQ DTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CASC4_ENST00000299957_chr15_44630515_+_TGM5_ENST00000220420_chr15_43533188_-_2103nt ATGGTGGGTTTCGGGGCCAACCGGCGGGCTGGCCGCCTGCCCTCTCTCGTGCTGGTGGTGCTGCTGGTGGTGATCGTCGTCCTCGCCTTC AACTACTGGAGCATCTCCTCCCGCCACGTCCTGCTTCAGGAGGAGGTGGCCGAGCTGCAGGGCCAGGTCCAGCGCACCGAAGTGGCCCGC GGGCGGCTGGAAAAGCGCAATTCGGACCTCTTGCTGTTGGTGGACACGCACAAGAAACAGATCGACCAGAAGGAGGCCGACTACGGCCGC CTCAGCAGCCGGCTGCAGGCCAGAGAGGGCCTCGGGAAGAGATGCGAGGATGACAAGGTTAAACTACAGAACAACATATCGTATCAGATG GCAGACATACATCATTTAAAGGAGCAACTTGCTGAGCTTCGTCAGGAATTTCTTCGACAAGAAGACCAGCTTCAGGACTATAGGAAGAAC AATACTTACCTTGTGAAGAGGTTAGAATATGAAAGTTTTCAGTGTGGACAGCAGATGAAGGAATTGAGAGCACAGCATGAAGAAAATATT AAAAAGTTAGCAGACCAGTTTTTAGAGGAACAAAAGCAAGAGACCCAAAAGATTCAATCAAATGATGGAAAGGAATTGGATATAAACAAT CAAGTAGTACCTAAAAATATTCCAAAAGTAGCTGAGAATGTTGCAGATAAGAATGAAGAACCCTCAAGCAATCATATTCCACATGGGAAA GAACAAATCAAAAGAGGTGGTGATGCAGGGATGCCTGGAATAGAAGAGAATGACCTAGCAAAAGTTGATGATCTTCCCCCTGTGATGAGG TGTCTGGGGATCCCTACCCGTGTGATCACCAACTTCGACTCTGGCCACGATACAGATGGAAACCTGATCATAGATGAGTATTATGACAAC ACAGGCAGGATTTTGGGGAATAAGAAGAAGGATACTATCTGGAACTTCCATGTCTGGAATGAGTGCTGGATGGCCCGGAAGGATCTGCCC CCTGCATATGGAGGCTGGCAGGTGCTGGACGCCACACCTCAGGAGATGAGCAACGGCGTCTACTGCTGTGGCCCTGCCTCTGTCAGAGCC ATCAAAGAAGGAGAAGTGGACCTGAACTATGACACGCCCTTTGTGTTTTCGATGGTGAATGCTGACTGCATGTCCTGGCTCGTCCAGGGA GGGAAGGAGCAGAAGCTTCACCAGGACACGAGTTCTGTTGGCAATTTTATCAGCACAAAGAGCATCCAGAGTGACGAGCGGGATGACATC ACAGAGAACTACAAGTATGAAGAAGGATCCCTCCAGGAGAGGCAGGTGTTTCTGAAGGCTCTGCAGAAGCTGAAGGCTAGAAGCTTCCAT GGCTCCCAAAGAGGAGCAGAGTTGCAACCTTCCAGGCCCACATCACTGAGCCAGGACAGCCCTCGGAGCCTGCATACACCTTCCCTTCGA CCCAGTGATGTGGTGCAAGTCTCCCTGAAATTCAAGCTGCTCGACCCGCCCAACATGGGCCAGGATATATGCTTTGTCCTGCTGGCCCTC AACATGTCCTCCCAGTTCAAGGACCTCAAAGTGAACCTGAGTGCCCAGTCTCTGCTGCACGATGGCAGCCCCCTGTCCCCATTCTGGCAG GACACAGCGTTCATCACACTCTCTCCTAAAGAAGCAAAGACCTACCCCTGCAAAATCTCCTATTCCCAGTACAGCCAGTACCTGTCAACA GACAAGCTGATCCGCATCAGTGCCCTGGGTGAAGAGAAAAGCAGTCCTGAGAAAATCCTGGTGAACAAGATCATCACCTTATCTTATCCA AGCATCACGATTAATGTTCTAGGAGCAGCCGTTGTGAACCAGCCACTCTCCATACAGGTGATATTTTCAAACCCCCTCTCGGAGCAGGTT GAGGACTGTGTGCTGACTGTGGAAGGAAGTGGCCTCTTCAAGAAACAGCAGAAAGTCTTCCTTGGAGTCCTCAAACCCCAACACCAAGCA AGCATCATTCTGGAGACCGTCCCCTTCAAGAGTGGACAAAGGCAGATCCAAGCTAATATGAGAAGCAACAAGTTTAAGGACATTAAGGGT >In-frame_CASC4_ENST00000299957_chr15_44630515_+_TGM5_ENST00000349114_chr15_43533188_-_2103nt ATGGTGGGTTTCGGGGCCAACCGGCGGGCTGGCCGCCTGCCCTCTCTCGTGCTGGTGGTGCTGCTGGTGGTGATCGTCGTCCTCGCCTTC AACTACTGGAGCATCTCCTCCCGCCACGTCCTGCTTCAGGAGGAGGTGGCCGAGCTGCAGGGCCAGGTCCAGCGCACCGAAGTGGCCCGC GGGCGGCTGGAAAAGCGCAATTCGGACCTCTTGCTGTTGGTGGACACGCACAAGAAACAGATCGACCAGAAGGAGGCCGACTACGGCCGC CTCAGCAGCCGGCTGCAGGCCAGAGAGGGCCTCGGGAAGAGATGCGAGGATGACAAGGTTAAACTACAGAACAACATATCGTATCAGATG GCAGACATACATCATTTAAAGGAGCAACTTGCTGAGCTTCGTCAGGAATTTCTTCGACAAGAAGACCAGCTTCAGGACTATAGGAAGAAC AATACTTACCTTGTGAAGAGGTTAGAATATGAAAGTTTTCAGTGTGGACAGCAGATGAAGGAATTGAGAGCACAGCATGAAGAAAATATT AAAAAGTTAGCAGACCAGTTTTTAGAGGAACAAAAGCAAGAGACCCAAAAGATTCAATCAAATGATGGAAAGGAATTGGATATAAACAAT CAAGTAGTACCTAAAAATATTCCAAAAGTAGCTGAGAATGTTGCAGATAAGAATGAAGAACCCTCAAGCAATCATATTCCACATGGGAAA GAACAAATCAAAAGAGGTGGTGATGCAGGGATGCCTGGAATAGAAGAGAATGACCTAGCAAAAGTTGATGATCTTCCCCCTGTGATGAGG TGTCTGGGGATCCCTACCCGTGTGATCACCAACTTCGACTCTGGCCACGATACAGATGGAAACCTGATCATAGATGAGTATTATGACAAC ACAGGCAGGATTTTGGGGAATAAGAAGAAGGATACTATCTGGAACTTCCATGTCTGGAATGAGTGCTGGATGGCCCGGAAGGATCTGCCC CCTGCATATGGAGGCTGGCAGGTGCTGGACGCCACACCTCAGGAGATGAGCAACGGCGTCTACTGCTGTGGCCCTGCCTCTGTCAGAGCC ATCAAAGAAGGAGAAGTGGACCTGAACTATGACACGCCCTTTGTGTTTTCGATGGTGAATGCTGACTGCATGTCCTGGCTCGTCCAGGGA GGGAAGGAGCAGAAGCTTCACCAGGACACGAGTTCTGTTGGCAATTTTATCAGCACAAAGAGCATCCAGAGTGACGAGCGGGATGACATC ACAGAGAACTACAAGTATGAAGAAGGATCCCTCCAGGAGAGGCAGGTGTTTCTGAAGGCTCTGCAGAAGCTGAAGGCTAGAAGCTTCCAT GGCTCCCAAAGAGGAGCAGAGTTGCAACCTTCCAGGCCCACATCACTGAGCCAGGACAGCCCTCGGAGCCTGCATACACCTTCCCTTCGA CCCAGTGATGTGGTGCAAGTCTCCCTGAAATTCAAGCTGCTCGACCCGCCCAACATGGGCCAGGATATATGCTTTGTCCTGCTGGCCCTC AACATGTCCTCCCAGTTCAAGGACCTCAAAGTGAACCTGAGTGCCCAGTCTCTGCTGCACGATGGCAGCCCCCTGTCCCCATTCTGGCAG GACACAGCGTTCATCACACTCTCTCCTAAAGAAGCAAAGACCTACCCCTGCAAAATCTCCTATTCCCAGTACAGCCAGTACCTGTCAACA GACAAGCTGATCCGCATCAGTGCCCTGGGTGAAGAGAAAAGCAGTCCTGAGAAAATCCTGGTGAACAAGATCATCACCTTATCTTATCCA AGCATCACGATTAATGTTCTAGGAGCAGCCGTTGTGAACCAGCCACTCTCCATACAGGTGATATTTTCAAACCCCCTCTCGGAGCAGGTT GAGGACTGTGTGCTGACTGTGGAAGGAAGTGGCCTCTTCAAGAAACAGCAGAAAGTCTTCCTTGGAGTCCTCAAACCCCAACACCAAGCA AGCATCATTCTGGAGACCGTCCCCTTCAAGAGTGGACAAAGGCAGATCCAAGCTAATATGAGAAGCAACAAGTTTAAGGACATTAAGGGT >In-frame_CASC4_ENST00000345795_chr15_44630515_+_TGM5_ENST00000220420_chr15_43533188_-_2103nt ATGGTGGGTTTCGGGGCCAACCGGCGGGCTGGCCGCCTGCCCTCTCTCGTGCTGGTGGTGCTGCTGGTGGTGATCGTCGTCCTCGCCTTC AACTACTGGAGCATCTCCTCCCGCCACGTCCTGCTTCAGGAGGAGGTGGCCGAGCTGCAGGGCCAGGTCCAGCGCACCGAAGTGGCCCGC GGGCGGCTGGAAAAGCGCAATTCGGACCTCTTGCTGTTGGTGGACACGCACAAGAAACAGATCGACCAGAAGGAGGCCGACTACGGCCGC CTCAGCAGCCGGCTGCAGGCCAGAGAGGGCCTCGGGAAGAGATGCGAGGATGACAAGGTTAAACTACAGAACAACATATCGTATCAGATG GCAGACATACATCATTTAAAGGAGCAACTTGCTGAGCTTCGTCAGGAATTTCTTCGACAAGAAGACCAGCTTCAGGACTATAGGAAGAAC AATACTTACCTTGTGAAGAGGTTAGAATATGAAAGTTTTCAGTGTGGACAGCAGATGAAGGAATTGAGAGCACAGCATGAAGAAAATATT AAAAAGTTAGCAGACCAGTTTTTAGAGGAACAAAAGCAAGAGACCCAAAAGATTCAATCAAATGATGGAAAGGAATTGGATATAAACAAT CAAGTAGTACCTAAAAATATTCCAAAAGTAGCTGAGAATGTTGCAGATAAGAATGAAGAACCCTCAAGCAATCATATTCCACATGGGAAA GAACAAATCAAAAGAGGTGGTGATGCAGGGATGCCTGGAATAGAAGAGAATGACCTAGCAAAAGTTGATGATCTTCCCCCTGTGATGAGG TGTCTGGGGATCCCTACCCGTGTGATCACCAACTTCGACTCTGGCCACGATACAGATGGAAACCTGATCATAGATGAGTATTATGACAAC ACAGGCAGGATTTTGGGGAATAAGAAGAAGGATACTATCTGGAACTTCCATGTCTGGAATGAGTGCTGGATGGCCCGGAAGGATCTGCCC CCTGCATATGGAGGCTGGCAGGTGCTGGACGCCACACCTCAGGAGATGAGCAACGGCGTCTACTGCTGTGGCCCTGCCTCTGTCAGAGCC ATCAAAGAAGGAGAAGTGGACCTGAACTATGACACGCCCTTTGTGTTTTCGATGGTGAATGCTGACTGCATGTCCTGGCTCGTCCAGGGA GGGAAGGAGCAGAAGCTTCACCAGGACACGAGTTCTGTTGGCAATTTTATCAGCACAAAGAGCATCCAGAGTGACGAGCGGGATGACATC ACAGAGAACTACAAGTATGAAGAAGGATCCCTCCAGGAGAGGCAGGTGTTTCTGAAGGCTCTGCAGAAGCTGAAGGCTAGAAGCTTCCAT GGCTCCCAAAGAGGAGCAGAGTTGCAACCTTCCAGGCCCACATCACTGAGCCAGGACAGCCCTCGGAGCCTGCATACACCTTCCCTTCGA CCCAGTGATGTGGTGCAAGTCTCCCTGAAATTCAAGCTGCTCGACCCGCCCAACATGGGCCAGGATATATGCTTTGTCCTGCTGGCCCTC AACATGTCCTCCCAGTTCAAGGACCTCAAAGTGAACCTGAGTGCCCAGTCTCTGCTGCACGATGGCAGCCCCCTGTCCCCATTCTGGCAG GACACAGCGTTCATCACACTCTCTCCTAAAGAAGCAAAGACCTACCCCTGCAAAATCTCCTATTCCCAGTACAGCCAGTACCTGTCAACA GACAAGCTGATCCGCATCAGTGCCCTGGGTGAAGAGAAAAGCAGTCCTGAGAAAATCCTGGTGAACAAGATCATCACCTTATCTTATCCA AGCATCACGATTAATGTTCTAGGAGCAGCCGTTGTGAACCAGCCACTCTCCATACAGGTGATATTTTCAAACCCCCTCTCGGAGCAGGTT GAGGACTGTGTGCTGACTGTGGAAGGAAGTGGCCTCTTCAAGAAACAGCAGAAAGTCTTCCTTGGAGTCCTCAAACCCCAACACCAAGCA AGCATCATTCTGGAGACCGTCCCCTTCAAGAGTGGACAAAGGCAGATCCAAGCTAATATGAGAAGCAACAAGTTTAAGGACATTAAGGGT >In-frame_CASC4_ENST00000345795_chr15_44630515_+_TGM5_ENST00000349114_chr15_43533188_-_2103nt ATGGTGGGTTTCGGGGCCAACCGGCGGGCTGGCCGCCTGCCCTCTCTCGTGCTGGTGGTGCTGCTGGTGGTGATCGTCGTCCTCGCCTTC AACTACTGGAGCATCTCCTCCCGCCACGTCCTGCTTCAGGAGGAGGTGGCCGAGCTGCAGGGCCAGGTCCAGCGCACCGAAGTGGCCCGC GGGCGGCTGGAAAAGCGCAATTCGGACCTCTTGCTGTTGGTGGACACGCACAAGAAACAGATCGACCAGAAGGAGGCCGACTACGGCCGC CTCAGCAGCCGGCTGCAGGCCAGAGAGGGCCTCGGGAAGAGATGCGAGGATGACAAGGTTAAACTACAGAACAACATATCGTATCAGATG GCAGACATACATCATTTAAAGGAGCAACTTGCTGAGCTTCGTCAGGAATTTCTTCGACAAGAAGACCAGCTTCAGGACTATAGGAAGAAC AATACTTACCTTGTGAAGAGGTTAGAATATGAAAGTTTTCAGTGTGGACAGCAGATGAAGGAATTGAGAGCACAGCATGAAGAAAATATT AAAAAGTTAGCAGACCAGTTTTTAGAGGAACAAAAGCAAGAGACCCAAAAGATTCAATCAAATGATGGAAAGGAATTGGATATAAACAAT CAAGTAGTACCTAAAAATATTCCAAAAGTAGCTGAGAATGTTGCAGATAAGAATGAAGAACCCTCAAGCAATCATATTCCACATGGGAAA GAACAAATCAAAAGAGGTGGTGATGCAGGGATGCCTGGAATAGAAGAGAATGACCTAGCAAAAGTTGATGATCTTCCCCCTGTGATGAGG TGTCTGGGGATCCCTACCCGTGTGATCACCAACTTCGACTCTGGCCACGATACAGATGGAAACCTGATCATAGATGAGTATTATGACAAC ACAGGCAGGATTTTGGGGAATAAGAAGAAGGATACTATCTGGAACTTCCATGTCTGGAATGAGTGCTGGATGGCCCGGAAGGATCTGCCC CCTGCATATGGAGGCTGGCAGGTGCTGGACGCCACACCTCAGGAGATGAGCAACGGCGTCTACTGCTGTGGCCCTGCCTCTGTCAGAGCC ATCAAAGAAGGAGAAGTGGACCTGAACTATGACACGCCCTTTGTGTTTTCGATGGTGAATGCTGACTGCATGTCCTGGCTCGTCCAGGGA GGGAAGGAGCAGAAGCTTCACCAGGACACGAGTTCTGTTGGCAATTTTATCAGCACAAAGAGCATCCAGAGTGACGAGCGGGATGACATC ACAGAGAACTACAAGTATGAAGAAGGATCCCTCCAGGAGAGGCAGGTGTTTCTGAAGGCTCTGCAGAAGCTGAAGGCTAGAAGCTTCCAT GGCTCCCAAAGAGGAGCAGAGTTGCAACCTTCCAGGCCCACATCACTGAGCCAGGACAGCCCTCGGAGCCTGCATACACCTTCCCTTCGA CCCAGTGATGTGGTGCAAGTCTCCCTGAAATTCAAGCTGCTCGACCCGCCCAACATGGGCCAGGATATATGCTTTGTCCTGCTGGCCCTC AACATGTCCTCCCAGTTCAAGGACCTCAAAGTGAACCTGAGTGCCCAGTCTCTGCTGCACGATGGCAGCCCCCTGTCCCCATTCTGGCAG GACACAGCGTTCATCACACTCTCTCCTAAAGAAGCAAAGACCTACCCCTGCAAAATCTCCTATTCCCAGTACAGCCAGTACCTGTCAACA GACAAGCTGATCCGCATCAGTGCCCTGGGTGAAGAGAAAAGCAGTCCTGAGAAAATCCTGGTGAACAAGATCATCACCTTATCTTATCCA AGCATCACGATTAATGTTCTAGGAGCAGCCGTTGTGAACCAGCCACTCTCCATACAGGTGATATTTTCAAACCCCCTCTCGGAGCAGGTT GAGGACTGTGTGCTGACTGTGGAAGGAAGTGGCCTCTTCAAGAAACAGCAGAAAGTCTTCCTTGGAGTCCTCAAACCCCAACACCAAGCA AGCATCATTCTGGAGACCGTCCCCTTCAAGAGTGGACAAAGGCAGATCCAAGCTAATATGAGAAGCAACAAGTTTAAGGACATTAAGGGT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CASC4_ENST00000299957_chr15_44630515_+_TGM5_ENST00000220420_chr15_43533188_-_2998nt CCGTGAGGTGTTGGGTTTGGGGGACGCTGGCAGCTGGGTTCTCCCGGTTCCCTTGGGCAGGTGCAGGGTCGGGTTCAAAGCCTCCGGAAC GCGTTTTGGCCTGATTTGAGGAGGGGGGCGGGGAGGGACCTGCGGCTTGCGGCCCCGCCCCCTTCTCCGGCTCGCAGCCGACCGGTAAGC CCGCCTCCTCCCTCGGCCGGCCCTGGGGCCGTGTCCGCCGGGCAACTCCAGCCGAGGCCTGGGCTTCTGCCTGCAGGTGTCTGCGGCGAG GCCCCTAGGGTACAGCCCGATTTGGCCCCATGGTGGGTTTCGGGGCCAACCGGCGGGCTGGCCGCCTGCCCTCTCTCGTGCTGGTGGTGC TGCTGGTGGTGATCGTCGTCCTCGCCTTCAACTACTGGAGCATCTCCTCCCGCCACGTCCTGCTTCAGGAGGAGGTGGCCGAGCTGCAGG GCCAGGTCCAGCGCACCGAAGTGGCCCGCGGGCGGCTGGAAAAGCGCAATTCGGACCTCTTGCTGTTGGTGGACACGCACAAGAAACAGA TCGACCAGAAGGAGGCCGACTACGGCCGCCTCAGCAGCCGGCTGCAGGCCAGAGAGGGCCTCGGGAAGAGATGCGAGGATGACAAGGTTA AACTACAGAACAACATATCGTATCAGATGGCAGACATACATCATTTAAAGGAGCAACTTGCTGAGCTTCGTCAGGAATTTCTTCGACAAG AAGACCAGCTTCAGGACTATAGGAAGAACAATACTTACCTTGTGAAGAGGTTAGAATATGAAAGTTTTCAGTGTGGACAGCAGATGAAGG AATTGAGAGCACAGCATGAAGAAAATATTAAAAAGTTAGCAGACCAGTTTTTAGAGGAACAAAAGCAAGAGACCCAAAAGATTCAATCAA ATGATGGAAAGGAATTGGATATAAACAATCAAGTAGTACCTAAAAATATTCCAAAAGTAGCTGAGAATGTTGCAGATAAGAATGAAGAAC CCTCAAGCAATCATATTCCACATGGGAAAGAACAAATCAAAAGAGGTGGTGATGCAGGGATGCCTGGAATAGAAGAGAATGACCTAGCAA AAGTTGATGATCTTCCCCCTGTGATGAGGTGTCTGGGGATCCCTACCCGTGTGATCACCAACTTCGACTCTGGCCACGATACAGATGGAA ACCTGATCATAGATGAGTATTATGACAACACAGGCAGGATTTTGGGGAATAAGAAGAAGGATACTATCTGGAACTTCCATGTCTGGAATG AGTGCTGGATGGCCCGGAAGGATCTGCCCCCTGCATATGGAGGCTGGCAGGTGCTGGACGCCACACCTCAGGAGATGAGCAACGGCGTCT ACTGCTGTGGCCCTGCCTCTGTCAGAGCCATCAAAGAAGGAGAAGTGGACCTGAACTATGACACGCCCTTTGTGTTTTCGATGGTGAATG CTGACTGCATGTCCTGGCTCGTCCAGGGAGGGAAGGAGCAGAAGCTTCACCAGGACACGAGTTCTGTTGGCAATTTTATCAGCACAAAGA GCATCCAGAGTGACGAGCGGGATGACATCACAGAGAACTACAAGTATGAAGAAGGATCCCTCCAGGAGAGGCAGGTGTTTCTGAAGGCTC TGCAGAAGCTGAAGGCTAGAAGCTTCCATGGCTCCCAAAGAGGAGCAGAGTTGCAACCTTCCAGGCCCACATCACTGAGCCAGGACAGCC CTCGGAGCCTGCATACACCTTCCCTTCGACCCAGTGATGTGGTGCAAGTCTCCCTGAAATTCAAGCTGCTCGACCCGCCCAACATGGGCC AGGATATATGCTTTGTCCTGCTGGCCCTCAACATGTCCTCCCAGTTCAAGGACCTCAAAGTGAACCTGAGTGCCCAGTCTCTGCTGCACG ATGGCAGCCCCCTGTCCCCATTCTGGCAGGACACAGCGTTCATCACACTCTCTCCTAAAGAAGCAAAGACCTACCCCTGCAAAATCTCCT ATTCCCAGTACAGCCAGTACCTGTCAACAGACAAGCTGATCCGCATCAGTGCCCTGGGTGAAGAGAAAAGCAGTCCTGAGAAAATCCTGG TGAACAAGATCATCACCTTATCTTATCCAAGCATCACGATTAATGTTCTAGGAGCAGCCGTTGTGAACCAGCCACTCTCCATACAGGTGA TATTTTCAAACCCCCTCTCGGAGCAGGTTGAGGACTGTGTGCTGACTGTGGAAGGAAGTGGCCTCTTCAAGAAACAGCAGAAAGTCTTCC TTGGAGTCCTCAAACCCCAACACCAAGCAAGCATCATTCTGGAGACCGTCCCCTTCAAGAGTGGACAAAGGCAGATCCAAGCTAATATGA GAAGCAACAAGTTTAAGGACATTAAGGGTTACAGGAATGTTTATGTAGACTTTGCATTATAAATTCTGGAACAACGCGCCAGACGTGTGA ATTTCAAGCTTCAGGAAAAGGAGCAAGTTCAAATGCAAGCTGCGCCATTCCCCACCACAACAGAGGCTTCACAGGGCTCCAGCAAGAGCC ACAGAGGGGATGACGTGTTCATTTTCTGTCTCTCCTGACTCCACTAGAAATTTAAGCTCCATGAGGGCAAAGACTTTGCTTTGTTTACTA CCCCTATACTCAGAACCATTTCTGGCATATGCTAGGCACTCAACAAATATTTTTTGAATGAATGAATAGGAGACTCCAGCATCCAGAGAA CAGGTAGGAAATGTCTATGGATGGATATTTCCCTGGACCATTTGCACAGCTCCCCTGGACTCTTTTCAGGGCCCAGGGATTCCACTGTGT CCCATCCAGAGATTCCAGGATTCCAGTCTCCTATCCAGAAGCGTGATTTGGCACAGAGGTCAGAGGATACTGGTAGGACTTGGCCATGAC TTAACTGCCCCCTGCCCCAGATATCCAGGAAAGAAAAAGACAGGCTGAACAGCTCACTGTTGTTTTGTTGTTGCGAAAGCTAATTCCCTA >In-frame_CASC4_ENST00000299957_chr15_44630515_+_TGM5_ENST00000349114_chr15_43533188_-_2435nt CCGTGAGGTGTTGGGTTTGGGGGACGCTGGCAGCTGGGTTCTCCCGGTTCCCTTGGGCAGGTGCAGGGTCGGGTTCAAAGCCTCCGGAAC GCGTTTTGGCCTGATTTGAGGAGGGGGGCGGGGAGGGACCTGCGGCTTGCGGCCCCGCCCCCTTCTCCGGCTCGCAGCCGACCGGTAAGC CCGCCTCCTCCCTCGGCCGGCCCTGGGGCCGTGTCCGCCGGGCAACTCCAGCCGAGGCCTGGGCTTCTGCCTGCAGGTGTCTGCGGCGAG GCCCCTAGGGTACAGCCCGATTTGGCCCCATGGTGGGTTTCGGGGCCAACCGGCGGGCTGGCCGCCTGCCCTCTCTCGTGCTGGTGGTGC TGCTGGTGGTGATCGTCGTCCTCGCCTTCAACTACTGGAGCATCTCCTCCCGCCACGTCCTGCTTCAGGAGGAGGTGGCCGAGCTGCAGG GCCAGGTCCAGCGCACCGAAGTGGCCCGCGGGCGGCTGGAAAAGCGCAATTCGGACCTCTTGCTGTTGGTGGACACGCACAAGAAACAGA TCGACCAGAAGGAGGCCGACTACGGCCGCCTCAGCAGCCGGCTGCAGGCCAGAGAGGGCCTCGGGAAGAGATGCGAGGATGACAAGGTTA AACTACAGAACAACATATCGTATCAGATGGCAGACATACATCATTTAAAGGAGCAACTTGCTGAGCTTCGTCAGGAATTTCTTCGACAAG AAGACCAGCTTCAGGACTATAGGAAGAACAATACTTACCTTGTGAAGAGGTTAGAATATGAAAGTTTTCAGTGTGGACAGCAGATGAAGG AATTGAGAGCACAGCATGAAGAAAATATTAAAAAGTTAGCAGACCAGTTTTTAGAGGAACAAAAGCAAGAGACCCAAAAGATTCAATCAA ATGATGGAAAGGAATTGGATATAAACAATCAAGTAGTACCTAAAAATATTCCAAAAGTAGCTGAGAATGTTGCAGATAAGAATGAAGAAC CCTCAAGCAATCATATTCCACATGGGAAAGAACAAATCAAAAGAGGTGGTGATGCAGGGATGCCTGGAATAGAAGAGAATGACCTAGCAA AAGTTGATGATCTTCCCCCTGTGATGAGGTGTCTGGGGATCCCTACCCGTGTGATCACCAACTTCGACTCTGGCCACGATACAGATGGAA ACCTGATCATAGATGAGTATTATGACAACACAGGCAGGATTTTGGGGAATAAGAAGAAGGATACTATCTGGAACTTCCATGTCTGGAATG AGTGCTGGATGGCCCGGAAGGATCTGCCCCCTGCATATGGAGGCTGGCAGGTGCTGGACGCCACACCTCAGGAGATGAGCAACGGCGTCT ACTGCTGTGGCCCTGCCTCTGTCAGAGCCATCAAAGAAGGAGAAGTGGACCTGAACTATGACACGCCCTTTGTGTTTTCGATGGTGAATG CTGACTGCATGTCCTGGCTCGTCCAGGGAGGGAAGGAGCAGAAGCTTCACCAGGACACGAGTTCTGTTGGCAATTTTATCAGCACAAAGA GCATCCAGAGTGACGAGCGGGATGACATCACAGAGAACTACAAGTATGAAGAAGGATCCCTCCAGGAGAGGCAGGTGTTTCTGAAGGCTC TGCAGAAGCTGAAGGCTAGAAGCTTCCATGGCTCCCAAAGAGGAGCAGAGTTGCAACCTTCCAGGCCCACATCACTGAGCCAGGACAGCC CTCGGAGCCTGCATACACCTTCCCTTCGACCCAGTGATGTGGTGCAAGTCTCCCTGAAATTCAAGCTGCTCGACCCGCCCAACATGGGCC AGGATATATGCTTTGTCCTGCTGGCCCTCAACATGTCCTCCCAGTTCAAGGACCTCAAAGTGAACCTGAGTGCCCAGTCTCTGCTGCACG ATGGCAGCCCCCTGTCCCCATTCTGGCAGGACACAGCGTTCATCACACTCTCTCCTAAAGAAGCAAAGACCTACCCCTGCAAAATCTCCT ATTCCCAGTACAGCCAGTACCTGTCAACAGACAAGCTGATCCGCATCAGTGCCCTGGGTGAAGAGAAAAGCAGTCCTGAGAAAATCCTGG TGAACAAGATCATCACCTTATCTTATCCAAGCATCACGATTAATGTTCTAGGAGCAGCCGTTGTGAACCAGCCACTCTCCATACAGGTGA TATTTTCAAACCCCCTCTCGGAGCAGGTTGAGGACTGTGTGCTGACTGTGGAAGGAAGTGGCCTCTTCAAGAAACAGCAGAAAGTCTTCC TTGGAGTCCTCAAACCCCAACACCAAGCAAGCATCATTCTGGAGACCGTCCCCTTCAAGAGTGGACAAAGGCAGATCCAAGCTAATATGA GAAGCAACAAGTTTAAGGACATTAAGGGTTACAGGAATGTTTATGTAGACTTTGCATTATAAATTCTGGAACAACGCGCCAGACGTGTGA >In-frame_CASC4_ENST00000345795_chr15_44630515_+_TGM5_ENST00000220420_chr15_43533188_-_2969nt GCAGCTGGGTTCTCCCGGTTCCCTTGGGCAGGTGCAGGGTCGGGTTCAAAGCCTCCGGAACGCGTTTTGGCCTGATTTGAGGAGGGGGGC GGGGAGGGACCTGCGGCTTGCGGCCCCGCCCCCTTCTCCGGCTCGCAGCCGACCGGTAAGCCCGCCTCCTCCCTCGGCCGGCCCTGGGGC CGTGTCCGCCGGGCAACTCCAGCCGAGGCCTGGGCTTCTGCCTGCAGGTGTCTGCGGCGAGGCCCCTAGGGTACAGCCCGATTTGGCCCC ATGGTGGGTTTCGGGGCCAACCGGCGGGCTGGCCGCCTGCCCTCTCTCGTGCTGGTGGTGCTGCTGGTGGTGATCGTCGTCCTCGCCTTC AACTACTGGAGCATCTCCTCCCGCCACGTCCTGCTTCAGGAGGAGGTGGCCGAGCTGCAGGGCCAGGTCCAGCGCACCGAAGTGGCCCGC GGGCGGCTGGAAAAGCGCAATTCGGACCTCTTGCTGTTGGTGGACACGCACAAGAAACAGATCGACCAGAAGGAGGCCGACTACGGCCGC CTCAGCAGCCGGCTGCAGGCCAGAGAGGGCCTCGGGAAGAGATGCGAGGATGACAAGGTTAAACTACAGAACAACATATCGTATCAGATG GCAGACATACATCATTTAAAGGAGCAACTTGCTGAGCTTCGTCAGGAATTTCTTCGACAAGAAGACCAGCTTCAGGACTATAGGAAGAAC AATACTTACCTTGTGAAGAGGTTAGAATATGAAAGTTTTCAGTGTGGACAGCAGATGAAGGAATTGAGAGCACAGCATGAAGAAAATATT AAAAAGTTAGCAGACCAGTTTTTAGAGGAACAAAAGCAAGAGACCCAAAAGATTCAATCAAATGATGGAAAGGAATTGGATATAAACAAT CAAGTAGTACCTAAAAATATTCCAAAAGTAGCTGAGAATGTTGCAGATAAGAATGAAGAACCCTCAAGCAATCATATTCCACATGGGAAA GAACAAATCAAAAGAGGTGGTGATGCAGGGATGCCTGGAATAGAAGAGAATGACCTAGCAAAAGTTGATGATCTTCCCCCTGTGATGAGG TGTCTGGGGATCCCTACCCGTGTGATCACCAACTTCGACTCTGGCCACGATACAGATGGAAACCTGATCATAGATGAGTATTATGACAAC ACAGGCAGGATTTTGGGGAATAAGAAGAAGGATACTATCTGGAACTTCCATGTCTGGAATGAGTGCTGGATGGCCCGGAAGGATCTGCCC CCTGCATATGGAGGCTGGCAGGTGCTGGACGCCACACCTCAGGAGATGAGCAACGGCGTCTACTGCTGTGGCCCTGCCTCTGTCAGAGCC ATCAAAGAAGGAGAAGTGGACCTGAACTATGACACGCCCTTTGTGTTTTCGATGGTGAATGCTGACTGCATGTCCTGGCTCGTCCAGGGA GGGAAGGAGCAGAAGCTTCACCAGGACACGAGTTCTGTTGGCAATTTTATCAGCACAAAGAGCATCCAGAGTGACGAGCGGGATGACATC ACAGAGAACTACAAGTATGAAGAAGGATCCCTCCAGGAGAGGCAGGTGTTTCTGAAGGCTCTGCAGAAGCTGAAGGCTAGAAGCTTCCAT GGCTCCCAAAGAGGAGCAGAGTTGCAACCTTCCAGGCCCACATCACTGAGCCAGGACAGCCCTCGGAGCCTGCATACACCTTCCCTTCGA CCCAGTGATGTGGTGCAAGTCTCCCTGAAATTCAAGCTGCTCGACCCGCCCAACATGGGCCAGGATATATGCTTTGTCCTGCTGGCCCTC AACATGTCCTCCCAGTTCAAGGACCTCAAAGTGAACCTGAGTGCCCAGTCTCTGCTGCACGATGGCAGCCCCCTGTCCCCATTCTGGCAG GACACAGCGTTCATCACACTCTCTCCTAAAGAAGCAAAGACCTACCCCTGCAAAATCTCCTATTCCCAGTACAGCCAGTACCTGTCAACA GACAAGCTGATCCGCATCAGTGCCCTGGGTGAAGAGAAAAGCAGTCCTGAGAAAATCCTGGTGAACAAGATCATCACCTTATCTTATCCA AGCATCACGATTAATGTTCTAGGAGCAGCCGTTGTGAACCAGCCACTCTCCATACAGGTGATATTTTCAAACCCCCTCTCGGAGCAGGTT GAGGACTGTGTGCTGACTGTGGAAGGAAGTGGCCTCTTCAAGAAACAGCAGAAAGTCTTCCTTGGAGTCCTCAAACCCCAACACCAAGCA AGCATCATTCTGGAGACCGTCCCCTTCAAGAGTGGACAAAGGCAGATCCAAGCTAATATGAGAAGCAACAAGTTTAAGGACATTAAGGGT TACAGGAATGTTTATGTAGACTTTGCATTATAAATTCTGGAACAACGCGCCAGACGTGTGAATTTCAAGCTTCAGGAAAAGGAGCAAGTT CAAATGCAAGCTGCGCCATTCCCCACCACAACAGAGGCTTCACAGGGCTCCAGCAAGAGCCACAGAGGGGATGACGTGTTCATTTTCTGT CTCTCCTGACTCCACTAGAAATTTAAGCTCCATGAGGGCAAAGACTTTGCTTTGTTTACTACCCCTATACTCAGAACCATTTCTGGCATA TGCTAGGCACTCAACAAATATTTTTTGAATGAATGAATAGGAGACTCCAGCATCCAGAGAACAGGTAGGAAATGTCTATGGATGGATATT TCCCTGGACCATTTGCACAGCTCCCCTGGACTCTTTTCAGGGCCCAGGGATTCCACTGTGTCCCATCCAGAGATTCCAGGATTCCAGTCT CCTATCCAGAAGCGTGATTTGGCACAGAGGTCAGAGGATACTGGTAGGACTTGGCCATGACTTAACTGCCCCCTGCCCCAGATATCCAGG >In-frame_CASC4_ENST00000345795_chr15_44630515_+_TGM5_ENST00000349114_chr15_43533188_-_2406nt GCAGCTGGGTTCTCCCGGTTCCCTTGGGCAGGTGCAGGGTCGGGTTCAAAGCCTCCGGAACGCGTTTTGGCCTGATTTGAGGAGGGGGGC GGGGAGGGACCTGCGGCTTGCGGCCCCGCCCCCTTCTCCGGCTCGCAGCCGACCGGTAAGCCCGCCTCCTCCCTCGGCCGGCCCTGGGGC CGTGTCCGCCGGGCAACTCCAGCCGAGGCCTGGGCTTCTGCCTGCAGGTGTCTGCGGCGAGGCCCCTAGGGTACAGCCCGATTTGGCCCC ATGGTGGGTTTCGGGGCCAACCGGCGGGCTGGCCGCCTGCCCTCTCTCGTGCTGGTGGTGCTGCTGGTGGTGATCGTCGTCCTCGCCTTC AACTACTGGAGCATCTCCTCCCGCCACGTCCTGCTTCAGGAGGAGGTGGCCGAGCTGCAGGGCCAGGTCCAGCGCACCGAAGTGGCCCGC GGGCGGCTGGAAAAGCGCAATTCGGACCTCTTGCTGTTGGTGGACACGCACAAGAAACAGATCGACCAGAAGGAGGCCGACTACGGCCGC CTCAGCAGCCGGCTGCAGGCCAGAGAGGGCCTCGGGAAGAGATGCGAGGATGACAAGGTTAAACTACAGAACAACATATCGTATCAGATG GCAGACATACATCATTTAAAGGAGCAACTTGCTGAGCTTCGTCAGGAATTTCTTCGACAAGAAGACCAGCTTCAGGACTATAGGAAGAAC AATACTTACCTTGTGAAGAGGTTAGAATATGAAAGTTTTCAGTGTGGACAGCAGATGAAGGAATTGAGAGCACAGCATGAAGAAAATATT AAAAAGTTAGCAGACCAGTTTTTAGAGGAACAAAAGCAAGAGACCCAAAAGATTCAATCAAATGATGGAAAGGAATTGGATATAAACAAT CAAGTAGTACCTAAAAATATTCCAAAAGTAGCTGAGAATGTTGCAGATAAGAATGAAGAACCCTCAAGCAATCATATTCCACATGGGAAA GAACAAATCAAAAGAGGTGGTGATGCAGGGATGCCTGGAATAGAAGAGAATGACCTAGCAAAAGTTGATGATCTTCCCCCTGTGATGAGG TGTCTGGGGATCCCTACCCGTGTGATCACCAACTTCGACTCTGGCCACGATACAGATGGAAACCTGATCATAGATGAGTATTATGACAAC ACAGGCAGGATTTTGGGGAATAAGAAGAAGGATACTATCTGGAACTTCCATGTCTGGAATGAGTGCTGGATGGCCCGGAAGGATCTGCCC CCTGCATATGGAGGCTGGCAGGTGCTGGACGCCACACCTCAGGAGATGAGCAACGGCGTCTACTGCTGTGGCCCTGCCTCTGTCAGAGCC ATCAAAGAAGGAGAAGTGGACCTGAACTATGACACGCCCTTTGTGTTTTCGATGGTGAATGCTGACTGCATGTCCTGGCTCGTCCAGGGA GGGAAGGAGCAGAAGCTTCACCAGGACACGAGTTCTGTTGGCAATTTTATCAGCACAAAGAGCATCCAGAGTGACGAGCGGGATGACATC ACAGAGAACTACAAGTATGAAGAAGGATCCCTCCAGGAGAGGCAGGTGTTTCTGAAGGCTCTGCAGAAGCTGAAGGCTAGAAGCTTCCAT GGCTCCCAAAGAGGAGCAGAGTTGCAACCTTCCAGGCCCACATCACTGAGCCAGGACAGCCCTCGGAGCCTGCATACACCTTCCCTTCGA CCCAGTGATGTGGTGCAAGTCTCCCTGAAATTCAAGCTGCTCGACCCGCCCAACATGGGCCAGGATATATGCTTTGTCCTGCTGGCCCTC AACATGTCCTCCCAGTTCAAGGACCTCAAAGTGAACCTGAGTGCCCAGTCTCTGCTGCACGATGGCAGCCCCCTGTCCCCATTCTGGCAG GACACAGCGTTCATCACACTCTCTCCTAAAGAAGCAAAGACCTACCCCTGCAAAATCTCCTATTCCCAGTACAGCCAGTACCTGTCAACA GACAAGCTGATCCGCATCAGTGCCCTGGGTGAAGAGAAAAGCAGTCCTGAGAAAATCCTGGTGAACAAGATCATCACCTTATCTTATCCA AGCATCACGATTAATGTTCTAGGAGCAGCCGTTGTGAACCAGCCACTCTCCATACAGGTGATATTTTCAAACCCCCTCTCGGAGCAGGTT GAGGACTGTGTGCTGACTGTGGAAGGAAGTGGCCTCTTCAAGAAACAGCAGAAAGTCTTCCTTGGAGTCCTCAAACCCCAACACCAAGCA AGCATCATTCTGGAGACCGTCCCCTTCAAGAGTGGACAAAGGCAGATCCAAGCTAATATGAGAAGCAACAAGTTTAAGGACATTAAGGGT |
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FusionGenePPI for CASC4_TGM5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CASC4 | VDR, ELAVL1, APP, GRAMD3, PTPN1, PTPN2, SYNC, SPPL2B, TRIM25 | TGM5 | CCDC51, SPICE1, RFTN1, UBB, FTH1, ZNHIT6, DOCK7, PDZD11, EIF4E2, TWISTNB, VWA9 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CASC4_TGM5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CASC4_TGM5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CASC4 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Tgene | TGM5 | C1853354 | Peeling skin syndrome, acral type | 1 | CTD_human;ORPHANET;UNIPROT |
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